Protein Alignment Tmc and tmc-1

DIOPT Version :9

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: NP_508221.3
• Gene: tmc-1 / 188483
• WormBaseID: WBGene00020490
• Length: 1285
• Species: Caenorhabditis elegans
• Alignment Length: 1788
• Identity: 445/1788 - (24%)
• Similarity: 664/1788 - (37%)
• Gaps: 621/1788 - (34%)

  Fly   206 SSRRASSPMDHV-----------LDSVERRRSSVYTTSSE----------------EGTNQESTQ 243
            ::||||...:|.           .||:..|.||..|...|                :|..|..|.
 Worm     4 AARRASLRKEHTPTNEKFGDLSKQDSLGERASSKLTLDDELYDILYAFGETDAFINKGDKQRETD 68

  Fly   244 EQ--------IFENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRD 300
            |.        :.|.||..||||..::.|.|.:.:|.:.::.|:.|:.:||.      .:|||
 Worm    69 EDGNPLTRQALLERIRQKKEVIGKLRCQAWSMTRKRRTLKLAQKYLEQHES------KVSRS--- 124

  Fly   301 LWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIP 365
              ..:...|..|.|..||..::|.|.|||||.:||.|||||||.|:||||||||:::|||||.:.
 Worm   125 --HLYMEEMRKRARLMKRSFSNFKTYLIPWESKIKRIESHFGSVVSSYFTFLRWIVFVNIMITLI 187

  Fly   366 LVAFVIGPEYFAT------KHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPMFYGYYSSTS 424
            .:.||:.||..|.      :...|..||::...|...|..|...|.::|||:|||:||||||...
 Worm   188 ALVFVVLPETLADSVANEGRFNRTKTRKQIPANERVHADELAVVWHYDGYLRYSPLFYGYYSDDP 252

  Fly   425 GISTS-GYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLS-SKDDECVFSWKLFTGWDFMIG 487
            .:... .|.||||||:..:.::.|||.|.|||||.|:|.|||| ||.::.:|:||||||||:.||
 Worm   253 FLGNKIKYALPLAYFMVTLTIFAYSFFAILRKMAANARMSKLSGSKAEQYIFNWKLFTGWDYTIG 317

  Fly   488 HAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQ---RILVNILVMGLLGLSGATVVLLVN 549
            ::|||.|.:.:||:..:|::   |:.|||......:||   |:..||::..:||.|...::..|.
 Worm   318 NSETASNTVMAVVIKLRESI---ADIKKDAHGKFRLLQFSLRVFANIIICAMLGFSIYCIIFAVQ 379

  Fly   550 HSEDLAKHDNWLSRNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLYSL 614
            .|: :....|..::|.|...::.::...||||:.:|..||:|||..||..|.|::||..:|..:|
 Worm   380 KSQ-VQDDGNLFTKNQVPSVVSTITHVFPMIFDLIGKMENYHPRTALRAHLGRVLILYTVNYITL 443

  Fly   615 MFSFIYKINSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDSTSTA 679
            :|:                            |...:.|||....:||            .|:|..
 Worm   444 IFA----------------------------LFEKMTALRDRVNSTS------------TSSSHR 468

  Fly   680 TWGEDGGGLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAMVPP 744
            |..:.||                     :|                             |.|..|
 Worm   469 TKRQQGG---------------------WN-----------------------------PNMQRP 483

  Fly   745 TLPTTLPTTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPTTTT 809
                                                                             
 Worm   484 ----------------------------------------------------------------- 483

  Fly   810 TSPWTTLPPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIPNST 874
                   ||..:..|....::.....|....|.:.:
 Worm   484 -------PPYASRAEVRQMSDFLAANTRRFQTVSQR----------------------------- 512

  Fly   875 TNSATLSTIPATLNTTNLPLNSTTKLTTTTSTEKPQ-GEDNFIYTTGEDEGSYDYGSDSTSDAPD 938
                                  ||:..||..|..|| |.    :........:..|:.|||
 Worm   513 ----------------------TTRSVTTPFTVAPQFGP----FNVNNPNAVFHNGTHSTS---- 547

  Fly   939 NNSYSDITDYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKYSR 1003
                               |:.|....:|                          .|.||.. .|
 Worm   548 -------------------FESQILGPKA--------------------------LPIFTPP-PR 566

  Fly  1004 RHRNESAVSAGQPRETTESVNATPSRWPFNWASFRQTTPRTTT-TRRVPSGILTKEEWERLRRLR 1067
            ::...:..:.||               .|....|    ||... |:..|           |.|:|
 Worm   567 KYPGFTPGNVGQ---------------QFGGPDF----PRNQVYTKSTP-----------LPRVR 601

  Fly  1068 GRITTTTSTSTTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTTE 1132
                            .:|.|.|.||...|.    :..:.|.:.:.|:..|::.|..|....:.|
 Worm   602 ----------------TKPPWVYTTTHPPLV----QNRAMTTTMSKSAKKGNSKNLDDDILLSNE 646

  Fly  1133 EDEYTTTEGSENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTTQ 1197
            .                  :.:||......:||.:
 Worm   647 T------------------IQMSEAALRRNHDGHN------------------------------ 663

  Fly  1198 SSDSKQLTTVKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAPL 1262
                                                ..:||||.:|||:.|::..|.:.:|::.|
 Worm   664 ------------------------------------NDICWETIIGQEIVKLVTMDLIFTILSIL 692

  Fly  1263 CIDFLRALFVRYVNQNWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVKL 1327
            .||..|.|:::|.:..||||:|.|||:||:||:|||:|.:|||||.:|:|:||:|.|..||.:||
 Worm   693 VIDLFRGLWIKYCSSWWCWDIETTFPEYGEFKVAENVLHIINNQGMIWLGLFFAPLLPAINNIKL 757

  Fly  1328 MIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSEY 1392
            :|:||.|.|.|:|||||...:|:||:|:||||.:||..|.||.||||:.|..:.||..||||:.|
 Worm   758 IILMYIRGWAVMTCNVPAREIFRASRSSNFYLGILLIWLLLCTLPVGFVIASMSPSRSCGPFARY 822

  Fly  1393 NRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLRTQLQ 1457
            ......:|......:.:.:...:.::.|...|||::|.||||||:|.||...|||||.||:.||.
 Worm   823 QHFYTVVTREIEKRVDQTVLSYIRHIASPGVVIPIILFLILIIYFLFSLVRGLREANTDLQAQLV 887

  Fly  1458 KEREEERKKIFK---------------------VP--EVKQAEPTATTLTNRWRKV--LEASSPV 1497
            .||.||:||||:                     :|  |.::.||        ||:.  :||...:
 Worm   888 HERTEEKKKIFELAGGKKNKFEKDRDKKRSNDYIPLIEQRRREP--------WRQYHEMEADHAL 944

  Fly  1498 TPTQPPDFDTEEYKNQARKELISRIMKKALRKGSATSDEDSF--------VRRDDDDTDTEHQDS 1554
            ......:.|..|.::..|:.|.:..: :|:.....|....:|        ..|:.:|.::...|.
 Worm   945 ASDSSEESDINEDEDDERQPLTAYPL-RAIETPPETLQVTAFHPSLGSLIENREMEDEESASGDQ 1008

  Fly  1555 LP--HDEEAKDKRF-GLSRLQQIRRTRKPSLVDI----VQIAKQERARAGSIVAGTSSSGTGNFP 1612
            ||  |    |...| |.|.:|..:.....|...|    :|:|..|..||  ::.....:..|
 Worm  1009 LPMIH----KSVSFQGPSHMQMRQSISTESCSQISRSAIQVATPEEIRA--LLRPYLEAKYG--- 1064

  Fly  1613 IKETHPKSRFKVEKHERKDRGSMKDKKDTRHRQSPQQQQQPPPYESPKDNEHDPDTNSRIVSASL 1677
            |...|....|.::.|        ....:|..|:|.:.......|      ||..|.:...|::::
 Worm  1065 IPYQHGIKSFPIDVH--------TPPNNTPSRRSSKYNSFVSLY------EHTRDDHKNFVASTI 1115

  Fly  1678 LRRHKEQAEGEEPPTTPDAPQTPNSPVEP---------VEQALEESTPETPTLAKSKFHIVDEKK 1733
                   .|.:|.|...|..||.:..|.|         ..:||.|.       .|||..::..|.
 Worm  1116 -------KETDEDPGKSDKKQTSSKDVAPDFMPWPSADEARALREK-------MKSKTPLMLTKT 1166

  Fly  1734 PPPHEVEDKPLPTPKESGSGGGSLGKFKFRKHKFKSNNVAAVKPEPEVFKFDERSVERSSDVPAT 1798
                .||:||         .||...:.:||            .|.|...|::.::.|..::...|
 Worm  1167 ----TVEEKP---------KGGKSSESEFR------------PPVPIHRKYNIQTTEEENEEEET 1206

  Fly  1799 HAAEYLNNEPSGTEEQDRSLPSPTPSQGQGHHQRQLSVLSRQGRKKIGNLLALVREAVNLKKDDV 1863
            .:|      |..::::.|...|||.:.......|        .:.||                 |
 Worm  1207 DSA------PESSKKRFRISVSPTKTIAPASASR--------AQHKI-----------------V 1240

  Fly  1864 EQAGSDES------PGPTTPTYLAYTPPPPPSV 1890
            .||.|..|      |.|.....|...|...|.|
 Worm  1241 SQASSSSSIPHGRQPDPNKKASLVLPPLRAPRV 1273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101	54/105 (51%)
		DUF612	<1447..1844	CDD:282585	96/445 (22%)
tmc-1	NP_508221.3	TMC	672..778	CDD:285101	54/105 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166703
Domainoid	1	1.000	151	1.000	Domainoid score	I2661
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	531	1.000	Inparanoid score	I661
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000928
OrthoInspector	1	1.000	-	-		otm14504
orthoMCL	1	0.900	-	-		OOG6_104383
Panther	1	1.100	-	-	LDO	PTHR23302
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X599
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980