Protein Alignment Tmc and TMC8

DIOPT Version :9

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: XP_024306385.1
• Gene: TMC8 / 147138
• HGNCID: 20474
• Length: 738
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 80/283 - (28%)
• Similarity: 130/283 - (45%)
• Gaps: 38/283 - (13%)

  Fly  1237 CWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFV-RYVNQNWCWDMEKTFPQYGDFKIAENIL 1300
            |||.|:|:||.|:.:|:.|:::.....:...|.|.| |:..:.|.| :|:.     :|.:.:|:|
Human   422 CWENSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAW-LERE-----EFLVPKNVL 480

  Fly  1301 TLINNQGQVWMGIFFSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLLTM 1365
            .::..|...|||:|:.|.|.|:|.|.|.:..|.:.:.:|..:......|:||.|..|:..:||..
Human   481 DIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLLG 545

  Fly  1366 LFLCVLPVGYAI---VW-----LRPSWHCGPFSEYNRIAEFITNTTRNALPKQLHEPLDYLTSSS 1422
            |.|..:|:||.:   .|     :..||.||.|:.|:...:.:.......||......|.||.|.:
Human   546 LLLAAVPLGYVVSSPTWPSLASIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHA 610

  Fly  1423 TVIPLLLLLILIIYYLVSLTGALREANQDLRTQLQKEREEERKKIFKVPEVKQAEPTATTLTNRW 1487
            ...|||::|.|::...||.|.|...|...||.||          :::|.|             :|
Human   611 FSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQL----------VWQVQE-------------KW 652

  Fly  1488 RKVLEASSPVTPTQPPDFDTEEY 1510
            ..|.:.|..:....|.|....:|
Human   653 HLVEDLSRLLPEPGPSDSPGPKY 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101	29/106 (27%)
		DUF612	<1447..1844	CDD:282585	13/64 (20%)
TMC8	XP_024306385.1	TMC	422..532	CDD:311658	34/115 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910