Protein Alignment Tmc and Tmc1

DIOPT Version :9

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: NP_083229.1
• Gene: Tmc1 / 13409
• MGIID: 2151016
• Length: 757
• Species: Mus musculus
• Alignment Length: 1312
• Identity: 285/1312 - (21%)
• Similarity: 432/1312 - (32%)
• Gaps: 583/1312 - (44%)

  Fly   176 DDEESYTISVSAIMQRRASVRGYRGKRGSRSSRRASSPMDHVLDSVER------RRSSVYTTSSE 234
            |.|||.:......:.||.|:|..| || :|.......|.....|...|      ||..:...:.|
Mouse    12 DTEESSSEEEEDKLPRRESLRPKR-KR-TRDVINEDDPEPEPEDEETRKAREKERRRRLRRGAEE 74

  Fly   235 EGTNQESTQEQIFENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTR 299
            |....|...|::...:..::::|.:||.:||.:.||::::::||.:|:.:||||      .:...
Mouse    75 EEEIDEEELERLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGAL------GKGKG 133

  Fly   300 DLWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAI 364
            ..|..||::||.:|..:.|:..:|....:|||.:||.|||.|||.|||||.||||:..||:::.:
Mouse   134 KKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFV 198

  Fly   365 PLVAFVIGPEY-FATKHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPMFYGYYSSTSGIST 428
            ...:.::.||| :...:|.. |||.:...|...|.|....::|.|..:||.:|||||.:...|..
Mouse   199 LTFSLIMLPEYLWGLPYGSL-PRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGW 262

  Fly   429 SGYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAH 493
            ..::|||:|||..::...|||:..|:.|.:|..:.. ...|:...||||:|..||::||:.|||.
Mouse   263 LNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDG-GGDDNTFNFSWKVFCSWDYLIGNPETAD 326

  Fly   494 NRIASVVVGFKEALLEEAEKKKDNRNWRVILQRILVNILVMGLLGLSGATVVLLVNHSEDLAKHD 558
            |:..|:.:.||||::||...:.:.....:...|.|.|..|...||.||..:...|..|::.|:.|
Mouse   327 NKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQD 391

  Fly   559 ----NWLSRNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLYSLMFSFI 619
                .|..:|.:|:.|:||..|.|.:|:.....|::||...|:..|.||..|.:.|||..:.:.:
Mouse   392 PDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALM 456

  Fly   620 YKINSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDSTSTATWGED 684
            .:||:        |:|.|
Mouse   457 DEINN--------KIEEE----------------------------------------------- 466

  Fly   685 GGGLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAMVPPTLPTT 749
                                                         .|:..|:|
Mouse   467 ---------------------------------------------KLVKANIT------------ 474

  Fly   750 LPTTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPTTTTTSPWT 814
                                                          :|
Mouse   475 ----------------------------------------------LW----------------- 476

  Fly   815 TLPPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIPNSTTNSAT 879
                                                                             
Mouse   477 ----------------------------------------------------------------- 476

  Fly   880 LSTIPATLNTTNLPLNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDSTSDAPDNNSYSD 944
                                            |.|.|                       .:|
Mouse   477 --------------------------------EANMI-----------------------KAY-- 484

  Fly   945 ITDYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKYSRRHRNES 1009
                                                                          |||
Mouse   485 --------------------------------------------------------------NES 487

  Fly  1010 AVSAGQPRETTESVNATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERLRRLRGRITTTT 1074
            .                                         ||:
Mouse   488 L-----------------------------------------SGL-------------------- 491

  Fly  1075 STSTTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTTEEDEYTTT 1139
                                                      .|:||.|
Mouse   492 ------------------------------------------SGNTTGA---------------- 498

  Fly  1140 EGSENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTTQSSDSKQL 1204
                  |::|...|:                        |:|.
Mouse   499 ------PFFVHPADV------------------------PRGP---------------------- 511

  Fly  1205 TTVKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAPLCIDFLRA 1269
                                            ||||.:|||..::.|.|.|.:.|..|..|||||
Mouse   512 --------------------------------CWETMVGQEFVRLTVSDVLTTYVTILIGDFLRA 544

  Fly  1270 LFVRYVNQNWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVKLMIMMYFR 1334
            .|||:.|..||||:|..:|.|.:|.|:.|:|.||.|||.:|||.||:|.|..||:::|...|||:
Mouse   545 CFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQ 609

  Fly  1335 SWIVLTCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSEYNRIAEFI 1399
            .|.|:.||||...|||||:||||||.:||.:|||..:||.|.||.|.||:.|||||..||:.|.|
Mouse   610 CWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVI 674

  Fly  1400 TNTTRNALPKQLHEPLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLRTQLQKEREEER 1464
            ..|..:..|..:.:.|..|::...||.::|:::|.||||.:.....:.||.||:.:::::..|.:
Mouse   675 GETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENK 739

  Fly  1465 KKIFKVPEVKQA 1476
            .:..|:...:.|
Mouse   740 MRNKKMAAARAA 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101	52/105 (50%)
		DUF612	<1447..1844	CDD:282585	7/30 (23%)
Tmc1	NP_083229.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..74		17/63 (27%)
		TMC	517..623	CDD:285101	52/105 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849493
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000928
OrthoInspector	1	1.000	-	-		otm43258
orthoMCL	1	0.900	-	-		OOG6_104383
Panther	1	1.100	-	-	O	PTHR23302
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840