Protein Alignment Tmc and TMC2

DIOPT Version :10

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: XP_005260717.1
• Gene: TMC2 / 117532
• HGNCID: 16527
• Length: 931
• Species: Homo sapiens
• Alignment Length: 1459
• Identity: 329/1459 - (22%)
• Similarity: 489/1459 - (33%)
• Gaps: 645/1459 - (44%)

  Fly    99 DRGGWQMQSSADAKREFYKGQRGRRAASQEDHRSYELNDFPLQNQSSDAESCHQEPHFAHQRSPG 163
            ||.|.:..|....|.|...|:||.:.:.:|..........|.:.|:....  |:|.
Human    54 DRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRR--HREE--------- 107

  Fly   164 IGFDEDGGGGDIDDEESYTISVSAIMQRRASVRGYRGKRGSRSSRRASSPMDHVLDSVERR---- 224
            :|..|.|..                 :|....|..|.:|.|...|.|:...:..:...|.:
Human   108 LGEQERGEA-----------------ERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQ 155

  Fly   225 ---RSSVYTTSSEEGTN-QESTQEQIFENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHE 285
               |||...:|:..|.: .|....||.|.:...|::|.:::.:|||:.|||..:|:|:.:|.::|
Human   156 KKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYE 220

  Fly   286 GALQERFAMSRSTRDLWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFT 350
            |||.:     ...:.|:| :|:|||.:|..:||:..:|.|..||||::||:|||||||.|||||.
Human   221 GALGK-----GKGKQLYA-YKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFI 279

  Fly   351 FLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPM 415
            ||||:..||:::...:...||.||........:.|||.:...|...|.:....|:||||:|||.:
Human   280 FLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSAL 344

  Fly   416 FYGYYSSTSGISTSGYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFT 480
            |||||::...|....|:||:|||:..|.|:.||.:..:|.||.|::.|....:.|...||:|:||
Human   345 FYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFT 409

  Fly   481 GWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQRILVNILVMGLLGLSGATVV 545
            .||::||::|||.|:.||:...|||::::|.|..|:.........|:|.|.|::..|..||..:.
Human   410 SWDYLIGNSETADNKYASITTSFKESIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIY 474

  Fly   546 LLVNHSEDLAKHDN--WLSRNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNM 608
            .:|..|:..:|..|  |..||.|.:.|:||..|.|.:||.:...||:|||..|:.||.||..|.:
Human   475 FVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFL 539

  Fly   609 LNLYSLMFSFIYKINSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFD 673
            .|||:.:.:.:..::        |||.||             |.::.:|..| |:....|.|
Human   540 GNLYTFLLALMDDVH--------LKLANE-------------ETIKNITHWT-LFNYYNSSG--- 579

  Fly   674 DSTSTATWGEDGGGLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTT 738
                   |.|                 :|.|
Human   580 -------WNE-----------------SVPR---------------------------------- 586

  Fly   739 PAMVPPTLPTTLPTTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEET 803
                ||..|..:|
Human   587 ----PPLHPADVP---------------------------------------------------- 595

  Fly   804 SPTTTTTSPWTTLPPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDT 868
                                                                             
Human   596 ----------------------------------------------------------------- 595

  Fly   869 EIPNSTTNSATLSTIPATLNTTNLPLNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDST 933
                                                                             
Human   596 ----------------------------------------------------------------- 595

  Fly   934 SDAPDNNSYSDITDYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFT 998
                                                                             
Human   596 ----------------------------------------------------------------- 595

  Fly   999 SKYSRRHRNESAVSAGQPRETTESVNATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERL 1063
                                                                             
Human   596 ----------------------------------------------------------------- 595

  Fly  1064 RRLRGRITTTTSTSTTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSS 1128
               ||
Human   596 ---RG------------------------------------------------------------ 597

  Fly  1129 STTEEDEYTTTEGSENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPD 1193
                                                                             
Human   598 ----------------------------------------------------------------- 597

  Fly  1194 STTQSSDSKQLTTVKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSI 1258
                                                      .||||::|.|..::.|.|.|::.
Human   598 ------------------------------------------SCWETAVGIEFMRLTVSDMLVTY 620

  Fly  1259 VAPLCIDFLRALFVRYVNQNWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLIN 1323
            :..|..|||||.|||::|..||||:|..||.|.:|.|:.|:|.||.|||.:|||.|::||||.||
Human   621 ITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGIN 685

  Fly  1324 LVKLMIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGP 1388
            :::|:..|||:.|.|::.|||||.|||||:|||||:.|||.:|||.:|||.|.|:.|.||:.|||
Human   686 VLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGP 750

  Fly  1389 FSEYNRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLR 1453
            ||..||:.:.:..|..|..|..|.:...:|.:...:||.:||:.|.||||.|::.:|..||..||
Human   751 FSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLR 815

  Fly  1454 TQLQ--KEREEERKKIFKVPEVKQAEPT-------ATTLTNRWRKVLEASSPVTPTQPPDFDTEE 1509
            .::|  :|.|:..|.:......:.:|.|       ||.|    :...|.::|.:.:|....|
Human   816 KKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQL----QLTKEETTPPSASQSQAMD--- 873

  Fly  1510 YKNQARKELISRIMKKALRKGSATSDEDS 1538
                          |||  :|..||:..|
Human   874 --------------KKA--QGPGTSNSAS 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1237..1352	CDD:462275	60/114 (53%)
TMC2	XP_005260717.1	PRK12678	49..>155	CDD:237171	25/128 (20%)
		SF-CC1	95..>218	CDD:273721	34/150 (23%)
		TMC	599..714	CDD:462275	60/114 (53%)