Protein Alignment Tmc and TMC1

DIOPT Version :9

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: XP_016869745.1
• Gene: TMC1 / 117531
• HGNCID: 16513
• Length: 761
• Species: Homo sapiens
• Alignment Length: 1320
• Identity: 282/1320 - (21%)
• Similarity: 427/1320 - (32%)
• Gaps: 590/1320 - (44%)

  Fly   167 DEDGGGGDIDDEESYTISVSAIMQRRASVRGYRGKRGSRSSRRASSPMDHVLDSVERR-RSSVYT 230
            ||.......::||     |...:.||.|:|..| || :|.......|.....|...|: |.....
Human    16 DETEESSSEEEEE-----VEDKLPRRESLRPKR-KR-TRDVINEDDPEPEPEDEETRKAREKERR 73

  Fly   231 TSSEEGTNQESTQEQIFENIRLH----KEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQER 291
            ...:.|..:|...|:..|.::..    :::|.:||.:||.:.||::::::||.:|:.:||||
Human    74 RRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGAL--- 135

  Fly   292 FAMSRSTRDLWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLM 356
               .:.....|..||::||.:|..:.|:..:|....:|||.:||.|||.|||.|||||.||||:.
Human   136 ---GKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMY 197

  Fly   357 WVNIMIAIPLVAFVIGPEY-FATKHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPMFYGYY 420
            .||:::.|...:.::.||| :...:|.. |||.:...|...|.|....::|.|..:||.:|||||
Human   198 GVNMVLFILTFSLIMLPEYLWGLPYGSL-PRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYY 261

  Fly   421 SSTSGISTSGYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFM 485
            .:...|....::|||:|||..::...|||:..|:.|.:|..:.. ...|:...||||:||.||::
Human   262 DNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDG-GGDDNTFNFSWKVFTSWDYL 325

  Fly   486 IGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQRILVNILVMGLLGLSGATVVLLVNH 550
            ||:.|||.|:..|:.:.||||:.||...:.:.....:...|.|.|..|...||.||..:...|..
Human   326 IGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKR 390

  Fly   551 SEDLAKHD----NWLSRNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNL 611
            |::.|:.|    .|..:|.:|:.|:||..|.|.:|:.....|::||...|:..|.||..|.:.||
Human   391 SQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNL 455

  Fly   612 YSLMFSFIYKINSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDST 676
            |..:.:.:.:||:        |:|.|
Human   456 YVFILALMDEINN--------KIEEE--------------------------------------- 473

  Fly   677 STATWGEDGGGLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAM 741
                                                                 .|:..|:|
Human   474 -----------------------------------------------------KLVKANIT---- 481

  Fly   742 VPPTLPTTLPTTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPT 806
                                                                  :|
Human   482 ------------------------------------------------------LW--------- 483

  Fly   807 TTTTSPWTTLPPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIP 871
                                                                             
Human   484 ----------------------------------------------------------------- 483

  Fly   872 NSTTNSATLSTIPATLNTTNLPLNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDSTSDA 936
                                                    |.|.|
Human   484 ----------------------------------------EANMI-------------------- 488

  Fly   937 PDNNSYSDITDYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKY 1001
                                                                             
Human   489 ----------------------------------------------------------------- 488

  Fly  1002 SRRHRNESAVSAGQPRETTESVNATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERLRRL 1066
                                                                             
Human   489 ----------------------------------------------------------------- 488

  Fly  1067 RGRITTTTSTSTTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTT 1131
                                                                   .|:::|.|
Human   489 -------------------------------------------------------KAYNASFS-- 496

  Fly  1132 EEDEYTTTEGSENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTT 1196
                    |.|...|::|...|:                        |:|.
Human   497 --------ENSTGPPFFVHPADV------------------------PRGP-------------- 515

  Fly  1197 QSSDSKQLTTVKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAP 1261
                                                    ||||.:|||..::.|.|.|.:.|..
Human   516 ----------------------------------------CWETMVGQEFVRLTVSDVLTTYVTI 540

  Fly  1262 LCIDFLRALFVRYVNQNWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVK 1326
            |..|||||.|||:.|..||||:|..:|.|.:|.|:.|:|.||.|||.:|||.||:|.|..||:::
Human   541 LIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILR 605

  Fly  1327 LMIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSE 1391
            |...|||:.|.|:.||||...|||||:||||||.:||.:|||..:||.|.||.|.||:.|||||.
Human   606 LHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSG 670

  Fly  1392 YNRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLRTQL 1456
            .||:.|.|..|..:..|..:.:.|..|::...||.::|:::|.||||.:.....:.||.||:.::
Human   671 KNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKM 735

  Fly  1457 QKEREEERKKIFKVPEVKQA 1476
            :.:..|.:.:..|:...:.|
Human   736 KMQALENKMRNKKMAAARAA 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101	52/105 (50%)
		DUF612	<1447..1844	CDD:282585	7/30 (23%)
TMC1	XP_016869745.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000928
OrthoInspector	1	1.000	-	-		otm41193
orthoMCL	1	0.900	-	-		OOG6_104383
Panther	1	1.100	-	-	O	PTHR23302
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.840