DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmc and tmc3

DIOPT Version :9

Sequence 1:NP_001303362.1 Gene:Tmc / 26067066 FlyBaseID:FBgn0267796 Length:2036 Species:Drosophila melanogaster
Sequence 2:XP_021333389.1 Gene:tmc3 / 101882109 -ID:- Length:1153 Species:Danio rerio


Alignment Length:1783 Identity:421/1783 - (23%)
Similarity:625/1783 - (35%) Gaps:755/1783 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 ESYTISVSAIMQRR-ASVRGYRGKRGSRSSRRASSPMDHVLDSVERRRSSVYTTSSEEGTNQEST 242
            |..||:...|..:| .|:|        ::|||..||.        ...:.......::|...:|.
Zfish     3 EPATITRPLISSKRHKSIR--------KNSRRIYSPY--------HDNNGPSDDEDKDGERVDSN 51

  Fly   243 Q-EQIFENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRDLWARFK 306
            . |::|:||:..||:|.:::::|||||:|||:::||:..|.::||.|........:..||..:. 
Zfish    52 DPEEMFQNIQFQKEIIANIRIKPWPIRRKLKVLKQAREIVLKYEGRLTRTRGYQAAGADLLKKI- 115

  Fly   307 ILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVI 371
                      .|...:.:.:.||||:|||:|||||||||||||.|||||..:||::.|...||::
Zfish   116 ----------SRVLYNIVVLFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIV 170

  Fly   372 GPEY-----FATKHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPMFYGYYSSTSGISTSGY 431
            .||.     |.|...:|.|::..:.     |.:|.|.|...|||:||.:|||||.:...|.::||
Zfish   171 LPELLAGAPFGTTRSKTIPKEHFAS-----AQDLDTIWSLGGYLQYSVLFYGYYGNVRKIGSAGY 230

  Fly   432 KLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAHNRI 496
            :|||||||..:.|:.|||:..|||||:|||.|...:.|:...|.|::|..||::||:.|.|.::.
Zfish   231 RLPLAYFLVGMAVFAYSFITLLRKMAKNSRMSLAGASDENYTFCWRVFCAWDYLIGNLEAAESKG 295

  Fly   497 ASVVVGFKEALLEEAEKKKDNRNWRVILQRILVNILVMGLLGLSGATVVL--LVNHSEDLAKHDN 559
            |::|...:||::||.|||||.....:|..|||.||||  ||.|:|:..::  :|:.|:.|.:...
Zfish   296 AAIVNSIREAIVEEQEKKKDTSLAVLISLRILANILV--LLSLTGSIYIIYFVVDRSQKLEQEKP 358

  Fly   560 WLS---RNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLYSLMFSFIYK 621
            .|:   :|.|:|.::|::...|..||.:...|.:|||..||.||||:::|.:.|||||:.:.:.|
Zfish   359 ELTLWEKNEVSVVVSLITMIAPSAFELVSQLEMYHPRTSLRFQLARVLVLYLGNLYSLIIALLDK 423

  Fly   622 INSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDSTSTATWGEDGG 686
            :||                                                              
Zfish   424 VNS-------------------------------------------------------------- 426

  Fly   687 GLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAMVPPTLPTTLP 751
                                                                             
Zfish   427 ----------------------------------------------------------------- 426

  Fly   752 TTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPTTTTTSPWTTL 816
                          :.:|:|..         |..::.:|:..::|...||:              
Zfish   427 --------------MSSAIPVA---------PGNVSDSTSYLATISQPTED-------------- 454

  Fly   817 PPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIPNSTTNSATLS 881
                                                                          .||
Zfish   455 --------------------------------------------------------------NLS 457

  Fly   882 TIPATLNTTNLPLNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDSTSDAPDNNSYSDIT 946
            ||                                                    .||        
Zfish   458 TI----------------------------------------------------VPD-------- 462

  Fly   947 DYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKYSRRHRNESAV 1011
                                                        |||          ||      
Zfish   463 --------------------------------------------LAE----------RH------ 467

  Fly  1012 SAGQPRETTESVNATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERLRRLRGRITTTTST 1076
                      ::..:||                                  |..|...:||..| 
Zfish   468 ----------NITLSPS----------------------------------LLELNNSVTTVKS- 487

  Fly  1077 STTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTTEEDEYTTTEG 1141
               ||||.:| .|.:                                                  
Zfish   488 ---STTTAQP-MRIQ-------------------------------------------------- 498

  Fly  1142 SENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTTQSSDSKQLTT 1206
                         |.:..|:.|:.:|.                   :.:.|              
Zfish   499 -------------SVLNQTVLYEYNSR-------------------SQQDP-------------- 517

  Fly  1207 VKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALF 1271
                                          ||||.:|||:.|:.:.|.:.::.:.|.|||:|.|.
Zfish   518 ------------------------------CWETYVGQEMLKLSIIDMIFTVASILLIDFIRGLV 552

  Fly  1272 VRYVNQNWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVKLMIMMYFRSW 1336
            |||::...|||:|..||:||:||||||:|.||.|||.:|||.||||.|...|::||:.:||.|||
Zfish   553 VRYLSDCCCWDLESKFPEYGEFKIAENVLHLIYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSW 617

  Fly  1337 IVLTCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSEYNRIAEFITN 1401
            .||||||||:.|||||:||||||::||.|||||:||..:|||..|||.:|||||...:|.:.|:.
Zfish   618 AVLTCNVPHQQVFKASRSNNFYLAMLLFMLFLCMLPTIFAIVRYRPSQYCGPFSGQEKIYDIISE 682

  Fly  1402 TTRNALPKQLHEPLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLRTQLQKEREEERKK 1466
            |..|..|....:.:.|:||...|:|.||||.::||||.|:..:|:..|..||.|||.||.|::||
Zfish   683 TIANDFPLWFSKVMSYVTSPVVVLPALLLLFMLIYYLQSIARSLKFTNSQLRLQLQTERTEDKKK 747

  Fly  1467 IFKVPEVKQAEPTATTLTNRWRKVLEASSPVTPTQPPDFDTEEYKNQARKELISRIMKKALRKGS 1531
            :|::...:...|              ......|.|..|..:.|  :.||.....|      |.||
Zfish   748 VFQLAAARLQAP--------------EGGDKNPEQESDITSVE--SSARSASPPR------RNGS 790

  Fly  1532 ATSDEDSFVRRDDDDTDTE--HQDSLPHDEEAKDKRFGLSRLQQIRRTRKPSLVDIVQIAKQERA 1594
            .::.|......|...|.|:  .:..:|....|               ||.|| |.:.|..|.|.|
Zfish   791 VSNFESPIRPADSIQTITQSASRSDVPRAAGA---------------TRSPS-VPVRQKHKAEHA 839

  Fly  1595 RAG--------SIV----------------AGTSSSGTGNFPIKETH-----PKSRFKVEKHERK 1630
            .:.        |:.                :|...|.:|:...|..|     |.:|:....|   
Zfish   840 ASSAHRMYSSPSVPQRQVRQRQVEFIPVRHSGYMGSTSGSSRSKSYHNMAYNPCTRYTENIH--- 901

  Fly  1631 DRGSMKDKKDTRHRQSPQQQQQPPPYESPKD--------------NEHDP-----DTNSRIVSAS 1676
                    .|...|::.:.....|...:.:.              ||||.     .||:||    
Zfish   902 --------SDPLFRKTLRPMHTEPSVITAQSYVGRRAHTTRYVIVNEHDARKKIMRTNTRI---- 954

  Fly  1677 LLRRHKEQAEGEEPPTTPDAPQTPNSPVEPVEQALEESTPETPTLAKSKFHIVDEKKPPPH--EV 1739
              .||..         .||.|:.    ||...:.::...|.||           .:...||  |.
Zfish   955 --PRHYR---------LPDEPEI----VELYPRNVKCYIPRTP-----------HRSHQPHLSEE 993

  Fly  1740 EDKPLPTPKESGSGGGSLGKFKFRKHKFKSNNVAAVKPEPEVF---------------KFDERSV 1789
            |::....||.|...|.|           :..:::.::|.|..:               ..||...
Zfish   994 EEEDEEDPKTSTRRGSS-----------RPKSLSDIRPTPRFYIGDSVNSQLSMEHGIYGDEEEY 1047

  Fly  1790 ERSSDVPATHAAEYLN----------------------NEPSGTEEQDRSLPSPTPSQGQG---- 1828
            .:..|....|.....|                      .|||.||....||.|.:..|...    
Zfish  1048 GQEDDWVNLHPCSQTNVRGPESTHRYGETYVKPKTKHKVEPSLTESDSASLASSSDQQNSSTDQY 1112

  Fly  1829 -----HHQRQLSVLSRQGRKKIGNLLAL 1851
                 :.::.|...::..:||..|.:.|
Zfish  1113 IQVIHNKEKYLKPSAKMTKKKAKNSVTL 1140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TmcNP_001303362.1 TMC 1242..1348 CDD:285101 58/105 (55%)
DUF612 <1447..1844 CDD:282585 94/494 (19%)
tmc3XP_021333389.1 TMC 518..633 CDD:311658 65/114 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000928
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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