DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tmc and tmc3

DIOPT Version :9

Sequence 1:NP_001303362.1 Gene:Tmc / 26067066 FlyBaseID:FBgn0267796 Length:2036 Species:Drosophila melanogaster
Sequence 2:XP_012814975.1 Gene:tmc3 / 100494092 XenbaseID:XB-GENE-981378 Length:1102 Species:Xenopus tropicalis


Alignment Length:1735 Identity:420/1735 - (24%)
Similarity:614/1735 - (35%) Gaps:705/1735 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 SVRGYRGKRGSRSSRRASSPMDHVLDSVERRRSSVY-----TTSSE-----EGTNQESTQEQIFE 248
            ||.|....:.|:|.:|..|         .||::|:|     :.|.|     :|..:.:..|.||:
 Frog     3 SVSGSAALKPSKSMKRYKS---------VRRKASIYRVPPHSNSDEDDDDADGKEENNDPETIFQ 58

  Fly   249 NIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRDLWARFKILMAARW 313
            ||::.||::.:::.:||.:|:||:.:||||..|.::||.|..       ||.    ::...|..|
 Frog    59 NIQIQKEIVANIRCRPWAMRQKLRSLRQAKEIVLKYEGRLTR-------TRG----YQAAGAELW 112

  Fly   314 RHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFAT 378
            |...|...:|..:.||||:|||:|||||||||||||.|||||..:||::.|...|||:.||..|.
 Frog   113 RKLLRVLYNFAVLFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFVVIPEILAG 177

  Fly   379 KHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPMFYGYYSSTSGISTSGYKLPLAYFLTAVL 443
            ....:...|::.|.|...|.:|.|.|...|||:||.:|||||.....|..:||:|||||||..:.
 Frog   178 APFGSTVNKKIPDKEFSSAQDLNTIWSLGGYLQYSVLFYGYYGRERKIGRAGYRLPLAYFLVGMA 242

  Fly   444 VYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAHNRIASVVVGFKEALL 508
            |:.|||:..|||||:|||.|..|:.|:...|.||:|..||::||:.|.:.::.|::|...:||:|
 Frog   243 VFAYSFITLLRKMAKNSRLSMASASDENYTFCWKIFCAWDYLIGNPEASESKTAAIVNSIREAIL 307

  Fly   509 EEAEKKKDNRNWRVILQRILVNILVMGLLGLSGATVVL--LVNHSEDLAKHDNWLS---RNAVNV 568
            ||.||.:.......|..|||.||||  ||.|:|:..::  :|:.|:.|.:....||   :|.|:|
 Frog   308 EEQEKHRSKNLAVTISLRILANILV--LLSLAGSIYIIYFVVDRSQKLERTKIELSLWEKNEVSV 370

  Fly   569 TMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLYSLMFSFIYKINSKEKPLQMLK 633
            .::|::...|..||.:...|.:|||..||.||||:::|.:.|||||:.:.:.|:||         
 Frog   371 VVSLITMIAPSAFELVAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNS--------- 426

  Fly   634 LENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDSTSTATWGEDGGGLFSTTAAAALI 698
            :.|.||                          .||.||                           
 Frog   427 MSNSTN--------------------------DTSTGL--------------------------- 438

  Fly   699 STTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAMVPPTLPTTLPTTFPTTLPTTLP 763
                                                                             
 Frog   439 ----------------------------------------------------------------- 438

  Fly   764 TTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPTTTTTSPWTTLPPSTTTTEATTT 828
                                :.|..|.|.|.|           :|....|               
 Frog   439 --------------------APLYATAAFTMS-----------STAAPDW--------------- 457

  Fly   829 TERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIPNSTTNSATLSTIPATLNTTNLP 893
                    :...|:||                    ::|.:                 ||.||  
 Frog   458 --------DLNRTSTL--------------------ALDMD-----------------LNITN-- 475

  Fly   894 LNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDSTSDAPDNNSYSDITDYSSEPSEIEDF 958
                                                                             
 Frog   476 ----------------------------------------------------------------- 475

  Fly   959 DEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKYSRRHRNESAVSAGQPRETTESV 1023
                        :||                                                  
 Frog   476 ------------MAK-------------------------------------------------- 478

  Fly  1024 NATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERLRRLRGRITTTTSTSTTSTTTRRPRW 1088
                |..|.||     |:|..:.|      ::.|.|                             
 Frog   479 ----SMSPVNW-----TSPVASVT------LVAKNE----------------------------- 499

  Fly  1089 RYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTTEEDEYTTTEGSENRPYYVGYVD 1153
                                                                             
 Frog   500 ----------------------------------------------------------------- 499

  Fly  1154 ISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTTQSSDSKQLTTVKLTPLERKQKR 1218
                                                                             
 Frog   500 ----------------------------------------------------------------- 499

  Fly  1219 LKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFVRYVNQNWCWDM 1283
                              ||||.:|||:.|:.:.|.:.::.:.|.|||.|.|.|||::...|||:
 Frog   500 ------------------CWETYVGQEMLKLSIIDMIFTVASILLIDFFRGLIVRYLSDCCCWDL 546

  Fly  1284 EKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVV 1348
            |..||:||:||||||:|.|:.|||.:|||.||||.|...|:.||:.:||.|||.||||||||:.|
 Frog   547 ESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVFKLIGLMYLRSWAVLTCNVPHQQV 611

  Fly  1349 FKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSEYNRIAEFITNTTRNALPKQLHE 1413
            |:||:||||||::||.|||||:||..:|||..:||.:|||||...:|.:.|:.|.:...|...::
 Frog   612 FRASRSNNFYLAMLLFMLFLCMLPTVFAIVRYKPSVNCGPFSGQEKIYDIISETIKTDFPAWFNK 676

  Fly  1414 PLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLRTQLQKEREEERKKIFKVPEVKQAEP 1478
            .:.|::|...|:|.||||.::||||.|:..:|:..|..||||||.||.|::||:|::...:    
 Frog   677 VMSYVSSPVVVLPALLLLFMLIYYLQSIARSLKFTNNQLRTQLQTERIEDKKKVFQMAIAR---- 737

  Fly  1479 TATTLTNRWRKVLEASSPVTPTQPPDFDTEEYKNQARKELISRIMKKALRKGSATSDEDSFVRRD 1543
                        |:..........||.|....::.||        ....||..:..:.:|.|.:.
 Frog   738 ------------LQNKDGCEKKTEPDSDIISQESSAR--------SSTPRKNGSVVNFESPVSKG 782

  Fly  1544 DDDTDTEHQDSLPHDEEAKDKRFGLSRLQQIRRTRKPSLVDIVQIAKQERARAGSIVAGTSSSG- 1607
                                     ||:|.|  ::..|.||:.|        |.|::...|.|| 
 Frog   783 -------------------------SRIQTI--SQSASRVDVPQ--------AESLIHSPSISGM 812

  Fly  1608 ---------TGNFPIKETH----PKSRFKVEKHERKD----------RGSMKDKKDTRHRQSPQQ 1649
                     |....||::.    .::.:|...|:::|          :|..:...|.....:|..
 Frog   813 PKQRTEHVSTRPSSIKQSGVRDVDRTNYKPILHKKQDHNVFSEPLFRKGIKQSSPDHHGAGAPSF 877

  Fly  1650 QQQPPPYESPKDNEHDPDTNSRIVSASLLRRH-KEQAEGEEPPTTPD-----APQTPNSPVEPVE 1708
            ..:.||......||.  |:..::.|.|.|.|| :.:..|:.....|.     ..|.|..|..|..
 Frog   878 VAKRPPTRYFIVNEQ--DSRMKLCSTSKLPRHFRMEESGDIVELYPRNIRRYVVQHPRRPYSPYL 940

  Fly  1709 QALEESTPETPTLAKSK--FHIVDEKKPPPHEVEDKPLPTPKESGSG------------GGSL-G 1758
            ...||.......:.||.  ..:.|.:.||...:.|:   |..:..||            |..| |
 Frog   941 SEDEEDDLHRVLMRKSNRPHSMSDLRHPPRFYIGDR---TDNQMLSGRDVAKMQYKSWEGSFLDG 1002

  Fly  1759 KFKFRKHKFKSNNVAAVKPEPEVFKFDERSVERSSDVPATHAAEYLNNEPSGTEEQDRSLPSPTP 1823
            :....:.|....|:          ...|..|||...|.:.|..     ||..||....|..|.:.
 Frog  1003 EKLHNRKKIHHKNI----------DLAEHFVERHRKVKSKHKL-----EPCLTESDSVSNTSSSD 1052

  Fly  1824 SQGQGHHQRQLSVLSRQGRKKIGNLLALVREAVNLKKDDVEQAGS 1868
            .|.....| .:.|:..:. |.|.|...|.|:..   |..|:..||
 Frog  1053 QQNSSTDQ-YIQVIHNKD-KFIKNSGKLTRKKA---KTTVDLNGS 1092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TmcNP_001303362.1 TMC 1242..1348 CDD:285101 57/105 (54%)
DUF612 <1447..1844 CDD:282585 92/441 (21%)
tmc3XP_012814975.1 TMC 500..615 CDD:369533 63/114 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 149 1.000 Domainoid score I4409
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 550 1.000 Inparanoid score I1116
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000928
OrthoInspector 1 1.000 - - otm48405
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X599
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
66.050

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