Protein Alignment Tmc and tmc6

DIOPT Version :10

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: XP_004918677.2
• Gene: tmc6 / 100380197
• XenbaseID: XB-GENE-5811999
• Length: 772
• Species: Xenopus tropicalis
• Alignment Length: 731
• Identity: 164/731 - (22%)
• Similarity: 275/731 - (37%)
• Gaps: 237/731 - (32%)

  Fly   135 LNDFPLQNQ-----SSDAESCHQEPHFAHQR---SPGIGFDEDGGGGDIDDEESYTISVSAIMQR 191
            |.|.|..|:     ||..|:..||..|..|:   .|...|.|.      ||..:.|:.:.|.|..
 Frog     6 LLDIPEDNEGDSLGSSTFENGEQETRFGKQQQYTDPDAAFYEQ------DDHLTATMKILANMPS 64

  Fly   192 RASVRG------------YRGKRGSR-----SSRRASSPMDHVLDSV-----ERRRSSVYTTSSE 234
            |...|.            .|.:||.:     |.:|::.|...:.|.|     |::|..|....:.
 Frog    65 RTIGRSQGAMLSEYYNRTMRRRRGRKRPSVYSLQRSARPSLRLRDGVSDEQDEQQRLLVSELQNT 129

  Fly   235 EGTNQESTQEQIFENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTR 299
            .|||:.          ||         |:.:|:  .|.:.|:.|..:....|..::|......|:
 Frog   130 SGTNRS----------RL---------LKSFPL--SLNVKRELKQSINDAGGLWRQRNVNPCCTQ 173

  Fly   300 DLWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAI 364
               .|.::.|... :.|....:.||: |.||.:.:|:|...|||.|.|||.||:.|:..||.::.
 Frog   174 ---LRDEVTMCIH-QCWIFSLSVFLS-LRPWHVALKQIGGRFGSSVLSYFVFLKTLLEFNIFLSF 233

  Fly   365 PLVAFVIGPEYFATKHGETDPRKRMSDPEARVAGNLFTFWEF---EGYLKYSPMFYGYYSS---- 422
            ..:.|::.|:       ...|   ::.|..||    ||..|.   .||...:.|:|||||:
 Frog   234 LCIVFIVIPQ-------AVHP---LNIPNPRV----FTGLELLTGAGYFSSTLMYYGYYSNLTLN 284

  Fly   423 ---TSGISTSG---------YKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVF- 474
               :||.:.:.         |.:||||..|....::.:.:..:.:|:              |.|
 Frog   285 ENCSSGFNITACPAGRAWFPYHMPLAYLFTIGAAFVSTCIILVYRMS--------------CSFG 335

  Fly   475 ------------SWKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQRI 527
                        :.|:|:.|||.:....:...:..::.:..||.|.|..:..:.     |:|::.
 Frog   336 DSFRVGLFRGATAVKVFSSWDFKVTQNRSVQRQRENIHMQLKEMLSERLQSDRP-----VVLKKQ 395

  Fly   528 LVNILVMGL-----LG--LSGATVVLLVNHSEDLAK-HDNWLSRNA----------VNVTMTLLS 574
            |.:|.:..|     ||  |..|.||.|:  ||.|.: |...:.|..          :.:.:::|:
 Frog   396 LKSIFIHTLSWALCLGSWLGAAVVVYLL--SEHLHQDHRARVKRGGEPEVEAMLLPLPLAVSVLN 458

  Fly   575 FFLPMIFEALGLFE-----------------------------NWHPRQQLRL-----------Q 599
            ..||.::.||||:|                             :|..|:...|           :
 Frog   459 LLLPYMYHALGLWEKLDFPVLEVYVAICRNLILKIVVLGVMCYHWLIRKTKFLENKCWETFVGQE 523

  Fly   600 LARIMILNML-NLYSLMF-SFIYKINSKEKPLQMLKLENE--TNTMELKNLLSSIEALRAMTPTT 660
            |.|.:|:::| :|...:| .|:::|..::|..:..:.|.:  .|.:||
 Frog   524 LYRFVIMDLLFSLLDTLFGEFLWRIILEKKYKKKCRTEFDIARNVLEL----------------- 571

  Fly   661 SLYGESTSDGLFDDSTSTATWGEDGGGLFSTTAAAALISTTVQRLKCYNM-TVKCSKLRRNIIS- 723
             :|.:            |..|   .|.||..      :...||.||...: .:|.:.|.||..|
 Frog   572 -IYSQ------------TLAW---LGVLFCP------LLPVVQVLKLLLLFYIKKASLMRNCRSP 614

  Fly   724 -----GKHLATTLMVL 734
                 ..|:.||.:.|
 Frog   615 SKPWRASHMNTTFLTL 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1237..1352	CDD:462275
tmc6	XP_004918677.2	TMC	515..621	CDD:462275	28/144 (19%)