DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmc and LOC100149241

DIOPT Version :9

Sequence 1:	NP_001303362.1	Gene:	Tmc / 26067066	FlyBaseID:	FBgn0267796	Length:	2036	Species:	Drosophila melanogaster
Sequence 2:	XP_017210326.1	Gene:	LOC100149241 / 100149241	-ID:	-	Length:	726	Species:	Danio rerio

Alignment Length:	529	Identity:	125/529 - (23%)
Similarity:	207/529 - (39%)	Gaps:	124/529 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 EDHRSYELN---------DFPLQNQSSDAESCHQEPHFAH--QRSPGIGFDEDGGGGDIDDEESY 181
            ||...:||.         .|.|.:.:.|.|:.:.||...|  |||                  |:
Zfish    13 EDGDLFELEAVWRPNREVRFDLTHANEDIEAHYNEPKHRHTLQRS------------------SW 59

  Fly   182 TISVSAIMQRRASVRGYRGKRGSRSSRRASSPMDHVLDSVERRRSSVYTTSSEEGTNQESTQEQI 246
            :.|...::....|       |..:.::.|:........:.:||..|:.|...:..|:|:...:.
Zfish    60 SSSTQKVLSSMPS-------RSMKWNQAAAVNQSRSTKTQQRRPLSICTEDQDVFTDQDDYVDD- 116

  Fly   247 FENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRDL---WARFKIL 308
                    |:::  |||...:.:..:|:|:....|:.           .|..|:|   |...|..
Zfish   117 --------ELLK--KLQGLSVGESAQLLREMPLSVSE-----------KRQMRELVVCWESGKPR 160

  Fly   309 MAAR-----W----------RHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWV 358
            .|.|     |          ..|.....|    |..|:...|.|.:|||.||.|||.|||.|:..
Zfish   161 SANRPLCLYWFQTCLKKVVHSDWSGRQKS----LQLWQKVFKNISAHFGMGVLSYFVFLRRLLLF 221

  Fly   359 NIMIAIPLVAFVIGPEYFATKHGETDPRKRMSDP--------EARVAGNLFTFWEFE--GYLKYS 413
            |:::.:....|::.|:              :|:|        ||....||   |...  |.|..|
Zfish   222 NLLLMLINGLFLLLPQ--------------LSNPSSSTRTSSEAEHKSNL---WMLTGMGILTDS 269

  Fly   414 PMFYGYYSSTSGIST---SGYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFS 475
            .||||:||.....|:   ..|.:||||..|.......:.|..:..|::....|:.|:.....||
Zfish   270 VMFYGHYSDCQNGSSECFENYNIPLAYIFTFGTGMFVTCVKLVYNMSKAFGKSQSSTNTRSLVF- 333

  Fly   476 WKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQRILVNILVMGLLGLS 540
             |:|..|||.:....:...:..::....|| :|.|...||..||...:|:.:.:::||..:..|.
Zfish   334 -KVFCSWDFKVYKKRSVRLQSVNICTQLKE-MLSELSCKKQKRNLCSMLRWLSLHLLVWSICLLC 396

  Fly   541 GATVVLLVNHSEDLAKHDNWLSRNAVNVTMTLL-------SFFLPMIFEALGLFENWH-PRQQLR 597
            ....:..||:.. |.:..|  |.:|..|.:.:|       |..||::|:.|...|.:: |..::.
Zfish   397 MGACIFAVNYFH-LVRPIN--SHDAEPVYLLILPLAVSAYSRLLPVLFDMLSRVEQYNSPDIRIY 458

  Fly   598 LQLARIMIL 606
            :.:||.::|
Zfish   459 VSIARNLLL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101
Tmc	NP_001303362.1	DUF612	<1447..1844	CDD:282585
LOC100149241	XP_017210326.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840