Protein Alignment Tmc and tmc8

DIOPT Version :9

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: XP_009304608.1
• Gene: tmc8 / 100004462
• ZFINID: ZDB-GENE-081114-2
• Length: 684
• Species: Danio rerio
• Alignment Length: 671
• Identity: 159/671 - (23%)
• Similarity: 272/671 - (40%)
• Gaps: 135/671 - (20%)

  Fly   177 DEESYTISVSAIMQRRASVRGYRGKRGSRSSRRASSPMDHVLDSVERRRSSVYTTSSEEGTNQES 241
            :.|..||:    .||..|...|.....|.|.....:.:..:|.|.:..|.:    .:::.|:.::
Zfish     2 EREDKTIT----FQRLLSDESYSSDLSSDSCEYYQTEIFGLLPSTQTHRRA----HADDITHDQN 58

  Fly   242 TQEQIFENIRLHKEVIQSVKLQPW----PIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRDLW 302
                  |.:||.:..        |    |:| .|.:..|.|..: |....||:|   |..:.|.|
Zfish    59 ------ERLRLDRIC--------WNPNVPLR-NLPVCLQDKRDI-RDRQHLQKR---SIGSWDAW 104

  Fly   303 ARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLV 367
            .|.:  ...| |..|.:....::.|:||...|..||..||.||.:||.|||:|:.:|::..:.:.
Zfish   105 RRSQ--QTTR-RRLKEQVGRAVSGLLPWRHMIHRIEGQFGVGVKAYFVFLRYLLGLNLLYCVIIG 166

  Fly   368 AFVIGPEYFATKHGETDPRKRMSDPE-ARVAGNLFTFWEFEGYLKYSPMFYGYYSSTSGISTSGY 431
            ..|:.|.  ....||:   ....:|: :.:..::|.   ..|.|:.|.:|:.:|:..| :..:..
Zfish   167 GSVLVPT--LVYRGES---TETQNPDWSSLYKDMFV---GSGVLEKSAVFHSFYTRGS-LDGACL 222

  Fly   432 KLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETA---- 492
            ..||.:.|..|.:...|.:..:|:.....::|.::.|......|:|:|:||||.|...:.|
Zfish   223 NTPLLFLLGMVSIIFLSIIMLVRRTVVGYKHSWITGKHFSSNLSYKVFSGWDFSIQSPQAASLKQ 287

  Fly   493 ---HNRIASVVVGFKEALLEEAEKKKDNRNW-RVILQRILVNILVMGLLGLSGATVVLLVNHSED 553
               .|.:.   :..:|.......|::....| |::|.|||:|:.|:.|  |:|:.|  |:.::..
Zfish   288 NFTRNELK---MDLEEQAFHARVKQRTLTQWVRLVLFRILLNLAVLFL--LTGSFV--LIYYAIH 345

  Fly   554 LAKHDNWLSRNAV------NVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLY 612
            |.:.....|...|      .:||||::..||.||..:..||::....||.|.|.|.:.|.:.:|.
Zfish   346 LQQSCTDESTECVMLKYLPPITMTLINIALPRIFTKISEFEDYSLTIQLNLTLIRSIFLKLASLS 410

  Fly   613 SLMFSFI--------YKINSKEKPLQ-------MLKLENETN----TMELKNLLSS-IEALRAMT 657
            ..:|.||        .:...|:|.|:       :|..|||..    .:.:.|||.. ..|.....
Zfish   411 IYLFFFICADKDYQFCQFGQKKKTLKPSQHNRTILCEENEFGKEMYKLTIFNLLEGFFSAFCVAY 475

  Fly   658 PTTSLYGESTSDGL--------FD--------DSTSTATWGEDGGGLFSTTAAAALISTTVQRLK 706
            |.|.|..:..|..|        |:        .::.|..|    .|:|......|:  :|::.|.
Zfish   476 PRTFLVEKFPSSRLAQILGNNQFEITLNVLDLVNSQTVMW----VGVFYCPLLPAI--STLRLLI 534

  Fly   707 CY---NMTVK--CSKLRR-------------NIISGKHLATTLMVLNLT--TPAMVPPTLPTTLP 751
            .|   ..||.  |:..:|             .::.|..::...:|:|:.  .|....|...|.
Zfish   535 LYYIKKFTVMRCCAPAQRMFRTASSSVLFHFTLLLGLFMSVVTLVVNINRFNPGGCGPFSGTR-- 597

  Fly   752 TTFPTT------LPTTLPTTL 766
            |.|..|      ||....:|:
Zfish   598 TVFDVTNDCKEMLPNWAKSTI 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101
		DUF612	<1447..1844	CDD:282585
tmc8	XP_009304608.1	TMC	451..553	CDD:285101	21/107 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910