DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WDY and Wdr95

DIOPT Version :9

Sequence 1:	NP_001303588.1	Gene:	WDY / 26067056	FlyBaseID:	FBgn0267449	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_017176434.1	Gene:	Wdr95 / 381693	MGIID:	1923042	Length:	1099	Species:	Mus musculus

Alignment Length:	1104	Identity:	252/1104 - (22%)
Similarity:	407/1104 - (36%)	Gaps:	333/1104 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TKSAVEYQTISS-------TQSHSAEE----QSERLHKWISKDQLEKLYSSFLNTPERH---VGI 61
            |:..:...::||       |..|.|:.    ::|::.:.::.::|.:|.:.|....:|.   :.:
Mouse    67 TRERMRSHSVSSQEPTHRRTPLHHADPAQSLRAEKIEQQVTLEELRRLNALFQEHEKRGSQLLDM 131

  Fly    62 DELRIILEELDITFNDSM--YTRLFLKINQNRDFKVDWNEFVSYLIFGFQEEDPSSQKE---SLI 121
            :..:.::::...:.:.|:  ..:||:||:.....::.|:.|.:||...:.|:..::.::   ||:
Mouse   132 ETFKCMMKQSLRSHSKSIGQIEQLFMKIDYEAVGRIQWDSFCTYLQLEYSEQAKAAARQAEASLL 196

  Fly   122 LP------ISGPPMVRKSEHRSAICCLALLKAKSDQVPIDEVTETINF------------SFGGE 168
            ||      ..|.|::|            :|....|.:.......||.|            .||
Mouse   197 LPAIQQRLTYGRPVLR------------ILPLPDDTLITLREDGTIYFWSLQLKLKRKKPIFG-- 247

  Fly   169 DSPEASGMWV---------------TASHEGMMRFWTSHMEP-IRTASSESICMSYAFFNNGKVH 217
            .|......||               |.|.| :..:..|::|| .|....|::.:...:.:.....
Mouse   248 KSTSRKSRWVTDIVSMPQYNKVIVGTGSRE-LQLYELSNLEPYCRIGGLEAVPLKLDYCSVEPDK 311

  Fly   218 SKLILGDYAGNVRVLSYSPHLRGPFQAKPGAALIEVVWSDILRGKIPQFFPKEYINLHNEMVS-- 280
            ..::.||..|.|.:|         |.|..|..|  ..|.     |:|:......|.||:.|.|
Mouse   312 CLILYGDDQGCVNIL---------FLASVGELL--RTWK-----KMPRVEDMPSITLHSVMASPN 360

  Fly   281 --CVYFSLH------------MNALFASA---------------------------------EYR 298
              .|.:.:|            |.|:.:|:                                 |.|
Mouse   361 AEYVRWKVHGDFVSQLNYYESMKAVISSSNHEPTALVIGSLLNRLEHGGFTVGATDIKEKLNEIR 425

  Fly   299 NTKK--YRGRCPGMIMVTYDE----RSNFRIPLGVSTFFVAESHNIVVTGGPDTFVRIWDVYIPT 357
            |..|  ..|.....:.:...:    |:.||:..||..|......|::||||.|..:|:|:.|:|.
Mouse   426 NVGKNVKMGNSSACLALPQRQAECNRTVFRVHKGVKAFSFCRRKNLLVTGGLDRIIRVWNPYLPG 490

  Fly   358 EPSAILTGHNGGIVLVFVQPEENKVYSVDYQKIIKVWDLHEHTLLQTY--------GDLVRLIHH 414
            :|:.:|.||...::.|.|..|||||:|:.....:|||||..|....|.        |:|...:
Mouse   491 KPTGVLRGHRAPVMYVHVAFEENKVFSMSADNTVKVWDLETHGCCCTISSKASGIKGELTACL-- 553

  Fly   415 SETDLTYYYHSHLRELVVAGRKL----ISIKCCPR---VRVDLTDGNTHAAPVSVVLYNRLFRNI 472
                    |....|.|.||...|    :.:...|.   ||       :|..||....||..||::
Mouse   554 --------YLPGPRALCVATGTLAFLHLKVGSVPESHLVR-------SHQEPVVCCRYNPAFRHV 603

  Fly   473 VSCGLDSYIIVWDPWTGRRKIIMKSCHTKMIYGEIIDIEITAACFDPLEQFLLTGARDGSLKIWN 537
            |||...|.:.|||..|||:        .....|...:..||...||...:.|:||.|||.||||:
Mouse   604 VSCCEASVVKVWDFETGRQ--------VSEFIGTHGNAGITCLTFDSSGRRLVTGGRDGCLKIWS 660

  Fly   538 YNNAVVVRNMSIMPDQ-EVTAVIWV-VDR---ILAMGWDRQVTEFNDVVGREYGDPKKWPKF--- 594
            |||...:..:....:| ||....:: |:|   ::|:||||::..:.|:       |:.:..|
Mouse   661 YNNGHCLHTLQHDENQSEVCDCTYMEVNRNRCVIAVGWDRRINVYFDI-------PRDFHHFRKP 718

  Fly   595 -----------HTDDITCADVKLGEGVVTATYSGEIIFWKLETGQPYRRYSVMDPTRFIELKLTA 648
                       |.:||.|........:.|::|.||||.|.:.:|..|.:
Mouse   719 QPHWQDDLNHGHKEDILCVAQCPPFLLATSSYDGEIIVWNVISGHMYCK---------------- 767

  Fly   649 EEEKFIRQSKRLASRLTHSGNHSLQTGRAGRSTVLNRPE--DNRDYGTDIPISVQAVLFLQTRPQ 711
                                              ||.|.  |.:|:......||..:.||:||..
Mouse   768 ----------------------------------LNTPSPMDGQDHREGPDRSVSQLAFLKTRLT 798

  Fly   712 TLKHGS-VFISLDTG----FIQVYSHHQRGGYIVEFL----------AVHKTGDCVLTMCTDRKN 761
            .|...| ..||...|    |.:::|   ..|.:..|.          .|..:||.:
Mouse   799 KLDSASAALISNGPGGSVCFWKLFS---GSGLVANFTPSREKAQVSGIVVTSGDTL--------- 851

  Fly   762 RYLYTGTAFGYIKVWYIVNFCVPESEKTHVCMPKLRLEFIFLRKELFMTRAKRAVRNQAEPLLVS 826
              .|.....|:|.|:.|..:.:..:|.                              || |..|:
Mouse   852 --AYLADQHGFIHVYDIQEYGLQGTEL------------------------------QA-PNTVT 883

  Fly   827 SYKGHLKAINSIAFINLPKIIFTGSHDYSCRLWTQGGRYLGTLGTVLPWSRLTPFERAGDDNHLY 891
            |::.|:..:.|:..|....|:.:.|.|.:.|||:|.|.|:||.|...||...||     |.....
Mouse   884 SWRAHVSMVTSLELIEGGSIVLSSSLDCTVRLWSQDGAYIGTFGQNHPWDVFTP-----DSWGHP 943

  Fly   892 RMPPDI-KKVASSTTLKVISGIQAETSIKISNGKTVEDREEETAQTE--DVTELRKLLDKPVKE 952
            |:|.:| ....|..|.:|:     ||.:...   .:|.|:|:...||  |..|..|..:.|..|
Mouse   944 RVPFEILTDPRSMPTHRVL-----ETDVPAG---CLEGRQEQDHGTEEKDPCEAEKTPNPPSPE 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WDY	NP_001303588.1	WD40	76..557	CDD:225201	146/590 (25%)
		WD40 repeat	279..316	CDD:293791	11/87 (13%)
		WD40	337..623	CDD:295369	98/319 (31%)
		WD40 repeat	370..406	CDD:293791	15/43 (35%)
		WD40 repeat	460..497	CDD:293791	15/36 (42%)
		WD40	512..869	CDD:295369	90/392 (23%)
		WD40 repeat	512..538	CDD:293791	14/25 (56%)
		WD40 repeat	555..593	CDD:293791	10/41 (24%)
		WD40	595..>859	CDD:225201	54/280 (19%)
		WD40 repeat	600..622	CDD:293791	7/21 (33%)
Wdr95	XP_017176434.1	EF-hand_8	125..178	CDD:372744	9/52 (17%)
		WD40	450..758	CDD:238121	104/339 (31%)
		WD40 repeat	462..498	CDD:293791	13/35 (37%)
		WD40 repeat	504..544	CDD:293791	15/39 (38%)
		WD40 repeat	549..584	CDD:293791	8/44 (18%)
		WD40 repeat	592..627	CDD:293791	14/42 (33%)
		WD40 repeat	635..671	CDD:293791	17/35 (49%)
		WD40 repeat	679..727	CDD:293791	11/54 (20%)
		WD40 repeat	734..757	CDD:293791	8/22 (36%)
		WD40 repeat	787..832	CDD:293791	13/47 (28%)
		WD40	799..>939	CDD:225201	42/189 (22%)
		WD40 repeat	840..883	CDD:293791	12/84 (14%)
		WD40 repeat	892..916	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12473
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3794
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774295at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42847
orthoMCL	1	0.900	-	-		OOG6_104360
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4823
SonicParanoid	1	1.000	-	-		X3062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.900