DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WDY and LOC100498290

DIOPT Version :9

Sequence 1:	NP_001303588.1	Gene:	WDY / 26067056	FlyBaseID:	FBgn0267449	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_017951623.2	Gene:	LOC100498290 / 100498290	-ID:	-	Length:	921	Species:	Xenopus tropicalis

Alignment Length:	1055	Identity:	210/1055 - (19%)
Similarity:	370/1055 - (35%)	Gaps:	285/1055 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RIILEELDITFNDSMYTRLFLKINQNRDFKVDW--------NEFVSYLIFGFQEEDPSSQKESLI 121
            ||.||:..|:|.......:.||:.       :|        |:.||:.:.....|.|..:....|
Frog    23 RICLEQHSISFCVQSVLAMSLKLG-------NWEMLAQQQRNKKVSFHLPATVAETPHREPLIQI 80

  Fly   122 LPISGPPMVRKSEHRSAICCLALLKAKSDQVPIDEVTETINFSFGGEDSPEASGMWV-------- 178
            .|:....::...:........:.||.|.::..:||           .........|:
Frog    81 SPMPDNSLLVVGQDGLISVWTSDLKLKKNRFILDE-----------NKQQNRKMKWIADLTLMPQ 134

  Fly   179 -------TASHEGMMRFW-TSHMEP-IRTASSESICMSYAFFNNGKVHSKLILGDYAGNVRVL-- 232
                   |...|  :||: .|:.|| .:....|::.:...:.........|..||..|.:.|:
Frog   135 YNKLIVGTCDRE--LRFYELSNFEPYCQIIGLETLPLHLGYSTRDTDEGVLYFGDEQGCINVILI 197

  Fly   233 -SYSPHLRGPFQAK-----PGAALIEVVWS----DILRGKIPQFFPKE--YINLHNEMVS----- 280
             |.:..:|...:.:     |..:: :::.|    .::|.|:...:..:  |:|..:.::|
Frog   198 SSVAETIRSWTKCQIIDDIPSVSM-DIIESAGHVKLIRWKVHNDWVTQIRYVNAIDSIISSSNDD 261

  Fly   281 -------CVYFSLHMNA----LFASAEYRNTKK-YRGRCPGMIMVTYDERSNFRIPLGVSTFFVA 333
                   ||..:.:|..    |..|:..|:.:. ..|..|....::  :.|.|::..||..|...
Frog   262 YTALVIGCVEGTKNMQKRLKDLMDSSSTRSKRSMLSGNVPPKRNIS--DESLFKVKRGVKAFDFC 324

  Fly   334 ESHNIVVTGGPDTFVRIWDVYIPTEPSAILTGHNGGIVLVFVQPEENKVYSVDYQKIIKVWDLHE 398
            :.:||:||||.|..||||:.|:|..|:.:|.||:..|..:.:..|.:|:|||.....:.|||:.|
Frog   325 KENNILVTGGLDRIVRIWNPYVPGWPTGLLRGHSSPITFLQIADENSKIYSVSTDCTVMVWDIEE 389

  Fly   399 HTLL--------QTYGDLVRLIHHSETDLTYYYHSHLRELVVAGRKLISIKCCPRVRVDLTDGNT 455
            ||.|        |..|::.          |.::.|..|.|.:|......::....:........:
Frog   390 HTCLINVISKASQIKGEIA----------TCFFSSQFRALYIATDSFSMLQLQHSITHPDVPSVS 444

  Fly   456 HAAPVSVVLYNRLFRNIVSCGLDSYIIVWDPWTGRRKIIMKSCHTKMIYGEIIDIEITAACFDPL 520
            |..||:...||:....:|||...|.|.:||..||:....::..|.        ...||....|..
Frog   445 HKEPVTCCQYNQYLEQVVSCSEGSVIKIWDLLTGKLVSEVRGAHG--------SAAITCLALDNT 501

  Fly   521 EQFLLTGARDGSLKIWNYNNAVV---------VRNMSIMPDQEVTAVIWVVDR--ILAMGWDRQV 574
            ...:.:.|:|||||.|:.::..|         |.: |:...|......|:.::  :::.|..:|:
Frog   502 GSRMFSVAKDGSLKQWDLSSTSVSCLTTLKEAVAD-SLTDGQYDCTYAWLHNKRFMISAGCGKQI 565

  Fly   575 TEFND-----VVGREYGDP---KKWPKFHTDDITCADVKLGEGVVTATYSGEIIFWKLETGQPYR 631
            |...|     |:..:|.:.   ......|..:|.|........|.:::..|||..|.:.:|
Frog   566 TILPDQQDSAVLENQYPNHTLISNMRNKHKGEILCVASCPPNLVASSSSDGEIFIWDVTSG---- 626

  Fly   632 RYSVMDPTRFIELKLTAEEEKFIRQSKRLASRLTHSGNHSLQTGRAGRSTVLNRPEDNRDYGTDI 696
                   .....|.:..:||.                  |.:||.:
Frog   627 -------NMMCSLGIPKQEEL------------------SNETGSS------------------- 647

  Fly   697 PISVQAVLFLQTR-------------PQ---TLKH----GSVFISLDTGFIQVYSHHQRGGYIVE 741
            .:.:|.::||.:|             |.   |..|    |.||.|..:      ||:|..   |.
Frog   648 DLIIQKLIFLSSRDWKNECAVLAASGPNGQITFWHIFDGGKVFGSFPS------SHYQTA---VR 703

  Fly   742 FLAVHKTGDCVLTMCTDRKNRYLYTGTAFGYIKVWYIVNFCV--PESEKTHVCMPKLRLEFIFLR 804
            .:|:.:...   |:|...:..|:|         :|.|..:.:  ||:.
Frog   704 DMAISEDDS---TLCAADQLFYVY---------IWNISQYALHGPEAH----------------- 739

  Fly   805 KELFMTRAKRAVRNQAEPLLVSSYKGHLKAINSIAFINLPKIIFTGSHDYSCRLWTQGGRYLGTL 869
                            .|.|:..::.|...|..:..::..|::.|.|.|.:.|||:..|..:||.
Frog   740 ----------------PPPLIHCWRAHQCDITRVVPVSKYKLVVTSSVDCTVRLWSMKGEPIGTF 788

  Fly   870 GTVLPWSRLTPFE--------RAGDDNHLYRMPPDIKKVASSTTLKVISGIQAETSIKISNGKTV 926
            |....|.......        ||..|.|     |.            .||..|:.|      .:.
Frog   789 GQSELWEAKKRESWIGQQSDGRANTDEH-----PS------------ASGCGAQHS------SSS 830

  Fly   927 EDREEETAQTEDVTELRKLLDKPVKEPI--VGKHFELPGRSILDQHIELDTTQSYIAVFTQLKV- 988
            |::..::...|.:.....:.||.:.|.:  ...|....|:....:.:||..|...:..:..|::
Frog   831 EEQNNKSYSPEFIGISVPVDDKDIAEELHRSRSHSAQRGKMFGPKQVELHQTCGKLNAYQSLQIC 895

  Fly   989 --HSTEMLERLPTPA 1001
              .|.....|.|.||
Frog   896 DLMSVTTNVRRPNPA 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WDY	NP_001303588.1	WD40	76..557	CDD:225201	117/553 (21%)
		WD40 repeat	279..316	CDD:293791	9/53 (17%)
		WD40	337..623	CDD:295369	80/312 (26%)
		WD40 repeat	370..406	CDD:293791	14/43 (33%)
		WD40 repeat	460..497	CDD:293791	12/36 (33%)
		WD40	512..869	CDD:295369	73/397 (18%)
		WD40 repeat	512..538	CDD:293791	10/25 (40%)
		WD40 repeat	555..593	CDD:293791	7/47 (15%)
		WD40	595..>859	CDD:225201	48/285 (17%)
		WD40 repeat	600..622	CDD:293791	5/21 (24%)
LOC100498290	XP_017951623.2	WD40	73..474	CDD:421866	90/426 (21%)
		WD40 repeat	127..169	CDD:293791	8/43 (19%)
		WD40 repeat	174..214	CDD:293791	7/39 (18%)
		WD40 repeat	243..282	CDD:293791	6/38 (16%)
		WD40 repeat	318..355	CDD:293791	16/36 (44%)
		WD40	354..632	CDD:421866	68/307 (22%)
		WD40 repeat	361..402	CDD:293791	13/40 (33%)
		WD40 repeat	408..444	CDD:293791	5/45 (11%)
		WD40 repeat	449..485	CDD:293791	12/35 (34%)
		WD40 repeat	494..531	CDD:293791	10/36 (28%)
		WD40 repeat	544..590	CDD:293791	7/45 (16%)
		WD40	594..>788	CDD:421866	52/295 (18%)
		WD40 repeat	598..644	CDD:293791	12/74 (16%)
		WD40 repeat	651..681	CDD:293791	6/29 (21%)
		WD40 repeat	702..728	CDD:293791	7/37 (19%)
		WD40 repeat	744..778	CDD:293791	7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3629
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774295at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47959
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.970