DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WDY and efcab8

DIOPT Version :9

Sequence 1:	NP_001303588.1	Gene:	WDY / 26067056	FlyBaseID:	FBgn0267449	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_031750586.1	Gene:	efcab8 / 100494912	XenbaseID:	XB-GENE-6462842	Length:	1058	Species:	Xenopus tropicalis

Alignment Length:	1109	Identity:	241/1109 - (21%)
Similarity:	418/1109 - (37%)	Gaps:	291/1109 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PERHVGIDELRIILEEL--DITFNDSMYTRLFLKINQNRDFKVDWNEFVSYLIFGFQEED----- 112
            |..::.:||.|.:|.:|  ...|:|.| ..||.:::.:.|..|||.||.:||:..:::.|
Frog   111 PAGNMTLDEFRRVLCDLFGSECFDDDM-ELLFNEVDTSCDGYVDWGEFCTYLLLQYRKRDYRMIG 174

  Fly   113 ---------------PSSQKESLILPISG-PPMVRKSEHRSAICC---LALLKAKSDQVPIDE-- 156
                           ...:..|.||.||. |||...|..::.:..   |||...||.:|..:.
Frog   175 RVTFLGQPVIRLCTRNKQEPTSRILAISSPPPMWLLSVSKTGVLTTWDLALHPQKSYEVAAEYPD 239

  Fly   157 -----------VTETINFSFGGEDSPEASGMWVTASHEGMMRFWTSHM---EPIRTASSESICMS 207
                       ||:.::.       |.|:.:.:..:...:..|..|.|   |.....:...:..:
Frog   240 SQAGKRRFKCWVTDAVHL-------PNANKIAIATTSRDIHFFDVSTMNLFEEFHLFALNHVPTT 297

  Fly   208 YAFFNN---GKVHSKLILGDYAGNVRVLSYSPHLRG----PFQAKPGAALIEVVWSDILRGKIPQ 265
            ::::.|   .:..|.|:.|...|.:.||.......|    ||...||...|.:
Frog   298 FSYWYNKQSPESRSLLLWGGDNGAMNVLWLLQPQTGVFEKPFSQHPGPTKIYM------------ 350

  Fly   266 FFPKEYINLHNEMVSC-VYFSLHMNALFASAEYRNTKKYRGRCP--------------GMIMVTY 315
                :.:..|::::|. |...:|..|:        ||..  .||              .::::..
Frog   351 ----QELKDHSKLLSYQVIPDVHPEAI--------TKLI--YCPEKQLIITSSGSAQSSLLIMDI 401

  Fly   316 DERS---NFRIPLGVSTFFVAESHNIVVTGGPDTFVRIWDVYIPTEPSAILTGHNGGIVLVFVQP 377
            :::.   .::|..||..|....:.|::||||.|..||:|:.|:...|.|:|..|:..|:.|.:..
Frog   402 NQKGKVYTWKINKGVQCFDYCRALNLLVTGGFDHKVRLWNQYVTCRPIAVLPEHSMAILDVMIYQ 466

  Fly   378 EENKVYSVDYQKIIKVWDLHEHTLLQTYGDLV-------------------RLIHHSETDLTYYY 423
            ...:::|.....::||||:...|.|.|   ||                   .|:..:.:.|...|
Frog   467 PLGQIFSFSKDSVLKVWDIPSQTCLHT---LVLKFPCIQPGRIQEQGSFPFLLVPTNPSRLLVCY 528

  Fly   424 HSHLRELVVAGRKLISIKCCPRVRVDLTDGN--THAAPVSVVLYNRLFRNIVSCGLDSYIIVWDP 486
            ..::..|.:|             |.:.|:|.  ||.|||:.:||:.....||:...||.:.|||.
Frog   529 SDYIGILRLA-------------RAEPTEGTFFTHRAPVTCLLYSSFCHLIVTGSEDSTVAVWDV 580

  Fly   487 WTGRRKIIMKSCHTKMIYGEIIDIEITAACFDPLEQFLLTGARDGSLKIWNYNNAVVVRNMSIMP 551
            .||.:.:::.:.|.:.        |:|....|..::.|:||||:|::||||..|...:..:..:.
Frog   581 ETGAKSLLLGNAHGQE--------EVTCMALDKAQRRLITGARNGTIKIWNIQNGHNLHQLEPVE 637

  Fly   552 DQEVTAVIWVVDRI-LAMGWDRQVTEFNDVVGREYGDPK----KWPKFHTDDITCADVKLGEGVV 611
            |.|:|.::...:.: |.:||:|::..::.....|...|.    |..:.|.:||..||.....|::
Frog   638 DAEITCIVASQENVFLTVGWNRKIVTYDIPKTNEVYVPANHSWKGGQLHQEDILTADFCPSLGLL 702

  Fly   612 -TATYSGEIIFWKLETGQPYRRYSVMDPTRFIELKLTAEEEKFIRQSKRLASRLTHSGNHSLQTG 675
             ||::.||||.|..||.:.|                     .::||..:..|
Frog   703 ATASFDGEIILWNAETQRLY---------------------LYLRQCPQARS------------- 733

  Fly   676 RAGRSTVLNRPEDNRDYGTDIPISVQAVLFLQTRPQTLKHGSVFISLDTGFIQVYSHHQRGGYIV 740
                                 |..|..:.|||.| ...:..::.:|.:.|.::.:.....|....
Frog   734 ---------------------PAPVDKLFFLQKR-SAKREAAILVSSEAGTLRWWRVTNGGQEWG 776

  Fly   741 EFLAVHKTGDCVLTMCTDRKNRYLYTGTAFGYIKVWYIVNFCVPESEKTHVCMPKLRLEFIFLRK 805
            .|.|..:....||.:.:|:.||.|.:|...|.::||.|..:.:..:.:|:.|.|
Frog   777 SFYAQDEADCSVLGLASDKANRVLVSGDTLGLVQVWDISAYGLQAAAQTYTCRP----------- 830

  Fly   806 ELFMTRAKRAVRNQAEPLLVSSYKGHLKAINSIA--FINLPKIIFTGSHDYSCRLWTQGGRYLGT 868
                            |||. |:..|..|:.|:.  ..:....|.:||.|.:.:|||..|:.:||
Frog   831 ----------------PLLY-SWGAHDSAVVSVEHFLYDSEPFIASGSSDKTAKLWTVDGKQVGT 878

  Fly   869 LGTVLPWSRLTP-----FERAGDDNHLYRMPPDIKKVASSTTLKVISGIQAETSIKISNGKTVED 928
            .|....|....|     ....|.:.         |....:..|:::.|:   |.|:       |:
Frog   879 FGQSKCWKLSDPTSYLDSRSEGSEG---------KGPRGAGGLEILPGV---TEIQ-------EE 924

  Fly   929 REEETAQTEDVTELRKLLDKPVKEPIVGKHFELPGRSILDQHIELDTTQSYIAV-FTQLKV---- 988
            ..|..|.|....:|.::|.:.:.:...|...|....|..::...:...:..... .|.:.|
Frog   925 NSEGRALTPAPEDLPEILSQEIPDLATGSSSEASLGSAQEESTNMAAARKERRQRLTDIDVNKCN 989

  Fly   989 ---HSTEMLERLPTPAVVSRVQTENYMDHYIPVEGKVDVSGSAINIKQPSRRRSDKASDTRNVNT 1050
               |.....:.|.||||     .|..:...:||                ..|.|..||..|..:.
Frog   990 RFGHICSPFQALITPAV-----QEISLPPGLPV----------------MMRSSSGASSERQDSG 1033

  Fly  1051 LGAR 1054
            :|.|
Frog  1034 IGGR 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WDY	NP_001303588.1	WD40	76..557	CDD:225201	129/566 (23%)
		WD40 repeat	279..316	CDD:293791	8/51 (16%)
		WD40	337..623	CDD:295369	87/312 (28%)
		WD40 repeat	370..406	CDD:293791	10/35 (29%)
		WD40 repeat	460..497	CDD:293791	12/36 (33%)
		WD40	512..869	CDD:295369	83/364 (23%)
		WD40 repeat	512..538	CDD:293791	11/25 (44%)
		WD40 repeat	555..593	CDD:293791	8/42 (19%)
		WD40	595..>859	CDD:225201	55/266 (21%)
		WD40 repeat	600..622	CDD:293791	9/22 (41%)
efcab8	XP_031750586.1	EF-hand_8	111..164	CDD:404678	19/53 (36%)
		WD40 repeat	252..288	CDD:293791	7/42 (17%)
		WD40 repeat	291..340	CDD:293791	9/48 (19%)
		WD40 repeat	373..412	CDD:293791	4/48 (8%)
		WD40	413..715	CDD:238121	90/325 (28%)
		WD40 repeat	417..454	CDD:293791	14/36 (39%)
		WD40 repeat	459..495	CDD:293791	10/38 (26%)
		WD40 repeat	555..593	CDD:293791	11/37 (30%)
		WD40 repeat	598..634	CDD:293791	13/35 (37%)
		WD40 repeat	642..681	CDD:293791	7/38 (18%)
		WD40	678..>879	CDD:421866	61/284 (21%)
		WD40 repeat	690..727	CDD:293791	14/57 (25%)
		WD40 repeat	737..779	CDD:293791	8/42 (19%)
		WD40 repeat	786..812	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11223
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46319
OrthoDB	1	1.010	-	-		D774295at2759
OrthoFinder	1	1.000	-	-		FOG0008237
OrthoInspector	1	1.000	-	-		otm47959
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930