Protein Alignment PRY and Pkd1l2

DIOPT Version :10

• Sequence 1: NP_001104126.3
• Gene: PRY / 26067055
• FlyBaseID: FBgn0267489
• Length: 1247
• Species: Drosophila melanogaster
• Sequence 2: XP_038954049.1
• Gene: Pkd1l2 / 691069
• RGDID: 1588631
• Length: 2492
• Species: Rattus norvegicus
• Alignment Length: 1310
• Identity: 253/1310 - (19%)
• Similarity: 444/1310 - (33%)
• Gaps: 322/1310 - (24%)

  Fly    40 LHSLHQEWFTTKVSLNGLILVDY----------------FQTNSSERKEAFLWYRTSNLEKTLAF 88
            |..|...|.:.:|.|...:||:.                ...|.|:::|:  ..|:|.
  Rat   482 LSGLRASWASDRVELGWDLLVNVSVAHGTLEELTFEVAGLNANFSQKEES--GGRSSG------- 537

  Fly    89 FGVSTDMQMPYDECYFHASEV-NFFSNGFFSV--IALITSDGL-YGNEVQAKTYTFVKTNLHITC 149
               |..:.:|.:..:.....| |.||:....:  :.:....|| ..:.::|:.....|.::.:..
  Rat   538 ---SYRVAVPAEGTFLVTVHVRNAFSDLSLDIGNVTVTAPSGLREPSGMKAEAENGHKWDMKVFT 599

  Fly   150 EPTFYIPRCHDSSRPLHYETSKVVVIRAVFTRHCPMDNF-IQYYWTL-------HDSTDTGKLHN 206
            ||..|:....|                  .|...|.|:. :.::|:.       ....:...||
  Rat   600 EPELYVDPFTD------------------VTLGWPDDDLSLDFHWSCGHCWAQWKTCVERQLLH- 645

  Fly   207 TAYSTGNRVIIPAYSQPNNQTLRVMLLIRSTF--DPLRTATT--------------KQSIVFSSS 255
                |..|                 ||:..||  .||.:|.|              .:..::.|:
  Rat   646 ----TDQR-----------------LLVLHTFCLPPLNSAVTLHLAILRGQELERETERCLYVSA 689

  Fly   256 RQLINVNIACVSNCNGNKYTIQMPIHLKGQCLRC----QNKKISKWIW--------RVEGLP--- 305
            ...:...|:|..||.        |:......|..    ....::.:.|        :.|.||
  Rat   690 PLDLGPQISCQKNCR--------PVKADQDVLLTVTVGDETPVAMFNWYLDDTSPEKAEPLPAAC 746

  Fly   306 -VEGASKRLIFDVKETKKRLL-----------GIHLNVEAVNRYNSKLTYYGTSWVFLEKNMGPA 358
             :.|...|.:..:......||           .||:.|.|:..:     .||.....:.....|.
  Rat   747 RLRGFWPRSLTLLHSNSSVLLLNSSFLQTWGPVIHIRVTALTDH-----AYGEDTHVISMLPPPE 806

  Fly   359 DTMCTISPRVGNAHETQFLLHCNQSQARFKPLQYCIGVENFLVDECKSDEDI-QVRLPPTEH--- 419
            ...|.|.|..|:. .|.|.:.|:...|. .|::||..|::.....|..:..: .|.||..|.
  Rat   807 VPACVIDPEEGSV-LTSFAIFCSTPTAP-GPVEYCFCVQSGSCLHCGPEPALPAVYLPRGEEKDG 869

  Fly   420 ----VVVMICDHFSVCDDVTVTVEVRRLEMDDSDNTVKEALSLARHWFEYADWQKAFLLLYQVAK 480
                ||:.:.|.....:...:.|:|...:....|.|.:|.:|.......|.:.....|||  :||
  Rat   870 FVLTVVISVTDQAGDREQTHMAVKVGHDDTGVEDVTFQETVSDRITTALYHEHGHEELLL--LAK 932

  Fly   481 LIKSKERLLNFIDTLYVYEPQTTVQLAHLVRLTKRVVL-SLEP----LDDMEVNVVARMLQLISS 540
            .:.|:   ||..|    ..|.:......:.|..:.:|| ||..    |::|:      .:|.::.
  Rat   933 AVSSE---LNKED----QGPGSGRLRMDIKRKVRELVLRSLSTVTTGLENMQ------RVQALAE 984

  Fly   541 TFRLIINSNELNTLMDIYYETMVNELCDILNKLNTE----WEYIPKSQCRAESESCLNIDNFRNR 601
            ..|.:.:.:|..||:..:      |....|.: |||    .:..||.|.|.|:.        |..
  Rat   985 ALREVTHHSEELTLVAQW------EASQALQR-NTEALLAAKVHPKDQRRQEAT--------RAM 1034

  Fly   602 LEQMSVLRPQGLEHIN------NWLHAHW---------KLSSCLFYMGMGTARRLHPEEGPKLIE 651
            .|.:..:....|.|.:      |...||.         :|.|.|.   :||.    |...|.::.
  Rat  1035 FEAVGSVLKASLSHGSDEPAEANSSQAHIVAQLLQVVDRLQSALL---LGTL----PGGLPAILA 1092

  Fly   652 RSTFSMRMESFDLDQDRNLEFQSADSMHTLIFTDKLLDELKRRLRTDEVLISIRSHKQSQYWWYP 716
            .|:.|:..   |..|.|:.:   ..|:||              ...|.|:..:    .:..:..|
  Rat  1093 TSSVSVYT---DRIQPRSWQ---GSSVHT--------------TAADSVIFIL----PATTFLCP 1133

  Fly   717 EQESHTQV-LVVNAYTINNIWKKSQ-EVAEPFQYISKLKINLSEGDPINEPTRQISKRGIDFDDP 779
            .::|...| :.:.:::.|....:|. ||:..   :..|::..|.|.||  |.:.:|
  Rat  1134 TEDSQEPVDIRMMSFSQNPFPSRSHFEVSGT---VGGLRLTSSSGRPI--PVKNLS--------- 1184

  Fly   780 EEDIENVIHDCVYTSLEVRMYRTELYGHSVLGVTFTQADIDFCVLIRMTNIPKL----------N 834
             ::||.::   ...|..::.....|.....|.|..|..|....:.:.......|          |
  Rat  1185 -QNIEILL---PRISTRIKPNTLSLATGDALSVNVTAGDAALGIQLHWGPGVALTLSLGYGYHPN 1245

  Fly   835 EMERDSST---CLVRAGVLKQTTLLLRNRCEKSQPVYIYLRAANISEPWNNFFHSGAFFAFSTDI 896
            |...|:.|   .:..||.| .|.:|........:.:| |||... .:...:..........:|.:
  Rat  1246 ETSYDAQTRLPAVADAGDL-PTWILYPEDLPFGEGIY-YLRVVP-KDDLESTSDRNLTVGITTFL 1307

  Fly   897 RSCRIWNYARPEPSWQNFACM--PELNKSIHFGIHCRCNYISDFDADGMPIIAVPMNLKCHL--- 956
            ..|..|:.|  :.:|.|..|.  |....|   ..||.||:::.|   |...:.:|..:..|.
  Rat  1308 AHCVFWDEA--QGTWDNSGCRVGPRTTTS---QTHCLCNHLTFF---GSTFLVMPNAIDVHQTAE 1364

  Fly   957 ------ERPIVGQSYQIIIFFFSLSSFVIIYIFYSMQSVSDWDKK---LYTELFPVGGKCYRGDL 1012
                  :.|:|..:...:...     :|::.|:...:.:.|..|.   :..:..|.....|   |
  Rat  1365 LFATFEDNPVVVTTVGCLCMV-----YVLVVIWARRKDIQDQAKAKVIVLEDNDPFAQYHY---L 1421

  Fly  1013 VLMCTFGGRYNAGTSANIIFAFKFFNQTRDIIVYQDPVFRTFKRNSTISLRLQNKHFCIPTG--- 1074
            |.:.| |.|..|.||:.:.......:...:.....|.....|:|.. :.:.|.:..|  |.|
  Rat  1422 VTVYT-GHRRGAATSSKVTLTLYGSDGESEPHHLSDSDAAVFERGG-VDVFLLSTLF--PLGELQ 1482

  Fly  1075 -IAMRHDNSGVYPHFFCRNVVVCDLQTNEGQLFSIQQWIKCYTVYKTVTSFSLINTDDGKFHCGK 1138
             :.:.|||||..|.::...|:|.|...::...|....|:........:.....:.|:..:.....
  Rat  1483 SLRLWHDNSGDRPSWYVSRVLVYDPVVDQKWYFLCNSWLSIDVGDCVLDKVFPVATEQDRKQFSH 1547

  Fly  1139 LRFLHAMENFMGN--WY-LFQPIIGPWRFGTERLAFCKWER-SCIFIGKLFIAITFVVLFFGRTE 1199
            |.|......|...  || :|        ..:.|.:|.:.:| ||.| ..|...:...::|:|
  Rat  1548 LFFTKTSTGFQDGHIWYSVF--------CNSTRSSFTRVQRVSCCF-SMLLCTMLTSIMFWG--- 1600

  Fly  1200 PMACDPSPKK 1209
             :..||:.:|
  Rat  1601 -VPKDPAEQK 1609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRY	NP_001104126.3	REJ	<217..476	CDD:366875	59/309 (19%)
		PLAT	1019..1111	CDD:412108	22/95 (23%)
Pkd1l2	XP_038954049.1	CLECT	70..186	CDD:153057
		Gal_Rha_Lectin_PKD1L2	189..285	CDD:438688
		REJ	<697..894	CDD:366875	42/211 (20%)
		GPS	1308..1347	CDD:460350	13/46 (28%)
		PLAT_polycystin	1418..1537	CDD:238850	27/125 (22%)
		Polycystin_dom	2013..2209	CDD:466668
		PKD_channel	2211..2433	CDD:462341