DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-3 and DNAH11

DIOPT Version :9

Sequence 1:	NP_001104482.3	Gene:	kl-3 / 26067053	FlyBaseID:	FBgn0267432	Length:	4593	Species:	Drosophila melanogaster
Sequence 2:	NP_001264044.1	Gene:	DNAH11 / 8701	HGNCID:	2942	Length:	4516	Species:	Homo sapiens

Alignment Length:	4806	Identity:	1392/4806 - (28%)
Similarity:	2313/4806 - (48%)	Gaps:	572/4806 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DQEREDQQRRRYQLLREMRQQ-RISSLGPNQRYVLEICADLLGIDPEEIVTGIVDESKYVEN--- 92
            ::|.|:::....:..|...|. |:..||..       .|.:||...|:       .|:|:|:
Human    36 EEEEENEEEAAARRARSFAQDARVRFLGGR-------LAMMLGFTEEK-------WSQYLESEDN 86

  Fly    93 --VNGIF-EEKGPMAIMISNATMLGYPTDSGRYQEKLKYTEIQRSVCLRSDLVDLIGKWTVVYRL 154
              |.|.| |...|..::.|.|.       |||....   .||.|         |...|...:
Human    87 RQVLGEFLESTSPACLVFSFAA-------SGRLAAS---QEIPR---------DANHKLVFI--- 129

  Fly   155 NNEKSIDNRSVSD--EVAIFMISAEERNSCLNVVKTFMDHVLKPSIEAVTEFGLAEKEQTQKF-- 215
             ::|..::..|:|  :|.:|   .|.....|..|..|:|.:|.|.        |:.|...:.:
Human   130 -SKKITESIGVNDFSQVVLF---GELPALSLGHVSAFLDEILVPV--------LSNKNNHKSWSC 182

  Fly   216 -------FHI----LNMYNTFLKSSE------ATVSSRVNFDISHELFKGLLLVRWQIEASSKIL 263
                   :||    ..||....|.|.      .||:.:::.|              |..:.:|..
Human   183 FTSQDMEYHIEVMKKKMYIFRGKMSRRTLLPIPTVAGKMDLD--------------QNCSENKPP 233

  Fly   264 TRVRLVERYFE----QWLRQIQGILVEGKQIQRDTPDVGPLQMLVN------------WRRMLAR 312
            :..|::....|    :|..|||.|      |:||:     :|.|:|            |......
Human   234 SNERIILHAIESVVIEWSHQIQEI------IERDS-----VQRLLNGLHLSPQAELDFWMMRREN 287

  Fly   313 YTTITEFVTSRAFNNHKDCLTLSRSS---KLLNRWAEIDNQVTLALNEAKDNVRYISSLQKFWDP 374
            .:.|.:.:.:.........||..:||   .|.:.:..::|    ||.||:|...|:..|::....
Human   288 LSCIYDQLQAPVVLKMVKILTTKQSSYFPTLKDIFLAVEN----ALLEAQDVELYLRPLRRHIQC 348

  Fly   375 LYRS---SPNVIISSLPGLMVAIRNVSKTAHYFNTPVNVTGLMVKISNQLTITSKNYITDNE--H 434
            |..:   ...::|:.|...:..|.:.||   ::|||..|..|:.:..|.....:..|::..:  .
Human   349 LQETEFPQTRILIAPLFHTICLIWSHSK---FYNTPARVIVLLQEFCNLFINQATAYLSPEDLLR 410

  Fly   435 SKVMENYKNIY--IHTVDEMKNS---------------NERPWTVSSVYILTCLQKFLQRLEKVK 482
            .::.|:.:.:.  ::.:...|||               ..|||...|..:.....|||.||.|::
Human   411 GEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRKLRPWDFQSHLVFCRFDKFLDRLIKIE 475

  Fly   483 WIANTDITYSILDRIMISGMERFNAMIKGARMTISSQL-----------YDPLNYRIETFDLDFE 536
            .|..|.:.:..|:|:...|.:  .|::.|....:|.:|           |||.:.....|:.|:.
Human   476 DIFATTLEFEKLERLEFGGTK--GAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYV 538

  Fly   537 KFVNEVEEAEVGMQQFVKLLSTECPSAASVMLVLKRF-----EALSLECLCLDRRYLEVAEMLER 596
            .|.::..|.:..:...:......|....:...:|..|     :.:.:|...|  .|..:..|...
Human   539 AFKSKTLEFDRRLGTIICEAFFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSL--HYSTLVHMFNT 601

  Fly   597 EMFLLKDVYNE-----ERGNPFIPRNLPPVAGRIIWIRSIFKKIDLPMQAL-KLRQCVLAHKKAQ 655
            |:.:.|.:|||     |.|:..:.:|:|..:|.:.|.:.:.:::.:..... .||...|.:....
Human   602 ELDVCKQLYNEHMKQIECGHVVLNKNMPFTSGNMKWAQQVLQRLQMFWSNFASLRYLFLGNPDHA 666

  Fly   656 RTVRYYNYMNGIICHYEMAYHKAWFDYVEEVRC--LLNAPIMTINKEEAIYIVNIDRAILQLISE 718
            ...:.|..|..::..:|...:..|...|:|: |  .||.|::..:....:..||.|..::.::.|
Human   667 LVYQKYVEMTTLLDQFESRIYNEWKSNVDEI-CEFNLNQPLVKFSAINGLLCVNFDPKLVAVLRE 730

  Fly   719 TEWMWKL-NLEVPNMAATITYCKDRLLGPATTLKLMLQRYDRLRTSLTPVFINIMRFRLQEISIL 782
            .:::..| ..::|:.|..|...::.:|.....|.|::|.|::|:.:|..|...::...|:.|...
Human   731 VKYLLMLKKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQ 795

  Fly   783 LKPSLSTVTWISENLEDYVEKVCMKIKEVETFFNLILDIEDLRILQEMYSISDYLYIYVPEEPVS 847
            |..:.:.:|| .::...|:|:|.....|:|  ..:....::::::|:  ::..:....:|..
Human   796 LTAATTWLTW-QDDCWGYIERVRAATSELE--HRVERTQKNVKVIQQ--TMRGWARCVLPPR--- 852

  Fly   848 SYEFVEESNKLRSEIERILEKKSVCMERAVVDIINMFIDLLDFEQTD--------SKGRRVFQLP 904
                    .:.|.|....||.|.           ::|.......|.|        .:.|::|:..
Human   853 --------REHRREAAFTLEDKG-----------DLFTKKYKLIQGDGCKIHNLVEENRKLFKAN 898

  Fly   905 PEKLNDTNWRTEGFLPIDKWDFIQFHKIYRTIYLAPEDVLRTLQFRNYENIRYEL-YHLRNDCMD 968
            |.              :|.|      |||  :....:.|:...    ::.|.::| :.|:|....
Human   899 PS--------------LDTW------KIY--VEFIDDIVVEGF----FQAIMHDLDFFLKNTEKQ 937

  Fly   969 L--FSYYNSKIIL---ALVAGSKRSLD--------FVRQNILRTNWRTNPMKPILHTDLEIDFYN 1020
            |  ..::.:::||   .:|  .|.|||        .:.:.:|..::|.:.....:.|.|||..|
Human   938 LKPAPFFQAQMILLPPEIV--FKPSLDREAGDGFYDLVEEMLCNSFRMSAQMNRIATHLEIKNY- 999

  Fly  1021 GCYIQPNLEIMQNDFNNAVLCCTEINYFVSTWGKQAKTQERRDRRVTVDENKYERSYFRYVMEHK 1085
                       |||.:| :|...|:                                      .:
Human  1000 -----------QNDMDN-MLGLAEV--------------------------------------RQ 1014

  Fly  1086 DVIRAVQNLANGLLSYKSDMEEFQRDMFEKYKYLWAEDREDIINSFVL----------------- 1133
            :::..|.|:.|.:|.:        |:..|.:.|||.:||.:.:..|:|
Human  1015 EIMNRVVNVINKVLDF--------RNTLETHTYLWVDDRAEFMKHFLLYGHAVSSDEMDAHANEE 1071

  Fly  1134 --TNPLTVD-IRDMFLHYDNISLKIETMSAKRIIGP-IEVRMGSTIEKLVSESKKWK-VLLGHLL 1193
              ..|.|:: .::....|:.:.:::......|:... .:|.|......|::..|||. :...|||
Human  1072 IPEQPPTLEQFKEQIDIYEALYVQMSKFEDFRVFDSWFKVDMKPFKVSLLTIIKKWSWMFQEHLL 1136

  Fly  1194 SVQYKKQLDEMIEFITEQNNILDKPIN--DLDDVRQAMVVLEKVRDNYIEMDVSLQLITDTYSLF 1256
            .... ..|:|:.|||.|.::.|.:.:|  |.|.:...||.|..||......|...:.:.:|.:|.
Human  1137 RFVI-DSLNELQEFIKETDSGLQRELNEGDHDGLVDIMVHLLAVRSRQRATDELFEPLKETITLL 1200

  Fly  1257 SQFYIYVPQEDYDKVEGLQVLFNKMLENAKKVSDRISEMEEPLLRELNDGIATFVQE---FYD-- 1316
            ..:...:|::.|.::|.|.    :..|..||::..:.....|    |::...|.:::   .:|
Human  1201 ESYGQKMPEQVYIQLEELP----ERWETTKKIAATVRHEVSP----LHNAEVTLIRKKCILFDAK 1257

  Fly  1317 ---FNLDFDLNGPMVEGISAKEASDRVFLFQNRFDELWRKFEMYSSGEKLFGLPITDYPLLHQRK 1378
               |...|....|:  |.:|:.....:.......:.|..:........:||.:.:.:|..:.|.:
Human  1258 QAEFRERFRHYAPL--GFNAENPYTALDKANEELEALEEEMLQMQESTRLFEVALPEYKQMKQCR 1320

  Fly  1379 REFNYLNRLYSLYIQVLKTITDYYEMPWADVNIEKISAELSDFQLRCRKLPKGMQSWPAFIDLKT 1443
            :|...|..|:.:.|.|.::|.::.:..|..:::|::..||..|......|.|.::.|.|:..|:.
Human  1321 KEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEG 1385

  Fly  1444 KIDDFNETCPLLELMTNKAMKERHWIRLNALFNTDFDPTNPKFTLGKLLEAPILKYKEDVEDICV 1508
            .:.|...:...:..:.:.|:::|||.:|.......| ..|...||..||...:.:.::||..|..
Human  1386 TVKDMTASLRAITELQSPALRDRHWHQLMKAIGVKF-LINEATTLADLLALRLHRVEDDVRRIVD 1449

  Fly  1509 GASKELDIEAKLKQIVSDWSLVSLQLGQFKNRGDLVLKGGETLEIISSLEDSLMIMNSLASNRYN 1573
            .|.|||..|..:.:|...|:.:..........|..:||..|  ::..:||.:.:.:.:|..::|.
Human  1450 KAVKELGTEKVITEISQTWATMKFSYEVHYRTGIPLLKSDE--QLFETLEHNQVQLQTLLQSKYV 1512

  Fly  1574 APFKKDIQLWLSKLVNTGD-ILEKWLMVQNLWIYLEAVFV-GGDISKQLPMEAKRFTNIDKSYVK 1636
            ..|.:.:..|.:|| |..| ::..|:.||..|.:||::|| ..||..||..:|:||..:|..:.:
Human  1513 EYFIEQVLSWQNKL-NIADLVIFTWMEVQRTWSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKE 1576

  Fly  1637 IMMRAREIPNAVDCCTGDESLATNLTWLLDQLETCQKSLTGYLESKRLVFPRFFFVSDPVLLEIL 1701
            :|.:..::.|.:: .|...:|...|..|..:|..|:|:|..|||:||:.||||:|||...||:||
Human  1577 LMFKTAKVENVLE-ATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSADLLDIL 1640

  Fly  1702 GQASDPTSIQPHLLSIFDAIATVDF---QEKSIDIIESMNSMNREKVKFENTVQCLGSVELWLGR 1763
            .:.:.|..:..||..:||:||.:.|   |:.|......|.|..:|.|.|:...:|:|.||.||.:
Human  1641 SKGAQPKQVTCHLAKLFDSIADLQFEDNQDVSAHRAVGMYSKEKEYVPFQAECECVGHVETWLLQ 1705

  Fly  1764 LLKEMQDTIRTILAQMSVSLND-PEFNFAEEFPSFCGQAGVVGVQLLWTKDSEYALRKCRTD-KT 1826
            |.:.||:|:|..:.:..|:..: |...:..:||:   |..:...|:.||.|...|..:.... :|
Human  1706 LEQTMQETVRHSITEAIVAYEEKPRELWIFDFPA---QVALTSSQIWWTTDVGIAFSRLEEGYET 1767

  Fly  1827 IMKRTNNKFLVLLNFFIDLTVKDLTSLDRIRFETMVTIHVHQRDIFDDLCTLRIKSAGDFEWQKQ 1891
            .:|..:.|.:..||..|.|.:.:|...||.:..|:.||.||.||:...|.:.::.|...|.|..|
Human  1768 ALKDFHKKQISQLNTLITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSQ 1832

  Fly  1892 ARFYYNEDNDDVIVGITDVNFVYQNEYLGVTERLAITPLTDRCYITLAQAVGMCMGGAPAGPAGT 1956
            .|..:.:......|.|.|..|.|..||||.:.||.||||||||||||.|::.:.|.|||||||||
Human  1833 LRHRWEDTQKHCFVNICDAQFQYFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGT 1897

  Fly  1957 GKTETTKDMGRALGKLVVVFNCSDQMDFRGLGRIYKGLAQSGSWGCFDEFNRIELPVLSVAAQQI 2021
            ||||||||:|||||.:|.|||||:|||::.:|.|||||.|:|:||||||||||.:.||||.|.|:
Human  1898 GKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKGLVQTGAWGCFDEFNRISVEVLSVVAVQV 1962

  Fly  2022 YIVLTARKEKRSTFIFLDGDIVSLNPEFGIFITMNPGYAGRQELPENLKIMFRTVAMMVPDRQII 2086
            .::..|.:.::..|:|| |:.::|.|..|||||||||||||.|||||||.:||..||:.||.::|
Human  1963 KMIHDAIRNRKKRFVFL-GEAITLKPSVGIFITMNPGYAGRTELPENLKALFRPCAMVAPDIELI 2026

  Fly  2087 IRVKMASCGFKENVVLSRKMYTLYKLCEEQLSKQVHYDFGLRNILSVLRTLGSQKRSNPNDTEET 2151
            ..:.:.:.||.:...|:||..|||.||:|.||||.|||:|||.|.|||...||.||.:.|..|:.
Human  2027 CEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQ 2091

  Fly  2152 IVMRVLRDMNVSKLIDEDEGLFVSLVDDMFPGIKLTTNVYKDLQKAIIKVCDELGYVNNPEWNLK 2216
            ::||.|||.|:.|::.:|..:|:.||.|:||.:.:........::.:.:...||.......:.||
Human  2092 VLMRALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILK 2156

  Fly  2217 VVQLYETSLVRHGLMLMGPTGSGKTSCTVCMLRCFTEMGRTHKEMR-------MNPKAITAPQMF 2274
            ||||.|...|||.:.::|..|:||:.    :||   .:.||:..|:       :||||:|..::|
Human  2157 VVQLEELLAVRHSVFVVGNAGTGKSK----ILR---TLNRTYVNMKQKPVWNDLNPKAVTTDELF 2214

  Fly  2275 GRLDVATNDWTD---------GIFSTLWRRSLKVPQHQNCWIVLDGPVDAVWIENLNSVLDDNKT 2330
            |.:..||.:|.|         |:||::.|....:......||||||.:|.:|||:||:|:||||.
Human  2215 GFIHHATREWKDGKIVYSYFIGLFSSILREQANLKHDGPKWIVLDGDIDPMWIESLNTVMDDNKV 2279

  Fly  2331 LTLANGDRIKMADNSKLVFEPDNVDNASPATVSRVGMVFTSSSVLSWKIYMEAWLLKQGEDSEVF 2395
            ||||:.:||.:....:|:||..::.:|:||||||.|:::.:...|.|..|:.:|:.::...||
Human  2280 LTLASNERIALTPFMRLLFEIHHLRSATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQSE-- 2342

  Fly  2396 RRCYDVLYDDAHVFLQSRLLAKMR--------ILEAIYIRQMLDIMDGLLL--DLPLRTEKAL-E 2449
            :....:|:|.    .....|.|:|        |.|:..::.:..:::.||.  ::|..:.|.: |
Human  2343 KANLTILFDK----YVPACLDKLRTSFKTITSIPESSLVQTLCVLLECLLTPENVPSDSPKEVYE 2403

  Fly  2450 RIFLFSLMWSLGAVL---ELSE-REKLEEFLLKHVSKLRWPKRGVNETIFEYYVDDNGNWQH--- 2507
            ..|:|:.:|:.|..|   ::|: :.....:..|.:..:::|.:|   |||:||||      |
Human  2404 VYFVFACIWAFGGTLLQDQISDYQADFSRWWQKEMKAVKFPSQG---TIFDYYVD------HKTK 2459

  Fly  2508 ----WSTRVEEFRYPEDEIPEFSSILVPNVDNVRTAFLLHNIAKQLKQVLLIGEQGTAKTVMIKA 2568
                |:.::.:|....| :| ..::||...:..|..:.:..:.::.|.::|:|..|..|||.:..
Human  2460 KLLPWADKIAQFTMDPD-VP-LQTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGD 2522

  Fly  2569 YMGHYDPEVHIFKSFNFSSATTPNMYQRIIESYVEKRQGTTYGPPNQRAMTIFIDDINMPVINEW 2633
            .:.... |.:|.....|:..||....|:|:|..:||:.|..|||...:.:..||||:|||.::.:
Human  2523 TLASLS-EDYIVSRVPFNYYTTSTALQKILEKPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLY 2586

  Fly  2634 GDQITNEIVRQMIEQRGFYSLERPGDFSTIMDIQMLSAMIHPGGGRNDIPNRLKRHLCIFNCTLP 2698
            |....:.::||.|:...:|..::. ....|.:.|.::.| :|..|...|..||:||..:|....|
Human  2587 GTVQPHTLIRQHIDYGHWYDRQKV-MLKEIHNCQYVACM-NPMVGSFTINPRLQRHFTVFAFNFP 2649

  Fly  2699 SNNSMDQIFKSIGAGYFSPDRLGDEVVEVIPLLVPLTRIFWQNVKAKMLPTPANFHYVFNLRDLS 2763
            |.::::.|:..|.:.:|........::...|.|:..|..|.|.:....|||...|||:|||||||
Human  2650 SLDALNTIYGQIFSFHFQQQAFAPSILRSGPTLIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLS 2714

  Fly  2764 RIWEGILKVKHEECKSVDQILKLWCHECTRVISDRFTAEKDKIWFSSKMISDAELNIKEFMEFYP 2828
            .:::|||....|..|....::.||.||..||..|:...:||...|..:|:..|   .|.|
Human  2715 NVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETA---YKYF----- 2771

  Fly  2829 EEPTYWVDFLRDAPEGQEEEDEEMSFEPPKIY----------EEIPSFDFVRSKVLVFMSQFNEY 2883
                             |..|..|..:.|.||          ..:|..|:...|.::     .|.
Human  2772 -----------------EGIDSHMLLQQPLIYCHFADRGKDPHYMPVKDWEVLKTIL-----TET 2814

  Fly  2884 IRGYN-----MDLVFFMDALKHLMIVSRIISNPRGNALLVGVGGSGKQSLTRLSSFIAGYKFFQM 2943
            :..||     |.||.|.||::|:..:|||:..|:|.||||||||||||||:||::::.|.:.||:
Human  2815 LDNYNELNAAMHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQI 2879

  Fly  2944 TLTRSYNTGNLTEDLKFLYRTAGLDGNGMTFIFTANEIKEESFLEFINNILSSGEIANLFAKDEL 3008
            |||..|....|..||..||...|.......|:.|..::.:||||..||::|:||||.:||:.:::
Human  2880 TLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDV 2944

  Fly  3009 DEMYSELIPVMKKHQPRRPATQDNLYDFFISRARYNLHIALCFSPVGEKFRMRSLKFPGLISGCV 3073
            |::.|.:  ..:.|......:::|.:.||::|.|..|.|.|||||||...|:|:.|||.:::...
Human  2945 DKIISGI--HNEVHALGMVDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIVNCTA 3007

  Fly  3074 IDWFQKWPEDARIAVSRHYLTDYQIVCSEKV-KDQVIDIMSWIHESVQETCLSYYDRFRRVTFVT 3137
            ||||..||::|.::|||.::.:.:.:  |.| ||.:...|:.:|.:|.|....||...||..:.|
Human  3008 IDWFHAWPQEALVSVSRRFIEETKGI--EPVHKDSISLFMAHVHTTVNEMSTRYYQNERRHNYTT 3070

  Fly  3138 PKSLISFLESYKLLYKDKQDHIVIMSERMSSGLDKLDEAGASVAILKKDLIEMNKVIALASEEAE 3202
            |||.:..:..:|.|.|.||:.:....||:.:|:.||....:.|..||..|......:.|.:.:||
Human  3071 PKSFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAE 3135

  Fly  3203 DVLATV--EQSKAAAEIVKVEVAEKKG---QAEVLVKNISAVKHVAEAKLEKALPALEEAEAALK 3262
            .::..:  :..|.:.|....:..|:|.   |.||..|     :...||.|.||.|||..|.|||.
Human  3136 ALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQK-----QRECEADLLKAEPALVAATAALN 3195

  Fly  3263 TIKAADIATVRKLGKPPYLITLIMDCVCILF--RRKVKPIRPDTEKAFIQSSWDESLKVMSDT-S 3324
            |:...:::.::....||..:|.:...|.:|.  |.:|...|          ||..:...|... .
Human  3196 TLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDR----------SWKAAKVFMGKVDD 3250

  Fly  3325 FLRKIVEYPTDLINAEMVDMM-VPYFQYPQYTFEAAKVACGNVAGLLSWTMAMSKYFEVNKEVLP 3388
            ||:.::.|..:.|....:.:: ..|.:.|::.....:......|||.:|.:.:.|::||..:|.|
Human  3251 FLQALINYDKEHIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEP 3315

  Fly  3389 LKANLAVQEAKYQKASSDLQEAEELLQQKENELAEVQQTLEDAVSKKDAVLDEAKKCQDKMDAAT 3453
            .:..||....:...|:..|:...:.|...:..|:.:..:.|.|.::|....:|..:....:..|.
Human  3316 KRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLAN 3380

  Fly  3454 ALIGGLAGEKIRWTEQIASFKSETDRLVGDVILLTAFLSYTGPFNQEFRSDL-QSIWTKQIIEKM 3517
            .|:..|..:||||.:.|.||:::...|.|||:|..||:||.|||.:::|.:| ...|...:.:|:
Human  3381 RLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQELVHCKWVPFLQQKV 3445

  Fly  3518 -IPISANVNIIESLTDRSQIGEWNIQGLPTDELSIQNGIISTKAMRFPLLIDPQSQGKVWIKNKE 3581
             ||::..:::|..|||.:.|..||.:|||:|.:|.:|..|.|...|:||:||||.||..|||||.
Human  3446 SIPLTEGLDLISMLTDDATIAAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKY 3510

  Fly  3582 KQNKVIVTTLNHKYFRNHLEDSVSMGIPIIIEDVAEELDPCLDNLLDRNLLKVGTQYKIKIGDKE 3646
            ..: :.||.|..|.|.|.:|.:::.|..|:||::.|.:||.||.||.||.:|.| :| |:|||||
Human  3511 GMD-LKVTHLGQKGFLNAIETALAFGDVILIENLEETIDPVLDPLLGRNTIKKG-KY-IRIGDKE 3572

  Fly  3647 VDWNPAFRCYITTKLPNPAYTPEIFARTSIIDFTVTMRGLEDQLLGRVILAERKELEDERVQLVE 3711
            .::|..||..:.|||.||.|.||:.|:|::::||||..|||.|||..|:..||.:|  |:::||.
Human  3573 CEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDL--EKLKLVL 3635

  Fly  3712 TVTGNMKK--MKELEANLLQKLSTTKGSLLDDVTVIEVLNTSKNTAIEVKEKIEIAKVTEAKINA 3774
            |...|..|  :|.||.:||.:||..:||.|||..::|.|..:|.|..|::.|:..||..|.|||.
Human  3636 TKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKINE 3700

  Fly  3775 AREEYRVVATRGSVLYFLVCSMARVNNMYQTSLVQFLERFDASMYNSSKTHITQKRIKRIINYLT 3839
            |||.||.||.|.|:|||::..:.::|.:||.||..|...|..::..:.|....|.||..::..:|
Human  3701 ARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRAIEQADKVEDMQGRISILMESIT 3765

  Fly  3840 FEIYRYKSRGLYEKDKFLFVLLMALSI---DRQLELITFDEFQVFIKGGAALNLNDCPPVPFRWT 3901
            ..::.|.|:.|:||||..|:..||..|   .::::.:..|....|......|:     ||.|  .
Human  3766 HAVFLYTSQALFEKDKLTFLSQMAFQILLRKKEIDPLELDFLLRFTVEHTHLS-----PVDF--L 3823

  Fly  3902 TDETWLNLVQLTNLTPFVNILSKVSGNERAWFTWYKKDAPENEIIPDGYNSLDPFRKMLLVRSWC 3966
            |.::|..:..:..:..|..|...|.|:.:.|..|.:.:.||.|.:|..:......:|::|:|:..
Human  3824 TSQSWSAIKAIAVMEEFRGIDRDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLILLRAMR 3888

  Fly  3967 MDRTISQCRKYIANSLGDRFAEPVVLNFEELLLESRELMPMICFLSLGSDPSSNIELLAKK---- 4027
            .||.....|.::...||.::.|...|:..:...||....|:...||.|.|...::|:|.|:
Human  3889 PDRMTYALRNFVEEKLGAKYVERTRLDLVKAFEESSPATPIFFILSPGVDALKDLEILGKRLGFT 3953

  Fly  4028 -NELKCHPISMGQGQEIHARKLILSCLEDGGWVLLQNCHLGLEYMVELTVQILELERQGKDAAVN 4091
             :..|.|.:|:|||||..|...:....:.|.||:|||.||..:::..|. ::||...||.    :
Human  3954 IDSGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLE-KLLERFSQGS----H 4013

  Fly  4092 PNFRIWITTEPHPK-----FPITLLQMCLKYTNEPPAGIRAGLKRTYTNLSQDFLDY-SQSPFYL 4150
            .::|::::.|..|.     .|..||:..:|.|||||.|:.|.|.....|..||.|:. |:...:.
Human  4014 RDYRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEICSKEQEFK 4078

  Fly  4151 PLVYSISFLHTVVQERRKFGPLGWNIPYEFNSSDWYASCLFVQNHLDDIEQGKGISWVTVRYMLG 4215
            .:::|:.:.|..|..|.:|||.||:..|.||..|.......:.|:|   |....:.|..:||:.|
Human  4079 SILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYL---EANSKVPWEDLRYLFG 4140

  Fly  4216 EVQYGGRVTDDYDKRLLNTFTRVWFHDTLFEDCFQFFKGYKVYSFKEQEAYLAAIDDMANVDPPQ 4280
            |:.|||.:|||:|::|...:...:.:.:|.||......|:....:.:...|...|::|...:.|.
Human  4141 EIMYGGHITDDWDRKLCRVYLEEFMNPSLTEDELMLAPGFAAPPYLDYAGYHQYIEEMLPPESPA 4205

  Fly  4281 VYGFHSNAEITYQTNTMRNILDEIMSIQPKESSAG--TGESREDRVARQVKEMLSKTPLAFDLFD 4343
            :||.|.||||.:.|.|...:...::.:||:.:.:|  .|:|.|::|...:.::|.|.|..|::.:
Human  4206 LYGLHPNAEIEFLTVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAE 4270

  Fly  4344 VKQHLIAMGATSSMNIFLR---QEIDRMQRIIILVRSIFKDLLLAVEGTIIMSENLRDALDNIFN 4405
            :.|      ..|:.:.::.   ||.:||..:|..:|...:.|.|:::|.:.:|..:......:..
Human  4271 IMQ------KNSNRSPYVLVCFQECERMNILIREIRISLEQLDLSLKGELALSPAVEAQQFALSY 4329

  Fly  4406 ARVPTVFKRGSWVSS-SLGFWFTELLERHTQFYNWCFG-ARPVVFWMSGFFNPQGFLTAMRQEVA 4468
            ..||..:.:.::.|: .|..||.:||.|..:...|... ..|.|.|:|||||||.||||:.|.:|
Human  4330 DTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSGFFNPQSFLTAIMQTMA 4394

  Fly  4469 RAHQGWALDQVTMHNDVLKVGPEECKKPPKEGVFVYGLFVDGAGWDKRTSRLVEATNKVLFTLMP 4533
            |.:: |.||:..:..||.|...|:...||:||.:::|||::||.||.:...:|||..|.|...||
Human  4395 RKNE-WPLDKTRLTADVTKKTKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELACPMP 4458

  Fly  4534 VIHIYAIFSTAAKNSKLYTCPVYKKINRTDL---NYICALWLQSNKHPDHWTLRGVALLCD 4591
            ||...|......:..:.|.||||    ||.|   :||....|:|.:....|.|.|||||.:
Human  4459 VIFAKATPVDRQETKQTYECPVY----RTKLRGPSYIWTFRLKSEEKTAKWVLAGVALLLE 4515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-3	NP_001104482.3	DHC_N1	266..800	CDD:285571	123/599 (21%)
		DHC_N2	1378..1778	CDD:285579	120/404 (30%)
		P-loop_NTPase	1914..2145	CDD:304359	139/230 (60%)
		P-loop_NTPase	2229..2364	CDD:304359	55/150 (37%)
		P-loop_NTPase	2521..2790	CDD:304359	78/268 (29%)
		P-loop_NTPase	2889..3151	CDD:304359	105/262 (40%)
		MT	3164..3506	CDD:289543	93/351 (26%)
		AAA_9	3538..3754	CDD:289547	101/217 (47%)
		Dynein_heavy	3900..4582	CDD:281078	210/702 (30%)
DNAH11	NP_001264044.1	Stem. /evidence=ECO:0000250	1..1854		447/2035 (22%)
		DHC_N1	239..812	CDD:285571	122/596 (20%)
		DHC_N2	1319..1722	CDD:285579	120/407 (29%)
		P-loop_NTPase	1855..2084	CDD:304359	139/229 (61%)
		AAA 1. /evidence=ECO:0000250	1855..2076		135/221 (61%)
		AAA 2. /evidence=ECO:0000250	2136..2366		81/242 (33%)
		P-loop_NTPase	2169..2313	CDD:304359	55/150 (37%)
		P-loop_NTPase	2471..2741	CDD:304359	80/274 (29%)
		AAA 3. /evidence=ECO:0000250	2472..2719		72/251 (29%)
		AAA 4. /evidence=ECO:0000250	2817..3066		101/252 (40%)
		P-loop_NTPase	2818..3085	CDD:304359	107/270 (40%)
		Stalk. /evidence=ECO:0000250	3072..3403		86/345 (25%)
		MT	3097..3441	CDD:289543	94/358 (26%)
		AAA 5. /evidence=ECO:0000250	3459..3686		107/231 (46%)
		AAA_9	3468..3680	CDD:289547	101/216 (47%)
		Dynein_heavy	3820..4506	CDD:281078	212/706 (30%)
		AAA 6. /evidence=ECO:0000250	3896..4122		70/230 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810