DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-3 and Dhc64C

DIOPT Version :9

Sequence 1:	NP_001104482.3	Gene:	kl-3 / 26067053	FlyBaseID:	FBgn0267432	Length:	4593	Species:	Drosophila melanogaster
Sequence 2:	NP_001261432.1	Gene:	Dhc64C / 38580	FlyBaseID:	FBgn0261797	Length:	4661	Species:	Drosophila melanogaster

Alignment Length:	5062	Identity:	1268/5062 - (25%)
Similarity:	2226/5062 - (43%)	Gaps:	931/5062 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPERNVKRLRKLFG--------VSRNMLKR-AARRPSVSDQEREDQQRRRYQLLREMR--QQRI 54
            :|...|...:||...        |.||.:|. .:.:|:..:.|:|   :..||:..::.  ..|:
  Fly    52 LDDPVNQDTIRKFLSDPQVQALYVQRNCIKEDDSEQPAEGEDEKE---QVTYQISNDVHFTNSRM 113

  Fly    55 SSLGPNQRYVLEICADLLGIDPEEIVTGIVDESKYVEN----VNGIFEEKGP---MAIMISNAT- 111
            :||...:|          |:        :|:..|.:.:    :|  |.:..|   :...||.:.
  Fly   114 ASLACIKR----------GL--------VVEADKSIHSQLRLIN--FSDGSPYETLHAFISKSLA 158

  Fly   112 --MLGYPTDSGR-----------YQEKLKYTE-----IQRSVCLRSDLVDLIGKWTVVYRLNNEK 158
              ...|..:|||           .::||...|     :|:::    |:.::        .|...:
  Fly   159 PYFKSYVKESGRADRDGDKMAPSVEKKLAELEMGLLHLQQNI----DIPEI--------TLTAHQ 211

  Fly   159 SIDN--RSVSDE-----VAIFMISAEERNSCLNVVKTFMDHVLKPSIEAVTE------------- 203
            :::|  |..::|     ||.|....|: :|.||:::..::..: ..|:.||:
  Fly   212 TVNNVIRKCAEENRKAKVADFGDKVED-SSFLNLLQNGVNRWI-AEIKKVTKLNRDPGSGTALQE 274

  Fly   204 -----------FGLAEKEQTQ------------KFFHILNMY--NTFLKSSEATVSS----RVNF 239
                       :.:.||.::.            |.||....:  :|.||.:.|||:.    ..:|
  Fly   275 ISFWLNLERALYRIQEKRESPEVALTLDILKHGKRFHATVSFDTDTGLKQALATVADYNPLMKDF 339

  Fly   240 DISH-----ELFKGLLLVRWQIEASSKILTRVRLVERYFEQWLRQIQGILVEGKQIQRDTPDVGP 299
            .|:.     ||.|    :|..::.....|.:||..:...::.|:.|:.       |.||...  .
  Fly   340 PINDLLSATELEK----IRPAVQQIFAHLRKVRNTKYPIQRCLKLIEA-------ISRDLSQ--Q 391

  Fly   300 LQMLVNWRRMLARYTTITEFVTSRAFNNHKDCLTLSRSSKLLNRWAEIDNQVTLALNEAKDNVRY 364
            |..::..||::  :....||  .|..|   .|.      ::.:.|.:..:::...|.:.....|
  Fly   392 LLKVLGTRRLM--HIPFDEF--ERVMN---QCF------EIFSCWDDEYDKLQGLLRDIVKKKR- 442

  Fly   365 ISSLQKFWDPLYRSSPNVIISSLPGLMVAIRNVSKTAHYFNTPV----NVTGLMVKISNQLTITS 425
            ...|:..|    |.||  ....|...|..:|...:......|.:    ..|...|.....:..|.
  Fly   443 DEHLKMVW----RVSP--AHKKLQTRMEHMRKFRRQHEQLRTVILRVLRPTKPAVGDDGNVVETK 501

  Fly   426 KNYITDNEHSKVMEN----YKNI-YIHTVDEMKNSNERPWTVSSVYILTCLQKFLQRLEKVKWIA 485
            :.|..|...:..:|.    |:|: .:..:|..|..:| .|..:       ::::.:::::|:
  Fly   502 QPYSLDAADANAIEEVNLAYENVKEVDCLDITKEGSE-AWEAA-------VKRYEEKIDRVE--- 555

  Fly   486 NTDITYSILDRI--------MISGMERFNAM-----IKGARMTISSQLYDPLNYRIETFDLDFEK 537
             |.||..:.|::        |.....||||:     |:||.....:||...:...||..   .||
  Fly   556 -TRITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIEAL---HEK 616

  Fly   538 FVNEVEEAEVGMQQFVKLLSTECPSAASVMLVLKRFEALSLECLCLDRRYLEVAEMLEREMFLLK 602
            |                  ..:.|.:.|..                                 |.
  Fly   617 F------------------KVQYPQSKSCR---------------------------------LS 630

  Fly   603 DVYNEERGNPFIPRNLPPVAGRIIWIRSIFKKIDLPMQALKLRQCVLAHKKAQRTVRYYNYMNGI 667
            .|           |:||||||.|||.|.|..::.:                         |:..:
  Fly   631 SV-----------RDLPPVAGSIIWARQIDNQLTM-------------------------YLKRV 659

  Fly   668 ICHYEMAYHKAWFDYVEEVRCLLNAPIMTINKEEAIYIVNIDRAILQLISETEWMWKLNLEVPNM 732
                |....|.|..::|..:...:....              ||.|. ||:....|...::..|.
  Fly   660 ----EDVLGKGWETHIEGQKLKADGDSF--------------RAKLS-ISDVFHEWARKVQERNF 705

  Fly   733 AATITYCKDRLLGPATTLKLMLQRYDRLRTSLTPVFINIMRFRLQEISILLKPSLSTVTWISENL 797
            .:|         |...|::....|..|         .|::|.|:
  Fly   706 GST---------GRIFTIESTRSRIGR---------GNVLRLRV--------------------- 731

  Fly   798 EDYVEKVCMKIKEVETFFNLILDIEDLRILQEMYSISD-YLYIYVPEEPVSSYEFVEESNKLRS- 860
             :::.::....|||....||...: .|.|:.:.:..:. |.|.....|.|.:||...|....||
  Fly   732 -NFLPEIITLAKEVRNIKNLGFRV-PLTIVNKAHQANQIYPYAISLIESVRTYERTLEKLNNRSL 794

  Fly   861 ---EIERILEKKSVC-----MERAVVDIINMFIDLLDFEQTDSKGRRVFQLPP------------ 905
               .:.:|.::.|:.     :.:.|:::::..|.|: :|.        ::|.|
  Fly   795 AQNSVFKIEDRASIVPLVAGLRKDVLNLVSEGIGLI-WES--------YKLDPYVIRLSECVTQF 850

  Fly   906 -EKLNDTNWRTEGFLPID-------KWDFIQFHKIYRTIYLAPEDVLRTLQFRNYENIRYELYHL 962
             ||::|. ...|..|.:|       .:....|.:|...|..|.:|    |..|.|.|:...:..|
  Fly   851 QEKVDDL-LVVEEQLDVDVRSLETCPYSAATFVEILSKIQHAVDD----LSLRQYSNLSVWVTRL 910

  Fly   963 RNDCMDLFSYYNSKIILALVA----------GSKRSLDFVRQNILRTNWRTN-PMKP-------- 1008
            ..:       ...|:.|.|.|          |:|:.:|        |:..|: |.:|
  Fly   911 DEE-------VEKKLALRLQAGIQAWTEALTGNKKEVD--------TSMDTDAPAQPTHKLGGDP 960

  Fly  1009 -ILHTDLEIDFYN-GCYIQPNLE-----IMQNDFNNAVLCCTEI-----NYFVSTWGKQAKTQER 1061
             |.:...||...| ..|:.|::|     |||..|....:..:::     .|.|..  ::..:|..
  Fly   961 QIQNAVHEIRITNQQMYLYPSIEEARFQIMQQFFAWQAIVTSQVRLQSTRYQVGL--EKHVSQTY 1023

  Fly  1062 RDRRVTVDENK-YERSYFRYVMEHKDVIRAVQNLANGLLSYKSDMEEFQRDMFEKYKY------- 1118
            |:....:.|.| .|.:|  ..:|.|  :..|:|..:..|.|:| :.:.|.||.    |
  Fly  1024 RNLLTKLPEGKILENAY--GAIEQK--VSEVRNYVDEWLRYQS-LWDLQADML----YGRLGEDV 1079

  Fly  1119 -LWAEDREDIINSFVLTNPLTVDIRDMFLHYDNISLKIETMSAKRIIGPIEVRMGSTIEKLVSES 1182
             ||.:...||..|           |..|          :|...:|..|||.:.......|:..:.
  Fly  1080 NLWIKCLNDIKQS-----------RTTF----------DTSDTRRAYGPIIIDYAKVQAKVTLKY 1123

  Fly  1183 KKW-KVLLGH---LLSVQYKKQLDEMIEFITEQNNILDKPINDLD----------DVRQAMVVLE 1233
            ..| |..||.   ||..       ||..|    ::.:.|...||:          |....:..::
  Fly  1124 DSWHKEALGKFGTLLGT-------EMTSF----HSKVSKSRTDLEMQSIEAASTSDAVSFITYVQ 1177

  Fly  1234 KVRDNYIEMDVSLQLITDTYSL-------FSQFYIYVPQEDYDKVEGLQVLFNKMLENA-KKVSD 1290
            .::.:.|..|..:::..:...:       |...:::|     |.:||....||::::.. ..:..
  Fly  1178 SLKKDMIAWDKQVEVFREAQRILERQRFQFPNTWLHV-----DNIEGEWSAFNEIIKRKDTAIQT 1237

  Fly  1291 RISEMEEPLLRELNDGIATFVQEFYDFNLDFDLNGPMVEGISAKEASDRVFLFQNRFDELWRKFE 1355
            :::.::..::.| :..:.|   ...||..|::...|....|...:|..::.:|::::..|..:.:
  Fly  1238 QVASLQAKIVAE-DKAVET---RTVDFLNDWEKTKPTGGKIRPDDALQQLQIFESKYSRLKEERD 1298

  Fly  1356 MYSSGEKLFGL-----PITDYPLLHQRKREFNYLNRLYSLYIQVLKTITDYYEMPWADVNIEKIS 1415
            .....::...|     |......::....|...|..::|...:|...|.:..|.||..|...|:.
  Fly  1299 NVVKAKEALELQESAVPNNSAERMNVALEELQDLRGVWSELSKVWTQIDETREKPWLSVQPRKLR 1363

  Fly  1416 AELSDFQLRCRKLPKGMQSWPAFIDLKTKIDDFNETCPLLELMTNKAMKERHWIRLNALFNTDFD 1480
            .:|.....:.::||..::.:.::..:|..|..:.:...|:..:.:.|:|||||.:|......::.
  Fly  1364 QQLEAMMAQLKELPARLRMYESYEYVKKLIQSYIKVNMLIVELKSDALKERHWKQLTKQLRVNWV 1428

  Fly  1481 PTNPKFTLGKLLEAPILKYKEDVEDICVGASKELDIEAKLKQIVSDWSLVSLQLGQFKNRGDLVL 1545
            .::  .:||::.:..:.|.:..|:||.:.|..|:.:|..|||:...|....|.|..::|: ..::
  Fly  1429 LSD--LSLGQVWDVNLQKNEGIVKDIILVAQGEMALEEFLKQVRESWQNYELDLINYQNK-CRII 1490

  Fly  1546 KGGETLEIISSLEDSLMIMNSLASNRYNAPFKKDIQLWLSKLVNTGDILEKWLMVQNLWIYLEAV 1610
            :|.:  ::.:.:::.:..:.::..:.|...|:::...|..||.....:.:.|:.||..|:|||.:
  Fly  1491 RGWD--DLFNKVKEHINSVAAMKLSPYYKVFEEEALTWEEKLNRINALFDVWIDVQRRWVYLEGI 1553

  Fly  1611 FVG-GDISKQLPMEAKRFTNIDKSYVKIMMRAREIPNAVDCCTGDESLATNLTWLLDQLETCQKS 1674
            |.| .||...||:|..||.:|...::.:|.:..:.|..:| .....::..:|..|.|.|...||:
  Fly  1554 FSGSADIKTLLPVETSRFQSISSEFLGLMKKVTKSPKVMD-VLNIPAVQRSLERLADLLGKIQKA 1617

  Fly  1675 LTGYLESKRLVFPRFFFVSDPVLLEILGQASDPTSIQPHLLSIFDAIATVDFQEKSIDIIESMNS 1739
            |..|||.:|..||||:||.|..||||:|.:.:...:|.|...:|..:|.:...|:: ::|..::|
  Fly  1618 LGEYLERERTSFPRFYFVGDEDLLEIIGNSKNIARLQKHFKKMFAGVAAILLNEEN-NVILGISS 1681

  Fly  1740 MNREKVKFENTVQCL--GSVELWLGRLLKEMQDTIRTILAQMSVSLN-------DPEFNFAEEFP 1795
            ...|:|.|.|.|..:  ..:..||..:.|:|:.|:.::|||....:.       ||: .:.|...
  Fly  1682 REGEEVHFMNPVSTVEHPKINEWLSLVEKQMRFTLASLLAQAVQDIKQFRDGKIDPQ-AYMEWCD 1745

  Fly  1796 SFCGQAGVVGVQLLWTKDSEYALRKC--RTDKTIMKRTNNKFLVLLNFFIDLTVKDLTSLDRIRF 1858
            .:..|..|:..|:||::|.|.||::.  ......|:|........||...|..:::...|.|.:.
  Fly  1746 KYQAQIVVLAAQILWSEDVESALQQASENNQSKPMQRVLGNVESTLNVLADSVLQEQPPLRRRKL 1810

  Fly  1859 ETMVTIHVHQRDIFDDLCTLRIKSAGDFEWQKQARFYYNEDNDDVIVGIT----DVNFVYQNEYL 1919
            |.::...||:|.:...|....:.|...|:|..:.|||::....:|:..:|    :..|.|..|||
  Fly  1811 EHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYFDPRQTEVLQQLTIHMANARFFYGFEYL 1875

  Fly  1920 GVTERLAITPLTDRCYITLAQAVGMCMGGAPAGPAGTGKTETTKDMGRALGKLVVVFNCSDQMDF 1984
            ||.:||..||||||||:|:.||:...:||:|.|||||||||:.|.:|..||:.|:||||.:..||
  Fly  1876 GVQDRLVQTPLTDRCYLTMTQALESRLGGSPFGPAGTGKTESVKALGNQLGRFVLVFNCDETFDF 1940

  Fly  1985 RGLGRIYKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTARK-----EKRSTFIFLDGDIVS 2044
            :.:|||:.||.|.|:|||||||||:|..:||..:|||..:..|.|     .|.|..:.|.|..|.
  Fly  1941 QAMGRIFVGLCQVGAWGCFDEFNRLEERMLSACSQQIQTIQEALKYEMDSNKESITVELVGKQVR 2005

  Fly  2045 LNPEFGIFITMNPGYAGRQELPENLKIMFRTVAMMVPDRQIIIRVKMASCGFKENVVLSRKMYTL 2109
            ::|:..||||||||||||..||:|||.:||::||..||||:|..|.:.|.||:....|:.|:...
  Fly  2006 VSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTTPDRQLIAEVMLFSQGFRSAEKLACKIVPF 2070

  Fly  2110 YKLCEEQLSKQVHYDFGLRNILSVLRTLGSQKRSN----------------------PNDTEETI 2152
            :|||:||||.|.|||||||.:.|||.:.|:.||..                      .|..|:.|
  Fly  2071 FKLCDEQLSNQSHYDFGLRALKSVLISAGNVKRDRIMKIKEQMKQRGDENIDEASVAENLPEQEI 2135

  Fly  2153 VMRVLRDMNVSKLIDEDEGLFVSLVDDMFPGIKLTTNVYKDLQKAIIKVCDE------------- 2204
            :::.:.:..|.||:.||..|..||:.|:||.:..|....|.|::.|.|||.|
  Fly  2136 LIQSVCETMVPKLVAEDIPLLFSLLSDVFPNVGYTRAEMKGLKEEIRKVCQEDYLVCGEGDEQGA 2200

  Fly  2205 ------LGYVNNPEWNLKVVQLYETSLVRHGLMLMGPTGSGKTSCTVCMLRCFTEM----GRTHK 2259
                  ||    ..|..||:|||:.|.:.||||::||:||||::....:|:.....    |..|.
  Fly  2201 AWMEKGLG----STWVDKVLQLYQISNLNHGLMMVGPSGSGKSTAWKTLLKALERFEGVEGVAHV 2261

  Fly  2260 EMRMNPKAITAPQMFGRLDVATNDWTDGIFSTLWRRSL-----KVPQHQNCWIVLDGPVDAVWIE 2319
               ::||||:...::|.||..|.:||||:|:.:.|:.:     ::.:.|  ||:.||.||..|:|
  Fly  2262 ---IDPKAISKEALYGVLDPNTREWTDGLFTHILRKIIDNVRGEINKRQ--WIIFDGDVDPEWVE 2321

  Fly  2320 NLNSVLDDNKTLTLANGDRIKMADNSKLVFEPDNVDNASPATVSRVGMVFTSSSVLSWKIYMEAW 2384
            ||||||||||.|||.||:|:.:..|.:::||..::..|:.|||||.|||:.|..|||.::..|.:
  Fly  2322 NLNSVLDDNKLLTLPNGERLSLPPNVRVMFEVQDLKFATLATVSRCGMVWFSEDVLSTEMIFENY 2386

  Fly  2385 L------------------LKQGEDSE-------------------------VFRRCYDVLYDDA 2406
            |                  :|..:|.|                         :..|..:...|..
  Fly  2387 LSRLRSIPLEDGDEDFVGVIKPAKDKEEEVSPSLQVQRDIALLLLPFFSADGIVVRTLEYAMDQE 2451

  Fly  2407 HVFLQSRLLAKMRILEAIYIRQMLDIMDGLLL-------DLPL---RTEKALERIFLFSLMWSLG 2461
            |:...:||    |.|.:::  .||:.....:|       |.|.   :.|..:.:..::|::||..
  Fly  2452 HIMDFTRL----RALSSLF--SMLNQAARNVLTFNAQHPDFPCSADQLEHYIPKALVYSVLWSFA 2510

  Fly  2462 AVLELSEREKLEEFLLKHVSKLRWPKRGVNETIFEYYVDDNGNWQHWSTRVEEFRYPEDEIPEFS 2526
            ...:|..|..|.:| ::.|:.:..| ......|.:|.|:.:|:|..||.:|........::.. .
  Fly  2511 GDAKLKVRIDLGDF-VRSVTTVPLP-GAAGAPIIDYEVNMSGDWVPWSNKVPVIEVETHKVAS-P 2572

  Fly  2527 SILVPNVDNVRTAFLLHNIAKQLKQVLLIGEQGTAKTV-MIKAYMGHYDPEVHIFKSFNFSSATT 2590
            .|:||.:|.||...||:....:.|.::|.|..|:.||: :..|.....|.||   ...|||||||
  Fly  2573 DIVVPTLDTVRHESLLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEV---VGLNFSSATT 2634

  Fly  2591 PNMYQRIIESYVEKRQ---GTTYGPPN-QRAMTIFIDDINMPVINEWGDQITNEIVRQMIEQRGF 2651
            |.:..:..:.|.|.|:   |....|.. .:.:.:|.|:||:|.::.:|.|.....:||::|.:||
  Fly  2635 PELLLKTFDHYCEYRKTPNGVVLSPVQIGKWLVLFCDEINLPDMDSYGTQRVISFLRQLVEHKGF 2699

  Fly  2652 Y--------SLERPGDFSTIMDIQMLSAMIHP-GGGRNDIPNRLKRHLCIFNCTLPSNNSMDQIF 2707
            |        ||||         ||.:.|...| ..||..:.:|..||:.|.....|...|:.||:
  Fly  2700 YRASDQAWVSLER---------IQFVGACNPPTDPGRKPLSHRFLRHVPIIYVDYPGETSLKQIY 2755

  Fly  2708 KSIGAGYFSPDRLGDEVVEVIPLL----VPLTRIFWQNVKAK-------MLPTPANFHYVFNLRD 2761
                 |.||     ..::.::|.|    .|||....:...|.       |.|     |||::.|:
  Fly  2756 -----GTFS-----RAMLRLMPALRGYAEPLTNAMVEFYLASQDRFTQDMQP-----HYVYSPRE 2805

  Fly  2762 LSRIWEGILK-VKHEECKSVDQILKLWCHECTRVISDRFTAEKDKIWFSSKMISDAELNI----- 2820
            ::|...||.: ::..:...|:.:::||.||..|:..||...:.::.|.:.        ||
  Fly  2806 MTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRLFQDRLVDDSERRWTNE--------NIDLVGQ 2862

  Fly  2821 KEFMEFYPEE----PTYWVDFL-RD-APEGQEEEDEEMSFEPPKIYEEIPSFDFVRSKVLVFMSQ 2879
            |.|.....||    |..:.::| :| .|..:||..|                 :|.:::.||
  Fly  2863 KHFPGINQEEALQRPILYSNWLSKDYMPVNREELRE-----------------YVHARLKVF--- 2907

  Fly  2880 FNEYIRGYNMDLVFFMDALKHLMIVSRIISNPRGNALLVGVGGSGKQSLTRLSSFIAGYKFFQMT 2944
               |....::.||.|.:.|.|::.:.||...|:|:.||:||.|:||.:|:|..:::.|...||:.
  Fly  2908 ---YEEELDVPLVLFDEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIK 2969

  Fly  2945 LTRSYNTGNLTEDLKFLYRTAGLDGNGMTFIFTANEIKEESFLEFINNILSSGEIANLFAKDELD 3009
            :...|.:.:..|||:.:.|.:|.....:.||...:.:.:..|||.:|.:|::||:..||..||
  Fly  2970 VHNKYTSEDFDEDLRCVLRRSGCKDEKIAFILDESNVLDSGFLERMNTLLANGEVPGLFEGDE-- 3032

  Fly  3010 EMYSELIPVMKKHQPRRPA---TQDNLYDFFISRARYNLHIALCFSPVGEKFRMRSLKFPGLISG 3071
              |:.|:...|:...|...   :.|.||.:|..:...|||:....:|..:..:.|:...|.|.:.
  Fly  3033 --YTTLMTQCKEGAQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLKDRAATSPALFNR 3095

  Fly  3072 CVIDWFQKWPEDARIAVSRHYLTDYQI-------------VC-----SEKVKDQVIDIMSWIHES 3118
            ||::||..|.:.|...|.:.:.|...:             ||     :...:|.||:...::|::
  Fly  3096 CVLNWFGDWSDSALFQVGKEFTTRVDLEKPNWHAPDFFPSVCPLVPANPTHRDAVINSCVYVHQT 3160

  Fly  3119 VQETCLSYYDRFRRVTFVTPKSLISFLESYKLLYKDKQDHIVIMSERMSSGLDKLDEAGASVAIL 3183
            :.:.......|..|...|||:..:.|:..:..||.:|:..:......::.||:|:.|....|..:
  Fly  3161 LHQANARLAKRGGRTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEM 3225

  Fly  3184 KKDLIEMNKVIALASEEAEDVLATVEQSKAAAEIVKVEVAEKKGQ-AEVLVKNISAVKHVAEAKL 3247
            :|.|....:.:...:|.|...|..:.|.:..||..|::..|.:.: |:..||.....|:|. |.|
  Fly  3226 QKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVM-ADL 3289

  Fly  3248 EKALPALEEAEAALKTIKAADIATVRKLGKPPYLITLIMDCVCILFRRKVKPIRPDTEKAFIQSS 3312
            .:..||:.:|:||:|:|:...:..||.:..||.::.|.::.:|:|.....             :.
  Fly  3290 AQVEPAVIDAQAAVKSIRKQQLVEVRTMANPPSVVKLALESICLLLGENA-------------TD 3341

  Fly  3313 WDESLKVMSDTSFLRKIV-EYPTDLINAEMVD-MMVPYFQYPQYTFE---AAKVACGNVAGLLSW 3372
            |.....|:...:|:..|| .:.|:.|..::.: |...|...|.|.||   .|.:|||   .::.|
  Fly  3342 WKSIRAVIMRENFINSIVSNFGTENITDDVREKMKSKYLSNPDYNFEKVNRASMACG---PMVKW 3403

  Fly  3373 TMAMSKYFEVNKEVLPLKANLAVQEAKYQKASSDLQEAEELLQQKENELAEVQQTLEDAVSKKDA 3437
            .:|..:|.::.|.|.||:..|...|.:.....:..:|.::|::|.|..:|..::.....:|:..|
  Fly  3404 AIAQIEYADMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQA 3468

  Fly  3438 VLDEAKKCQDKMDAATALIGGLAGEKIRWTEQIASFKSETDRLVGDVILLTAFLSYTGPFNQEFR 3502
            :..:.:..|.|:|.:.||:..|..|:.||.....:|||:...::|||:|..||::|.|.|:|.:|
  Fly  3469 IKTDLENVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYR 3533

  Fly  3503 SDLQSIWTKQIIEKMIPISANVNIIESLTDRSQIGEWNIQGLPTDELSIQNGIISTKAMRFPLLI 3567
            .:|.:.|::.:....|...|::...|.|::..:...|....||||:|..:|.|:..:..|:||:|
  Fly  3534 LNLFTTWSQHLQAASIQYRADIARTEYLSNPDERLRWQANALPTDDLCTENAIMLKRFNRYPLII 3598

  Fly  3568 DPQSQGKVWIKNKEKQNKVIVTTLNHKYFRNHLEDSVSMGIPIIIEDVAEELDPCLDNLLDRNLL 3632
            ||..|...::.|:....|:..|:.....||.:||.::..|.|::::|| |..||.|:.:|:|.|.
  Fly  3599 DPSGQATTFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNPLLVQDV-ENYDPILNPVLNRELR 3662

  Fly  3633 KVGTQYKIKIGDKEVDWNPAFRCYITTKLPNPAYTPEIFARTSIIDFTVTMRGLEDQLLGRVILA 3697
            :.|.:..|.:||:::|.:|:|..:::|:.|...:.|:|.:|.:.::||||...|:.|.|.:|:.|
  Fly  3663 RTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQCLNQVLKA 3727

  Fly  3698 ERKELEDERVQLVETVTGNMK-KMKELEANLLQKLSTTKGSLLDDVTVIEVLNTSKNTAIEVKEK 3761
            ||.:::::|..|:: :.|..: ::::||.:|||.|:..||.:|||.:||..|.|.|..|.::.:|
  Fly  3728 ERPDIDEKRSDLLK-LQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQK 3791

  Fly  3762 IEIAKVTEAKINAAREEYRVVATRGSVLYFLVCSMARVNNMYQTSLVQFLERFDASMYNSSKTHI 3826
            ::......|:|....::|..::...|.:||.:.|:.:|:.:||.||..||:.|...:||:.|...
  Fly  3792 VDETDKVIAEIETVSQQYLPLSVACSNIYFTMDSLNQVHFLYQYSLKMFLDIFSTVLYNNPKLEG 3856

  Fly  3827 TQKRIKR--IINYLTFEI-YRYKSRGLYEKDKFLFVLLMA-LSIDRQLELITFDEFQVFIKGGAA 3887
            .....:|  |:....|:: |...:||:...|:..|.|||. :.:....|.....||..|::....
  Fly  3857 RTDHSERLGIVTRDLFQVCYERVARGMIHIDRLTFALLMCKIHLKGTSESNLDAEFNFFLRSREG 3921

  Fly  3888 LNLNDCPPVPFRWTTDETWLNLVQLTNLTP-FVNILSKVSGNERAWFTWYKKDAPENEIIP---D 3948
            |..|   |.|....:.|...::.:|....| |..:|.||....... .|.::.:|| :::|   |
  Fly  3922 LLAN---PTPVEGLSAEQIESVNRLALRLPIFRKLLEKVRSIPELG-AWLQQSSPE-QVVPQLWD 3981

  Fly  3949 GYNSLDPF----RKMLLVRSWCMDRTISQCRKYIANSLGDRFAEPVVLNFEELLLESREL----M 4005
            ...:|.|.    .::||::::..||.|:.....:...||:.|........:...:..::|    .
  Fly  3982 ESKALSPIASSVHQLLLIQAFRPDRVIAAAHNVVNTVLGEDFMPNAEQELDFTSVVDKQLNCNTP 4046

  Fly  4006 PMICFLSLGSDPSSNIELLAKKNELKCHPISMGQGQEIH-ARKLILSCLEDGGWVLLQNCHLGLE 4069
            .::|.:. |.|.|..::.||.:...:...|::|..:..: |.:.|....:.|.||||:|.||..:
  Fly  4047 ALLCSVP-GFDASGRVDDLAAEQNKQISSIAIGSAEGFNQAERAINMACKTGRWVLLKNVHLAPQ 4110

  Fly  4070 YMVELTVQILELERQGKDAAVNPNFRIWITTEPHPKFPITLLQMCLKYTNEPPAGIRAGLKRTYT 4134
            ::|       :||::......:..||:::|.|.:||.|:.||:....:..|||.||||.|.||::
  Fly  4111 WLV-------QLEKKMHSLQPHSGFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGIRANLLRTFS 4168

  Fly  4135 NLSQDFLDYSQSPFYLPLVYSISFLHTVVQERRKFGPLGWNIPYEFNSSDWYASCLFVQNHLDDI 4199
            .:....:..:.|. ...|.:.:::.|.:||||.::.||||...||||.||...:|..:...:|..
  Fly  4169 TVPAARMMKTPSE-RARLYFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDTWIDTT 4232

  Fly  4200 EQGK------GISWVTVRYMLGEVQYGGRVTDDYDKRLLNTFTRVWFHDTLFEDCFQFFK----- 4253
            ..|:      .:.|..:..:|.:..|||::.:|:|:|||.:|.:..|....||..|....
  Fly  4233 AMGRTNLPPEKVPWDALVTLLSQSIYGGKIDNDFDQRLLTSFLKKLFTARSFEADFALVANVDGA 4297

  Fly  4254 --GYKVYSFKE---QEAYLAAIDDMANVDPPQVYGFHSNAEITYQTNTMRNILDEIMSI------ 4307
              |.:..:..:   ::.:|..|:::.:...|...|..:|||....|....:::.:::.:
  Fly  4298 SGGLRHITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAEKVLLTTRGTDLVSKLLKMQQLEDD 4362

  Fly  4308 ---------QPKESSAGTGESREDRVARQVK-------EMLSKT--PLAFDLFDVKQHLIAMGAT 4354
                     |.::|:.|.||.......:.:.       |:|.|.  .|...:.::|..|..
  Fly  4363 DELAYSVEDQSEQSAVGRGEDGRPSWMKTLHNSATAWLELLPKNLQVLKRTVENIKDPLYR---- 4423

  Fly  4355 SSMNIFLRQEIDRMQRIIILVRSIFKDLLLAVEGTIIMSENLRDALDNIFNARVPTVFKR----- 4414
                 :..:|:....|::..|....:|::|..:|....:.:.|..|..:....:|..:||
  Fly  4424 -----YFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPA 4483

  Fly  4415 GSWVSSSLGFWFTEL------LERHTQFYNWCFGAR-----PVVFWMSGFFNPQGFLTAMRQEVA 4468
            |..|..    |.|:.      |::.:|..:.. ||:     ||  |:.|..||:.::||.||.||
  Fly  4484 GCTVIQ----WITDFSNRVQQLQKVSQLVSQA-GAKELQGFPV--WLGGLLNPEAYITATRQCVA 4541

  Fly  4469 RAHQGWALDQVTMHNDVLKVGPEECKKPPKEGVF-VYGLFVDGAGWDKRTSRLVEATNKVLFTLM 4532
            :|: .|:|:::.:...:...|   .|...|:..| |.||.:.||.. |....|:.:|  ::..|.
  Fly  4542 QAN-SWSLEELALDVTITDAG---LKNDQKDCCFGVTGLKLQGAQC-KNNELLLAST--IMMDLP 4599

  Fly  4533 PVIHIYAIFSTAAKNSKLYTCPVYKKINRTDLNYICALWLQSNKHPDHWTLRGVALL 4589
            ..|..:...|:..:.||| |.|||....||:|.:...|.:.:.:....:..||||:|
  Fly  4600 VTILKWIKISSEPRISKL-TLPVYLNSTRTELLFTVDLAVAAGQESHSFYERGVAVL 4655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-3	NP_001104482.3	DHC_N1	266..800	CDD:285571	95/555 (17%)
		DHC_N2	1378..1778	CDD:285579	106/402 (26%)
		P-loop_NTPase	1914..2145	CDD:304359	125/257 (49%)
		P-loop_NTPase	2229..2364	CDD:304359	58/143 (41%)
		P-loop_NTPase	2521..2790	CDD:304359	83/294 (28%)
		P-loop_NTPase	2889..3151	CDD:304359	75/282 (27%)
		MT	3164..3506	CDD:289543	92/347 (27%)
		AAA_9	3538..3754	CDD:289547	75/216 (35%)
		Dynein_heavy	3900..4582	CDD:281078	178/751 (24%)
Dhc64C	NP_001261432.1	DHC_N1	240..839	CDD:285571	142/803 (18%)
		DYN1	1022..4338	CDD:227570	963/3486 (28%)
		DHC_N2	1326..1724	CDD:285579	108/404 (27%)
		P-loop_NTPase	1870..2103	CDD:304359	123/232 (53%)
		P-loop_NTPase	2227..2367	CDD:304359	59/144 (41%)
		P-loop_NTPase	2572..2835	CDD:304359	83/289 (29%)
		Cas4_I-A_I-B_I-C_I-D_II-B	2834..>2943	CDD:294426	33/139 (24%)
		P-loop_NTPase	2916..3194	CDD:304359	75/281 (27%)
		MT	3208..3544	CDD:289543	94/352 (27%)
		AAA_9	3569..3784	CDD:289547	75/216 (35%)
		Dynein_heavy	3925..4636	CDD:281078	180/748 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450619
Domainoid	1	1.000	230	1.000	Domainoid score	I503
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47047
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	1	1.100	-	-	P	PTHR10676
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840