Protein Alignment Myo81F and MYH13

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_003793.2
• Gene: MYH13 / 8735
• HGNCID: 7571
• Length: 1938
• Species: Homo sapiens
• Alignment Length: 2158
• Identity: 488/2158 - (22%)
• Similarity: 857/2158 - (39%)
• Gaps: 564/2158 - (26%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            ||..|:.:.|..:..||..||.:.:||||:|...:.|||||.:.::..:.::.|...|..:..||
Human    90 DMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPH 154

  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTIT-----------SNVSSWVQ 130
            :|::::.||..::.|..||:.:|:||||||||.:||.::||..||.           ..:...::
Human   155 IFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKETQPGKMQGTLE 219

  Fly   131 QQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERN 195
            .||::||.:|||||||||.|||||||||||:::.|.....:....|..||||:||:|||...||:
Human   220 DQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERS 284

  Fly   196 YHIMYQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFV 260
            |||.||:::..:..:.........|.:| .:::.......::: :|::..|...|..:|......
Human   285 YHIFYQIMSNKKPELIDLLLISTNPFDF-PFVSQGEVTVASID-DSEELLATDNAIDILGFSSEE 347

  Fly   261 IDGVFKVISSILWLGNIEF--------IDVDG-EVTDLTRSDQEAISIISMLLGLSRCDFKKVLL 316
            ..|::|:..:::..||::|        .:.|| ||.|..          ..|:||:..:..|.|.
Human   348 KVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKA----------GYLMGLNSAEMLKGLC 402

  Fly   317 IRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGF 381
            ..::.|..........:::...:..|||||:|.|||.|:|::||...:..|....|:|||||.||
Human   403 CPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGF 467

  Fly   382 ENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKPPRC 445
            |.|..||.||||||:|||||.:||||::|.|||..|:.|||.:..::| .|...|:|::|| |..
Human   468 EIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEK-PMG 531

  Fly   446 VFKLLTEQCHMPQGSDLAFLSNMHTE-------FESHPNYIKGSDRRHWETEFGIKHYAGLVIYA 503
            :|.:|.|:|..|:.:|.:|.:.::.:       |:. |...||....|    |.:.||||.|.|.
Human   532 IFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQK-PKPAKGKAEAH----FSLVHYAGTVDYN 591

  Fly   504 VGGFVEKNRD-VQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSSKSK----CTVSDNFR 563
            :.|:::||:| :.:.|:..|...|..:.....|.|...:..:|...:...|.|    .|||..||
Human   592 IAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGKKKGSSFQTVSAVFR 656

  Fly   564 NQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKD 628
            ..|..|:..|::|.|.:|||:.||..|.|...:..||:.||:..||::.|||.|:|||..:.:.|
Human   657 ENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYAD 721

  Fly   629 FIVRYKCL------------IKNKSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLE 681
            |..||:.|            .||.|    :|.|.:|    .:...:::.|.:|:|.:.....|||
Human   722 FKQRYRILNASAIPEGQFIDSKNAS----EKLLNSI----DVDREQFRFGNTKVFFKAGLLGLLE 778

  Fly   682 TNRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRM---RRSAIVIQS 743
            ..|.:.|.                 :.:.:.|||.      ||:.:|:.|.:|   |.|...||.
Human   779 EMRDEKLV-----------------TLMTSTQAVC------RGYLMRVEFKKMMERRDSIFCIQY 820

  Fly   744 RLRGVF-----------------------AREVAAALREMKRVDEEL----KKRDGIYEQLTSI- 780
            .:|...                       .:|:|....:.:|..|||    .:|..:.|::.|:
Human   821 NIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLL 885

  Fly   781 ------------TTKTLADCE-----------------RSIQEELSVLAHISDNIRASAKPLSDK 816
                        .|:.|.|.|                 :.:.|.|.....::..:.|..:.|.||
Human   886 QEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDK 950

  Fly   817 NDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDS 881
                    .||:|::..:|:.....:.:.|.|.||.            ||||.||:...
Human   951 --------CSSLKRDIDDLELTLTKVEKEKHATENK------------VKNLSEEMTAL------ 989

  Fly   882 FDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLNSEPIYE-AIN-LYKLTTTKE-------- 936
              .:...||  ||..::|.|          :....|:...:.| .:| |.|:....|
Human   990 --EENISKL--TKEKKSLQE----------AHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEG 1040

  Fly   937 -IKKEKYMLLDYKSIK---DNSKKPSTSSVF----VKYQIDER-----------------ENRRK 976
             :::||.:..|.:..|   :...|.|..|:.    .|.||:|:                 |....
Human  1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHS 1105

  Fly   977 QRVEKKIHEL--TLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAK 1039
            .:.:|||.||  .:.::.::|..:::....:|...:     ||:.:...||...::. |...:|:
Human  1106 LQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRS-----DLARELEEISERLEEA-SGATSAQ 1164

  Fly  1040 HEMTM-----FSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQI--IQYI-VG 1096
            .||..     |.|..:         |.|...|.........:..:.:..||...||  :|.: ..
Human  1165 IEMNKKREAEFQKMRR---------DLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220

  Fly  1097 LGIEREELRDEI-----FIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKS 1156
            |..|:.||:.||     .|:.:.:|::  ||:.|.|.                        ::..
Human  1221 LEKEKSELKMEIDDMASNIEALSKSKS--NIERTCRT------------------------VEDQ 1259

  Fly  1157 MIELDGKLRQYSQWCFD-NCKSTKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPT 1220
            ..|:..|..|.:|...| |.:..::.|:
Human  1260 FSEIKAKDEQQTQLIHDLNMQKARLQTQ------------------------------------- 1287

  Fly  1221 DTAGDAVQKLAEKLNL---TTTDGWAIYQN----RPDGEEHIKSYDYLYDVISS----------- 1267
              .|:...::.||.:|   .|....|:.|.    :...||..|:.:.:...:.|
Human  1288 --NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350

  Fly  1268 WEMKQATYAGTKKTTNGSSSGENQF--VFKKRLFKSTHELSQDPVEVSMLYSQAVHSVVKKDEFP 1330
            :|.:|...|..::..:.::|...|:  .::....:.|.||.    |.....:|.:....:..|..
Human  1351 YEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELE----EAKKKLAQRLQEAEENTETA 1411

  Fly  1331 VSEKVALQLA--GLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFWIPILAQAHRQYGS 1393
            .|:..:|:..  .||.:|          .:...|:........:..::|:.:..:||:..::...
Human  1412 NSKCASLEKTKQRLQGEV----------EDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDE 1466

  Fly  1394 SRNALTAKVLYLSCVMQYPLYGTTMFKVNYKGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKY 1458
            |:..|.|      ...:.....|.:||:.     |....::     |.:..:..|:|::  |.:.
Human  1467 SQAELEA------AQKESRSLSTELFKMR-----NAYEEVV-----DQLETLRRENKNL--QEEI 1513

  Fly  1459 VDIESILLDPSDSFITISLNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSN 1523
            .|:                  :.|:.:|   |.:|.|::|.......:|:|:            .
Human  1514 SDL------------------TEQIAET---GKNLQEAEKTKKLVEQEKSDL------------Q 1545

  Fly  1524 WILNNLECSKKYKGTTKEDRLRLYQNVVLCRRHLVDMNIVKKPHDFGGFLRNTLR---------- 1578
            ..|..:|.|.::: .:|..|::|..:.|   :..:|..:::|..:.....||:.|
Human  1546 VALEEVEGSLEHE-ESKILRVQLELSQV---KSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD 1606

  Fly  1579 ----------RLSKHR---LEKLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQEE 1630
                      ||.|..   |.::..::|.:.::..||.|   |             :.|:..|.:
Human  1607 AEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK---H-------------LRTVQGQLK 1655

  Fly  1631 ALMIQVFDSILTYSGLGS--------SGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQLIK 1687
            ...:.:.|::.:...|..        :|..:...|:..:.:.|:...:.:.::.||
Human  1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELL--------- 1711

  Fly  1688 QTTDHPDANSRVNL---KNWALLSVLCSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAEN 1749
                  ||:.||.|   :|.:|::            .:|.|.|.:.:|.::           .||
Human  1712 ------DASDRVQLLHSQNTSLIN------------TKKKLEADIAQCQAE-----------VEN 1747

  Fly  1750 CFFRTQGTRRRQWTPSREEILCTTNRRPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKI--- 1811
            ....::....:                   :|....|....:.|.:.....:..||.:||.:
Human  1748 SIQESRNAEEK-------------------AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793

  Fly  1812 -----GLLDNAK------GYSIYEVIGNSERSLSSEEKVCDVMAKWEKYQITSQQGFQKNTTLIS 1865
                 ..||.|:      |....:.:.|..|.|.:|   .||..|.....:.....:::....::
Human  1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENE---LDVEQKRGAEALKGAHKYERKVKEMT 1855

  Fly  1866 QQNQYMFLFKKHLFFDNYINLEDIVEKELLYHQILHNLRSERYPITEMEAIMLTAL------QSQ 1924
            .|.:     :.|   .|.:.|:|:|:|      :...::|.:....|.|....|.|      |.:
Human  1856 YQAE-----EDH---KNILRLQDLVDK------LQAKVKSYKRQAEEAEEQANTQLSRCRRVQHE 1906

  Fly  1925 L----ERGDCCES 1933
            |    ||.|..||
Human  1907 LEEAAERADIAES 1919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	234/694 (34%)
		MyTH4	1091..1194	CDD:459939	20/109 (18%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	16/120 (13%)
		B41	1202..1419	CDD:214604	35/238 (15%)
		PH-like	1415..1523	CDD:473070	17/107 (16%)
		MyTH4	1664..1771	CDD:459939	16/109 (15%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	20/118 (17%)
		B41	1781..1992	CDD:214604	37/177 (21%)
		PH-like	1988..2076	CDD:473070
MYH13	NP_003793.2	Myosin_N	33..77	CDD:460670
		MYSc_Myh13	100..770	CDD:276887	234/695 (34%)
		Actin-binding. /evidence=ECO:0000250	659..681		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	761..775		3/13 (23%)
		Myosin_tail_1	850..1927	CDD:460256	232/1349 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1917..1938		2/3 (67%)