DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo81F and MYO2

DIOPT Version :9

Sequence 1:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster
Sequence 2:NP_014971.1 Gene:MYO2 / 854504 SGDID:S000005853 Length:1574 Species:Saccharomyces cerevisiae


Alignment Length:1442 Identity:395/1442 - (27%)
Similarity:666/1442 - (46%) Gaps:255/1442 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTIN-IFNKQTISEYHTCKLGDLSP 75
            |:|.:|.::|..:...:..||:...||||:|.:|:|.||:..:: ::.:..|..|...:.|:|.|
Yeast    74 DLTSLSYLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGELEP 138

  Fly    76 HVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQ---------Q 131
            |:||:||.||..:.:|..||..|:|||||||||.|.|:|::|..::....|:.||         |
Yeast   139 HLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEMSETEQ 203

  Fly   132 QILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNY 196
            :||..|.|:|||||||||||||||||||::::.||.:..|.|..|..||||:||:.:|...||||
Yeast   204 KILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERNY 268

  Fly   197 HIMYQLVAQGQKNIGI-ANT---FHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIP 257
            ||.|||:|      |: |.|   .||..|..|.|:|.....|||...::|::.....|.|::.|.
Yeast   269 HIFYQLMA------GLPAQTKEELHLTDASDYFYMNQGGDTKINGIDDAKEYKITVDALTLVGIT 327

  Fly   258 QFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINV 322
            :.....:||:::::|.:||||......:.:  ..:|:..:.:...|||:...:|.|.:..:||..
Yeast   328 KETQHQIFKILAALLHIGNIEIKKTRNDAS--LSADEPNLKLACELLGIDAYNFAKWVTKKQIIT 390

  Fly   323 RGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINN--CTNPGQDD--AKFLGVLDIFGFEN 383
            |.......|...:||..:.::||.:||.:|.|||..||.  | ||..:|  :.|:|||||:|||:
Yeast   391 RSEKIVSNLNYSQALVAKDSVAKFIYSALFDWLVENINTVLC-NPAVNDQISSFIGVLDIYGFEH 454

  Fly   384 FSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFK 448
            |..|||||.||||.||||.:.||.:||.|||..|..|.|.::.:||.||.||::::|. ...:..
Yeast   455 FEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIEN-KLGILS 518

  Fly   449 LLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRD 513
            ||.|:..:|.|||.::...::...:..|.....|..|..:|:|.:.|||..|.|.|.||:|||||
Yeast   519 LLDEESRLPAGSDESWTQKLYQTLDKSPTNKVFSKPRFGQTKFIVSHYALDVAYDVEGFIEKNRD 583

  Fly   514 VQQDVMFEYMSYSKDVFI-----------KDLSTYQDIQFINSSYPRGSSK--------SKCTVS 559
            ...|...|.:..|.:..:           |.|...:.::...:    ||.|        .|.|:.
Yeast   584 TVSDGHLEVLKASTNETLINILEGLEKAAKKLEEAKKLELEQA----GSKKPGPIRTVNRKPTLG 644

  Fly   560 DNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHL 624
            ..|:..|..|::.:.:|...|:||||||..|....:::.:||.||:..||::.|||...|||...
Yeast   645 SMFKQSLIELMNTINSTNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRW 709

  Fly   625 SHKDFIVRYKCLIKNKSFE--YPQKYLTN---------ILEKNGMPTTEWQIGKSKIFLRNAAYE 678
            :.::|::||..||.::.::  :.:|..|.         ||:......:::|||.:|||.:.....
Yeast   710 TFEEFVLRYYILIPHEQWDLIFKKKETTEEDIISVVKMILDATVKDKSKYQIGNTKIFFKAGMLA 774

  Fly   679 LLETNRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRF---MRMRRSAIV 740
            .||..|.:.::.:.|:|||..:..|.:|.:|:..||:..:|:..:|:.:|.|.   |:: ..|.:
Yeast   775 YLEKLRSNKMHNSIVMIQKKIRAKYYRKQYLQISQAIKYLQNNIKGFIIRQRVNDEMKV-NCATL 838

  Fly   741 IQSRLRGVFAR-EVAAALREM----KRVDEELK----KRDGIYEQLTSITTKTLADCERSIQEEL 796
            :|:..||...| .|.:.||.:    |::.:|||    |::..|....:|.:|.     |:.:...
Yeast   839 LQAAYRGHSIRANVFSVLRTITNLQKKIRKELKQRQLKQEHEYNAAVTIQSKV-----RTFEPRS 898

  Fly   797 SVLAHISDNI--------RASAKPLSD-KNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENA 852
            ..|....|.:        ||:.:.|.. |.|:.|   .:.:|:.:..|:|....|.::       
Yeast   899 RFLRTKKDTVVVQSLIRRRAAQRKLKQLKADAKS---VNHLKEVSYKLENKVIELTQN------- 953

  Fly   853 LIKEINDNWNNLVKNLDEEI-GLCIHTEDS-----------------FDSQKTGKLFTTKTVRTL 899
            |..::.:|     |.:.|.| .|.:..|:|                 .|:||:..:...||:.. 
Yeast   954 LASKVKEN-----KEMTERIKELQVQVEESAKLQETLENMKKEHLIDIDNQKSKDMELQKTIEN- 1012

  Fly   900 PEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKE-KYMLLDYKSIKDNSKK-----PS 958
                            ||.|..          .|.|:.:.| :.|:..:..:|:.|||     ..
Yeast  1013 ----------------NLQSTE----------QTLKDAQLELEDMVKQHDELKEESKKQLEELEQ 1051

  Fly   959 TSSVFVKYQ-----IDERENRRKQRVEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFN----- 1013
            |....|:||     :.......|:.:.:....::|..:...:.......:::....:.||     
Yeast  1052 TKKTLVEYQTLNGDLQNEVKSLKEEIARLQTAMSLGTVTTSVLPQTPLKDVMGGGASNFNNMMLE 1116

  Fly  1014 THDLS-SDCNFISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKY 1077
            ..||| :|.|.      |.:|:..:..:.:...|            .|.||.|.:..:..||.:.
Yeast  1117 NSDLSPNDLNL------KSRSTPSSGNNHIDSLS------------VDRENGVNATQINEELYRL 1163

  Fly  1078 MRGELNAERELQIIQYIVGLGIERE-ELRDE-IFIQCIRQSRNNPNIDWTDRIWIILCLSIVAF- 1139
            :       .:.:|:...:..|:.:. |:.|. :.||..::     ::.:..||.||:...:..| 
Yeast  1164 L-------EDTEILNQEITEGLLKGFEVPDAGVAIQLSKR-----DVVYPARILIIVLSEMWRFG 1216

  Fly  1140 --QPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIV 1202
              :.|:......::.|:|.:.:|.|                   ..:.|.....:|.:|.|    
Yeast  1217 LTKQSESFLAQVLTTIQKVVTQLKG-------------------NDLIPSGVFWLANVREL---- 1258

  Fly  1203 CRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISS 1267
              :.|:.....:|....|...|...::..|.::|.|       :.:.|.|.      ..|::.:.
Yeast  1259 --YSFVVFALNSILTEETFKNGMTDEEYKEYVSLVT-------ELKDDFEA------LSYNIYNI 1308

  Fly  1268 WEMKQATYAGTKKTTN---------GSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAVHSV 1323
            | :|:......||..|         |.|:||.. .|..::|.:|.|.:.|.:   :.:..:::..
Yeast  1309 W-LKKLQKQLQKKAINAVVISESLPGFSAGETS-GFLNKIFANTEEYTMDDI---LTFFNSIYWC 1368

  Fly  1324 VKKDEFPVSEKV 1335
            :|  .|.:..:|
Yeast  1369 MK--SFHIENEV 1378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo81FNP_001303492.1 MYSc 8..685 CDD:214580 258/720 (36%)
Motor_domain 23..673 CDD:277568 252/697 (36%)
MyTH4 1091..1194 CDD:279165 16/107 (15%)
B41 1202..1419 CDD:214604 27/143 (19%)
UBQ 1202..1297 CDD:294102 20/103 (19%)
FERM_M 1307..1419 CDD:278785 4/29 (14%)
PH-like 1415..1523 CDD:302622
MyTH4 1664..1771 CDD:279165
UBQ 1780..1860 CDD:294102
B41 1781..1992 CDD:214604
FERM_B-lobe 1893..1984 CDD:271216
PH-like 1988..2076 CDD:302622
MYO2NP_014971.1 COG5022 2..1567 CDD:227355 395/1442 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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