Protein Alignment Myo81F and Myo15b

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_001389323.1
• Gene: Myo15b / 690323
• RGDID: 1597365
• Length: 3072
• Species: Rattus norvegicus
• Alignment Length: 2721
• Identity: 480/2721 - (17%)
• Similarity: 883/2721 - (32%)
• Gaps: 1009/2721 - (37%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            |:..:..:.:..:...|..|::...|||:.|.:|||:||::.:.:|:.:..:.||..|..:.:||
  Rat   678 DLARLRLVCDSSVLLCLKKRFHLGRIYTFGGPLLLALNPHQPLPLFSSEVSASYHPRKAPNTTPH 742

  Fly    77 VFAVAEAAYTSIVDDNINQACV-ISGESGAGKTESTKFILQYLCTITSNVSSWVQQQILEANTIL 140
            :||:..||| |:...:...:|: :.|.||:||||:.|.||::|.:|..........|:.:...:|
  Rat   743 IFAIGVAAY-SLSQSSGQDSCILLGGHSGSGKTEAAKKILKFLSSIEQKPMEASGAQLEDILPVL 806

  Fly   141 EAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQ---------------- 189
            .:||:|||..|.|:||||:...:|. ....|.|..:..||||.||:.||
  Rat   807 SSFGHAKTILNANASRFGQETHLCL-QQGVIVGASMSHYLLETSRVVFQVMTSLLPTPSPALKVG 870

  Fly   190 --------------------SEGERNYHIMYQLVAQGQKNIGIANT----FHLRPAEFYKYLNTS 230
                                ::.||::|:.|:|:|      |:..|    ..|:..|.|.|||..
  Rat   871 KRTGHSPQTLLPTKPVSLPKAQAERSFHVFYELLA------GLDPTEREQLSLQGPEAYYYLNQG 929

  Fly   231 NSEKINMNLESKKFDAVTMAFTVLQIPQFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQE 295
            .:.::....:::.|..:..|..||.:....:..|:.|:::||.||||.|       :...|..||
  Rat   930 GACRLQGKEDAQDFKELVKALRVLGLCTEELTAVWAVLATILHLGNICF-------SSSERESQE 987

  Fly   296 AISIISML-LGLSRCDFKKVLLIRQINVRGNITE-----------IPLKIKEALENRHALAKALY 348
            ..::.|.. :.|:    .::|.:...::.|.:|:           .||.::.|::.|.||||.||
  Rat   988 VAAVSSWAEIHLA----ARLLQVHPEHLEGAVTKRVTDTPYGLVSRPLPVEGAIDARDALAKTLY 1048

  Fly   349 SKMFTWLVSKINNCTNPGQ--DDAKFLGVLDIFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFA 411
            :::||||:.:||...:|.:  |....:.|:|:||||....|..||||.|..:|:|..|.:..:.|
  Rat  1049 ARLFTWLLKQINVRLSPPREADGVTAIAVVDVFGFEALRVNGLEQLCSNLASERLQFFSSQRLLA 1113

  Fly   412 LEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHP 476
            .|:.:.:.|.:.:..:.......||::|...|..:..:|..|..:||.:|..||...|.....||
  Rat  1114 QEEEVCQQELLKWVPIPQLPRESCLDLLVGHPHSLLSILDTQTWLPQATDHTFLQKCHYHHGDHP 1178

  Fly   477 NYIKGSDRRHWETE-----FGIKHYAGLVIYAVGGFVEKNRDVQQDVMFEYMSYSKDVFIKDLST 536
            :|.|        ::     |.::||||.|.|.|..||.:|||            |.|..:.::..
  Rat  1179 SYAK--------SQLPLPIFTVRHYAGTVTYQVHKFVNRNRD------------SLDPAVLEMLR 1223

  Fly   537 YQDIQFINSSYPR-----GSSKSKCTVSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYN 596
            ...:|.:.|.:..     |:.:||.|::..|:..|..|:..|..:..:.:.|:.|:..|.|...:
  Rat  1224 QSQLQLMGSLFQEAEPQAGTEQSKPTLASRFQQSLGDLLARLGRSHVYVIHCLNPSPGKLPGLLD 1288

  Fly   597 SSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNKSFEYPQKYLTN-------ILE 654
            ...|.:||:..||::||..|...||:.:..:.|:.|::.|...:     ||.:::       :.|
  Rat  1289 VEHVAEQLRQAGVLEIIGTRSTHFPVRVPFQVFLARFRALGSGR-----QKAVSDRERCGAILRE 1348

  Fly   655 KNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQ 719
            ..|..:..:.:|.:::.|:....:.||               :.|.:        |..||:|.:.
  Rat  1349 VLGAESPRYHLGATQVLLQEQGRQQLE---------------QLWAQ--------RRSQALLTLH 1390

  Fly   720 HAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALREMKRVDEELKKRDGIYEQLTSITTKT 784
            ...|....|.|...:.|    :|:|:||:.||:     |.::|
  Rat  1391 RGLRACITRQRLRLLPR----MQARVRGLQARK-----RYLRR---------------------- 1424

  Fly   785 LADCERSIQEELSVLAHISDNIRASAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAF 849
                 ||...:|:.:..::..:....:.|.......|...|..:.    ::|         .|..
  Rat  1425 -----RSALGQLNTILLVAQPLLRRRQKLQCSRGPQSGEPRGKVS----SMD---------PGRL 1471

  Fly   850 ENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSIS 914
            |                 :..::...:...:...::.||.:  |:::           ||.|.:.
  Rat  1472 E-----------------IPAQLAALLERAEGHQARLTGSI--TESL-----------PPEVPVR 1506

  Fly   915 ANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQRV 979
            .:|...|                              |..:.|.:|.|...:|..
  Rat  1507 PSLTLPP------------------------------DIDQFPFSSFVSTSFQKP---------- 1531

  Fly   980 EKKIHELTLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTM 1044
                                                       |:..|.|
  Rat  1532 -------------------------------------------FLPRPGQ--------------- 1538

  Fly  1045 FSKSDKIPTSH-IHMYDPENVVLSCSMFRELCKYM-RGELNAERELQIIQYIVGLGIEREELRDE 1107
                   |.:. :...|.||...:..:.|.:.:.: .|.|.:.:|..:..|:|.....|..||||
  Rat  1539 -------PLAEPLTRLDGENPQQALEINRVMLRLLGEGSLQSWQEQTMGTYLVQRAQRRPGLRDE 1596

  Fly  1108 IFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKS---------MIELDGK 1163
            :|.|.:.|..:||:...|.|.|.::.:.:.:|.|:..|.:..:.|:...         ..:|.|.
  Rat  1597 LFSQLVAQLWHNPDEQQTQRGWALMAILLSSFPPTPALEKPLLKFVSDQAPSGMAALCQHKLLGA 1661

  Fly  1164 LRQYSQWCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQ 1228
            |.|        .....::.|.:||:.:|..|..|.|.:....|..:..:.:.:|....|......
  Rat  1662 LEQ--------TPLAPMAARSHPPTQLEWKAGLRRGRMALDVFTFNEESYSAEVESWTTGEQLAG 1718

  Fly  1229 KLAEKLNLTTTD-GWAIYQNRPDGEEHIKSYDYLYDVISSWE----------------------- 1269
            .:.:...|.... ||::..:..|..:.:...|::.|:|...|
  Rat  1719 WILQSRGLEAPPRGWSVSLHSGDAWQDLLGCDFVLDLIGQTEDLGDSAGPHDYPITPLGLAENIP 1783

  Fly  1270 -------------------------------------------------------MKQATYAGTK 1279
                                                                   ::|. :|..:
  Rat  1784 PAPGVQAPSLPPGLPPGPAPTLPSSRSPGEASRPGNLDGFLDHLFEPVLTPGVSDLEQG-WALNR 1847

  Fly  1280 KTTNGSSSGENQ----FVFKKRLFKSTHELSQDPVEVSML------------------------- 1315
            :...|.|.|..|    .|:...:...:::.:..|..:.|:
  Rat  1848 RMKGGGSIGPTQQGYPMVYPGMVQAPSYQPAMIPAPIPMMPAMGTVPTVPAMMVPPQPQPLMPSL 1912

  Fly  1316 -------------------------------------------------YSQAVHSVV------- 1324
                                                             .|||..|.:
  Rat  1913 DSRQLAEQQQNFIHQQAMILAQQMTAQAMSLSLEQQNQRRQHQAQAPGAASQAPPSTIAPKAKKP 1977

  Fly  1325 --------------------------------------KKDEF------PVSEKVALQLAGLQ-- 1343
                                                  |:|.|      |:..|.....|.:|
  Rat  1978 PAPQEKPANDPEPLDVSFREDTPEEAEIRPQRPKSFQQKRDYFQKMGQEPIKVKTVKPPAKVQIP 2042

  Fly  1344 -----------AQVALGDP----------------------------------------SN---- 1353
                       |||:...|                                        ||
  Rat  2043 QEETEEDEEETAQVSPPPPPPPVVKKPLKQSRTKTGKEDEVEPAQKEEPTRDGAPKVQSSNSTPQ 2107

  Fly  1354 -------------------QPKPEYYSDINSF------LPIRISKTREQQFW------------- 1380
                               ||..|..:.|..:      :|:.:..||..:.:
  Rat  2108 QPSRSPPMVKSSDSTPQRPQPSREIRNIIRMYQSRPGPVPVPVQPTRPFKTFQKKNDPKDEALAK 2172

  Fly  1381 --------IPILAQAH-------------------------RQYGSSRN---------------- 1396
                    .|:.:..|                         .:.|..|:
  Rat  2173 LGINGASSPPLTSPTHGKSSPPAVAPRPKARPRLEPSTSIREKQGPLRDLFGPCSPNPPTAPAPP 2237

  Fly  1397 ---------------------ALTAKV--------------------------LYLSCVMQYP-- 1412
                                 |||..:                          |:|...:.||
  Rat  2238 PPLPPPLSLPGEPKSPLVESRALTEPMEDRGISTKLLVPSGSVCFSYANAPWKLFLRKEVFYPRE 2302

  Fly  1413 -------------------------------------LYG--------------------TTMFK 1420
                                                 |.|                    ....:
  Rat  2303 NFSHPYCLNLLCQQILRDTFTESCTRISQDERHKMKGLLGDLEVGLDSLDVAEDGIKKRIVVAAR 2367

  Fly  1421 VNYKGYWN--------LASNI-ILGIHYDGIMFIN-PEDKS-------VVFQFKYVDIESILLDP 1468
            .|:..|::        ..|:: :||:.:.|:..:. .:|.|       .:..:.|.::.::.. .
  Rat  2368 DNWANYFSRIFPVSGESGSDVQLLGVSHRGLRLLKVTQDPSFHLDQLKTLCSYSYAEVLAVQC-R 2431

  Fly  1469 SDSFITISLNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSNWILNNLECSK 1533
            |.|.:.:|| :|.||:..:.:..::....:.|:.|.  |.|.|     |..||.::|.::.....
  Rat  2432 STSTLELSL-KSEQLILHTTWARTMKAMVEQFLSEL--KKDSG-----YVIALRSYITDDNSLLS 2488

  Fly  1534 KYKGTTKEDRLRLYQNVVL----------CRRHLVDMNIVKKPH----DFGGFLRNTLRRLS--- 1581
            .::|    |.:||.....|          .|..|...::|:...    .|....||:.:|.|
  Rat  2489 FHRG----DLIRLLPVAALEPGWQFGSAGGRSGLFPADMVQPAAAPDLSFSLGKRNSWQRKSNRV 2549

  Fly  1582 ----KHRLEKLRSEVGSNTQE--------------HGETYKGFS-------HTFW---------- 1611
                :.|...||.:..|...|              |..|.:.|:       || |
  Rat  2550 TGPAQERPTHLRKQEPSEASEATSVTTYSSLSADSHNYTMREFALRYFRKPHT-WLTQMSAGTKE 2613

  Fly  1612 -------AFSKQQIP-----FCISTISDQEEALMIQVFDSILTYSGLGSSGESISRAEDEHIRII 1664
                   .::|..|.     ||    ::......:..|.:::.:.|    .:...|.:|| :.::
  Rat  2614 TTVVSLIQYTKDPIQESLTIFC----NEDTNTKAVAGFKALMQFMG----DQPKPRGKDE-LALL 2669

  Fly  1665 QSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKNWALLSVLCSVILPS---MKAVRKYL- 1725
            ..::..|  :|.|.:|:|.|:|||.|.||......  ..|::||:......||   |..|.|:|
  Rat  2670 YELLKLC--QEDLRDEMYCQVIKQVTGHPQPKHCA--LGWSILSLFTGFFAPSTTLMPYVTKFLQ 2730

  Fly  1726 ----IAHLKRCSSDFLSEEGKYARYAE-------NCFFRTQGTRRRQWTPSREEILCTTNRRPCY 1779
                ...|.:.|.:.|....||....:       :.|.:.|.:|          :|.
  Rat  2731 DSSPSQELAQSSQENLQRTVKYGGRQQLPLPGEMHAFLKGQASR----------LLL-------- 2777

  Fly  1780 SKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGL--LDNAKGYSIYEVIGNSE--RSLSSEEKVC 1840
              .:...|..|....|..:.|.:|||.:..::|:  |:..:.::::.:.|..|  |.||:.|.:.
  Rat  2778 --IHLPGGVDYRTNTQTFTVAGEVLEELCGQMGITDLEEVQEFALFIIKGEGELVRPLSTPEYIN 2840

  Fly  1841 DVMAKWEKYQITSQQGFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVEKELLYHQILHNLRS 1905
            :|:                       ::|.:.|..:.|.::..::.::....|..|.|:|.:...
  Rat  2841 NVI-----------------------KDQDISLHSRRLGWETPLHFDNTTYIETHYGQVLRDYLQ 2882

  Fly  1906 ERYPIT---EMEAIMLTALQ--SQLERGDCCESITDYRAVASHCLPPRFVPNIPH---------E 1956
            .:..::   |.:...|.|.|  |:...|...|              |..:..||.         .
  Rat  2883 GKLIMSAQAEAQLAQLAAFQHLSKASTGPPSE--------------PELLSYIPKPLQGQVNTAS 2933

  Fly  1957 AVAMHHQSLRGMLPIEAKKA---FLNLIKSWPLHRATIFDVMQSFTTNWPRTLWLAIDQKGIHLL 2018
            ..::..|.||.|.....:||   |:......||...|::.|::......|..:.|.::::.:.|:
  Rat  2934 IKSLVIQELRQMQGYNEQKAQIGFIETTTQLPLFGHTVYVVLRVSKLALPGPVLLGLNRQHLVLM 2998

  Fly  2019 EHRSRNVLCTYGYDSIIS---FSP----NLNSLMIFTGTEKKQSKVILTTPQAYQI 2067
            :..|..:.|:.....:..   .||    ....|.:..|:......:.|..|||.::
  Rat  2999 DPSSEKLCCSIALKDLQRLHLMSPLEEDGPPGLELNYGSADNPQTIWLELPQAQEL 3054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	194/721 (27%)
		MyTH4	1091..1194	CDD:459939	27/111 (24%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	19/183 (10%)
		B41	1202..1419	CDD:214604	57/674 (8%)
		PH-like	1415..1523	CDD:473070	25/144 (17%)
		MyTH4	1664..1771	CDD:459939	29/121 (24%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	19/108 (18%)
		B41	1781..1992	CDD:214604	43/231 (19%)
		PH-like	1988..2076	CDD:473070	15/87 (17%)
Myo15b	NP_001389323.1	PHA03169	27..>269	CDD:223003
		MYSc_Myo35	688..1367	CDD:276861	194/722 (27%)
		MyTH4	1582..1684	CDD:459939	27/109 (25%)
		PABP-1234	<1853..1968	CDD:130689	9/114 (8%)
		SPATA3	2093..>2129	CDD:434837	3/35 (9%)
		SH3_MYO15B	2472..2526	CDD:213001	12/57 (21%)
		MyTH4	2622..2768	CDD:470587	35/158 (22%)
		FERM_M	2858..2972	CDD:459788	24/127 (19%)
		PH-like	2968..3068	CDD:473070	15/87 (17%)