Protein Alignment Myo81F and myo15ab

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_073805445.1
• Gene: myo15ab / 570113
• ZFINID: ZDB-GENE-090312-149
• Length: 4449
• Species: Danio rerio
• Alignment Length: 2624
• Identity: 557/2624 - (21%)
• Similarity: 931/2624 - (35%)
• Gaps: 915/2624 - (34%)

  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDL 73
            |..|||:|.::.|..:..||.:|::.::||||.||||::||||:..||:....:.:|....:.|.
Zfish  2056 GTEDMTQMEQLTEPAVLINLKIRFDQELIYTYIGSILVSVNPYQLFNIYGTDMVLQYEGHAMADN 2120

  Fly    74 SPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQQQILEANT 138
            .||:||:|..|||:::|...||..:||||||:||||:||.:|:||..|....:  :.||||||..
Zfish  2121 PPHLFAIANVAYTTMMDIKQNQCIIISGESGSGKTEATKLVLRYLTAIHHKRN--ITQQILEATP 2183

  Fly   139 ILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMYQLV 203
            :||:||||||.|||||||||||::: |.:...|.|.:...||||:|||.||::.||||||.|:::
Zfish  2184 LLESFGNAKTVRNDNSSRFGKFVEI-FLEEGVISGAITSQYLLEKSRIVFQAKDERNYHIFYEML 2247

  Fly   204 AQGQKNIGIAN----TFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVIDGV 264
            |      |:.:    .|:|:.||.|.|||...:..|....:.:.|..:..|..:|.........:
Zfish  2248 A------GLPSHTKRAFYLQEAETYYYLNQGGNCGITGKDDGEDFRRLQSAMDILHFSTEDQSSI 2306

  Fly   265 FKVISSILWLGNIEFIDVDGEVTDLTR--SDQEAISIISMLLGLSRCDFKKVLLIRQINVRGNIT 327
            |:|:||||.|||:.|..|:.||.:...  |.|| |..::.||.:|....:|.:..:.........
Zfish  2307 FRVLSSILHLGNVFFHRVETEVQETAGVVSTQE-IRAVADLLQISPEGLQKAITFKVTEAMREKI 2370

  Fly   328 EIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFENFSHNSFEQL 392
            ..||.::.|::.|.|:||.|||.:|.||..:||....| :::|..:.:|||:|||:...||||||
Zfish  2371 YTPLSVESAVDARDAVAKILYSLLFNWLTDRINGRVYP-RNEALSISLLDIYGFESLVFNSFEQL 2434

  Fly   393 CINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTEQCHMP 457
            ||||.||.|..||:..:|..||..|..|.|.:..:.||||..|::::...|..:.::|.:|...|
Zfish  2435 CINYANETLQFFFSKIIFKQEQEEYIREQINWKELTFTDNQACIDLISAKPHGLLRILDDQSCFP 2499

  Fly   458 QGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRD-VQQDVMFE 521
            |.:|..||...|....::|.|   |..:....||.:.||||.|.|.|..|::||.| |:|:|:..
Zfish  2500 QATDNTFLQKCHYHHGNNPLY---SKPKMPLPEFTVYHYAGRVTYQVHKFLDKNFDQVRQEVLDL 2561

  Fly   522 YMSYS----KDVFIKD---LSTYQDIQFINSSYPRGSSKSKCTVSDNFRNQLQSLIDVLQNTKPW 579
            :|...    .::|||.   |:..:.....:|:..|....|  ||:..|:..||.|:|.::...|:
Zfish  2562 FMQSQNRTVSNLFIKHSEMLNQQKGAMNRSSTVTRRYQPS--TVAAKFQQSLQELLDKMERCNPF 2624

  Fly   580 YVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNKSFEY 644
            :|||||||..|.|..::..||..||:|.|::|.||||:||:||.:....|:.|||.|:..|.
Zfish  2625 FVRCIKPNNNKEPGIFDPELVATQLRYSGILDTIRIRKEGYPIRVPFHKFLNRYKALLGMKK--- 2686

  Fly   645 PQ--------KYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQKNWKK 701
            |.        ..||.:...|   ..::|:|.||:||:...|:|||:.|...::..|:.:|:..:.
Zfish  2687 PPPSDGDNCVMMLTKLCPIN---KGDYQVGVSKLFLKEEVYQLLESKRDRVMHIAALTLQRYVRM 2748

  Fly   702 YYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALREM--KRVD 764
            ::.::.||:.:..:..:|...:|:..|.||:|||.:.|..::.:|.:..|:....:..:  :|.:
Zfish  2749 FFARRKFLKFRLTMTHLQAHCKGFMARQRFLRMRINLIRHRAMIRLIVNRKRYIRINVLLARRAE 2813

  Fly   765 EELKK--RDGIYEQLTSITTKTLADCERSIQEELSVLAHISDNIRASAKPLSDKNDSDSNTARSS 827
            ||.::  .:.|..::.::|             :|.:.|.:...::|:|......:|
Zfish  2814 EERRRLELERISREVVNVT-------------QLVIPAELGGLLQATAGGRERHSD--------- 2856

  Fly   828 IKQNTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFT 892
                                                           |:            .|..
Zfish  2857 -----------------------------------------------CL------------ALVQ 2862

  Fly   893 TKTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKP 957
            ...::|.|:.|:|..                  ||.:.:|        ||:...::.:.......
Zfish  2863 APRIQTDPQLTLPLD------------------INNHLMT--------KYIRTHFRELLFGMLTA 2901

  Fly   958 STSSVFVKYQIDERENRRKQRVEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCN 1022
            ...:...:.:.|.:::              .:|:         |..||.|
Zfish  2902 PLENSLTRLEDDLKQD--------------AVDV---------FILILRF--------------- 2928

  Fly  1023 FISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERE 1087
                                               |.||                   .||..:|
Zfish  2929 -----------------------------------MGDP-------------------NLNGAQE 2939

  Fly  1088 LQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSF 1152
            .....||:..|:....:||||..|...|...|.|....:|.|:::...:.:|.||:.:.:|.:.|
Zfish  2940 NLFGNYIIQRGLATPPIRDEILAQIANQVWRNENSRNAERGWLLMAACLSSFAPSEKMEKYLLKF 3004

  Fly  1153 IKKSMIELDG-------KLRQYSQWCFDNCKSTKV--STRMYPPSSVEVAAMRRLGTIVCRFFFL 1208
            :  |...|:|       ||.|..|      ||..|  ::|.||||.:|..|.|:...:|.:....
Zfish  3005 V--SDYALNGFKALCQHKLLQAMQ------KSYLVPEASRTYPPSLLEWTATRKKAHMVLQVHCF 3061

  Fly  1209 DARTKAIDVHP----TDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISSWE 1269
            |..:....||.    ...|||.:|.  ..::..:..||::....|.....::.:||:.|::...|
Zfish  3062 DGVSFLCPVHSWTNGEGLAGDVLQH--RGVSAESRWGWSVLMKEPAQWVELEGHDYVLDLVCDLE 3124

  Fly  1270 M-----KQATY------------------------------------------------------ 1275
            :     ||.||
Zfish  3125 LLPDFPKQKTYFIISTEDPSKARPNASISLFGSGFDEDEDGPLSYANRMSAVPTNSLPISEGHYS 3189

  Fly  1276 --------------------------------------AGTKKTTNGSSSGENQFVFK------- 1295
                                                  :|..|...|....|.|...|
Zfish  3190 LDSEPSYDATQRGMDRYLDSLFDPVLSDAAGDFDASVLSGRMKGGGGVGGDEAQHTAKVTPLAAL 3254

  Fly  1296 ----------------------------------------------------------------- 1295
                                                                             
Zfish  3255 QPGAVRVLPPMPPMPGSPIMPSLPAVPPVPVPDQQHAVLAQQQQTILNQQAVIMAQQMTMQAMAM 3319

  Fly  1296 --------------------------------------------------------------KRL 1298
                                                                          .:.
Zfish  3320 VTSPVSSPPMSPLTSPPTSPPPTPYSTLPPSPYPAIPPSPYANIPPSPYAPMSAYSSPPVTPTQT 3384

  Fly  1299 FKST--HELSQD----------------------PVEVSMLYSQAVHSVVKKDEFPVSEKVALQL 1339
            |.||  :..|.:                      |.:.|:...||..:.:|.|..|......:.:
Zfish  3385 FASTPNYNASSETLKKKSSPPNTQPRSNTKTQATPSKGSLGKKQAPAAPIKLDSRPAKRHAPVAV 3449

  Fly  1340 AG---------------------------------LQAQVALGDPS------------------- 1352
            .|                                 .|.|....:|:
Zfish  3450 TGPMRSTPAPGTEVVKYSVSNSEHIVPSHNIKDIIKQYQTPTPEPAPLKQKRDGKGFVKKKNPHD 3514

  Fly  1353 -----------NQPKP------------------------------------------------- 1357
                       |.|.|
Zfish  3515 EAMQILKTQMDNPPPPQRHAPTPAAVSRDEGLKPTKSSKKKAPEPPLTLPPPVSRDLPVETESIQ 3579

  Fly  1358 ---------EYYSDIN----------SFLP--------------------------IRISKTREQ 1377
                     |:|:..|          .|.|                          :||:|...|
Zfish  3580 TPLHRSGTEEHYTYTNVPWKIYLRKEVFYPKDSWNHLLVLDLIFKQIVNDTFTEACVRITKEERQ 3644

  Fly  1378 QFWIPILAQAHRQYGSSRNA-----LTAKVLYLSCVMQYPLYGTTMFKVNYKGYWNLASNI-ILG 1436
            :     :.....|||...|.     ...|.:..:....:.:|.:.:|..:    .::.:.: :|.
Zfish  3645 K-----MKSLFAQYGIEPNTDVQDESVKKTVIAAARESWEIYFSRLFPAS----GSVGTGVQVLA 3700

  Fly  1437 IHYDGIMFIN--------PEDKSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTSLYGSSL 1493
            :.:.||..:.        |:...|:..:.|:||         .|:||.   |..:|:.:|....|
Zfish  3701 VSHTGIKLLKTVKSSTAAPDYFRVLRPYSYLDI---------LFVTIP---SPNMLEFNLMNEKL 3753

  Fly  1494 IESQKCFVFETPQKNDIGSLIIS-------YYPALSNWILNNLECSKKYKGTTKEDRLRL----- 1546
            |    .|..:.||...:..|.||       |..|..|:|..:......:||    |.:||
Zfish  3754 I----LFSAKAPQIKQMVDLFISHLKKDSEYVVAERNFITEDRSLLNFHKG----DIIRLQAMDG 3810

  Fly  1547 ------YQNVVLCRRHLVDMNIVKK-PHDFG------------------------GFL------- 1573
                  |..||  ::.::.:..:|: ..|||                        .||
Zfish  3811 LEEGQSYGCVV--KKKVIYLEELKRGTPDFGWRYGAVQGRSGAFPMECVVPVAAPDFLGLPAERR 3873

  Fly  1574 ---RNTLRRL--------------SKHRLEKLRSEVG----SNTQEHGETYKGFSHTFWAFSKQQ 1617
               |:...|:              :.|.|:......|    .:::..|.......:....|:::.
Zfish  3874 DEPRDRQGRVAASGAIALAVASTAAAHELDPSLESDGFGDFGDSEAEGNVVLDSQYNMVEFARKY 3938

  Fly  1618 IPFCISTISD------------QEEALMIQVFDSILTYSGLGSSGESISRAEDEHIRIIQSIM-D 1669
            ......:.||            ::.|.|::...:.:..|.:..:..:::|...|....|...| |
Zfish  3939 FRTSDGSKSDSFRDKSKKGKGSKDPAEMVKFNKNPILESLIDFTDPNMNRVASEIFLAIMKFMGD 4003

  Fly  1670 KCMKKES-----------------LLNELYLQLIKQTTDHPDANSRVNLKNWALLSVL-----CS 1712
            ..::.:|                 :.:|.|.|::||.|.:..:......|.|.||.:|     ||
Zfish  4004 HPLRGQSEQFVVCTFLKLTGEYGLMKDEAYCQVLKQITANTSSKPDSCQKGWRLLYILTAFYRCS 4068

  Fly  1713 VILPSMKAVRKYLIAHLKR-CSSDFLSEEGKYARYAENCFFRTQGTRRRQWTPSREEILCTTNRR 1776
            .:|      :.:|:..|:. |.|..:...| .|:..|....:|.....|...||..|:......|
Zfish  4069 EVL------KPFLLKFLRDVCRSPEVHFHG-IAKTCEQNLRKTFQFGGRSVYPSSMELKAIMAGR 4126

  Fly  1777 PCYSK---FYFMDGQYYSIEFQPSSTANDVLEIIKKKIGL--LDNAKGYSIYEVI--GNSERSLS 1834
            .  ||   |.|..|....::.:..|.|.||:|.:..::.|  |:....|:::.|.  |.:.|.|:
Zfish  4127 S--SKRQLFLFPGGIERHLKIKTCSVALDVIEELCYEMALQRLEAMDEYTVFIVTNRGQNVRPLN 4189

  Fly  1835 SEEKVCDVMAKWEKYQITSQQGFQKNTTLISQQNQYMFLFKKHLF-----FDNYINLEDIVEKEL 1894
            ..|.:.|:..:.|  ||.:               .|.|.|::.::     |||.:.:      .:
Zfish  4190 KREYILDIATEAE--QIDA---------------NYSFWFRRVIWAHPLKFDNELCV------TM 4231

  Fly  1895 LYHQILHNLRSERYPITEMEAIMLTALQSQLERGDCCE---------SITDYRAVASHCLPP--- 1947
            .|:|:|.:              .|..|.:.:.:|...|         :...:||..|...|.
Zfish  4232 HYNQVLPD--------------YLKGLLNIVPQGKISEQQFNQFAKLAALQHRAKDSLYTPTIHE 4282

  Fly  1948 --RFVP------NIPH---EAVAMHHQSLRGMLPIEAKKAFLNLIKSWPLHRATIFDVMQSFTTN 2001
              .::|      .||.   :.||.|..:::.:.|.:|:..||.|:.::|:..::.|.:..|....
Zfish  4283 LMEYIPVEIFGRQIPQQWMQLVAQHVHAVQSLNPHQARSQFLGLVCAFPMFGSSFFYIQSSSNNT 4347

  Fly  2002 WPRTLWLAIDQKGIHLLEHRSRNV 2025
            ......||::|.|:|.|...:..|
Zfish  4348 ISAPCILAVNQNGLHFLHKDTHEV 4371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	257/671 (38%)
		MyTH4	1091..1194	CDD:459939	34/111 (31%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	25/335 (7%)
		B41	1202..1419	CDD:214604	58/637 (9%)
		PH-like	1415..1523	CDD:473070	25/123 (20%)
		MyTH4	1664..1771	CDD:459939	30/130 (23%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	26/116 (22%)
		B41	1781..1992	CDD:214604	50/245 (20%)
		PH-like	1988..2076	CDD:473070	9/38 (24%)
myo15ab	XP_073805445.1	None