Protein Alignment Myo81F and myo10

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_005171458.2
• Gene: myo10 / 569779
• ZFINID: ZDB-GENE-070912-277
• Length: 2069
• Species: Danio rerio
• Alignment Length: 2354
• Identity: 587/2354 - (24%)
• Similarity: 942/2354 - (40%)
• Gaps: 664/2354 - (28%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTIN-IFNKQTISEYHTCKLGDLSP 75
            ||..:.::.:..|..||::||....||||.||||:|||||:::: :::...:..|....||::.|
Zfish    67 DMAALQDLHDGAILHNLHLRYTQKAIYTYIGSILVAVNPYESLSGLYDGAAVERYSRHHLGEIPP 131

  Fly    76 HVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTI---------TSNVSSWVQQ 131
            |::|:|...|.|:...:.||..:||||||||||||||.||::|..:         :...||.|::
Zfish   132 HIYAIANECYRSLWKRSNNQCVLISGESGAGKTESTKMILRFLSAMSQQSAALSTSKTASSHVEE 196

  Fly   132 QILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNY 196
            .|||::.|:||||||||..|:||||||||:|:.|..:..|:|..|.|||||::|:..|:.|||||
Zfish   197 AILESSPIMEAFGNAKTVHNNNSSRFGKFIQLHFSQHGNIQGGRITDYLLEKNRVVRQNPGERNY 261

  Fly   197 HIMYQLVA---QGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQ 258
            ||.|.|:|   ..||     .:|.|...|.:.||..|...|.....:::.|..|..|...:|..:
Zfish   262 HIFYALLAGTSAEQK-----ESFSLSAPEGFHYLGQSGCVKDKAINDTETFQEVLNALRTMQFGE 321

  Fly   259 FVIDGVFKVISSILWLGNIEFIDVDG-EVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINV 322
            ..|..|.:::|.||.:|||||:...| :|...|     |:|..:.||||......:||..|.:.:
Zfish   322 ENIKEVLRLLSGILHVGNIEFLTAGGAQVCSKT-----ALSKAADLLGLDCAQLAEVLTHRSMIL 381

  Fly   323 RGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFENFSHN 387
            ||.....||.:::|:::|.::|.||||:.|||::.|:||..| |.:|.:.:|:|||||||||..|
Zfish   382 RGEEISTPLTVEQAVDSRDSMAMALYSQCFTWIIRKLNNRIN-GSEDFRSIGILDIFGFENFEVN 445

  Fly   388 SFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTE 452
            .|||..|||.||||.::||.::|:|||..|..||:.::.|.:.||..||:::|| ...:..|:.|
Zfish   446 RFEQFNINYANEKLQEYFNKHIFSLEQLEYNKEGLVWDDVNWMDNGECLDLIEK-KLGLLALVNE 509

  Fly   453 QCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRDVQQD 517
            :.|.|:|:|...|..:|::...:..|||.....|   :||||||||.|:|.|.|.:|||||..:|
Zfish   510 ESHFPKGTDGTLLEKLHSQHSRNQFYIKPRVAVH---QFGIKHYAGEVVYDVRGILEKNRDTFRD 571

  Fly   518 VMFEYMSYSKDVFIKDLS------TYQDIQFINSSYPRGSSKSKCTVSDNFRNQLQSLIDVLQNT 576
            .:...:..|:..|:.||.      |.||.....|.|.|.      |||..|:|.|.||:..|..:
Zfish   572 DVLNLLRESRLDFVYDLFERVNAWTGQDTVKCGSKYRRP------TVSSQFKNSLHSLMSTLSTS 630

  Fly   577 KPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNKS 641
            .|::|||||||:.|.|..:..::||:||:|.|:::.::|||.||||..:.|||..||..|::..:
Zfish   631 NPFFVRCIKPNISKMPGQFEQTVVLNQLRYSGMLETVKIRRSGFPIRRTFKDFCSRYYVLMRALA 695

  Fly   642 FEYPQK----YLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQKNWKKY 702
            .....|    .|..:.:.:|   .|||:||:|:|:|.:....||..|:..:.|.|.|||.:...|
Zfish   696 LSEDLKGRSLLLLQLYDNSG---AEWQLGKNKVFMRESLELRLEKQRETEVLKAASIIQAHILGY 757

  Fly   703 YIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALREMKRVDEEL 767
            ..::.:.|....::.||..||....|.||..||.:.:.:|.||||..||.:...|.|.||..||.
Zfish   758 RARRQYRRLLLCIVVIQKNYRALYWRRRFQTMRWATVTLQKRLRGQRARRLYVHLLEEKRKREEE 822

  Fly   768 KKRD----------------------------GIYEQLTSITTK------------TLADC-ERS 791
            ::|.                            .:.|:|.|..|:            |..|. ::|
Zfish   823 ERRHREEQEALERERHRLLELELLAQAAEEARRLEEKLKSEQTQVVFPETITPDSITAEDSPQKS 887

  Fly   792 IQ-----EELSVLAHISDNIRASAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFEN 851
            |.     ||.|:...:||.:            .::.|.::|..:..:.|:...:.|...|.|.|.
Zfish   888 IPHESPIEETSLAEQVSDEV------------FEAETNQASQVEEILRLEREIEGLRRQKEAQEQ 940

  Fly   852 AL------------------------------IKEIN-DNWNNLVKNL----------------- 868
            :|                              :..:| |..:..|:|:
Zfish   941 SLTTQSLHRLQRLRDQELRRLEEEACKAAQQFLTSLNFDEIDECVRNIESSLGGSGGSQQGSPRG 1005

  Fly   869 -----DEEIGLCIHTEDSF------------DSQKTGKLFTTKTVRTLPEP------TVPPPPPP 910
                 ||.:|:   .||.|            |.|:|..:.|:.. .:..:|      .:||..|.
Zfish  1006 EEDEVDEGLGV---DEDGFKDSPNPSEHGHSDGQRTSGIRTSDD-SSEEDPYANDRVALPPVLPL 1066

  Fly   911 VSISANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDERENRR 975
            :..|       :|.|                              .||:|.....:.:.|.|..
Zfish  1067 IMPS-------VYRA------------------------------PPSSSGSTYSHAVLEEETE- 1093

  Fly   976 KQRVEKKIHELTLIDIHKDIHIDNSFYN---ILEFAENYFNTHDLSSDCNFISTPTQKGKSSDK- 1036
                        ||...:|...|...|:   ::....:....:|:.|..|..|..|....||..
Zfish  1094 ------------LIPPDEDSDYDADDYDEGGLIMRPPSLPPHNDIWSRENRSSLATSASVSSGAY 1146

  Fly  1037 --TAKHEMTMFSKS----DKIPTSHIHMYDPENVVLSC---SMFRELCKYMRGELNAERELQIIQ 1092
              ::....:.|..|    |:..|.....|..:: |.||   ..|........|.||:.:....:
Zfish  1147 RFSSDGPQSSFEDSEDDFDRFDTDDESSYRRDS-VYSCVTLPYFHSFLYIKGGLLNSWKRRWCV- 1209

  Fly  1093 YIVGLGIEREELRDEIFI------QCIRQ-------------SRNNPNIDWTDRIWIILCLSIVA 1138
                       |:||.|:      :.::|             ||.|    |..| |.:|
Zfish  1210 -----------LKDETFLWFRSRQEALKQGWLMKKGGGSSTLSRRN----WRRR-WFVL------ 1252

  Fly  1139 FQPSKLLFRYFVSFIK------------KSMIELDGKL---------RQY---SQWCFDNCKSTK 1179
             :.|||:  |:.:..:            |.:|::.||.         |.|   ::...|:.....
Zfish  1253 -RQSKLI--YYENDTEERMKGMLDMHEAKEIIDVTGKENGIDIVMPGRTYHLVAETAEDSSHWFS 1314

  Fly  1180 VSTRMYPPSSVEVAAM--------RRLGTI-------VCRFFFLD--ARTKAIDVHPTDTAGDAV 1227
            |.::::..:..|:..|        ..:||:       ||.   .|  .|..|..:.........:
Zfish  1315 VLSQVHMSTEQEIREMHDEQANPQNAVGTLDVGMIDSVCA---SDNPERPNAFVIITAHRVLHCM 1376

  Fly  1228 QKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQF 1292
            .:.||:::     .|.....|..|:..::..::   :|..|..|:         ..|||  :...
Zfish  1377 AESAEEMH-----HWITLLQRTKGDTRVQGQEF---IIRGWLYKE---------IRGSS--QANL 1422

  Fly  1293 VFKKRLFKSTHELSQDPVEVSMLYSQAVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKP 1357
            ..|||.|..||                 :||   |.:..||:.||:|..|.
Zfish  1423 KLKKRWFVLTH-----------------NSV---DYYKSSERNALKLGSLV-------------- 1453

  Fly  1358 EYYSDINSFLPIRISKTREQQFWIPILAQAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVN 1422
                 :||...:.:...|                                          :|:..
Zfish  1454 -----LNSLCSVLVPDER------------------------------------------VFRET 1471

  Fly  1423 YKGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTS 1487
              ||||::                      ||..|:    |..|   .|.:....:|.|..::|.
Zfish  1472 --GYWNVS----------------------VFGHKH----SYRL---YSKLQTEASRWANAVQTV 1505

  Fly  1488 LYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSNWILNNLECSKKYKGTTKEDRLRLYQNVVL 1552
            :....||::....:....::|.:.|.::.                            ::|:
Zfish  1506 IDSKPLIDTNTQRLILDIKENCLNSEVVE----------------------------QIYK---- 1538

  Fly  1553 CRRHLVDMNIVKKPHDFGGFLRNTLRRLSKHRLEK--LRSEVGSNTQ--EHGETYKGFSHTFWAF 1613
                                 ||.:.|.:.|.|..  |....|...|  :.|.:|
Zfish  1539 ---------------------RNPILRYTHHPLHTALLPLPYGDAQQSSDKGRSY---------- 1572

  Fly  1614 SKQQIPFCISTISDQEEAL-MIQVFDSILTYSGLGSSGESISRAEDEHIRIIQSIMDKCMKKESL 1677
                     .|:  |.||| :..|...:.|              |...|..||:::........|
Zfish  1573 ---------GTL--QAEALKLFNVLHQLET--------------EISAIPHIQTLLQTTHDLRPL 1612

  Fly  1678 LNELYLQLIKQTTDHPDANSRVNLKNWALLSVLCSVILPSMKAVRKYLIAHLKRCSSDFL-SEEG 1741
            .:||:.||||||:.||......::.:|.:::.||....|:.:::.|||..|.||....:. :|..
Zfish  1613 RDELFCQLIKQTSHHPKPGGPAHINSWRIIACLCCTFSPASRSILKYLKFHFKRTRELYPGTEME 1677

  Fly  1742 KYARYAENCFFRTQGTRRRQWTPSREEILCTTNRRPCYSKFYFMDGQYYSIEFQPSSTANDVLEI 1806
            :||.::::.....:|   |::.||:||:....:|:...:..|...|....|.....:||.:|:|.
Zfish  1678 RYAAFSQDALRHVRG---REYVPSQEELRAILSRQEMTATVYCHGGGSCKITINSHTTAGEVVEK 1739

  Fly  1807 IKKKIGLLDNAKGYSIYEVIGNSERSLSSEEKVCDVMAKWEKYQITSQQGFQKNTTLISQQNQYM 1871
            :.|.:.:.|....::::|...|::|::.|...|.|::||:||.....|.|           ..:.
Zfish  1740 LLKGLSMEDCRNMFALFEHNDNTDRAIESRTVVADILAKFEKLANKEQDG-----------ESWK 1793

  Fly  1872 FLFKKHLFFDNYINLEDIVEKELLYHQILHNLRSERYPITEMEAIMLTALQSQLERGDCCES--- 1933
            |.||...|.:......|.||...::.|....:...|||..|.....|.||:.|...||....
Zfish  1794 FYFKLFCFSEPENVPADSVEFAFMFEQAHEAVIRGRYPAPEETLQFLAALRLQYLLGDSSTQSAL 1858

  Fly  1934 ----------------------------------------------------------------- 1933
                                                                             
Zfish  1859 PELDQVFPMERLRARVQQSARSFASATPSTDRKRSSFLEGTLRRSFRGTLGRQRQEEEPAAIEAW 1923

  Fly  1934 ITDYRAVASHCLPPRFVPNIPHEAVAMHHQSLRGMLPIEAKKAFLNLIKSWPLHRATIFDVMQSF 1998
            :.|.:|....||..::             :.|:||...:|.|.::.|||.|..:.:|:||| :..
Zfish  1924 LQDEKAGLKSCLVEKW-------------RKLQGMEQDQAMKKYMGLIKEWQGYGSTLFDV-ECV 1974

  Fly  1999 TTNWPRTLWLAIDQKGIHLLEHRSRNVLCTYGYDSIISF---SPNLNSLMIFTGTEKKQSKVILT 2060
            ...:|..|||.:.:||:.:.:......|..:.|:.|:||   .||:..:.: .|.|     ::..
Zfish  1975 DGVYPGELWLGVSRKGVCVYKRGEPWPLEVFLYEVILSFGAPQPNVYKISV-EGRE-----LLFN 2033

  Fly  2061 TPQAYQITTLIREY 2074
            |.....|..|::.|
Zfish  2034 TSMVVDIAKLMKAY 2047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	272/673 (40%)
		MyTH4	1091..1194	CDD:459939	25/145 (17%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	21/109 (19%)
		B41	1202..1419	CDD:214604	34/218 (16%)
		PH-like	1415..1523	CDD:473070	18/107 (17%)
		MyTH4	1664..1771	CDD:459939	32/107 (30%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	25/104 (24%)
		B41	1781..1992	CDD:214604	53/278 (19%)
		PH-like	1988..2076	CDD:473070	23/90 (26%)
myo10	XP_005171458.2	None