Protein Alignment Myo81F and myo5ab

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_009296049.3
• Gene: myo5ab / 565267
• ZFINID: ZDB-GENE-050411-72
• Length: 1800
• Species: Danio rerio
• Alignment Length: 2013
• Identity: 500/2013 - (24%)
• Similarity: 803/2013 - (39%)
• Gaps: 525/2013 - (26%)

  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.||: :|.:||||.|.||:|:|||:::.|:....|:.|....:|
Zfish    69 VGENDLTALSYLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLPIYGSDIINAYSGQNMG 133

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTIT-SNVSSWVQQQILE 135
            |:.||:|||:|.||..:..|..||:.::|||||||||.|.|:.::|..|:: |:..:.|::::|.
Zfish   134 DMDPHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVSESSDDASVEEKVLA 198

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            :|.|:|||||||||||||||||||::::.||..:.|.|..:..||||:||:.||:..||||||.|
Zfish   199 SNPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHIIGANMRTYLLEKSRVVFQASEERNYHIFY 263

  Fly   201 QLVAQGQKNIGIANTFHLRP-----AEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFV 260
            ||.|       .|:....:|     |:.:.|.|...|..|....:.|:..|...||::|.|.:..
Zfish   264 QLCA-------CAHLPEFKPLKLGSADDFPYTNQGGSPVIVGVNDLKEMQATRKAFSLLGITEAH 321

  Fly   261 IDGVFKVISSILWLGNIE----------FIDVDGEV---TDLTRSDQEAISIISMLLGLSRCDFK 312
            ..|:|:::|:||.|||:|          ..|.:|.:   .|||....|:::
Zfish   322 QMGLFQILSAILHLGNVEVKERGSSSCSISDENGHLDMFCDLTEVSNESMA-------------- 372

  Fly   313 KVLLIRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLD 377
            ..|..:::.........|:...||:..|.||||.:|:|:|:|:||::|...:.......|:||||
Zfish   373 HWLCHKKLKTATETLNKPVTRLEAVNGRDALAKHIYAKLFSWIVSQVNKALSTSSKPHSFIGVLD 437

  Fly   378 IFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKP 442
            |:|||.|..|||||.||||.||||.:.||.:||.|||..|..|.|.:..::|.||.||:.::| .
Zfish   438 IYGFETFELNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIE-A 501

  Fly   443 PRCVFKLLTEQCHMPQGSDLAF---LSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAV 504
            ...:..||.|:|.||:|||.::   |.|.|.:..||....:.|::     .|.|.|:|..|.|..
Zfish   502 KMGLLDLLDEECTMPKGSDDSWAQKLYNTHLKKSSHFEKPRMSNK-----AFIILHFADKVEYQC 561

  Fly   505 GGFVEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQ---FINSSYPRGSSK----------SKC 556
            .||:|||:|...:.....:..||  |...|..:||.:   ..|::...|.:|          .|.
Zfish   562 DGFLEKNKDTVNEEQINVLKASK--FSLLLELFQDEESPAAPNTTASSGRAKFGRSTQSFREHKK 624

  Fly   557 TVSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFP 621
            :|...|||.|..|::.|..|.|.||||||||..|.|...:....:.||:..||::.|||...|||
Zfish   625 SVGLQFRNSLHLLMETLNATTPHYVRCIKPNDVKAPFMMDPHRAVQQLRACGVLETIRISAAGFP 689

  Fly   622 IHLSHKDFIVRYKCLIKNKSFEYPQKYLT--NILEKNGMPTTEWQIGKSKIFLRNAAYELLETNR 684
            ...::::|..||:.|:..|.....:| ||  ::||:......::|.||:|||.|......||..|
Zfish   690 SRWTYQEFFSRYQVLMTKKEILLDRK-LTCQSVLERLVQNKDKYQFGKTKIFFRAGQVAYLEKLR 753

  Fly   685 KDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRG------------------------- 724
            .|.|....:.|||..:.:..:|.:||.:||.:.:|...||
Zfish   754 ADKLRTACIHIQKTIRCWLARKKYLRIRQAAITLQKYTRGHQARCLCKTLRRTRAAVVFQKNTRM 818

  Fly   725 WRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALREMKRVDEELK--------------------K 769
            |..|.:::|.:.:|::||..|||..||      .|.||:..|.|                    |
Zfish   819 WAARRQYLRQKTAAVLIQRILRGYTAR------LEYKRLVCEHKALLIQRWVRGFLARWRYRRIK 877

  Fly   770 RDGIYEQ------LTSITTKTLADCERSIQEELSVLAHISDNIRASAKPLSDKNDSDSNTARSSI 828
            |..:|.|      |.....|.|....||::....:...:.:.|....:.|.:::
Zfish   878 RAVVYLQCCVRRMLARRELKKLKIEARSVEHYKKLNYGMENKIMQLQRKLDEQH----------- 931

  Fly   829 KQNTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTT 893
            |:|..        |.|..||.|:..:.|: :..:..:|.|.|......|.||...|
Zfish   932 KENRE--------LSEQIGAIESHSVVEL-EKLHVQLKTLQEAEEEARHREDLVTS--------- 978

  Fly   894 KTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPS 958
                                        :.|.:.|.:    :|::|.|.|:::.     |.|...
Zfish   979 ----------------------------LQEELELVR----RELEKNKEMVVEL-----NEKNTM 1006

  Fly   959 TSSVFVKYQIDERE--NRRKQRVEKKIH---ELTLIDIHKDI---------HIDNSFYNILEFAE 1009
            ..|        |:|  ||..|..|::|.   |:|..|:.:::         ...|.....|:..|
Zfish  1007 LKS--------EKEEMNRLIQEQEQQIREKSEVTNEDVTENLQTQLNEERFRYQNLLTEHLKLEE 1063

  Fly  1010 NYFNTHDLSS--DCNFISTP----TQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSC 1068
            .|   .||.|  :...|||.    ...|.||.::.....:|.:.|:   .|.:...|...|....
Zfish  1064 RY---ADLRSEKEAAEISTAGDSRADSGYSSSQSESIHSSMLTGSE---VSSLEKEDAVQVAADV 1122

  Fly  1069 SMFRELCKY----------MRGELNAERELQIIQYI-------VGLGIER--EELRDEIFIQCIR 1114
            |:..:|.:.          |:.|::.:.|..:::..       ..||.||  |.|:        |
Zfish  1123 SLLLKLQRRVAELEKENMDMQSEMDTKEEQLVLEKAKELEDCRKTLGAERDYEALK--------R 1179

  Fly  1115 QSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTK 1179
            |...:.|                    .||         ||.:.||...|.:.:     ..|.|.
Zfish  1180 QELESDN--------------------KKL---------KKDLQELRQSLSKGT-----GSKVTS 1210

  Fly  1180 VSTRMYP------PSSVEVAAMRRLGTIVCRFFFLDART-KAIDVHPTDTAGDAVQKLAEKLNLT 1237
            ...|.|.      .|:.|...:|:...::.|...:.... |..::.....:||:.:.....|...
Zfish  1211 PGGRAYNVILEQLNSTNEELEVRKEEVLILRSQLVSHEAFKHKELGTEGDSGDSSRSPTLDLTEL 1275

  Fly  1238 TTDG--WAIYQNRPDGEEHIKSYDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFVFKKRLFK 1300
            ..||  |..|       |.:|..:.:  ::|..:.::.::   :|.|..         .:..|..
Zfish  1276 NEDGELWMAY-------ESLKETNRI--LVSQLQTQRESH---EKETES---------LRAELQH 1319

  Fly  1301 STHELSQDPVEVSMLYSQAVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQ-------PKPE 1358
            ...||.|.    ..:.||::       |.|...::.   |.||.:::.....|.       .:.:
Zfish  1320 LKAELDQQ----QQMLSQSL-------ELPHDARIQ---ASLQHEISRLTQQNMDLLEQMGKQDK 1370

  Fly  1359 YYSDINSFLPIRISKTREQQFWIPILAQAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNY 1423
            ....:...|.|.:.|..|.:       ..|.:..|..|.|...             |.|:..|..
Zfish  1371 MVRKLKKQLKIYMKKFGEPE-------GVHFEQSSPENMLAES-------------GRTVSIVRK 1415

  Fly  1424 KGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKYVDIE----SILLDPS-DSFITISLNRSAQL 1483
            :.            .:.|::....||::.:|:....|::    ::.|.|. .::|.....|.|..
Zfish  1416 ER------------DFQGMLEYRREDENKLFKTLITDLKPRGVAVNLVPGLPAYILFMCLRHADY 1468

  Fly  1484 LKTSLYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSNWILNN---LECSKKYKGTTKEDRLR 1545
            ....|..|:|:.:....:..|.:|.       ..:.::|.|:.|.   |.|.|:|.|..
Zfish  1469 ANDDLRVSTLLNTSINSIKNTLKKR-------GDFESISFWLANTCRFLHCLKQYSGEE------ 1520

  Fly  1546 LYQNVVLCRRHLVDMNIVKKPHDFGGFLRNTLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTF 1610
                                     |:        |||           ||....|      |..
Zfish  1521 -------------------------GY--------SKH-----------NTPRQNE------HCL 1535

  Fly  1611 WAFSKQQIPFCISTISDQEEALMIQVFDSILTYSGLGSSGESISRA--EDEHIRIIQSIMDKCMK 1673
            ..|...:....:|.::.|....:|:|.::||.        ..|:.|  |.|.|:.:..:....|:
Zfish  1536 TNFDLSEYRQVLSDLAIQIYQQLIRVIENILQ--------PMIAPAMLEQETIQGVMGVKPTGMR 1592

  Fly  1674 K-------------ESLLNEL---YLQLIKQTTDHPDANSRVNLKNWALLSVLCSVILPSMKAVR 1722
            |             ||:|.:|   |..|::...|.......:..:.:    |:|||.|.:: .:|
Zfish  1593 KRTSSFHEENSHSLESILKQLDGFYFTLLQHGNDAEVVRQVIKQQFY----VICSVTLNNL-LLR 1652

  Fly  1723 KYLIAHLKRCSSDFLSEEGKYARYAENCFFRTQGTRRRQWTPSREEILCTTNRRPCYSKFYFMDG 1787
            |.:      ||            :::....|....:..:|...::                 :.|
Zfish  1653 KDM------CS------------WSKGLQIRYNVCQLEEWLLDKD-----------------LQG 1682

  Fly  1788 QYYSIEFQPSSTANDVLEIIKKKIGLLDNA----------------KGYSIYEVIGNSERSLS 1834
            .......:|...|..:|:|.||.   .|:|                |..|:|..:...|..:|
Zfish  1683 SGARESLEPLIQAAQLLQIKKKS---QDDADAICTMCTALTTQQIVKILSLYTPVNEFEERVS 1742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	256/687 (37%)
		MyTH4	1091..1194	CDD:459939	22/117 (19%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	14/103 (14%)
		B41	1202..1419	CDD:214604	36/226 (16%)
		PH-like	1415..1523	CDD:473070	18/112 (16%)
		MyTH4	1664..1771	CDD:459939	20/122 (16%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	14/76 (18%)
		B41	1781..1992	CDD:214604	14/70 (20%)
		PH-like	1988..2076	CDD:473070
myo5ab	XP_009296049.3	None