Protein Alignment Myo81F and myo5c

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_691143.2
• Gene: myo5c / 562676
• ZFINID: ZDB-GENE-131127-196
• Length: 1746
• Species: Danio rerio
• Alignment Length: 1985
• Identity: 476/1985 - (23%)
• Similarity: 786/1985 - (39%)
• Gaps: 503/1985 - (25%)

  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.||: .|.|||||.|.||:||||||.:.|:....|..|....:|
Zfish    68 VGENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQLPIYGDAVIHAYSGQNMG 132

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTIT-SNVSSWVQQQILE 135
            ||.||:|||||.||..:..:|.||:.::|||||||||.|.::.::|...:: |...:.|:.::|.
Zfish   133 DLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMVSKSGSKTRVEDKVLA 197

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            :|.|.||.||||||||||||||||:.::.||....|.|..:..||||:||:.||||.||||||.|
Zfish   198 SNPITEAIGNAKTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENERNYHIFY 262

  Fly   201 QLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKIN-------MNLESKKFDAVTMA-----FTV 253
            |:.|       .||    :|.  :|.|....:||.|       :.:|... |...||     |.:
Zfish   263 QMCA-------CAN----QPE--FKGLRLLGAEKFNYTRLGGEIEIEGVD-DRADMAETRRTFNL 313

  Fly   254 LQIPQFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIR 318
            |.:.:.....||||:::||.|||:.....|.|.:.:...|.. ::|...|:|:|..:..:.|..|
Zfish   314 LGLKENFQTDVFKVLAAILHLGNVIIKAKDPEKSFIGSRDPH-LAIFCDLMGVSTENMSRWLCHR 377

  Fly   319 QINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTN-PGQDDAKFLGVLDIFGFE 382
            :|.:.......|...:.|:..|.||||.:|:.:|.|::.|||:... ||:..: |:|||||:|||
Zfish   378 RIVLSTETVVKPQPRERAVNARDALAKHIYAHLFNWVIHKINHALMVPGKQHS-FIGVLDIYGFE 441

  Fly   383 NFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVF 447
            .|..|||||.||||.||||.:.||.:||.|||..|..|.|.:..::|.||.|.::::| ....:.
Zfish   442 TFEINSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIE-AKMGIL 505

  Fly   448 KLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNR 512
            .||.|:|..|||:|..:|..::....|.|.:.|   .|.....|.|:|:|..|.|...||:||||
Zfish   506 DLLDEECLFPQGTDKNWLQKLYNFLGSKPLFEK---PRLSNDSFMIQHFADKVEYQCKGFLEKNR 567

  Fly   513 DVQQDVMFEYMSYSKDVFI------KDLSTYQDIQFINSSYPRGSSKSK---CTVSDNFRNQLQS 568
            |...:.:.:.|..|:...:      ::..:...|..:..:.||..:.:|   .||.|.||:.|..
Zfish   568 DTLYEELVDIMRASQFALLAGFFKEEEADSGHKIIKVTPAQPRVKASNKQLRSTVGDKFRSSLYL 632

  Fly   569 LIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRY 633
            |::.|..|.|.||||||||.:|.|..|:|..|:.||:..||::.|||..:.:|...::.:|..||
Zfish   633 LMETLNATTPHYVRCIKPNEEKLPFEYDSRRVVQQLRACGVLETIRISAQSYPSRWTYVEFYSRY 697

  Fly   634 KCLIKNKSFEYPQKYLT--NILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQ 696
            ..|:.....:..:|..|  .:|::....:.:::.|::|||.|......||..|.|.|....|.||
Zfish   698 SILMSQSELKLGEKKQTCRTVLQRLIPDSNQYKFGRTKIFFRAGQVAYLEKLRLDHLRAACVTIQ 762

  Fly   697 KNWKKYYIQKSFLRNKQAVLRIQ------------------------------------------ 719
            |:.:.:..::|||..:||.|.||
Zfish   763 KHVRGWRQRRSFLNIRQAALIIQLYVRGKKQIRCTVTAQALKQGWAAIVIQRHCRGFLVRRIYQL 827

  Fly   720 --------HAY-RGWRLRIRFMRM--RRSAIVIQSRLRGVFAREVAAALREM------------- 760
                    .|: |||..|.|:.:|  ...|:|:|...|....|.....:|.:
Zfish   828 VLRAAVTIQAFTRGWMARKRYKKMVAEHKALVLQKYARAWLVRRRFQTMRRLVINVQLSYRVQQL 892

  Fly   761 -KRVDEELKKRDGIYEQLTSITTKTLADCER--SIQEELSVLAHISDNIRASAKPLSD------- 815
             |:|:|:.|:..|:.|:|||::.......|:  :::.||..|.:....:...||..|:
Zfish   893 RKKVEEQNKENCGLMEKLTSLSNARAQGLEKIQALEAELGKLTNEMSALVQRAKTNSEEANQAID 957

  Fly   816 --KND-----SDSNTARSSIKQNTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIG 873
              :||     .::......:|..||.:.:.|:                  |....|:::|:.|
Zfish   958 VLQNDKEKLVEENKALERKLKDTTVQMQDQFE------------------DVKRKLMEDLERE-- 1002

  Fly   874 LCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIK 938
                       ::..|:                        |..|||       |.|..:.|||
Zfish  1003 -----------ERLRKV------------------------AEHNSE-------LQKEDSDKEI- 1024

  Fly   939 KEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDE----RENRRKQRVEKKIHELTLIDIHKDIHIDN 999
                     .:||:.:::.....:.::.|::|    ....::|.::...|...:.|:.|:|
Zfish  1025 ---------VAIKEENRRLREERIRLQTQVEEDVKTNTELQEQMLQLTKHVKVIPDLRKEI---- 1076

  Fly  1000 SFYNILEF----AENYFNTHDLSSDCNF-ISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMY 1059
               |.|:.    ||......:|.:.... :.|....|.::::.....:...:..:.        .
Zfish  1077 ---NNLQIQRAEAEKTLRAQNLQARAKMNLITRQLLGDATEQDLIQRLNEEASDNN--------D 1130

  Fly  1060 DPENVVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREEL-RDEIFIQCIRQSRNNPNID 1123
            |..:::.:........|.|..:|..:::....| :..|..:.|.| ::...:|.:.|.:::.|..
Zfish  1131 DGADLITAFDGMERAAKVMETQLREQKDAHESQ-LEALIFKNEHLSKENEQLQALFQEKSDINQS 1194

  Fly  1124 WTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPS 1188
            ....:..:...::|..:     .:..||.:.:...||:.:|:  .|....:.|..::|:.::...
Zfish  1195 IGQEVTRLTAENMVIPE-----LKQQVSELNRHKHELESQLQ--DQTAEMSAKLKELSSALHLAV 1252

  Fly  1189 SVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEE 1253
            ..|.:..|||                            .::|.|...........|.:.:.:.::
Zfish  1253 EEEQSQRRRL----------------------------QEELTESQRRREETDRQISELQEENQQ 1289

  Fly  1254 HIKSYDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQ 1318
            ..|:.      |:..:.|......|.:.|..:...|.|...|.||.|...:
Zfish  1290 LKKAQ------ITESQAKNTLRLETSRLTAENMDFEEQLDMKDRLIKRLQD-------------- 1334

  Fly  1319 AVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFWIPI 1383
                               |:..||...|....:....|:.|..:..:      |..::...|.|
Zfish  1335 -------------------QIKALQTHAAANQKAAPAVPKEYLGMLEY------KKEDEGRLIRI 1374

  Fly  1384 LAQAHRQYGSSRN---ALTAKVLYLSCVMQYPLYGTTMFKVNYKGYWN-------LASNIILGIH 1438
            |....:..|...|   .|.|.:|:: |             |.:..|.|       |.:|||..:
Zfish  1375 LILELKPRGVGVNMIPGLAAHLLFM-C-------------VRHADYLNDGNKLKCLMNNIITAV- 1424

  Fly  1439 YDGIMFINPEDKSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTSLYGSSLIESQKCFVFE 1503
                       |.|:.:.
Zfish  1425 -----------KEVITEH----------------------------------------------- 1431

  Fly  1504 TPQKNDIGSLIISYYPALSNWILNN---LECSKKYKG-------TTKEDRLRLYQNVVLC--RRH 1556
              |:|         :..||.|:.|.   |.|.|:|.|       .|........:|..|.  |:.
Zfish  1432 --QEN---------FELLSFWLSNTYHFLNCLKQYSGEEEFMKHNTPRQNKNCLKNFDLSEHRQI 1485

  Fly  1557 LVDM--NIVKKPHDF--------------GGFLRNTLRRLSKHRLEKLRSEVGSNTQEHGETYKG 1605
            |.|:  ||.   |.|              |.....:|:.:|..:...||....|..::.|:
Zfish  1486 LSDLAINIY---HQFISVMEDALFPMIIPGMLEHESLQGISSMKPTGLRKRSSSVFEDGGD---- 1543

  Fly  1606 FSHTFWAFSKQQIPFCISTISD------QEEALMIQVFDSILTYSGLGSSG--------ESISRA 1656
             |.|..|||...|...:||.:.      .|..|..|:...:  :..:|||.        :..|..
Zfish  1544 -SSTSEAFSVSSILQKLSTFNSSMCQQGMEPQLQGQIVRQL--FYLIGSSSVNCILLRKDLCSCR 1605

  Fly  1657 EDEHIRIIQSIMDKCMKKESLLNE------------LYLQLIKQTTDHPDANSRVNLKNWALLSV 1709
            :...||...|.:::.::::.||:.            .:|..:.:|||...|..:......:.:.:
Zfish  1606 KGMQIRCNISYLEEWLREKDLLSSNAMETLGPLSQIAWLLQVNKTTDEDAAEIKQRCSELSAVQI 1670

  Fly  1710 LCSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRTQGTRRRQWTPSREEILCTTN 1774
            :  .||.|...:..:    .||.:..|:       |..:......:|
Zfish  1671 V--KILNSYTPIDDF----EKRVAPSFV-------RKVQALLQEREG------------------ 1704

  Fly  1775 RRPCYSKFYFMDGQY-YSIEFQPSSTANDVLEIIK 1808
                 |....||.|| :.:.| |..::...||:::
Zfish  1705 -----SSQLMMDSQYRFQVTF-PFCSSTQALELLQ 1733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	254/675 (38%)
		MyTH4	1091..1194	CDD:459939	17/103 (17%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	13/100 (13%)
		B41	1202..1419	CDD:214604	30/219 (14%)
		PH-like	1415..1523	CDD:473070	12/114 (11%)
		MyTH4	1664..1771	CDD:459939	16/118 (14%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	9/35 (26%)
		B41	1781..1992	CDD:214604	8/29 (28%)
		PH-like	1988..2076	CDD:473070
myo5c	XP_691143.2	COG5022	12..1333	CDD:227355	381/1413 (27%)
		MYSc_Myo5	82..739	CDD:276831	254/676 (38%)
		Myo5c_CBD	1366..1740	CDD:271260	88/499 (18%)