Protein Alignment Myo81F and myo10

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_001362203.1
• Gene: myo10 / 548806
• XenbaseID: XB-GENE-1018818
• Length: 2086
• Species: Xenopus tropicalis
• Alignment Length: 2310
• Identity: 599/2310 - (25%)
• Similarity: 964/2310 - (41%)
• Gaps: 556/2310 - (24%)

  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTI-NIFNKQTISEYHTCKLGD 72
            |..||..:|::.|..|..||..||..:.||||.||||.:|||||.| .:::...:..|....:|:
 Frog    64 GVEDMAALSDLHEGSIMYNLFQRYQQNKIYTYIGSILASVNPYKMIAGLYDCNAVELYSRHHMGE 128

  Fly    73 LSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSN---VSS-----WV 129
            :.||:||||...|..:...:.||..:||||||||||||||.||::|..::.:   :||     .|
 Frog   129 IPPHIFAVASECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSAMSQHSLEISSKEKTASV 193

  Fly   130 QQQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCV----ILDYLLEQSRITFQS 190
            :|.|||::.|:||||||||..|:||||||||:|:    |.|.||.:    |:|||||::|:..|:
 Frog   194 EQAILESSPIMEAFGNAKTVYNNNSSRFGKFIQL----NICQKGHIQGGRIVDYLLEKNRVVRQN 254

  Fly   191 EGERNYHIMYQLVAQGQKNIGIANTFHLRPAEFYKYLNTSN---SEKINMNLESKKFDAVTMAFT 252
            ..||||||.|.|:....|.  ..:.|:|..||.|.|||.|.   .|.|:   :.:.|..|..|..
 Frog   255 PEERNYHIFYALLEGAGKE--ERDAFYLLQAEKYHYLNQSGCILDETIS---DHETFQEVKAAME 314

  Fly   253 VLQIPQFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLI 317
            |::..:..:..:|::::.||.|||:|||...|...    |.:.|:...|.||||......:.|..
 Frog   315 VMKFSREEVREIFRLLAGILHLGNMEFITAGGAQI----SSKTALGRASELLGLDSEQMAEALTQ 375

  Fly   318 RQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFE 382
            |.:.:||.....||.:::|:::|.::|.||||:.|.|::.|||:... |:||.|.:|:|||||||
 Frog   376 RSMILRGEEISTPLSVEQAVDSRDSVAMALYSQCFAWVIMKINSRIK-GKDDFKSIGILDIFGFE 439

  Fly   383 NFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVF 447
            ||..|.|||..|||.||||.::||.::|:|||..|..||:.:|.:::.||..||:::|| ...:.
 Frog   440 NFEVNRFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLAWNAIDWIDNGECLDLIEK-KLGLL 503

  Fly   448 KLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNR 512
            .|:.|:.:.||.:|...|..:|.:..::..|:|.....|   .||:|||||.|:|.|.|.:||||
 Frog   504 ALINEESYFPQATDNTLLEKLHKQHANNHFYVKPRVAVH---NFGVKHYAGEVLYDVRGTLEKNR 565

  Fly   513 DVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSSKSKCTVSDNFRNQLQSLIDVLQNTK 577
            |..:|.:...:..|...||.||..:...:....:...|:...|.|||..|::.|.||:..|..:.
 Frog   566 DTFRDDLLNLLRESSLDFIYDLFEHVSSRNNQETLKSGNKHKKPTVSLQFKDSLHSLMAKLSTSN 630

  Fly   578 PWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNKSF 642
            |::|||||||:.|.|:.::.::||:||:|.|:::.:|||:.|||:.....||..|||.|:||.|.
 Frog   631 PFFVRCIKPNIHKMPDQFDDTVVLNQLRYSGMLETVRIRKAGFPVRRLFNDFCFRYKVLMKNLSL 695

  Fly   643 EYPQKYLTNI-LEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQKNWKKYYIQK 706
            ....|....: |..:....|||||||:|:|||.:....||..|...::|.|:|||.:...:..:|
 Frog   696 PEDMKGKCEVLLHLHDNTDTEWQIGKTKVFLRESLEHKLEKQRDIEVFKAALIIQAHIMGFVARK 760

  Fly   707 SFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALREMKRVDEELKKRD 771
            .:.:....|:.||..||.:..|.:|:|::::|:..|.:|||..||.:...|||.|:.:||.::|.
 Frog   761 QYKKVLYCVVVIQKNYRAFLWRRKFLRLKKAAVTFQRQLRGQIARRIYKQLREQKQREEEERRRK 825

  Fly   772 GIYEQL-------------------TSITTKTLADCERSIQEELSVLAHISDNIR-----ASAKP 812
            ...|:.                   .....|.:.:.||..||| ..||..::..|     |:...
 Frog   826 EEEERKKKEEEERRRREEEERLRKEEERKKKEIEERERHRQEE-ETLAKQAEEARKQQELAAMLE 889

  Fly   813 LSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENAL-------IKEINDNWNNLVKNLDE 870
            ..:.|:.|.......::: .:.|:...|.|...|...|.:|       ::|:.|   |.:|.|:|
 Frog   890 AQNHNEIDKQKENKQVEE-ILRLEKEIDDLQRQKEKQELSLTEASLQRLQELRD---NELKRLEE 950

  Fly   871 EIGLCIHTEDSFDSQKTGKL--------FTTKTVRTLPE----PTVPPPPPPVSISANLNSEPIY 923
            |  .|...::..:|....::        .:.......||    |.|....|..:.|.....|.:.
 Frog   951 E--ACRAAQEFLESLNFDEIDECVKNIEMSLSVSDVFPELSNIPGVSSTKPSFNFSQPYPEEEVD 1013

  Fly   924 EAI----NLYK------------------LTTTKEIKKEKYM---------------LLDYKSIK 951
            |..    ..:|                  .|:....:::.||               ||.....|
 Frog  1014 EGFEADDEAFKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNYTVGGPPQAATSNKLLSLDENK 1078

  Fly   952 DNSKKPSTSSVFVKYQIDERENRRKQRVEKKIHELTLIDIHKDIHIDN--------SFYNIL--E 1006
            .|.||.::..  ..|.:.|......|.....|......|...|.:.|.        :|.|.:  :
 Frog  1079 ANVKKLTSGE--STYCVPENAPCEPQNPGSIIIPDGDYDYDHDDYEDGAITSGSSVTFSNSVSSQ 1141

  Fly  1007 FAENY---FNTHDLSSDCNFISTPTQKGKSSDKTAKHEM-TMFSKSDKIPTSHIHMYDPENVVLS 1067
            ::.:|   ..|::.||...|.|...|   ||.:.::.|. :.|...|::......:|.    .:|
 Frog  1142 WSPDYNFSLGTYNGSSAYRFSSEGAQ---SSFEDSEEEFDSRFDTDDELSYRRDSVYS----CVS 1199

  Fly  1068 CSMFRELCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFI------QCIRQ----------- 1115
            ...|........|.:|:.::...:            |:||.|:      :.::|
 Frog  1200 LPYFHSYLYMKGGMMNSWKKRWCV------------LKDETFLWFRSKQEALKQGWLHKKGGGSS 1252

  Fly  1116 --SRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIK------------KSMIELDGK--- 1163
              ||.|    |..| |.:|       :.|||:  ||.:..:            |.:|:..||
 Frog  1253 TLSRRN----WKKR-WFVL-------RQSKLM--YFENDSEDRQKGTIELRDAKEVIDNTGKENG 1303

  Fly  1164 ------LRQY----------SQWCFDNCKSTKVSTRMYPPSSVEVAAM--------RRLGTI--- 1201
                  .|.|          |||       ..|.::::..:..|:..|        ..:||:
 Frog  1304 IDIIMENRTYHLIAESPEDASQW-------FSVMSQVHTSTEQEIREMHDEQANPQNAVGTLDVG 1361

  Fly  1202 ----VCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTD------GWAIYQNRPDGEEHIK 1256
                ||          |.| :| |.....|...|.::....||      .|.....|..|:..::
 Frog  1362 MIDSVC----------ASD-NP-DRPNSFVIITANRVLHCNTDTPEEMHHWITLLQRSKGDTRVE 1414

  Fly  1257 SYDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAVH 1321
            ..::   ::..|..|:     .|.:...||     ...|||.|..||.
 Frog  1415 GQEF---IVRGWLHKE-----VKNSPKMSS-----LKLKKRWFVLTHN----------------- 1449

  Fly  1322 SVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFW-IPILA 1385
               ..|.:..|||.|::|..|    .|....:..:||.          :|.|  |..:| :.:..
 Frog  1450 ---SLDYYKSSEKSAMKLGTL----VLNSLCSVVQPEE----------KIFK--ETGYWNVTVYG 1495

  Fly  1386 QAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNYKGYWNLA-SNIILGIHYDGIMFINPED 1449
            :.|                  |   |.||...:   |....|:.| .|:|
 Frog  1496 RKH------------------C---YRLYTKLL---NEATRWSSAIQNVI--------------- 1521

  Fly  1450 KSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLI 1514
                      |.::.:..|:...|        |.:|.:...|.::|       :..::|.|  |.
 Frog  1522 ----------DTKAPIDTPTQQLI--------QDIKENCLNSEVVE-------QIYRRNPI--LR 1559

  Fly  1515 ISYYPALSNWILNNLECSKKYKGTTKEDRLRLYQNVVLCRRHLVDMNIVKKPHDFGGFLRNTLRR 1579
            .:::|..|..:                                        |..:|....|.|:.
 Frog  1560 YTHHPLHSPLL----------------------------------------PLPYGDINLNLLKE 1584

  Fly  1580 LSKHRLEKLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQEEALMIQVFDSILTYS 1644
                                    ||:                :|:.|:    .|::|:|:
 Frog  1585 ------------------------KGY----------------TTLQDE----AIKIFNSL---- 1601

  Fly  1645 GLGSSGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKNWALLSV 1709
               ...||:|    :.:.|||.|:........|.:|||.||||||....:.....||.:|.:|:.
 Frog  1602 ---QQLESLS----DPVPIIQGILQTGHDLRPLRDELYCQLIKQTNKVSNPGCTGNLYHWQILTC 1659

  Fly  1710 LCSVILPSMKAVRKYLIAHLKRCSSDFL-SEEGKYARYAENCFFRTQGTRRRQWTPSREEILCTT 1773
            |.....||.:.| |||..||||....:. ||..|||.:   .:...:.::.|::.|||.||....
 Frog  1660 LSCTFPPSRRIV-KYLKFHLKRIREQYQGSEMEKYALF---IYDSLKKSKCREFVPSRAEIEALI 1720

  Fly  1774 NRRPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDNAKGYSIYEVIGNSERSLSSEEK 1838
            :|:...:..|...|....|.....:||.:|:|.:.:.:.:.|:...::::|..|.:::::.|...
 Frog  1721 SRQEVTTTVYCHGGGACKITINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGTTDKAIESRTV 1785

  Fly  1839 VCDVMAKWEKYQITSQQGFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVEKELLYHQ----I 1899
            |.||:||:||..::|:.|          ...:.|.||.:.|.|.....:|.||...::.|    :
 Frog  1786 VADVLAKFEKLAVSSEAG----------DKPWKFYFKLYCFLDTEHVPKDSVEYVFMFEQAHEAV 1840

  Fly  1900 LHNLRSERYPITEMEAIMLTALQSQLERGDCC------------------ESITDYRAVAS---H 1943
            :|.    .||..|....:|.||:.|..:||..                  ..||....|:|   .
 Frog  1841 IHG----HYPAPEETLQILAALRLQYTQGDYSLHTSVPEMEEFYPMQKLKARITQSTKVSSTSER 1901

  Fly  1944 CLPPR--FVPN-------------------------IPHEAVAMH------HQSLRGMLPIEAKK 1975
            |...|  |:..                         :..|.::..      .:..:||...:...
 Frog  1902 CERKRSSFLEGTLRRSFRSGSVSKQRLEEEQMQEMWVKEEVLSTRTNIIDKWKRFQGMNTDQCMS 1966

  Fly  1976 AFLNLIKSWPLHRATIFDVMQSFTTNWPRTLWLAIDQKGIHLLEHRSRNVLCTYGYDSIISF-SP 2039
            .::.|||.||.:.:|.||| :.....:|:.|||.:..:.:.:.:......|..:.|:.|:|| :|
 Frog  1967 KYMALIKEWPSYGSTFFDV-ECKEGGFPQELWLGVCVEAVSVYKRGEGRPLEVFHYEHILSFGAP 2030

  Fly  2040 NLNSLMIFTGTEKKQSKVILTTPQAYQITTLIREY 2074
            ..|:..|..    .:.:::..|....:|..|::.|
 Frog  2031 YANTYKIVV----DERELLFETSAVVEIAKLMKAY 2061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	269/666 (40%)
		MyTH4	1091..1194	CDD:459939	28/152 (18%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	23/113 (20%)
		B41	1202..1419	CDD:214604	43/223 (19%)
		PH-like	1415..1523	CDD:473070	16/108 (15%)
		MyTH4	1664..1771	CDD:459939	39/107 (36%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	24/104 (23%)
		B41	1781..1992	CDD:214604	55/268 (21%)
		PH-like	1988..2076	CDD:473070	20/88 (23%)
myo10	NP_001362203.1	SH3_19	7..58	CDD:465815
		MYSc_Myo10	77..727	CDD:276840	269/667 (40%)
		IQ	744..763	CDD:459869	6/18 (33%)
		SMC_N	871..>976	CDD:481474	21/110 (19%)
		MYO10_CC	901..951	CDD:465249	11/53 (21%)
		PH-like	<1210..>1237	CDD:473070	6/38 (16%)
		PH2_MyoX	1240..1341	CDD:270108	23/121 (19%)
		PH3_MyoX-like	1406..1531	CDD:270109	38/222 (17%)
		MyTH4	1574..1720	CDD:214535	53/204 (26%)
		FERM_F1_Myosin-X	1722..1817	CDD:340726	24/104 (23%)
		B41	1729..1983	CDD:214604	55/267 (21%)
		FERM_C_MyoX	1979..2067	CDD:270023	20/88 (23%)