Protein Alignment Myo81F and Myo28B1

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Alignment Length: 2291
• Identity: 597/2291 - (26%)
• Similarity: 976/2291 - (42%)
• Gaps: 455/2291 - (19%)

  Fly     2 MSIGRRVGFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYH 66
            |.|..:....||..:.::.|..|.:||..||...:|||||||:|:|:|||:.:.|:..:.|..|.
  Fly    61 MHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYR 125

  Fly    67 TCKLGDLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQQ 131
            ...|.:|.||:||:::.|:..:.....||..|||||||||||||||.|||||..| |...||::|
  Fly   126 NKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAI-SGKHSWIEQ 189

  Fly   132 QILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNY 196
            ||:|||.|:||||||||.||||||||||::::.|.....|:|..|..||||:|||.|||..||||
  Fly   190 QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNY 254

  Fly   197 HIMYQLVAQGQKNIGIANTFHLR-----PAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQI 256
            ||.|.::|    .:..|....|:     |:: |.||.......:....::|.|..:..|..||..
  Fly   255 HIFYCMLA----GLSTAERERLKLQEQSPSQ-YHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSF 314

  Fly   257 PQFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRS---DQEAISIISMLLGLSRCDFKKVLLIR 318
            ....:..:..::::||.|||:.|...  ||.:|..:   |...:..::.|||:........|..|
  Fly   315 KPEEVWSILSLLAAILHLGNLRFTAT--EVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQR 377

  Fly   319 QINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDD-AKFLGVLDIFGFE 382
            .|.|.|......|..:.|:|.|.|..|:||..:|..:|.:||...|...|. ...:|||||||||
  Fly   378 TIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFE 442

  Fly   383 NFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVF 447
            ||.:||||||||||.||.|.:||..::|.:||..|::|.|.:.|:||.||...|:::...|..:.
  Fly   443 NFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLM 507

  Fly   448 KLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNR 512
            .|:.|:...|:|:|...|..:|.:..:...|:||...:  .:.|||:||||:|:|...||:||||
  Fly   508 SLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQ--TSLFGIRHYAGVVMYNPLGFLEKNR 570

  Fly   513 DVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSSKSKCTVSDNFRNQLQSLIDVLQNTK 577
            |.....:...:..|.:.::.|:..::        .|..::|.:.|:...|||.|..|:..|....
  Fly   571 DSFSGDLRTLVQRSTNKYLVDIFPHE--------MPMDTAKKQPTLCVKFRNSLDMLMRTLSQAH 627

  Fly   578 PWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNKSF 642
            |:::||||||..|.|.|::..|.:.||:|.|:::..||||.|:||..:::.|:.||:.|:.
  Fly   628 PYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVP---- 688

  Fly   643 EYP---------QKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQKN 698
              |         :|....|.|......::.|.||:|:|||:.....||..|...:.|:.|.||:.
  Fly   689 --PVGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRG 751

  Fly   699 WKKYYIQKSFLRNKQAVLRIQHAYRG-----------------------WRLRIRFMRMRRSAIV 740
            .::...::...|.::|::.:|..:||                       .:|..:|..:|...|.
  Fly   752 IRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIK 816

  Fly   741 IQSRLRGVFAREVAAALREMKRVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLAHISDN 805
            :|:..||...|:........:|...:|||     |:|..:.....|       |||..|..:.:.
  Fly   817 LQALSRGYLVRKDFQKKLLERRKQNQLKK-----EELLKLAKMKEA-------EELLRLQQLKEQ 869

  Fly   806 IRASAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDE 870
            .....:...:|...:....::.               ..::.|...|.:::         |...:
  Fly   870 KEREQREQQEKRLQEEQRLKAE---------------AAARNALAMAAVQQ---------KRRTK 910

  Fly   871 EIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTK 935
            .:           .|:..|..|.:...:|     ||||..:.::|.|.:.|   |..:.::.|..
  Fly   911 PV-----------KQEAPKAPTLQARNSL-----PPPPTTLIVAAPLPTRP---ASAVTRINTIP 956

  Fly   936 EIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQRVEKKIHELT---LIDIHKDI-- 995
            |         ...:|...|.|.....|| ::..||.:     ...:|::.::   .|.:.|.:
  Fly   957 E---------SPGTIDVESSKQMVDDVF-RFLNDEPD-----AALRKLNNISSGDTIRLPKSVPN 1006

  Fly   996 HIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTMFSKS------------ 1048
            :||.|.::.|::|..||                    ....||:||.....||
  Fly  1007 NIDTSDFSYLKYAATYF--------------------GGGATAQHERKPLKKSLLKHEHPIDEMA 1051

  Fly  1049 ----------------DKIPTSHIHMYDPENV------VLSCS------MF-----RELCKYM-R 1079
                            |.:.:..:|::|.||:      :|:.|      :|     |.:.|.: .
  Fly  1052 SKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLAS 1116

  Fly  1080 GELNAER-----------ELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILC 1133
            ||..|:.           .|:.|.:|:|.||.:..|||||..|..:|...||:.....|.|::|.
  Fly  1117 GEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLS 1181

  Fly  1134 LSIVAFQPSKLLFRYFVSFIKKSMIELDG--KLRQYSQWCFDNCKSTKVS-TRMYPPSSVEVAAM 1195
            |.:..|.|||....:..||:|:...:|..  .|::..:        |.|: .|..|||..|:.|:
  Fly  1182 LCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLER--------TLVNGPRCQPPSLFELHAI 1238

  Fly  1196 RRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPD-------GEE 1253
            |....:......:|.:.:.:.|....||.:||.:|.:.:.||.|.|:.:..:...       |:|
  Fly  1239 RGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQE 1303

  Fly  1254 HIKSYDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQ 1318
            |:      .|.||..|.:|.             ....:...:|.:|.:.::.|.||....::|.|
  Fly  1304 HV------LDAISECEQRQL-------------DAPWKLYIRKEMFATWYDPSMDPKATQLIYKQ 1349

  Fly  1319 AVHSVVKKDEFPV-SEKVALQLAGLQAQVALGDPSN--QPKPEYYSDINSFLPIRISKTREQ--Q 1378
            .::. :|..|:.. |||....:..|...|..| |..  :.||   |:|.:|:|..:....|:  :
  Fly  1350 ILNG-LKCGEYRCRSEKDIAMVCALACFVEYG-PGEILRLKP---SEITAFVPSDLLAPGERAIE 1409

  Fly  1379 FWIPILAQAHRQYG---SSRNALTAKV-------LYLSCVMQYPLYGTTMFKVNYKGYWNLASN- 1432
            .|..::|..:.:..   ..:|.|..:.       :.|...:.:|:..:.:|:|..|....|.|:
  Fly  1410 NWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDE 1474

  Fly  1433 IILGIHYDGIMFINPEDKSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTSLYGSSLIESQ 1497
            ::|||:..|:..|: |.:.|:....:.::..:.::..|....::.....
  Fly  1475 LMLGINSAGLFLID-ETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVN---------------- 1522

  Fly  1498 KCFVFETPQKNDIGSLIISYYPALSNWILNNLECSKKY--------KGTTKEDRLRLYQ------ 1548
              ||.:.....|...:|        |::|:||.....|        :|.. ||.|.|..
  Fly  1523 --FVLQCSSAQDANEVI--------NYMLDNLRQRSSYGVALDPVVEGDL-EDCLVLNPGDLIEF 1576

  Fly  1549 ------------NVVLCRRHLVDMNIVKKPHDFGGFLRNTLRRLS-----KHRLEKLRSEVG--- 1593
                        |...|.|..|:       ..:|.||...:|.|:     ..:|:.:..| |
  Fly  1577 EAGVTGAQLMAGNAQDCYRGCVN-------GQWGQFLAGNVRVLATLTKPSEKLQDILRE-GRFQ 1633

  Fly  1594 -----------SNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQ-----------------EE 1630
                       |..::|..:....||........:.|  :|..|.:                 ::
  Fly  1634 EPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAP--LSKFSPEPLKAPLLKAVVKVPPLFQQ 1696

  Fly  1631 ALMIQVFDSILTYSGLGSSGESISRAEDEHIRI-IQSIMDKCMKKESLLNELYLQLIKQTTDHPD 1694
            ||::.  ..||.|.|      .|:|:   ::.: ...|....::...|.:|||.||:||.:|:|.
  Fly  1697 ALVMH--HHILKYMG------DIARS---NLPVNTDLIFQPALQHPLLCDELYCQLMKQLSDNPS 1750

  Fly  1695 ANSRVNLKNWALLSVLCSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFR-----T 1754
            :.|  ..:.|.||.:...::.||:..:|:.:|  |.|..:|.|         |:.|..|     .
  Fly  1751 SES--EKRGWDLLYLATGLVAPSVLVMRELII--LLRMRADAL---------ADACLKRLKRSLA 1802

  Fly  1755 QGTRRRQWTPSREEILCTTNRRPC---YSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDN 1816
            ||.|::  .|...|:.....|  |   |.|.||.|....:.|.:..:...:::..|.:::. |.:
  Fly  1803 QGQRKK--APHLIEVEGIQQR--CLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLE-LKS 1862

  Fly  1817 AKGYSIYEVIGNSERSLSSEEKVCDVMAK---WEKYQITSQQGFQKNTTLISQQNQYMFLFKKHL 1878
            ..||||:...|:...::..||.|.|.:.:   |.:         |:.|.......||...|.:.|
  Fly  1863 PVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLR---------QQRTIRSISDGQYQLHFMRKL 1918

  Fly  1879 FFDNYINLEDIVEKELL-YHQILHNLRSERYPITEMEAIMLTALQSQLERGDCCESITDYRAVAS 1942
            :.:|:.. ||:....:. |.|.||......|||...:|..|..|....:..           |:.
  Fly  1919 WLNNHPG-EDLNGDMIFSYPQELHKYLKGYYPIDCEQASRLAILVYSADHD-----------VSL 1971

  Fly  1943 HCLP---PRFVPN--IPHEAVAMHHQSLRGMLP---------IEAKKAFLNLIKSWPLHRATIFD 1993
            ..||   .|.:|.  ||.:.||...|.:   ||         ..||..||..:..:....:|.|.
  Fly  1972 QRLPEVLTRLIPEDLIPLQTVAEWRQQI---LPKVHRDHLTEDHAKILFLQELSHFACFGSTFFV 2033

  Fly  1994 VMQSFTTNWPRTLWLAIDQKGIHLLEHRSRNVLCTYGYDSIISFSPNLNSLMIFTGTEKKQSKVI 2058
            |.|......|.||.:||:..|.|:|:..::.:|.:|.|..:..:|...|...|..|.....||::
  Fly  2034 VKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIWSSGKNHFHIRFGNMIGASKLL 2098

  Fly  2059 LTTPQAYQITTLIREY 2074
            .:|.|.|::..|:..|
  Fly  2099 CSTTQGYKMDDLLASY 2114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	254/667 (38%)
		MyTH4	1091..1194	CDD:459939	34/105 (32%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	20/107 (19%)
		B41	1202..1419	CDD:214604	48/238 (20%)
		PH-like	1415..1523	CDD:473070	17/108 (16%)
		MyTH4	1664..1771	CDD:459939	31/111 (28%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	26/110 (24%)
		B41	1781..1992	CDD:214604	53/228 (23%)
		PH-like	1988..2076	CDD:473070	26/87 (30%)
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	254/668 (38%)
		IQ	765..785	CDD:197470	4/19 (21%)
		Atrophin-1	<820..>946	CDD:460830	29/180 (16%)
		MyTH4	1031..1239	CDD:470587	53/215 (25%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	21/109 (19%)
		B41	1248..1429	CDD:214604	44/204 (22%)
		PH-like	1454..1547	CDD:473070	21/119 (18%)
		MyTH4	1674..1819	CDD:214535	40/170 (24%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	23/103 (22%)
		B41	1827..2032	CDD:214604	53/229 (23%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	26/87 (30%)