Protein Alignment Myo81F and MYO15A

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_016880204.1
• Gene: MYO15A / 51168
• HGNCID: 7594
• Length: 3531
• Species: Homo sapiens
• Alignment Length: 2635
• Identity: 577/2635 - (21%)
• Similarity: 953/2635 - (36%)
• Gaps: 913/2635 - (34%)

  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDL 73
            |..|||::.::.|..:..||.:|:..::||||.||||::||||:...|:..:.:.:|:...||:.
Human  1223 GVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQYNGRALGEN 1287

  Fly    74 SPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQQ---QILE 135
            .||:||||..|:..::|...||..:||||||:||||:||.||:||..:  |....|.|   ||||
Human  1288 PPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAM--NQKREVMQQVIQILE 1350

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            |..:||:||||||.|||||||||||::: |.:...|.|.:...||||:|||.||::.||||||.|
Human  1351 ATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEGGVISGAITSQYLLEKSRIVFQAKNERNYHIFY 1414

  Fly   201 QLVAQGQKNIG----IANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVI 261
            :|:|      |    :...|.|:.||.|.|||...:.:|....::..|..:..|..||.......
Human  1415 ELLA------GLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFSSEDQ 1473

  Fly   262 DGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINVRG-- 324
            |.:|::::|||.|||:.|...:   ||.    ||..|::|..      :.:.|..:.||:..|
Human  1474 DSIFRILASILHLGNVYFEKYE---TDA----QEVASVVSAR------EIQAVAELLQISPEGLQ 1525

  Fly   325 -----NITE-------IPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLD 377
                 .:||       .||.::.|::.|.|:||.||:.:|:||::::|...:|.||... :.:||
Human  1526 KAITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSPRQDTLS-IAILD 1589

  Fly   378 IFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKP 442
            |:|||:.|.||||||||||.||.|...||..||..||..|..|.|.:..:.|.||.||:.::...
Human  1590 IYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLK 1654

  Fly   443 PRCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGF 507
            |..:.::|.:||..||.:|..||...|....::|.|   |..:....||.||||||.|.|.|..|
Human  1655 PYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLY---SKPKMPLPEFTIKHYAGKVTYQVHKF 1716

  Fly   508 VEKNRD-VQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSY-----PRGSSKSKC--------TV 558
            ::||.| |:|||:        |:|::  |..:.:..:.||:     |:...||..        ||
Human  1717 LDKNHDQVRQDVL--------DLFVR--SRTRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTV 1771

  Fly   559 SDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIH 623
            :..|:..|..|::.::...|.::||:|||.:|.|..:...:|:.||:|.||::.:|||:||||:.
Human  1772 AAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVR 1836

  Fly   624 LSHKDFIVRYKCLIKNKSFEYPQKYLTNILEKNG-------------MPTTEWQIGKSKIFLRNA 675
            |..:.||.||.||:.          |.:.|..||             ||.. :::|.||:||:..
Human  1837 LPFQGFIDRYCCLVA----------LKHDLPANGDMCVSVLSRLCKVMPNM-YRVGVSKLFLKEH 1890

  Fly   676 AYELLETNRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIV 740
            .|:|||:.|:..|...|:.:|:..:.::|::.|...:..::.:|...||:..|.|:.:||||.:.
Human  1891 LYQLLESMREHVLNLAALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSLVK 1955

  Fly   741 IQSRLRGVFAREVAAALREMKRV---------DEELKKRDGIYEQLTSITTKTLADCERSIQEEL 796
            .:|.:....:|.....||...|.         .|||.||:.:                  ....|
Human  1956 FRSLVHAYVSRRRYLKLRAEWRCQVEGALLWEQEELSKREVV------------------AVGHL 2002

  Fly   797 SVLAHISDNIRASAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENALIKEINDNW 861
            .|.|.::..::|.|
Human  2003 EVPAELAGLLQAVA--------------------------------------------------- 2016

  Fly   862 NNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLNSEPIYEAI 926
                     .:||.          :..::...:|.|...||.|..|       .::|:.|:
Human  2017 ---------GLGLA----------QVPQVAPVRTPRLQAEPRVTLP-------LDINNYPM---- 2051

  Fly   927 NLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQRVEKKIHELTLIDI 991
                                .|.::.:.|:|:...:.|.
Human  2052 --------------------AKFVQCHFKEPAFGMLTVP-------------------------- 2070

  Fly   992 HKDIHIDNSFYNILEFAENYFNTHDLSSDCNFISTP-TQKGKSSDKTAKHEMTMFSKSDKIPTSH 1055
                                            :.|| ||                     :|..|
Human  2071 --------------------------------LRTPLTQ---------------------LPAEH 2082

  Fly  1056 IHMYDPENVVLSCSMFRELCKYMRGE--LNAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRN 1118
             |       ..:.|:|:.:.::| |:  |:..||.....|||..|:...||||||..|...|..:
Human  2083 -H-------AEAVSIFKLILRFM-GDPHLHGARENIFGNYIVQKGLAVPELRDEILAQLANQVWH 2138

  Fly  1119 NPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFI------------KKSMIELDGKLRQYSQWC 1171
            |.|....:|.|::|...:..|.||....:|.:.|:            :..:::..|:.:|....
Human  2139 NHNAHNAERGWLLLAACLSGFAPSPCFNKYLLKFVSDYGRNGFQAVCQHRLMQAMGRAQQQGSG- 2202

  Fly  1172 FDNCKSTKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDT----AGDAVQK--L 1230
                     :.|..||:.:|..|.....::.......:....:..||...|    |||.::.  |
Human  2203 ---------AARTLPPTQLEWTATYEKASMALDVGCFNGDQFSCPVHSWSTGEEVAGDILRHRGL 2258

  Fly  1231 AEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISSWEM-----KQATY--AGTK--------- 1279
            |:...     ||.:..........:..:||:.|::|..|:     :|.:|  .||:
Human  2259 ADGWR-----GWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFIVGTEGPAASRGGP 2318

  Fly  1280 KTTNGSS----------------------------------SGENQFVFKKRLFKSTHELSQ--- 1307
            |...|:|                                  :||.:    .:...:||:.|.
Human  2319 KVVFGNSWDSDEDMSTRPQPQEHMPKVLDSDGYSSHNQDGTNGETE----AQRGTATHQESDSLG 2379

  Fly  1308 -----------------DPV--------------------------------------------- 1310
                             |||
Human  2380 EPAVPHKGLDCYLDSLFDPVLSYGDADLEKPTAIAYRMKGGGQPGGGSSSGTEDTPRRPPEPKPI 2444

  Fly  1311 ---EVSMLYSQAVHSVVKKDEFPVSEKVALQLAGLQAQ-----------------------VALG 1349
               :.|.|..|  .:.:.|....::.::.||...||.|                       |..|
Human  2445 PGLDASTLALQ--QAFIHKQAVLLAREMTLQATALQQQPLSAALRSLPAEKPPAPEAQPTSVGTG 2507

  Fly  1350 DP------------------------------------------SNQPKPEY--YSDINSF---L 1367
            .|                                          :..|.||.  ||.:||.   .
Human  2508 PPAKPVLLRATPKPLAPAPLAKAPRLPIKPVAAPVLAQDQASPETTSPSPELVRYSTLNSEHFPQ 2572

  Fly  1368 PIRISKTREQQFWIPILA---QAHRQYGS--------------------------------SRNA 1397
            |.:..|...:|:..|...   :|.|:.|.                                ||.|
Human  2573 PTQQIKNIVRQYQQPFRGGRPEALRKDGGKVFMKRPDPHEEALMILKGQMTHLAAAPGTQVSREA 2637

  Fly  1398 L----------------TAKVLYLSCVMQYPLYGTTMFKV---NYKGYWNLASNIIL--GIHYDG 1441
            :                |:.:...|......|..|.:.::   |:.||.:....|.|  .:.|..
Human  2638 VALVKPVTSAPRPSMAPTSALPSRSLEPPEELTQTRLHRLINPNFYGYQDAPWKIFLRKEVFYPK 2702

  Fly  1442 IMFINPEDKSVVFQFKYVDIESILLDP-SDSFITISLNRSAQLLKTSLYGSSLIESQKCFVFET- 1504
            ..:.:|....::|:       .||.|. |::.:.||  ...:|...:|:..:.:::||..|.|:
Human  2703 DSYSHPVQLDLLFR-------QILHDTLSEACLRIS--EDERLRMKALFAQNQLDTQKPLVTESV 2758

  Fly  1505 --------------------PQKNDIGS----LIISYYPALSNWILNNLECSKKYKGTTKEDR-- 1543
                                |....:|:    |.:|:.         .::..:..||..:...
Human  2759 KRAVVSTARDTWEVYFSRIFPATGSVGTGVQLLAVSHV---------GIKLLRMVKGGQEAGGQL 2814

  Fly  1544 --LRLY----------------------QNVVL--CRRH----LVDMNI--VKKPHDFGGFLRNT 1576
              ||.|                      :.|:|  .|.|    |||..|  :||..|:...:||.
Human  2815 RVLRAYSFADILFVTMPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILELKKDSDYVVAVRNF 2879

  Fly  1577 LRR----LSKHR----------------------------LEKLR-------------------- 1589
            |..    |:.|:                            ||:||
Human  2880 LPEDPALLAFHKGDIIHLQPLEPPRVGYSAGCVVRRKVVYLEELRRRGPDFGWRFGTIHGRVGRF 2944

  Fly  1590 --------------------------------------SEVG---------SNTQEHGE------ 1601
                                                  .|||         :.:.:|||
Human  2945 PSELVQPAAAPDFLQLPTEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSADHGEDALALP 3009

  Fly  1602 --TYKGFSHTFW----------------------------AFSKQQIPFCISTISDQEEALM-IQ 1635
              |...|:..::                            .|:|..:...:..:||...:.| ..
Human  3010 PYTMLEFAQKYFRDPQRRPQDGLRLKSKEPRESRTLEDMLCFTKTPLQESLIELSDSSLSKMATD 3074

  Fly  1636 VFDSILTYSG-LGSSGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRV 1699
            :|.:::.:.| ....|:|       .:.::.:::..|...|.:.:|.|.|::||.||:..:....
Human  3075 MFLAVMRFMGDAPLKGQS-------DLDVLCNLLKLCGDHEVMRDECYCQVVKQITDNTSSKQDS 3132

  Fly  1700 NLKNWALLSVL-----CSVILPSMKAVRKYLIAHLKRCSSDFLSEEG-KYARYAENCFFRTQGTR 1758
            ..:.|.||.::     ||.:|.          .||.|...|.....| .:...|:.|....|.|.
Human  3133 CQRGWRLLYIVTAYHSCSEVLH----------PHLTRFLQDVSRTPGLPFQGIAKACEQNLQKTL 3187

  Fly  1759 R---RQWTPSREEILCTTNRRPCYSKFYFMDGQY-YSIEFQPSSTANDVLEIIKKKIGLL--DNA 1817
            |   |...||..|:......|....:.:.:.|.. ..::.:..:.|.||:|.|..::.|.  :..
Human  3188 RFGGRLELPSSIELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVVEEICAEMALTRPEAF 3252

  Fly  1818 KGYSIYEVIGNSER--SLSSEEKVCDVMAKWEKYQITSQQGFQKNTTLISQQNQYMFLFKKHLFF 1880
            ..|.|:.|....:.  .||....:.||.::.|:.                 ...||..|:: :.:
Human  3253 NEYVIFVVTNRGQHVCPLSRRAYILDVASEMEQV-----------------DGGYMLWFRR-VLW 3299

  Fly  1881 DNYINLEDIVEKELLYHQILHNLRSERY-------PITEM--EAIMLTALQSQLERGDCCESITD 1936
            |..:..|:.:...:.|:|:|.:.....:       |..::  :...|.:||
Human  3300 DQPLKFENELYVTMHYNQVLPDYLKGLFSSVPASRPSEQLLQQVSKLASLQ-------------- 3350

  Fly  1937 YRAVASHCLP-----PRFVP-------------NIPHEAVAMHHQSLRGMLPIEAKKAFLNLIKS 1983
            :||.....||     ..::|             |:    |:.|.|..:.:.|.:|:..||.|:.:
Human  3351 HRAKDHFYLPSVREVQEYIPAQLYRTTAGSTWLNL----VSQHRQQTQALSPHQARAQFLGLLSA 3411

  Fly  1984 WPLHRATIFDVMQSFTTNWPRTLWLAIDQKGIHLLEHRSRNVLCTYGYDSIISF---SPNLNS-- 2043
            .|:..::.|.:........|....|||:..|::.|...:..::..:....|.|.   .|..||
Human  3412 LPMFGSSFFFIQSCSNIAVPAPCILAINHNGLNFLSTETHELMVKFPLKEIQSTRTQRPTANSSY 3476

  Fly  2044 --LMIFTGTEKKQSKVILTTPQAYQITTLIREYSE 2076
              :.|..|....|..:.|...|..::..::..:.|
Human  3477 PYVEIALGDVAAQRTLQLQLEQGLELCRVVAVHVE 3511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	261/697 (37%)
		MyTH4	1091..1194	CDD:459939	28/114 (25%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	24/156 (15%)
		B41	1202..1419	CDD:214604	63/461 (14%)
		PH-like	1415..1523	CDD:473070	25/138 (18%)
		MyTH4	1664..1771	CDD:459939	29/115 (25%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	19/109 (17%)
		B41	1781..1992	CDD:214604	42/242 (17%)
		PH-like	1988..2076	CDD:473070	17/94 (18%)
MYO15A	XP_016880204.1	SGP	<320..364	CDD:435798
		PHA03247	<723..1144	CDD:223021
		MYSc_Myo15	1236..1888	CDD:276838	261/698 (37%)
		IQ	1926..1947	CDD:197470	5/20 (25%)
		MyTH4	2066..2218	CDD:214535	44/249 (18%)
		PHA03247	<2433..2673	CDD:223021	32/241 (13%)
		SH3_MYO15A	2872..2951	CDD:213000	9/78 (12%)
		MyTH4	3051..3205	CDD:214535	38/170 (22%)
		FERM_M	3300..3420	CDD:459788	24/137 (18%)
		FERM_C_MyoXV	3416..3517	CDD:270022	18/96 (19%)