Protein Alignment Myo81F and MYO7A

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_011543348.2
• Gene: MYO7A / 4647
• HGNCID: 7606
• Length: 2258
• Species: Homo sapiens
• Alignment Length: 2279
• Identity: 586/2279 - (25%)
• Similarity: 977/2279 - (42%)
• Gaps: 464/2279 - (20%)

  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDL 73
            |..||..:.:::|.||.:||.:||...:|||||||||:|||||:.::|::.:.|.:|...|:|::
Human    96 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEM 160

  Fly    74 SPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQQQILEANT 138
            .||:||:|:..|.::..::.:|.|:||||||||||||||.|||:|..| |...||::||:|||..
Human   161 PPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAI-SGQHSWIEQQVLEATP 224

  Fly   139 ILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMYQLV 203
            ||||||||||.||||||||||::.:.|:....|:|..|..||||:||:..|:..|||||:.|.::
Human   225 ILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFYCML 289

  Fly   204 AQG-----QKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVIDG 263
             :|     :|.:|:..      |..|.||...|.......::|:::..:..|..||.........
Human   290 -EGMSEDQKKKLGLGQ------ASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWE 347

  Fly   264 VFKVISSILWLGNIEFIDVDGEVTDLTRSD------QEAISIISMLLGLSRCDFKKVLLIRQINV 322
            :.|::::||.|||:::     |.......|      ..:::..:.||.::..|....|..|.:..
Human   348 ISKLLAAILHLGNLQY-----EARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLIT 407

  Fly   323 RGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNC--TNPGQD---DAKFLGVLDIFGFE 382
            ||.....||..::||:.|.|..|.:|.::|.|:|.|||..  ..|.||   ..:.:|:|||||||
Human   408 RGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFE 472

  Fly   383 NFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVF 447
            ||:.|||||||||:.||.|.:||..:||.|||..|:.|.|.:.|:|||||...|:::...|..:.
Human   473 NFAVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNII 537

  Fly   448 KLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNR 512
            .|:.|:...|:|:|...|..::::.:.:.|||  ..:.:.||:|||.|:||:|.|...||:||||
Human   538 SLIDEESKFPKGTDTTMLHKLNSQHKLNANYI--PPKNNHETQFGINHFAGIVYYETQGFLEKNR 600

  Fly   513 DVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSS--KSKCTVSDNFRNQLQSLIDVLQN 575
            |.....:.:.:..|::.|||        |...:....|:.  |...|:|..|:..|:.|:..|..
Human   601 DTLHGDIIQLVHSSRNKFIK--------QIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGA 657

  Fly   576 TKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNK 640
            .:|::|||||||..|:|..::..|.:.||:|.|:::.|||||.|:||..|..:|:.||:.|:...
Human   658 CQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGV 722

  Fly   641 SFEYPQKYLTNILEKNGMPT----TEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQKNWKK 701
            ...|.|..|....::.....    .:|||||:||||::....|||..|...:....:::||..:.
Human   723 KPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRG 787

  Fly   702 YYIQKSFLRNKQAVLRIQHAYRGWR-------LRIRFMRMRR----------------------- 736
            :..:.:||:.|.|...||..:||..       :|:.|:|::.
Human   788 FKDRSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQA 852

  Fly   737 ----------------SAIVIQSRLRGVFAREVAAALR---------EMKRVDEELKKRDGIYEQ 776
                            :.:.:|:..||:.||.:...||         |..|:.||.|.|    ::
Human   853 RCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLR----KE 913

  Fly   777 LTSITTKTLADCERSIQEELSVLAHISDNIRASAKPLSDKNDS--------DSNTARSSIKQNTV 833
            :::  .|...:.||..||.|:.||.     ..:.:.|.:|..:        ....||.....::.
Human   914 MSA--KKAKEEAERKHQERLAQLAR-----EDAERELKEKEAARRKKELLEQMERARHEPVNHSD 971

  Fly   834 NLDNMFDFLCESKG----------AFENALIKEINDNWNNLV-KNLDEEIGLCIHTEDSFDSQKT 887
            .:|.||.||..|.|          .||     ::......:| ::||..:.|....|:.....|.
Human   972 MVDKMFGFLGTSGGLPGQEGQAPSGFE-----DLERGRREMVEEDLDAALPLPDEDEEDLSEYKF 1031

  Fly   888 GKLFTT---------KTVRTLPEPTV-----------------------PPPPPPVSISANLNSE 920
            .|...|         .|.|.|.:|.:                       ..|.|....:.:..||
Human  1032 AKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSE 1096

  Fly   921 PIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQRVEKKIHE 985
            .|.....:|:....|..|:|...|..    :..::.|              |.::|..|..|:..
Human  1097 KIPVMTKIYETLGKKTYKRELQALQG----EGEAQLP--------------EGQKKSSVRHKLVH 1143

  Fly   986 LTLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTMFSKSDK 1050
            |||                                       .:|.|.:::..|
Human  1144 LTL---------------------------------------KKKSKLTEEVTK----------- 1158

  Fly  1051 IPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFIQCIRQ 1115
                  .::|.|:.|...||..:     |...|.|:    :.:|:|.||.|..|||||:.|..:|
Human  1159 ------RLHDGESTVQGNSMLED-----RPTSNLEK----LHFIIGNGILRPALRDEIYCQISKQ 1208

  Fly  1116 SRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKV 1180
            ..:||:.....|.||::.|.:..|.||:...:|..:||       .|....|:.:|.:..:.|.|
Human  1209 LTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFI-------HGGPPGYAPYCEERLRRTFV 1266

  Fly  1181 S-TRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAI 1244
            : ||..|||.:|:.|.:....|:....|:|..||.:......||.:....||:|::|....|:::
Human  1267 NGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSL 1331

  Fly  1245 YQNRPDGEEHIKS-YDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFVFKKRLFKSTHELSQD 1308
            |....|....:.| .|::.|.||..|.    ||  |:......:...:..|:|.:|...|..|:|
Human  1332 YIALFDKVSSLGSGSDHVMDAISQCEQ----YA--KEQGAQERNAPWRLFFRKEVFTPWHSPSED 1390

  Fly  1309 PVEVSMLYSQAVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINS-------- 1365
            .|..:::|.|.|.. ||..|:...::.  .||.|.:|            :|:.|..|
Human  1391 NVATNLIYQQVVRG-VKFGEYRCEKED--DLAELASQ------------QYFVDYGSEMILERLL 1440

  Fly  1366 -----FLPIR-ISKTREQQFWIPILAQAHRQ--YGSSR-NALTAKVLYLSCV-MQYPLYGTTMFK 1420
                 ::|.| |:..:..:.|..:...||::  |...| :|...|...:|.. .::||    :|.
Human  1441 NLVPTYIPDREITPLKTLEKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPL----LFS 1501

  Fly  1421 VNYKGYW----NLASN-IILGIHYDGIMFINPEDKSVVFQFKYVDIESILLDPSDSFITISLN-- 1478
            ..|:.|.    :|..| :|:.:::.|:.|:: |.:.|:.:..:.:|.:: ....:..:.:||.
Human  1502 RFYEAYKFSGPSLPKNDVIVAVNWTGVYFVD-EQEQVLLELSFPEIMAV-SSSRECRVWLSLGCS 1564

  Fly  1479 --------------------------RSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISY 1517
                                      |.|:....| :..:.|:..: :.|.:....||..|::::
Human  1565 DLGCAAPHSGWAGLTPAGPCSPCWSCRGAKTTAPS-FTLATIKGDE-YTFTSSNAEDIRDLVVTF 1627

  Fly  1518 YPAL--------------------------------------------SNWILNNLECSKKYKGT 1538
            ...|                                            |.| .|.:....|.:|.
Human  1628 LEGLRKRSKYVVALQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMNSGW-ANGINERTKQRGD 1691

  Fly  1539 TKEDRLRLYQNVVLCRRHLVDM---------NIVK-------------KPHDFGGFLRNTLRRLS 1581
            ...|.:.:...|.:..|.:|.:         ::|:             ||:....|..:..|...
Human  1692 FPTDSVYVMPTVTMPPREIVALVTMTPDQRQDVVRLLQLRTAEPEVRAKPYTLEEFSYDYFRPPP 1756

  Fly  1582 KHRLEKLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQEEALMIQVFDSILTYSGL 1646
            ||.|.::..     ::..|:. :.:|||.....:..:...:.:....:||.:  .|.::|.|  :
Human  1757 KHTLSRVMV-----SKARGKD-RLWSHTREPLKQALLKKLLGSEELSQEACL--AFIAVLKY--M 1811

  Fly  1647 GSSGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKNWALLSVLC 1711
            |......:|:.:|   :...|.:..:|.|.|.:|.|:|::||.||:....|..  :.|.|| .||
Human  1812 GDYPSKRTRSVNE---LTDQIFEGPLKAEPLKDEAYVQILKQLTDNHIRYSEE--RGWELL-WLC 1870

  Fly  1712 SVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRTQGTRR---RQWTPSREEILCTT 1773
            :.:.|.    ...|:.|::|    || :..|:...|.:|..|.|...|   |::.|...|:....
Human  1871 TGLFPP----SNILLPHVQR----FL-QSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQ 1926

  Fly  1774 NR-RPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDNAKGYSIYEVIGNSERSLSSEE 1837
            :: ...:.|.||.|....:.|.:.|:.|.|..:.|..:: ||.:::|:|::..|.:...|:...:
Human  1927 HKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIATRL-LLKSSEGFSLFVKIADKVLSVPEND 1990

  Fly  1838 KVCDV---MAKWEKYQITSQQGFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVEKELLYHQI 1899
            ...|.   :..|.|.....:.|...:.|       |...|.|.|:.......:.:.:....|:|.
Human  1991 FFFDFVRHLTDWIKKARPIKDGIVPSLT-------YQVFFMKKLWTTTVPGKDPMADSIFHYYQE 2048

  Fly  1900 LHNLRSERYPITEMEAIMLTALQSQLERGDCCESITDY--------RAVASHCLPPRFVPNIPHE 1956
            |.......:..|..|.:.|.||..:::    .|....|        |.:....|..:..|:....
Human  2049 LPKYLRGYHKCTREEVLQLGALIYRVK----FEEDKSYFPSIPKLLRELVPQDLIRQVSPDDWKR 2109

  Fly  1957 AVAMHHQSLRGMLPIEAKKAFLNLIKSWPLHRATIFDVMQSFTTNWPRTLWLAIDQKGIHLLEHR 2021
            ::..:.....|....|||.|||.||..||...:..|:|...      ..|..|.::....|::||
Human  2110 SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKVH------HGLLRAEEEGNRALIKHR 2168

  Fly  2022 SRNV 2025
            ..::
Human  2169 DSSL 2172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	259/671 (39%)
		MyTH4	1091..1194	CDD:459939	35/103 (34%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	25/101 (25%)
		B41	1202..1419	CDD:214604	55/235 (23%)
		PH-like	1415..1523	CDD:473070	22/184 (12%)
		MyTH4	1664..1771	CDD:459939	32/109 (29%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	24/108 (22%)
		B41	1781..1992	CDD:214604	48/221 (22%)
		PH-like	1988..2076	CDD:473070	7/38 (18%)
MYO7A	XP_011543348.2	MYSc_Myo7	109..759	CDD:276832	259/672 (39%)
		CBD_MYO6-like	<796..>839	CDD:409646	9/42 (21%)
		tolA	<826..>996	CDD:236545	33/180 (18%)
		MAP7	<887..963	CDD:461709	18/86 (21%)
		MyTH4	1047..1283	CDD:214535	69/325 (21%)
		FERM1_F1_Myosin-VII	1287..1385	CDD:340612	26/103 (25%)
		B41	1289..1504	CDD:214604	56/239 (23%)
		FERM_C1_MyoVII	1498..1634	CDD:270019	23/143 (16%)
		SH3	1635..1699	CDD:473055	6/64 (9%)
		MyTH4	1793..1926	CDD:214535	40/151 (26%)
		FERM2_F1_Myosin-VII	1931..2028	CDD:340613	23/104 (22%)
		B41	1933..2145	CDD:214604	48/223 (22%)