Protein Alignment Myo81F and MYO1C

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_001074248.1
• Gene: MYO1C / 4641
• HGNCID: 7597
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1025
• Identity: 310/1025 - (30%)
• Similarity: 506/1025 - (49%)
• Gaps: 135/1025 - (13%)

  Fly     7 RVGFADMTEMSEI-DEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKL 70
            |||..|...:... .|....:||..|:..::||||.|.:|::||||:.:.|:::|.:..|.....
Human    45 RVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSF 109

  Fly    71 GDLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQY---LCTITSNVSSWVQQQ 132
            .::.||:||||:..|.::..:..:||.:|||||||||||:||.:||:   .|.......: |:.:
Human   110 YEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGA-VRDR 173

  Fly   133 ILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYH 197
            :|::|.:|||||||||.||||||||||:|.|.||......|..||.||||:||:..|:.||||:|
Human   174 LLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFH 238

  Fly   198 IMYQLVAQGQ----KNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQ 258
            |.|||:..|:    :.:|:.     |..:.|.||......|::...:...:..|..|.||:...:
Human   239 IFYQLLEGGEEETLRRLGLE-----RNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTE 298

  Fly   259 FVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINVR 323
            ..::.:..:::|:|.||||.|...:.....:|..:|  :..::.||.:.....::.|..|:|..:
Human   299 DEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQ--LKYLTRLLSVEGSTLREALTHRKIIAK 361

  Fly   324 GNITEIPLKIKEALENRHALAKALYSKMFTWLVSKIN------NCTNPGQDDAKFLGVLDIFGFE 382
            |.....||.:::|...|.|||||:||:.|||||.|||      :..:|.......||:|||:|||
Human   362 GEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFE 426

  Fly   383 NFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVF 447
            .|.||||||.||||.||||.:.|.......||..||.|||.:..|::.:|....:::|:..:.:.
Human   427 VFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGII 491

  Fly   448 KLLTEQCHMP-QGSDLAFLSNMHTEFESHPNYI--KGSDRRHWET----EFGIKHYAGLVIYAVG 505
            .:|.|:|..| :.:||.||..:....:.||:::  |.:|:|..::    ||.:.||||.|.|:|.
Human   492 SILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVT 556

  Fly   506 GFVEKNRDVQQDVMFEYMSYSKDVFIK---DLSTYQDIQFINSSYPRGSSKSKCTVSDNFRNQLQ 567
            ||::||.|:....:.|.|..||:..:.   |.|...|            .|...||:..|:..|.
Human   557 GFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSD------------KKRPETVATQFKMSLL 609

  Fly   568 SLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVR 632
            .|:::||:.:|.||||||||..|:|..::..|:..|:||||:::.:|:||.||.....::.|:.|
Human   610 QLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQR 674

  Fly   633 YKCLIKNKSFEY---PQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVI 694
            ||.|.......:   ||..:..::...|....|:::|::|||:|          ...||:.....
Human   675 YKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIR----------FPKTLFATEDA 729

  Fly   695 IQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAA---- 755
            ::            :|.:....:||.|:||:..|.:|:|::||||.|||..||...|..||
Human   730 LE------------VRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKW 782

  Fly   756 ALREMKRVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLAHISDNIRASAKPLSDKNDSD 820
            |.:.::|:             :.....:....|    .|....|.|:..:...:.:....:|..|
Human   783 AAQTIRRL-------------IRGFVLRHAPRC----PENAFFLDHVRTSFLLNLRRQLPQNVLD 830

  Fly   821 SN--TARSSIKQ-----NTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHT 878
            ::  |...::::     ..:.:.||....|.|           |:..|...::.......:....
Human   831 TSWPTPPPALREASELLRELCIKNMVWKYCRS-----------ISPEWKQQLQQKAVASEIFKGK 884

  Fly   879 EDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKEKYM 943
            :|:: .|...:||.:..:.|   ..:.|     .:...|.||||..|:.:.|........:.:.:
Human   885 KDNY-PQSVPRLFISTRLGT---DEISP-----RVLQALGSEPIQYAVPVVKYDRKGYKPRSRQL 940

  Fly   944 LL-----------------DYKSIKDNSKKPSTSSVFVKYQIDERENRRK 976
            ||                 ||.::...|....:.|:||.: :...:|::|
Human   941 LLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLH-VQRADNKQK 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	243/675 (36%)
		MyTH4	1091..1194	CDD:459939
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728
		B41	1202..1419	CDD:214604
		PH-like	1415..1523	CDD:473070
		MyTH4	1664..1771	CDD:459939
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728
		B41	1781..1992	CDD:214604
		PH-like	1988..2076	CDD:473070
MYO1C	NP_001074248.1	MYSc_Myo1	62..718	CDD:276829	243/675 (36%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		12/21 (57%)
		IQCG	751..781	CDD:467744	15/29 (52%)
		Myosin_TH1	874..1055	CDD:461801	23/126 (18%)