Protein Alignment Myo81F and MYO1A

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_005370.1
• Gene: MYO1A / 4640
• HGNCID: 7595
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 812
• Identity: 263/812 - (32%)
• Similarity: 424/812 - (52%)
• Gaps: 74/812 - (9%)

  Fly     8 VGFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGD 72
            ||..|:..:..:.|..:.:||.:||.:..||||.|:::::||||:.:.|:..:.|::|......:
Human     8 VGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFYE 72

  Fly    73 LSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQY---LCTITSNVSSWVQQQIL 134
            |.||::|:|..||.|:.|.:.:|..:|:||||:||||::|.::.|   :|.....|:| |::|:|
Human    73 LKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQVNS-VKEQLL 136

  Fly   135 EANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIM 199
            ::|.:|||||||||.||:|||||||:|.:.||......|.||.:||||:||:..|.:||||:||.
Human   137 QSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHIF 201

  Fly   200 YQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVIDGV 264
            |||:|...:.:..|.... |....|.|||...|....|: ::..|.||..|..|:...:..|..|
Human   202 YQLLAGADEQLLKALKLE-RDTTGYAYLNHEVSRVDGMD-DASSFRAVQSAMAVIGFSEEEIRQV 264

  Fly   265 FKVISSILWLGNIEFIDVDGEVTDLTRS---DQEAISIISMLLGLSRCDFKKVLLIRQINVRGNI 326
            .:|.|.:|.|||:...| :.:.:.:..|   |...:..|..::||:..:.::.|..|.:......
Human   265 LEVTSMVLKLGNVLVAD-EFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALCSRTMETAKEK 328

  Fly   327 TEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPG-QDDAKFLGVLDIFGFENFSHNSFE 390
            ....|.:.:|...|.||||.:||::|.|:|::||.....| .:..|.:|||||:|||....||||
Human   329 VVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYGFEILEDNSFE 393

  Fly   391 QLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTEQCH 455
            |..|||.||||.:.|.......||..|:.|||.:..|::.||....:::|...|.:..:|.|:|.
Human   394 QFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQRGILAMLDEECL 458

  Fly   456 MPQG--SDLAFLSNMHTEFESHPNY---IKGSDRRHWETEFGIK-----HYAGLVIYAVGGFVEK 510
            .| |  ||..||:.::..|..|.:|   :..:.:|.::...|:.     ||||.|.|.|..|::|
Human   459 RP-GVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKVTYNVTSFIDK 522

  Fly   511 NRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSSKSKC-----TVSDNFRNQLQSLI 570
            |.|:....:.:.|..::...::.|            :|.|:.|...     |....|::.:..|:
Human   523 NNDLLFRDLLQAMWKAQHPLLRSL------------FPEGNPKQASLKRPPTAGAQFKSSVAILM 575

  Fly   571 DVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKC 635
            ..|.:..|.|:||||||..::...::|.||..|.:|||:::.:|:||.|:.....:..|:.||:.
Human   576 KNLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRL 640

  Fly   636 LIKNKSFEYP------QKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVI 694
            |.::   .:|      ::.:..:|.:..|.:.|...||:|||:|:          ..||:
Human   641 LSRS---TWPHWNGGDREGVEKVLGELSMSSGELAFGKTKIFIRS----------PKTLF----- 687

  Fly   695 IQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAR----EVAA 755
                   |..::..||.:|....||..|||||.|..:..||:|.|:|.|..||...:    ::.|
Human   688 -------YLEEQRRLRLQQLATLIQKIYRGWRCRTHYQLMRKSQILISSWFRGNMQKKCYGKIKA 745

  Fly   756 ALREMKRVDEELKKRDGIYEQLTSITTKTLAD 787
            ::..::......|.|....:...|....||||
Human   746 SVLLIQAFVRGWKARKNYRKYFRSEAALTLAD 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	228/677 (34%)
		MyTH4	1091..1194	CDD:459939
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728
		B41	1202..1419	CDD:214604
		PH-like	1415..1523	CDD:473070
		MyTH4	1664..1771	CDD:459939
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728
		B41	1781..1992	CDD:214604
		PH-like	1988..2076	CDD:473070
MYO1A	NP_005370.1	MYSc_Myo1	22..681	CDD:276829	228/678 (34%)
		Actin-binding. /evidence=ECO:0000255	571..593		9/21 (43%)
		IQ	742..764	CDD:197470	3/21 (14%)
		Myosin_TH1	847..1042	CDD:461801