Protein Alignment Myo81F and MYH11

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Alignment Length: 2106
• Identity: 504/2106 - (23%)
• Similarity: 878/2106 - (41%)
• Gaps: 443/2106 - (21%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            ||.|::.::|..:..||..||.|.:||||:|...:.|||||.:.|::::.:..|...|..::.||
Human    89 DMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPH 153

  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSN---------------VS 126
            ::|:|:.||.|::.|..:|:.:.:|||||||||:||.::|||..:.|:               ..
Human   154 IYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAY 218

  Fly   127 SWVQQQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSE 191
            ..:::|:|:||.||||||||||.:||||||||||:::.||....|.|..|..||||:||...|:.
Human   219 GELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAR 283

  Fly   192 GERNYHIMYQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNS-EKINMNLESKKFDAVTMAFTVLQ 255
            .||.:||.|.::|..::.:    ...|....|..|...||. ..|....:.:.|.....|..::.
Human   284 DERTFHIFYYMIAGAKEKM----RSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMG 344

  Fly   256 IPQFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQI 320
            ..:.....:.||:||:|.||||.| ..:......:..|..|...:..|:|::..||.:.:|..:|
Human   345 FSEEEQLSILKVVSSVLQLGNIVF-KKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRI 408

  Fly   321 NVRGNITEIPLKIKE----ALENRHALAKALYSKMFTWLVSKINNCTN-PGQDDAKFLGVLDIFG 380
            .|..::.: ..:.||    |:|   |||||.|.::|.|:::::|...: ..:..|.|||:|||.|
Human   409 KVGRDVVQ-KAQTKEQADFAVE---ALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAG 469

  Fly   381 FENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKP-- 442
            ||.|..|||||||||||||||.:.|||.:|.|||..|:.|||.:|.::| .|..||:|::|:|
Human   470 FEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNN 534

  Fly   443 PRCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGF 507
            |..|..||.|:|..|:.:|.:|:..:.||..|||.:.|....:. :|||.|.||||.|.|....:
Human   535 PPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKD-KTEFSIIHYAGKVDYNASAW 598

  Fly   508 VEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFI----------NSSYPRGSSKSK---CTVS 559
            :.||.|...|.:...::.|.|.|:.||  ::|:..|          .||.|..|...|   .||.
Human   599 LTKNMDPLNDNVTSLLNASSDKFVADL--WKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVG 661

  Fly   560 DNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHL 624
            ..::.||..|:..|:||.|.:||||.||.:||....::.|||:||:..||::.|||.|:|||..:
Human   662 QLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRI 726

  Fly   625 SHKDFIVRYKCLIKN---KSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKD 686
            ..::|..||:.|..|   |.|...::....:::...:....::||:||||.|......||..|..
Human   727 VFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDL 791

  Fly   687 TLYKNAVIIQKNWKKYYIQKSFLRNKQ-------------AVLRIQHAYRGWRLRIR---FMRMR 735
            .:....:..|...:.|..:|:|.:.:|             |.|:::: ::.|||..:   .:::.
Human   792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRN-WQWWRLFTKVKPLLQVT 855

  Fly   736 RSAIVIQSRLRGVFAREVAAALREMKRVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLA 800
            |....:|::     ..|:.......::.:.|||:.:..:.|||.  .|.|  .:..:|.|..:.|
Human   856 RQEEEMQAK-----EDELQKTKERQQKAENELKELEQKHSQLTE--EKNL--LQEQLQAETELYA 911

  Fly   801 HISD-NIRASAKP-------------LSDKND--SDSNTARSSIKQNTVNLDNMFDFLCESKGAF 849
            ...: .:|.:||.             |.::.|  ......|..:.|..::|:...:   |.:.|.
Human   912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE---EEEAAR 973

  Fly   850 ENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSIS 914
            :...::::.....  :|.|::|| |.:..:::..|::          |.|.|..:.      .::
Human   974 QKLQLEKVTAEAK--IKKLEDEI-LVMDDQNNKLSKE----------RKLLEERIS------DLT 1019

  Fly   915 ANLNSEPIYEAINLYKLTTTKE---------IKKEKYMLLDYKSIKDNSKKPSTSSVF------- 963
            .|| :|...:|.||.||....|         :|||:....:.:.:|  .|....:|.|
Human  1020 TNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADL 1081

  Fly   964 ------VKYQIDERENR-------------RKQRVEKKIHELT--LIDIHKDIHIDNSFYNILEF 1007
                  :|.|:.::|..             :|....|||.||.  :.|:.:|:..:.:..|..|.
Human  1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

  Fly  1008 AENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFR 1072
            .:     .||..:...:.|..:  .:.|.||..:
Human  1147 QK-----RDLGEELEALKTELE--DTLDSTATQQ------------------------------- 1173

  Fly  1073 ELCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIV 1137
                    ||.|:||.::.  ::...::.|....|..:|.:||.......:.|::        :.
Human  1174 --------ELRAKREQEVT--VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ--------LE 1220

  Fly  1138 AFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIV 1202
            .|:.:|.........::|...:|.|:||...|                  :..||...::.
Human  1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQ------------------AKQEVEHKKKK---- 1263

  Fly  1203 CRFFFLDARTKAIDVHPTD------TAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYL 1261
                 |:|:.:.:....:|      ...|.|.||..::...|.     ..|..:|    |:....
Human  1264 -----LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG-----MLNEAEG----KAIKLA 1314

  Fly  1262 YDVISSWEMKQAT----YAGTKKTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAVHS 1322
            .||.|.....|.|    ...|::..|.|:        |.|..:......||.::..|...|.:..
Human  1315 KDVASLSSQLQDTQELLQEETRQKLNVST--------KLRQLEEERNSLQDQLDEEMEAKQNLER 1371

  Fly  1323 VVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFWIPILAQA 1387
            .:......:|:    ....||...:..:...:.|..:..:|.:     :::..|::      |.|
Human  1372 HISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIEN-----LTQQYEEK------AAA 1421

  Fly  1388 HRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNYKGYWNLASNIILGIH-YDGIMFINPEDKS 1451
            :.:...::|.|..::..|              .|:......|.||:..... :|.::   .|:|:
Human  1422 YDKLEKTKNRLQQELDDL--------------VVDLDNQRQLVSNLEKKQRKFDQLL---AEEKN 1469

  Fly  1452 VVFQFKYVD----IESILLDPSDSFITIS------------LNRSAQLLKTSLYGSSLIESQKCF 1500
            :  ..||.|    .|:...:.....::::            |.|:.::||..:  ..|:.|
Human  1470 I--SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM--EDLVSS---- 1526

  Fly  1501 VFETPQKNDIGSLIISYYPALSNWILNNLECSKKYKGTTK----------EDRLRLYQNVVLCRR 1555
                  |:|:|..:            :.||.||:...|..          ||.|:..::..|  |
Human  1527 ------KDDVGKNV------------HELEKSKRALETQMEEMKTQLEELEDELQATEDAKL--R 1571

  Fly  1556 HLVDMNIVKKPHDFGGFLRN---------TLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTFW 1611
            ..|:|..:|     |.|.|:         ..||..:.:|.:..:|:....::         ....
Human  1572 LEVNMQALK-----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ---------RALA 1622

  Fly  1612 AFSKQQIPFCI--------STISDQEEA------LMIQVFDSILTYSGLGSSGESISRAEDEHIR 1662
            |.:|:::...:        |.|..:|||      |..|:.|       .....|....:.||
Human  1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD-------FQRELEDARASRDE--- 1677

  Fly  1663 IIQSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKNWALLSVLCSVI--LPSMKAVRKYL 1725
            |..:..:...|.:||..:| :||.:.......|..:.:|:...|...|.|.:  ..:::..::.|
Human  1678 IFATAKENEKKAKSLEADL-MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741

  Fly  1726 IAHLKRCSSDFLSEEGKYARYAENCFFRTQ---------GTRR--RQWTPSREEILCTTNRRPCY 1779
            .|.:.:...:...|:|.....::.....||         .|.|  .|...|..:.|...|:. ..
Human  1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE-LR 1805

  Fly  1780 SKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDNAKGYSIYEVIGNSERSLSSEEKVCDVMA 1844
            ||.:.|:|...| :|:.:..|      ::.||..|:........|....::.....::|:.:::.
Human  1806 SKLHEMEGAVKS-KFKSTIAA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863

  Fly  1845 KWEKYQITSQQ---GFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVEKELLYHQILHNLRSE 1906
            :.|..:..::|   ..:|....:.|..:               .||:..|:....:.....|:.|
Human  1864 QVEDERKMAEQYKEQAEKGNARVKQLKR---------------QLEEAEEESQRINANRRKLQRE 1913

  Fly  1907 RYPITEMEAIM---LTALQSQLERGD 1929
            ....||....|   :.||:|:|.||:
Human  1914 LDEATESNEAMGREVNALKSKLRRGN 1939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	254/689 (37%)
		MyTH4	1091..1194	CDD:459939	16/102 (16%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	21/110 (19%)
		B41	1202..1419	CDD:214604	36/226 (16%)
		PH-like	1415..1523	CDD:473070	20/124 (16%)
		MyTH4	1664..1771	CDD:459939	21/119 (18%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	16/107 (15%)
		B41	1781..1992	CDD:214604	29/155 (19%)
		PH-like	1988..2076	CDD:473070
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951	254/690 (37%)
		Actin-binding. /evidence=ECO:0000250	668..690		11/21 (52%)
		Actin-binding. /evidence=ECO:0000250	769..783		7/13 (54%)
		Myosin_tail_1	855..1935	CDD:460256	229/1321 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		10/56 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979		17/82 (21%)
		C-terminal	1942..1979