DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo81F and MYH9

DIOPT Version :10

Sequence 1:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster
Sequence 2:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens


Alignment Length:2100 Identity:494/2100 - (23%)
Similarity:839/2100 - (39%) Gaps:524/2100 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            ||.|::.::|..:..||..||.|.:||||:|...:.:||||.:.|::::.:..|...|..::.||
Human    85 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPH 149

  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSS-----WVQQQILEA 136
            ::|:.:.||.|::.|..:|:.:.:|||||||||:||.::|||..:.|:..|     .:::|:|:|
Human   150 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQA 214

  Fly   137 NTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMYQ 201
            |.||||||||||.:||||||||||:::.||.|..|.|..|..||||:||...|::.||.:||.|.
Human   215 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYY 279

  Fly   202 LVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTM-AFTVLQIPQFVIDGVF 265
            |::...::  :.....|.|...|::|  ||........:.|.....|| |..::.||:....|:.
Human   280 LLSGAGEH--LKTDLLLEPYNKYRFL--SNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLL 340

  Fly   266 KVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINVRGNITEIP 330
            :|||.:|.||||.| ..:......:..|..|...:|.|||::..||.:.:|..:|.|..:..: .
Human   341 RVISGVLQLGNIVF-KKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQ-K 403

  Fly   331 LKIKE----ALENRHALAKALYSKMFTWLVSKINNCTN-PGQDDAKFLGVLDIFGFENFSHNSFE 390
            .:.||    |:|   |||||.|.:||.|||.:||...: ..:..|.|:|:|||.|||.|..||||
Human   404 AQTKEQADFAIE---ALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFE 465

  Fly   391 QLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKP--PRCVFKLLTE 452
            |||||||||||.:.|||.:|.|||..|:.|||.:|.::| .|..||::::|||  |..:..||.|
Human   466 QLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDE 530

  Fly   453 QCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRDVQQD 517
            :|..|:.:|.:|:..:..|..:||.:.|....:. :.:|.|.||||.|.|....::.||.|...|
Human   531 ECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKD-KADFCIIHYAGKVDYKADEWLMKNMDPLND 594

  Fly   518 VMFEYMSYSKDVFIKDLSTYQDIQFI----------NSSYPRGSSKSK----CTVSDNFRNQLQS 568
            .:...:..|.|.|:.:|  ::|:..|          .::.| |:.|::    .||...::.||..
Human   595 NIATLLHQSSDKFVSEL--WKDVDRIIGLDQVAGMSETALP-GAFKTRKGMFRTVGQLYKEQLAK 656

  Fly   569 LIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRY 633
            |:..|:||.|.:||||.||.:|:....:..||||||:..||::.|||.|:|||..:..::|..||
Human   657 LMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRY 721

  Fly   634 KCLIKN---KSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVI- 694
            :.|..|   |.|...::....:::...:.:..::||:||:|.|......||..| |....:.:| 
Human   722 EILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEER-DLKITDVIIG 785

  Fly   695 IQKNWKKYYIQKSFLRNKQ-------------AVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLR 746
            .|...:.|..:|:|.:.:|             |.|:::: ::.|||   |.:::           
Human   786 FQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRN-WQWWRL---FTKVK----------- 835

  Fly   747 GVFAREVAAALREMKRVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLAHISDNIRASAK 811
                     .|.::.|.:||:..::   |:|..:..|.||     .:..|:.:..:...:.|...
Human   836 ---------PLLQVSRQEEEMMAKE---EELVKVREKQLA-----AENRLTEMETLQSQLMAEKL 883

  Fly   812 PLSDKNDSDSNTARSSIKQNTVNLDNMFDFLC---ESKGAFENALIKEINDNWNNLVKNLDEEIG 873
            .|.::..:::.                   ||   |...|...|..:|:.:..::|...::||..
Human   884 QLQEQLQAETE-------------------LCAEAEELRARLTAKKQELEEICHDLEARVEEEEE 929

  Fly   874 LCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIK 938
            .|.|.:       ..|....:.::.|.|...             ..|...:.:.|.|:||..::|
Human   930 RCQHLQ-------AEKKKMQQNIQELEEQLE-------------EEESARQKLQLEKVTTEAKLK 974

  Fly   939 K--EKYMLLDYKSIKDNSKKPSTSSVFVKY--QIDERENRRKQRVE-KKIHELTLIDIHKDIHID 998
            |  |:.::|:.::.|...:|........::  .:.|.|.:.|...: |..||..:.|:.:.:..:
Human   975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039

  Fly   999 NSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPEN 1063
            ......||                    .|::....|.|        ..||:|            
Human  1040 EKQRQELE--------------------KTRRKLEGDST--------DLSDQI------------ 1064

  Fly  1064 VVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRI 1128
                                ||.:.||.:..:.|..:.|||:                       
Human  1065 --------------------AELQAQIAELKMQLAKKEEELQ----------------------- 1086

  Fly  1129 WIILCLSIV---AFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPSSV 1190
               ..|:.|   |.|.:..|         |.:.||:.::.:..    ::.:|.:.|         
Human  1087 ---AALARVEEEAAQKNMAL---------KKIRELESQISELQ----EDLESERAS--------- 1126

  Fly  1191 EVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHI 1255
                                |.|                 |||            |.|..|||..
Human  1127 --------------------RNK-----------------AEK------------QKRDLGEELE 1142

  Fly  1256 KSYDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFVFKKRLFK--STHELSQDPVEVSMLYSQ 1318
            .....|.|.:.|...:|...:..::..|         :.||.|.:  .|||....  |:...:||
Human  1143 ALKTELEDTLDSTAAQQELRSKREQEVN---------ILKKTLEEEAKTHEAQIQ--EMRQKHSQ 1196

  Fly  1319 AVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFWIPI 1383
            ||..:.::.|.....|..|:.|....:...|:.:|:.|                          :
Human  1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK--------------------------V 1235

  Fly  1384 LAQAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNYKGYWNLASNII-LGIHYDGI--MFI 1445
            |.|........|..:.|::..|.          ..|....:....||..:. |.:..|.:  :..
Human  1236 LLQGKGDSEHKRKKVEAQLQELQ----------VKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290

  Fly  1446 NPEDKSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTSLYGSSLIESQK-----CFVFETP 1505
            ..:.||......:..:||.|.|..:  :....||....|.|.|   ..:|.:|     ....|..
Human  1291 QSDSKSSKLTKDFSALESQLQDTQE--LLQEENRQKLSLSTKL---KQVEDEKNSFREQLEEEEE 1350

  Fly  1506 QKNDIGSLIISYYPALSNWILNNLECSKKYKGTTKEDRLRLYQNVV-LCRRH------------- 1556
            .|:::...|.:.:..::: :...:|.|.....|.:|.:.:|.:::. |.:||             
Human  1351 AKHNLEKQIATLHAQVAD-MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414

  Fly  1557 -----------LVDM--------NIVKKPHDFGGFLRNTLRRLSKHRLEKLRSEVGSNTQEHGET 1602
                       |||:        |:.||...|...|.......:|:..|:.|:|..:..:|....
Human  1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKAL 1479

  Fly  1603 YKGFSHTFWAFSKQQIPFCISTISDQEEALMIQVFDSILTYSGLGSSGESISRAEDEHIRIIQSI 1667
            ....:.......|.::.........:.|.||          |.....|:|:...|.....:.|.:
Human  1480 SLARALEEAMEQKAELERLNKQFRTEMEDLM----------SSKDDVGKSVHELEKSKRALEQQV 1534

  Fly  1668 MDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKNWALLSVLCSVILPSMKA------------ 1720
            .:...:.|.|.:||      |.|:.......|||:              :|||            
Human  1535 EEMKTQLEELEDEL------QATEDAKLRLEVNLQ--------------AMKAQFERDLQGRDEQ 1579

  Fly  1721 ---VRKYLIAHLKRCSSDFLSEEGKYARYA----------------------------------- 1747
               .:|.|:..::...:: |.:|.|....|                                   
Human  1580 SEEKKKQLVRQVREMEAE-LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643

  Fly  1748 ----ENCFFRTQGTRRRQWTPSREEILCTTNRRPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIK 1808
                ::|......||     .||||||.......  .|...|:.:...::.:.::......:..:
Human  1644 QAQMKDCMRELDDTR-----ASREEILAQAKENE--KKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701

  Fly  1809 KKIGLLDNAKGYSIYEVIGNSERSLSSEEKVCDVMAKWEKYQITSQQGFQKNTTLISQQNQYMFL 1873
            ::..|.|.....|     |....:|..:.::...:|:.|: ::..:||   ||.||:.:     |
Human  1702 ERDELADEIANSS-----GKGALALEEKRRLEARIAQLEE-ELEEEQG---NTELINDR-----L 1752

  Fly  1874 FKKHLFFDNY---INLE--DIVEKELLYHQILHNLRSERYPITEMEAIM-------LTALQSQL- 1925
            .|.:|..|..   :|||  ...:.|....|:....:..:..:.|||..:       :|||:::: 
Human  1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817

  Fly  1926 -----------ERGDCCESI 1934
                       ||...|:.:
Human  1818 QLEEQLDNETKERQAACKQV 1837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo81FNP_001303492.1 Motor_domain 23..673 CDD:473979 254/680 (37%)
MyTH4 1091..1194 CDD:459939 14/105 (13%)
FERM_F1_DdMyo7_like 1198..1299 CDD:340728 17/100 (17%)
B41 1202..1419 CDD:214604 38/218 (17%)
PH-like 1415..1523 CDD:473070 21/115 (18%)
MyTH4 1664..1771 CDD:459939 27/160 (17%)
FERM_F1_DdMyo7_like 1775..1880 CDD:340728 18/104 (17%)
B41 1781..1992 CDD:214604 33/177 (19%)
PH-like 1988..2076 CDD:473070
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838 275/790 (35%)
Myosin_N 27..72 CDD:460670
Motor_domain 95..764 CDD:473979 254/681 (37%)
Actin-binding 654..676 11/21 (52%)
Myosin_tail_1 841..1921 CDD:460256 218/1305 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 3/41 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137 9/76 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960
Blue background indicates that the domain is not in the aligned region.

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