Protein Alignment Myo81F and MYH2

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_060004.3
• Gene: MYH2 / 4620
• HGNCID: 7572
• Length: 1941
• Species: Homo sapiens
• Alignment Length: 1998
• Identity: 473/1998 - (23%)
• Similarity: 790/1998 - (39%)
• Gaps: 489/1998 - (24%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            ||..|:.:.|..:..||..||.:.:||||:|...:.|||||.:.::..:.::.|...|..:..||
Human    90 DMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPH 154

  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTI------------TSNVSSWV 129
            :|::::.||..::.|..||:.:|:||||||||.:||.::||..||            :..:...:
Human   155 IFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGTL 219

  Fly   130 QQQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGER 194
            :.||:.||.:|||||||||.|||||||||||:::.|.....:....|..||||:||:.||.:.||
Human   220 EDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLKAER 284

  Fly   195 NYHIMYQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNL-ESKKFDAVTMAFTVLQIPQ 258
            :|||.||:.:..:..:.........|   |.|...|..|....:: :.::..|...|..:|....
Human   285 SYHIFYQITSNKKPELIEMLLITTNP---YDYPFVSQGEISVASIDDQEELMATDSAIDILGFTN 346

  Fly   259 FVIDGVFKVISSILWLGNIEF--------IDVDG-EVTDLTRSDQEAISIISMLLGLSRCDFKKV 314
            .....::|:..:::..||::|        .:.|| ||.|..          :.|..|:..|..|.
Human   347 EEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKA----------AYLQSLNSADLLKA 401

  Fly   315 LLIRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIF 379
            |...::.|..........:::......|||||:|.|||.|:|::||...:..|....|:|||||.
Human   402 LCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIA 466

  Fly   380 GFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKPP 443
            |||.|..||.||||||:|||||.:||||::|.|||..|:.|||.:..::| .|...|:|::|| |
Human   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-P 530

  Fly   444 RCVFKLLTEQCHMPQGSDLAFLSNMHTEFESH---------PNYIKGSDRRHWETEFGIKHYAGL 499
            ..:|.:|.|:|..|:.:|.:|.:.:   ::.|         |..:||....|    |.:.||||:
Human   531 MGIFSILEEECMFPKATDTSFKNKL---YDQHLGKSANFQKPKVVKGKAEAH----FALIHYAGV 588

  Fly   500 VIYAVGGFVEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSSK--------SKC 556
            |.|.:.|::|||:|...:.:...  |.|.........:...|........|.:|        |..
Human   589 VDYNITGWLEKNKDPLNETVVGL--YQKSAMKTLAQLFSGAQTAEGEGAGGGAKKGGKKKGSSFQ 651

  Fly   557 TVSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFP 621
            |||..||..|..|:..|::|.|.:||||.||..|.|......|||.||:..||::.|||.|:|||
Human   652 TVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFP 716

  Fly   622 IHLSHKDFIVRYKCL----IKNKSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLET 682
            ..:.:.||..|||.|    |....|...:|....:|....:..|:::.|.:|:|.:.....|||.
Human   717 SRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEE 781

  Fly   683 NRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRM--RRSAI-VIQSR 744
            .|.|.|                       .|.:.|.|...||:..|:.:.||  ||.|| .||..
Human   782 MRDDKL-----------------------AQLITRTQARCRGFLARVEYQRMVERREAIFCIQYN 823

  Fly   745 LRGVF-----------------------AREVAAALREMKRVDEEL----KKRDGIYEQLTSITT 782
            :|...                       .:|:|....|.:::.:||    .||..:.|::.:: .
Human   824 IRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL-L 887

  Fly   783 KTLADCERSIQEELSVLAHISD----------NIRASAKPLSDKNDSDSN-----TAR------- 825
            |...|.:..:|.|...||...:          .:.|..|.::::.:.:..     ||:
Human   888 KEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 952

  Fly   826 -SSIKQNTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEI-GLCIHTEDSFDSQKTG 888
             |.:|::..:|:.....:.:.|.|.||.            ||||.||: ||         .:...
Human   953 CSELKKDIDDLELTLAKVEKEKHATENK------------VKNLTEEMAGL---------DETIA 996

  Fly   889 KLFTTKTVRTLPE---PTVPPPPPPVSISANLNSEPIYEAINLYKLTTTK------------EIK 938
            ||  ||..:.|.|   .|:.          :|.:|.  :.:|  .||..|            .::
Human   997 KL--TKEKKALQEAHQQTLD----------DLQAEE--DKVN--TLTKAKIKLEQQVDDLEGSLE 1045

  Fly   939 KEKYMLLDYKSIK---DNSKKPSTSSVF----VKYQIDERENRRKQRV----------------- 979
            :||.:.:|.:..|   :...|.:..|:.    .|.|:||:..:::..:
Human  1046 QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQL 1110

  Fly   980 EKKIHEL--TLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQK--GKSS------ 1034
            :|||.||  .:.::.::|..:.:     ..|:......|||.:...||...::  |.:|
Human  1111 QKKIKELQARIEELEEEIEAERA-----SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170

  Fly  1035 ---------------DKTAKHEMTMFSKSDKIPTSHIHMYDP----------------------- 1061
                           :.|.:||.|..:...|...|...:.:.
Human  1171 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235

  Fly  1062 ------ENVVLSCSMFRELCKYMRGEL----NAERELQIIQYIVGLGIEREELRDEIFIQCIRQS 1116
                  |.|..:.....::|:.:..:|    :.|.|.|  :.|..|..:|..|:.|       ..
Human  1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ--RLINDLTAQRGRLQTE-------SG 1291

  Fly  1117 RNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSM---IELDGKLRQYSQWCFDNCKST 1178
            ..:..:|..:.:       :......|..|...:..:|:.:   |:....|....|....:|...
Human  1292 EFSRQLDEKEAL-------VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349

  Fly  1179 KVSTRMYPPSSVEV-AAMRRLGTIVCRFFFLDARTK--AIDVHPTDTAGDAVQKLAEKLNLTTTD 1240
            :........|..|: .|:.:..|.|.::     |||  ...:..|:...:|.:|||::|..
Human  1350 REQYEEEQESKAELQRALSKANTEVAQW-----RTKYETDAIQRTEELEEAKKKLAQRLQA---- 1405

  Fly  1241 GWAIYQNRPDGEEHIKSY-------------------DYLYDV--------------------IS 1266
                      .|||:::.                   |.:.||                    ::
Human  1406 ----------AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460

  Fly  1267 SWEMK-QATYA------------GTK--KTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLY 1316
            .|:.| :.|:|            ||:  |..|......:|....||..|:..:...|..|.....
Human  1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG 1525

  Fly  1317 SQAVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPS----------NQPKPEYYSDINSFLPIRI 1371
            .:.:|.:.|..:....||..||.|..:|:.:|....          ||.|.|        :..:|
Human  1526 GKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE--------VDRKI 1582

  Fly  1372 SKTREQQFWIPILAQAH-RQYGSSRNALTAKV------LYLSCVMQYPL--------YGTTMFKV 1421
            ::..|:   |..|.:.| |...|.::.|.|::      :.|...|:..|        :...|...
Human  1583 AEKDEE---IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644

  Fly  1422 NYKGYWNLASNII--LGIHYDGIMFINPEDKSVVFQFKYVDIESILLDPSDSFITISL---NRSA 1481
            ..:.|.| ...|:  ..||.|..:....:.|.   |...|:..:.||......:..:|   .||.
Human  1645 ALRNYRN-TQGILKDTQIHLDDALRSQEDLKE---QLAMVERRANLLQAEIEELRATLEQTERSR 1705

  Fly  1482 QLLKTSLYGSS----LIESQKCFVFETPQK--NDIGSL--------------------IISYYPA 1520
            ::.:..|..:|    |:.:|...:..|.:|  .||..:                    .|:....
Human  1706 KIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770

  Fly  1521 LSNWILNNLECS-------KKYKGTTKEDRLRLYQNVVLCRRHLVDMNIVKKPHDFGGFLRNTLR 1578
            ::..:....:.|       |..:.|.|:.:|||.:...|..:              ||  :..::
Human  1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK--------------GG--KKQIQ 1819

  Fly  1579 RLSKHRLEKLRSEVGSNTQEHGETYKGF-SHTFWAFSKQQIPFCISTISDQEEALMIQ-VFD--- 1638
            :| :.|:.:|..||.|..:.:.|..||. .|     .::.......|..|::..|.:| :.|
Human  1820 KL-EARVRELEGEVESEQKRNAEAVKGLRKH-----ERRVKELTYQTEEDRKNILRLQDLVDKLQ 1878

  Fly  1639 -SILTYSGLGSSGESISRAEDEHIRIIQSIMDKCMKK----ESLLNEL 1681
             .:.:|.......|..|.......|.:|..:::..::    ||.:|:|
Human  1879 AKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	235/693 (34%)
		MyTH4	1091..1194	CDD:459939	15/106 (14%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	28/156 (18%)
		B41	1202..1419	CDD:214604	55/297 (19%)
		PH-like	1415..1523	CDD:473070	24/138 (17%)
		MyTH4	1664..1771	CDD:459939	5/22 (23%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728
		B41	1781..1992	CDD:214604
		PH-like	1988..2076	CDD:473070
MYH2	NP_060004.3	Myosin_N	33..77	CDD:460670
		MYSc_Myh2_mammals	100..772	CDD:276877	235/694 (34%)
		Actin-binding. /evidence=ECO:0000250	661..683		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	763..777		3/13 (23%)
		Myosin_tail_1	852..1929	CDD:460256	213/1190 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1149		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1174		2/18 (11%)