Protein Alignment Myo81F and Myo1a

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_001074688.1
• Gene: Myo1a / 432516
• MGIID: 107732
• Length: 1043
• Species: Mus musculus
• Alignment Length: 771
• Identity: 262/771 - (33%)
• Similarity: 411/771 - (53%)
• Gaps: 76/771 - (9%)

  Fly     8 VGFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGD 72
            ||..|:..:..:||..:.:||.:||.:..||||.|::::::|||:.:.|:..:.|::|......:
Mouse     8 VGVEDLILLEPLDEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQLPIYGPEFIAKYRDYTFYE 72

  Fly    73 LSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQY---LCTITSNVSSWVQQQIL 134
            |.||::|:|..||.|:.|.:.:|..:|:|||||||||::|.::.|   :|.....|:| |::|:|
Mouse    73 LKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNS-VKEQLL 136

  Fly   135 EANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIM 199
            ::|.:|||||||||.||:|||||||:|.:.||......|.||.:||||:||:..|.:||||:||.
Mouse   137 QSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIF 201

  Fly   200 YQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVIDGV 264
            |||:|.....:..|.... .....|.|||...| |:|...::..|.||..|.:|:...:..|..|
Mouse   202 YQLLAGADAQLLKALKLE-EDTSVYGYLNGEVS-KVNGMDDASNFRAVQHAMSVIGFSEEEIRQV 264

  Fly   265 FKVISSILWLGNIEFIDVDGEVTDLTRS---DQEAISIISMLLGLSRCDFKKVLLIRQINVRGNI 326
            .:|.:.:|.|||::..| :.:...:..|   |.:.|..|..::||:..:.::.|..|.:......
Mouse   265 LEVTALVLKLGNVKLTD-EFQANGIPASGICDGKGIQEIGEMMGLNSTELERALCSRTMETGKEK 328

  Fly   327 TEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQ-DDAKFLGVLDIFGFENFSHNSFE 390
            ....|.:.:|...|.||||.:||::|.|:|.:||.....|. :..|.:|||||:|||....||||
Mouse   329 VVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESIKVGTGEKKKVMGVLDIYGFEILEDNSFE 393

  Fly   391 QLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTEQCH 455
            |..|||.||:|.:.|.......||..|:.|||.:..||:.||.....::|...|.:..:|.|:|.
Mouse   394 QFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRGILAMLDEECL 458

  Fly   456 MPQG--SDLAFLSNMHTEFESHPNY---IKGSDRRHWETEFG-----IKHYAGLVIYAVGGFVEK 510
            .| |  ||..||:.::..|..|.:|   :..:.:|.::...|     |.||||.|.|.|.||::|
Mouse   459 RP-GVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCFRISHYAGKVTYNVTGFIDK 522

  Fly   511 NRDVQQDVMFEYMSYSKDVFIKDLS-TYQDIQ--FINSSYPRGSSKSKC-----TVSDNFRNQLQ 567
            |               .|:..:||| |....|  .:.|.:|.|:.|...     |....|:|.:.
Mouse   523 N---------------NDLLFRDLSQTMWKAQHPLLKSLFPEGNPKEASLKRPPTAGTQFKNSVA 572

  Fly   568 SLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVR 632
            .|:..|.:..|.|:||||||.|::...:.|.:|:.|.:|||:::.:|:||.|:.....:|.|:.|
Mouse   573 VLMKNLYSKNPNYIRCIKPNDQQQKGRFTSEMVMVQARYLGLLENVRVRRAGYAFRQGYKPFLER 637

  Fly   633 YKCLIKNKSFEYP------QKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKN 691
            |:.|.::   .:|      ::.:..:|....:.:.|...||:|||:|:          ..||:
Mouse   638 YRLLSRS---TWPRWNGDDREGVEKVLGSLTLSSEELAYGKTKIFIRS----------PKTLF-- 687

  Fly   692 AVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRG 747
                      |..::..||.:|....||..|||||.|..:.:||:|.|:|.:..||
Mouse   688 ----------YLEEQRRLRLQQLATLIQKVYRGWRCRTHYQQMRKSQILISAWFRG 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	235/680 (35%)
		MyTH4	1091..1194	CDD:459939
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728
		B41	1202..1419	CDD:214604
		PH-like	1415..1523	CDD:473070
		MyTH4	1664..1771	CDD:459939
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728
		B41	1781..1992	CDD:214604
		PH-like	1988..2076	CDD:473070
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	235/681 (35%)
		Actin-binding. /evidence=ECO:0000255	571..593		9/21 (43%)
		IQ	742..764	CDD:197470
		Myosin_TH1	847..1042	CDD:461801