Protein Alignment Myo81F and didum

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Alignment Length: 1544
• Identity: 431/1544 - (27%)
• Similarity: 692/1544 - (44%)
• Gaps: 258/1544 - (16%)

  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|.|:..||.||: ...|||||.|.||:|:|||..:.::....|..|....:|
  Fly    70 VGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMG 134

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVS-SWVQQQILE 135
            ||.||:||:||.|||.:..:|.|.:.::|||||||||.|.|:.::|...:..:.| :.|::::|.
  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLA 199

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDN---NCIKGCVILDYLLEQSRITFQSEGERNYH 197
            ::.|:||||||||||||||||||||.::.|.:.   ..::|..:..||||:||:.:|::||||||
  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264

  Fly   198 IMYQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVID 262
            |.|||.|...|...:.    |...:.:::||...:.:|....::::|:....|.|||......|.
  Fly   265 IFYQLCAARSKYPELV----LDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIA 325

  Fly   263 GVFKVISSILWLGNIEFI--------DVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQ 319
            .:.|:::.||.||||:..        :.|.:..|:..:|.. :.|.:.||.:|..|.::.||:|:
  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIH-LQITADLLRVSADDLRRWLLMRK 389

  Fly   320 INVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFENF 384
            |........||..|:.|...|.||||.:|:|:|.::|..:|...|.|.....|:|||||:|||.|
  Fly   390 IESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETF 454

  Fly   385 SHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRC-VFK 448
            ..|||||.||||.||||.:.||.:||.|||..|..|||.:..::|.||.||::::|.  |. |..
  Fly   455 EVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIES--RLGVLD 517

  Fly   449 LLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRD 513
            ||.|:|.||:|||.::...:..:....|::.|   .|...|.|.|||::..|.|.|.||:|||||
  Fly   518 LLDEECRMPKGSDESWAGKLIGKCNKFPHFEK---PRFGTTSFFIKHFSDTVEYDVNGFLEKNRD 579

  Fly   514 VQQDVMFEYMSYSKDVFIKDLSTYQDIQFI-----NSSYPRG---------------------SS 552
            .....:.:.:|.|.....|.:.|.::|..:     .||...|                     |.
  Fly   580 TVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSK 644

  Fly   553 KSKCTVSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRR 617
            :.:.||...|:..|.|||..|..|.|.||||||||..|....:.::.::.||:..||::.:||..
  Fly   645 QHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISA 709

  Fly   618 EGFPIHLSHKDFIVRYKCLIKNKSFEYPQKYLT--NILEKNGMPTTEWQIGKSKIFLRNAAYELL 680
            .|||....:.||.:||:.|:.....:.....|:  ||:.|......:::.|.::||.|......|
  Fly   710 AGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL 774

  Fly   681 ETNRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQ-HA----------------------- 721
            |..|.:...|...|:|...:::..::.|||.::.:..|| ||
  Fly   775 EQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSK 839

  Fly   722 -YRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALREMKR-VDEELKKRDGIYEQLTSITTKT 784
             .|||..|.|::|:|.|...||:..||:.||....|:|:..| |..:...|..:..:......:.
  Fly   840 YARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRN 904

  Fly   785 LADCERSIQE------------ELSVLAH-------ISDNIRASAKPLSDKNDSDSN----TARS 826
            :..|:.:|:.            |...::|       :.:.|.:..:.:.:.|..:||    |:..
  Fly   905 IIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEI 969

  Fly   827 SIKQNTVNLDNMFD-------FLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDS 884
            |:.:..:.|....:       ..|:.|.....||.|::....:..::.| ||.|   |.::.:.|
  Fly   970 SVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLL-EENG---HAQEEWIS 1030

  Fly   885 QK-TGKLFTTKTVRTLPEPTVPPPPPPVS-------ISANLNSEPIYEAINLYKLTTTKE-IKKE 940
            || |.:....:..|.:.|.........|:       :.|.:::..:.||..  :....|| |:.|
  Fly  1031 QKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQ--RAIKDKEVIENE 1093

  Fly   941 KYML------LDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQRVEKKIHELTLIDIHK--DIHI 997
            .:||      |...|...:::|.|.:|           ::.:..|.....:.|| ||::  |:..
  Fly  1094 NFMLKEELSRLTAGSFSLHARKASNAS-----------SQNEDDVGYASAKNTL-DINRPPDLLS 1146

  Fly   998 DNSFYN-----------ILE--------FAENYFNTHDLSSDCNFISTPTQKG-KSSDKTAKHEM 1042
            .|..||           |||        ..|.|..   |||.    ..||:.. :.|:...::|
  Fly  1147 KNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIK---LSSR----HKPTEDSFRVSELEVENE- 1203

  Fly  1043 TMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREELRDE 1107
            .:.|:.|::.||..|..:...:....:..:|..:..|.|....:.:.:.|......:|.|.|
  Fly  1204 KLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESL--- 1265

  Fly  1108 IFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWC- 1171
                   |.|.|...:..:           ||...||:.|...|.:|....|.:.||.:.:|..
  Fly  1266 -------QMRGNDVNELME-----------AFHSQKLINRQLESELKAITEEHNSKLVEMTQEIE 1312

  Fly  1172 -FDNCKS--TKV---STRMYPPSSVEVAAM------RRLGTIVCRFFFL-------DARTKAIDV 1217
             .:|.|.  .||   |...:..|:|:....      |.|...|.:|..:       :|:.||.
  Fly  1313 RLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAY-- 1375

  Fly  1218 HPTDTAGDAVQKLAE-----KLNLTTTD-GWAIYQNR---PDGEEHIKSYDYLYDVISSWEMKQA 1273
              ....|....|:.|     |.|.|:.| |..:.:.:   |.|.....|.|  .|.|    :::.
  Fly  1376 --RQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSD--LDKI----LQRL 1432

  Fly  1274 TYAGTKKTTNGSSSGENQFVFKKRLFKSTH--ELSQDPVEVSMLYSQAVHSVVK--KDEFPVSEK 1334
            ..|.|.:|..|...|...::    :|....  :|:....:|..|.|:.|..:.|  :...|:..:
  Fly  1433 LSALTPRTVVGLLPGFPAYL----IFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENR 1493

  Fly  1335 V-----ALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQ 1378
            |     ::.|..|..|              |.|::.::.....|..:||
  Fly  1494 VIWLVNSITLLNLMKQ--------------YGDVDEYVKFNTEKQNQQQ 1528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	253/691 (37%)
		MyTH4	1091..1194	CDD:459939	25/109 (23%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	25/116 (22%)
		B41	1202..1419	CDD:214604	41/202 (20%)
		PH-like	1415..1523	CDD:473070
		MyTH4	1664..1771	CDD:459939
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728
		B41	1781..1992	CDD:214604
		PH-like	1988..2076	CDD:473070
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	253/692 (37%)
		IQ	900..922	CDD:197470	2/21 (10%)
		SMC_prok_B	<942..1365	CDD:274008	96/469 (20%)
		Myo5_CBD	1424..1792	CDD:271254	25/129 (19%)