DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo81F and myh9a

DIOPT Version :10

Sequence 1:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster
Sequence 2:NP_001091647.3 Gene:myh9a / 333938 ZFINID:ZDB-GENE-030131-5870 Length:1961 Species:Danio rerio


Alignment Length:2146 Identity:495/2146 - (23%)
Similarity:884/2146 - (41%) Gaps:527/2146 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            ||.|::.::|..:..||..||.|.:||||:|...:.:||||.:.|:.::.:..|...|..::.||
Zfish    83 DMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEEIVEMYKGKKRHEMPPH 147

  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSS------------WV 129
            ::|:.:.||.|::.|..:|:.:.:|||||||||:||.::|||..:.|:..:            .:
Zfish   148 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSFKTKKDQSSIALSHGEL 212

  Fly   130 QQQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGER 194
            ::|:|:||.||||||||||.:||||||||||:::.||.|..|.|..|..||||:||...|::.||
Zfish   213 EKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKDER 277

  Fly   195 NYHIMYQLV-AQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQ 258
            .:||.|.|: ..|.|   :.:...|.....|::|:..| ..|....:.:.|.....||.::.||:
Zfish   278 AFHIFYYLLTGAGDK---LRSELCLEDYNKYRFLSNGN-VTIPGQQDRELFAETIDAFRIMGIPE 338

  Fly   259 FVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINVR 323
            ....|:.||:|::|.|||:.| ..:......:..|..|...:|.|||::..||.:.:|..:|.|.
Zfish   339 DEQTGLLKVVSAVLQLGNMSF-KKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVG 402

  Fly   324 GNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTN-PGQDDAKFLGVLDIFGFENFSHN 387
            .:..:.....::|.....|||||.|.::|.|||.:||...: ..:..|.|:|:|||.|||.|..|
Zfish   403 RDFVQKAQTQEQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELN 467

  Fly   388 SFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKP--PRCVFKL 449
            ||||||||||||||.:.|||.:|.|||..|:.|||.::.::| .|..||:|::|||  |..:..|
Zfish   468 SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILAL 532

  Fly   450 LTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRDV 514
            |.|:|..|:.:|.:|:..:..|..::|.:.|....:. :.:|.|.||||.|.|....::.||.|.
Zfish   533 LDEECWFPKATDKSFVEKVVQELGNNPKFQKPKKLKD-DADFCIIHYAGKVDYKANEWLMKNMDP 596

  Fly   515 QQDVMFEYMSYSKDVFIKDLSTYQDIQFI--------NSSYPRGSSKSK----CTVSDNFRNQLQ 567
            ..|.:...::.|.|.|:.:|  ::|:..|        ......|:.|::    .||...::.||.
Zfish   597 LNDNVATLLNQSVDKFVSEL--WKDVDRIVGLDKVAGMGESLHGAVKTRKGMFRTVGQLYKEQLM 659

  Fly   568 SLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVR 632
            :|:..|:||.|.:||||.||.:|:.......||||||:..||::.|||.|:|||..:..::|..|
Zfish   660 NLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQR 724

  Fly   633 YKCLIKN---KSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVI 694
            |:.|..|   |.|...::....:::...:.:..::||:||:|.|......||..| |....:.:|
Zfish   725 YEILTPNAIPKGFMDGKQACVLMVKALELDSNLYRIGQSKVFFRAGVLAHLEEER-DMKITDVII 788

  Fly   695 IQKNWKKYYI-QKSFLRNKQ-------------AVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRL 745
            ..:.|.:.|: :::|.:.:|             |.|:::: ::.|||   |.:::....|.:...
Zfish   789 SFQAWCRGYVARRAFAKRQQQLTAMRVIQRNCAAYLKLRN-WQWWRL---FTKVKPLLQVTRQEE 849

  Fly   746 RGVFAREVAAALRE-MKRVDEELKKRDGIYEQLTS----------ITTKTLADCE--RS-----I 792
            ..|...|....::| .::.:::||:.:...:||.:          ..|:...:.|  ||     :
Zfish   850 EMVAKEEELVKMKERQQQAEDQLKESEAKQKQLNAEKLALQEQLQAETELCQEAEEMRSRLTARM 914

  Fly   793 QEELSVLAHISDNIRASAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENALIKEI 857
            ||...||..:...:..     .::..:...:.:..::||..:|:...|   |.:.|.:...::::
Zfish   915 QEMEEVLHELESRLEE-----EEERVAQFQSEKKKMQQNIGDLEQQLD---EEEAARQKLQLEKV 971

  Fly   858 NDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKL------FTTKTVRTLPEPTVPPPPPPVSISAN 916
              ..:..:|.::|:: :.|..:::..|::..::      |||                      |
Zfish   972 --TMDAKLKKIEEDL-MVIEDQNAKLSKEKKQMEERISEFTT----------------------N 1011

  Fly   917 LNSEPIYEAINLYKLTTTKE---------IKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQID--- 969
            | :|...::.:|.||.|..|         ::||:.|   .:.::.|.:|....|..:..||.   
Zfish  1012 L-AEEEEKSKSLQKLKTKHETMITDLEDRLRKEEKM---RQELEKNRRKLEGDSTELHDQIAELQ 1072

  Fly   970 ------------------------ERENRRKQRVEKKIHEL--TLIDIHKDIHIDNSFYNILEFA 1008
                                    |.|...|...:|.|.|:  .:.::.:|:.::.:..|..|  
Zfish  1073 AQIAELRAQLAKKEEELQAALARIEEEAALKNAAQKSIREMEAQISELQEDLELEKAARNKAE-- 1135

  Fly  1009 ENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRE 1073
               ....||..:...:.|..:  .:.|.||..:                                
Zfish  1136 ---KQRRDLGEELEALKTELE--DTLDSTAAQQ-------------------------------- 1163

  Fly  1074 LCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVA 1138
                   ||.|:||.::.|  :...:|.|....|..:..:||..|.                  |
Zfish  1164 -------ELRAKRETEVTQ--LKKTLEDEARAHEQMLSEVRQKHNQ------------------A 1201

  Fly  1139 FQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIVC 1203
            |:                  ||:.:|.|                                     
Zfish  1202 FE------------------ELNEQLEQ------------------------------------- 1211

  Fly  1204 RFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYD--------- 1259
                 ..|:||    ..|.|..|::....:|.:...   ::.|::.|.|...|..:         
Zfish  1212 -----SKRSKA----SVDKAKQALESERNELQIELK---SLSQSKNDSENRRKKAESQLQELQVK 1264

  Fly  1260 ---------YLYDVISSWEMKQATYAGTK--------KTTNGSSSGENQFVFKKRLFKSTHELSQ 1307
                     .|.|.:|..:.:..:..||.        |.....|:.|:|       .|....|.:
Zfish  1265 HTESERQKHELLDKVSKMQAELESLQGTVTKVESKSIKAAKDCSAVESQ-------LKDAQALLE 1322

  Fly  1308 DPVEVSMLYSQAVHSV---------VKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDI 1363
            :.....:..|..:..:         :.::|....:.|..||...|||:|      :.|.:...:.
Zfish  1323 EETRQKLAISTRLRQLEDEQNNLKEMLEEEEESKKNVEKQLHTAQAQLA------EMKKKIEQEA 1381

  Fly  1364 NSFLPIRISKTREQQFWIPILAQAHRQYGSSRNALTAKVLYLSCVMQYPL---------YGTTMF 1419
            .|...:...|.:.|:....:|.|.     ..|||...|:......:|..|         ...|:.
Zfish  1382 QSLESMEDGKKKLQREVESVLQQL-----EERNASYDKLDKTKTRLQRELDDVLVDQGHLRQTVQ 1441

  Fly  1420 KVNYKGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKYVD----IESILLDPSDSFITIS---- 1476
            ::..|..           .:|.::   .|:||:  ..||.:    .|:...:.....:|::    
Zfish  1442 ELERKQK-----------KFDQML---AEEKSI--STKYAEERDRAEAEAREKETKSLTLARELE 1490

  Fly  1477 --------LNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSNWILNNLECSK 1533
                    |.|..:.|||.:  ..|:.|          |:|.|..:            :.||.:|
Zfish  1491 AMTDLKNELERVNKQLKTEM--EDLVSS----------KDDAGKSV------------HELERAK 1531

  Fly  1534 ----------KYKGTTKEDRLRLYQNVVLCRRHLVDMNIVK-------KPHDFGGFLRNTLRRLS 1581
                      |.:....||.|:|.::..|  |..|:|..:|       :..|..|  ....::|.
Zfish  1532 RGMEQQLEEMKTQLEELEDELQLTEDAKL--RLEVNMQALKAQFERDLQSRDEQG--EEKRKQLV 1592

  Fly  1582 KHRLEKLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQ--------EEA------L 1632
            | ::.::..|:....::..:...         .::::...:|.::.|        :||      |
Zfish  1593 K-QVREMEMELEDERKQRAQAVS---------VRKKLELDLSELAAQIDLANKARDEALKQLKKL 1647

  Fly  1633 MIQVFDSILTYSGLG-SSGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQL---------IK 1687
            ..|:.:.:..:..|. |..||:::|::...:|      |.|:.|  :.:|:..|         |:
Zfish  1648 QAQMKEQMREFEDLRLSRDESLNQAKENERKI------KSMEAE--IMQLHEDLAAADRAKRQIQ 1704

  Fly  1688 QTTD--HPDANSRVNLKNWALLSVLCSVILPSMKA-VRKYLIAHLKRCSSDFLSEE--------- 1740
            |..|  ..:.||: |.||             |:.: .|:.|.|.:.:...: |.||         
Zfish  1705 QERDELQDEINSQ-NAKN-------------SLSSDERRRLEARIAQLEEE-LEEEHLSVELVND 1754

  Fly  1741 --GKYARYAENCFFRTQGTRRRQWTPSREEILCTTNR--RPCYSKFYFMDGQYYSIEFQPSSTAN 1801
              .|.:..||.  ...:.|..|..:...|.:....:|  :....|...::|...| :::.:.|| 
Zfish  1755 RLKKASLQAEQ--VTVELTAERSNSQRLEGLRSQLDRQNKDMKQKLQELEGAVKS-KYKSTITA- 1815

  Fly  1802 DVLEIIKKKIGLLDNAKGYSIYEVIGNSERSLSSEEKVCDVMAKWEKYQITSQQGFQKNTTLISQ 1866
                 ::.||..|:......:.|...::::....|:|:.:|:.:.|..:..:.|    :.|...:
Zfish  1816 -----LETKIQQLEEQLDSEMKERQQSTKQVRRVEKKLKEVLLQVEDERRNADQ----SKTETEK 1871

  Fly  1867 QNQYMFLFKKHLFFDNYINLEDIVEKELLYHQILHNLRSERYPITEMEAIM---LTALQSQLERG 1928
            .|..:...|:        .||:..|:....:.....||.|....||..:.|   ::.|:::|.||
Zfish  1872 ANIRLKQMKR--------QLEETEEEAARANASCRKLRRELEDATESASAMNREVSTLKNKLRRG 1928

  Fly  1929 D 1929
            |
Zfish  1929 D 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo81FNP_001303492.1 Motor_domain 23..673 CDD:473979 246/681 (36%)
MyTH4 1091..1194 CDD:459939 13/102 (13%)
FERM_F1_DdMyo7_like 1198..1299 CDD:340728 20/126 (16%)
B41 1202..1419 CDD:214604 44/260 (17%)
PH-like 1415..1523 CDD:473070 20/123 (16%)
MyTH4 1664..1771 CDD:459939 26/129 (20%)
FERM_F1_DdMyo7_like 1775..1880 CDD:340728 18/106 (17%)
B41 1781..1992 CDD:214604 31/152 (20%)
PH-like 1988..2076 CDD:473070
myh9aNP_001091647.3 None
Blue background indicates that the domain is not in the aligned region.

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