Protein Alignment Myo81F and Myo10A

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Alignment Length: 3108
• Identity: 622/3108 - (20%)
• Similarity: 1056/3108 - (33%)
• Gaps: 1165/3108 - (37%)

  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTI-NIFNKQTISEYHTCKLGD 72
            |..|||.:.::.|..:..||.:||:..:|||:.||||:||||||.. :.:..:...:|....||.
  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220

  Fly    73 LSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTIT---SNVSSWVQQQIL 134
            |.||:||:..||:.::...   |..|||||||:|||||||.::|||..:.   .:.|:.:.:|||
  Fly   221 LPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282

  Fly   135 EANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIM 199
            ||..:|||||||:|.||||||||||:::|.| .:..|.|..|..||||:|||..|:.||||||:.
  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346

  Fly   200 YQLVAQGQKNIGIANT----FHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFV 260
            |:|:.      |::.|    :.|..|:.|.|||...::..:..::   ::::..|..||.:.:..
  Fly   347 YELLG------GLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGE 402

  Fly   261 IDGVFKVISSILWLGNIEF-----------IDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKV 314
            .:|:.:|::::|.|||:.|           ::|.        ||.| |...:.||.:|.....:.
  Fly   403 REGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVG--------SDAE-IKWAAHLLHISADGLHRA 458

  Fly   315 LLIRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNP-GQDDAKFLGVLDI 378
            |..|....|......||.|.:||:.|.|.|||||:.:|.||||:||:.... |..||..:.:|||
  Fly   459 LTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDI 523

  Fly   379 FGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPP 443
            ||||:.:.||||||||||.||.|..:||.:||.|||:.|..|.:.:..:.:.||.|.:.:|.|.|
  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKP 588

  Fly   444 RCVFKLLTEQCHMPQGSDLAFLSNMH-----TEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYA 503
            ..:..||.::.:.|:.:||:||...|     :|..:.|        |....|||:.||||.|.|.
  Fly   589 VGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARP--------RIGAQEFGVTHYAGQVWYC 645

  Fly   504 VGGFVEKNRDVQQDVMFEYMSYSKDVFI----KDLSTYQDIQFINSSYPRGSS------KSKC-T 557
            |.||::||||..:..:.|.::.|:...:    |.|...:|   ...:.|:||:      |.:. |
  Fly   646 VDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRD---AGKTLPKGSNGRFVTMKPRTPT 707

  Fly   558 VSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPI 622
            |:..|.:.||.|:..:....||:|||||||.:|.....:...||.||:|||::|.|:||:.|:|:
  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772

  Fly   623 HLSHKDFIVRYKCLIKN---KSFEYPQ--KYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLET 682
            .|..:.|:.||:.|:.:   :...|.:  :.|...:.:.|:...::|:|.:::|||.|.:..||:
  Fly   773 RLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALES 837

  Fly   683 NRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRG 747
            .|.:.|.:.||.:|::.:...:::...|.:.|..|:|..:||.|.:.|:.|:|:.|:..|...||
  Fly   838 GRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRG 902

  Fly   748 -----------------VFAREVAAALREMKRVDEELKKRDG------------IYEQLTS---- 779
                             ..|||.|...||.:...:.:.:|..            ||.:|..
  Fly   903 RQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPP 967

  Fly   780 ---------------------------------------------------ITTKTL---ADCER 790
                                                               ||...|   |..::
  Fly   968 HGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQ 1032

  Fly   791 SIQEELSVLAHI----SDNIRASAKP--LSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKG-- 847
            ..|:.|:|...|    :|.....||.  |:|.....:.::|....:..|.|.|....|..:.|
  Fly  1033 DFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEA 1097

  Fly   848 ------------------AFENALIKEIND----------------------------------- 859
                              ||...|::.::|
  Fly  1098 TRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSF 1162

  Fly   860 -----NWNNLVKNLDEEIGLCIHTE-------DSF------------------------------ 882
                 .|....:..|..:.|.:..|       ||:
  Fly  1163 VPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQ 1227

  Fly   883 ----------------------------DSQKTGKLFTTKTVRTLPE----PTVPPPPPP----- 910
                                        |..::|..|..   .|||:    |.||||.||
  Fly  1228 LTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFAR---TTLPDAVKRPAVPPPAPPTSSGK 1289

  Fly   911 -------------VSISANLN-------------------------------------------- 918
                         :|.|:.||
  Fly  1290 EDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCD 1354

  Fly   919 -SEPIYE-AINLYKLT--------------------------------------TTKEIKKEKYM 943
             .||::. .::..:|.                                      ::|...|.:|.
  Fly  1355 SQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYA 1419

  Fly   944 LLDYKSIKDNSKKPSTSS----VFVKYQ-------------------IDERENRR---------- 975
            ... .::.|.|:.||.:|    |.|..|                   :||..:.|
  Fly  1420 TRS-SAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGS 1483

  Fly   976 ---KQRVEKKIHELT--LIDIHKDIHIDNSFYNIL------------------EFAENYFNTHDL 1017
               :...|.:|.:|.  :.||.:.|.:..:...:.                  |..:......||
  Fly  1484 YEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDL 1548

  Fly  1018 SSDCNFISTPTQKGKSSDK-TAKHEMTM-------FSKSDKIPTSHIHMYDPENVVLSCSMFREL 1074
            ....|.:..|....:..|| |:|..:.:       ...:...|..|..|..|.......:::::
  Fly  1549 DDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQ- 1612

  Fly  1075 CKYMRGELNA--ERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNN-------PNIDWTDRIWI 1130
             :..|..|.:  .:.|||.|.::.   :.:.|:..:..|....:.||       |.|
  Fly  1613 -QVQRAFLQSAMAQNLQIQQQLLA---QNQALQTLLSQQAAAAAANNSTSPPPAPPI-------- 1665

  Fly  1131 ILCLSIVAFQP-------------SKLLF---------------------------RYFVSFIKK 1155
               ||.::..|             |.|:.                           |:|:....:
  Fly  1666 ---LSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGR 1727

  Fly  1156 SMIELDG----------------------KLRQYS------------------------------ 1168
            :.....|                      |:||:.
  Fly  1728 AKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASA 1792

  Fly  1169 ---QW-------------------------------------------------CFDNCKSTKVS 1181
               :|                                                 ...:..:||::
  Fly  1793 TAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLA 1857

  Fly  1182 TRMY-------PPSSV--------------EVAAMRRLGTIVCRFFFLDARTK------------ 1213
            .:.:       ||.||              :|.|...:.:.|.......|..|
  Fly  1858 KKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQ 1922

  Fly  1214 -----------------AIDVHPTDTAGDAVQKLAEKLN---LTTTDGW---------------- 1242
                             .:|.|.  |....::::..||:   ...:.||
  Fly  1923 LGGLFASVSGGNSGPGGVVDSHA--TVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPP 1985

  Fly  1243 --------------------------------------------------------AIYQNRPDG 1251
                                                                    |:.|.:...
  Fly  1986 PIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMIS 2050

  Fly  1252 EEHIKSYDYLYD---VISSWEMKQ-----------------------------ATYAGTKK---- 1280
            ..|:...|:...   .:::||..:                             |:.:|::|
  Fly  2051 SHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK 2115

  Fly  1281 -------------------------------------TTNG------------------------ 1284
                                                 ||.|
  Fly  2116 RERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHE 2180

  Fly  1285 ------SSSGENQFVFKKRLFKSTHELSQDPVEV------------------------------- 1312
                  :|||      .:....|.|..:..||.|
  Fly  2181 RKRKSSASSG------MREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTA 2239

  Fly  1313 SMLYSQAVHSV-VKKDEF----PVSEKVALQLAGLQAQVALGD-----PSNQPKPEYYSDINSFL 1367
            .:.|::....: |:|:.|    |:...|||.|  |.||| |||     |..:..|:..|...:.|
  Fly  2240 CLTYNRVPWKLRVRKEVFQPHEPIGPPVALDL--LFAQV-LGDVFGVTPCLRITPQEKSSALNML 2301

  Fly  1368 PIRISKTREQQFWIPILAQAHRQ--------YGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNYK 1424
                     ....:.:...::|.        .|....||..:.| :.....:|||...:|.|...
  Fly  2302 ---------HGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHL-VDMARDWPLYFARLFAVQGA 2356

  Fly  1425 GYWNLASNIILGIHYDGIMFINPE-DKSVVFQ-FKYVDIESILLDPSDSFITISLNRSAQLLKTS 1487
            ..:...|  |:|:.:.|:.....: |..:|.| ..:.:|:|.:..|..:.:.::|.....|...:
  Fly  2357 PLYPDVS--IMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHA 2419

  Fly  1488 LYGSSLIESQKCFVFETPQKNDIGSLIISYYPALS---NWILNNLECSKKYK---------GTTK 1540
            ...:::......||.|..:.....|.:.|...|.:   |..|..||..:.:.         |:.:
  Fly  2420 ARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQ 2484

  Fly  1541 EDRLRL----------------------------------------------------------- 1546
            .::|:.
  Fly  2485 NEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQR 2549

  Fly  1547 -----------------------------YQNVVLCRR---------HLVDMNIVKKPHDFGGFL 1573
                                         :|..:|.::         |.:|.|.::...:.|...
  Fly  2550 FLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPP 2614

  Fly  1574 RNTLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTFWA----FSKQQIPFCISTISDQEEALMI 1634
            ..|...|.:..::..|::...:...|.|.::..::..:|    :....|...:..:.:....|.:
  Fly  2615 SVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLRLPNDLAPLAL 2679

  Fly  1635 QVFDSILTYSGLGSSGESISRAED-EHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDH----PD 1694
            :.||.||.|.|      .|....| ..::.:.:::..|.|..:|.:|:|.||:||||.:    ||
  Fly  2680 ECFDCILRYCG------DIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPD 2738

  Fly  1695 ANSRVNLKNWALLSVL-----CSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRT 1754
            ::.|.    |.|||:|     ||      .|:|.||:.||...:||   ........|..|....
  Fly  2739 SSQRA----WRLLSILAAYFGCS------DALRPYLMEHLTSAASD---RRRSCHGTAAVCLTNL 2790

  Fly  1755 QGTRR---RQWTPSREEILCTTNRRPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLD- 1815
            :.|.|   |:..||.||:...:..|....:.|.:.|....:.....||.  |.::|.:...||.
  Fly  2791 RKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCSTV--VADVIAELCALLGV 2853

  Fly  1816 ----NAKGYSIYEVI-GNS-ERSLSSEEKVCDVMAKWEKYQITSQQGFQKNTTLISQQNQYMFLF 1874
                ..:.:|:|.:: |:: ...|:::|.:.||..:..|    |.|.|.    ||..::.:.|..
  Fly  2854 ESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELLK----SGQPFY----LIFCRSVWHFAL 2910

  Fly  1875 KKH-----LFFDNYINLEDIVEKELLYHQI--------LHNLRSERYPITEMEAIMLTALQSQLE 1926
            |:.     |:.            |:|::|:        |..|.....|:.||...| ..:.:.|.
  Fly  2911 KREPAPMPLYV------------EVLFNQVAPDYLEGLLLELPGNGVPVPEMVRDM-ARIAALLH 2962

  Fly  1927 RGDCCESITDYRAVASHCLPPRFVPNIPHEAVAMHH----------QS----LRGMLPIEAKKAF 1977
            |......:...:.:       :|:  :|..|:.:..          ||    :..:.|.:.|..|
  Fly  2963 RAADLSHVPAMKEI-------KFL--LPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQF 3018

  Fly  1978 LNLIKSWPLHRATIFDVMQSFTTNWP----------RTLWLAIDQKGIHLLEHRSRNVLCTYGYD 2032
            ||::.:|||..::.|.|.:.:....|          |.|.||::::|:..|:..:...|..:.:.
  Fly  3019 LNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFM 3083

  Fly  2033 SIISFSPNLNS------LMIFTGTEKKQSKVILTTPQAYQITTLIREYSEAAK 2079
            .:|| :..:.|      |.:..|...:|..:.:.|.||::|:.|:|:|...|:
  Fly  3084 EVIS-TRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMAQ 3135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	252/690 (37%)
		MyTH4	1091..1194	CDD:459939	26/274 (9%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	25/307 (8%)
		B41	1202..1419	CDD:214604	58/472 (12%)
		PH-like	1415..1523	CDD:473070	20/112 (18%)
		MyTH4	1664..1771	CDD:459939	38/118 (32%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	25/116 (22%)
		B41	1781..1992	CDD:214604	48/244 (20%)
		PH-like	1988..2076	CDD:473070	23/103 (22%)
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	252/691 (36%)
		PTZ00121	<828..>943	CDD:173412	29/114 (25%)
		MyTH4	1014..1171	CDD:470587	24/156 (15%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	4/66 (6%)
		MyTH4	2704..2810	CDD:459939	38/118 (32%)
		FERM_B-lobe	2920..3025	CDD:271216	21/126 (17%)
		FERM_C_MyoXV	3029..3138	CDD:270022	24/108 (22%)