Protein Alignment Myo81F and Myo5c

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_006243475.1
• Gene: Myo5c / 315820
• RGDID: 1309994
• Length: 1749
• Species: Rattus norvegicus
• Alignment Length: 1912
• Identity: 462/1912 - (24%)
• Similarity: 780/1912 - (40%)
• Gaps: 471/1912 - (24%)

  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.:|: .|.:||||:|.||:|:||||.:.|:....|..|....:|
  Rat    67 VGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMG 131

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTIT-SNVSSWVQQQILE 135
            |:.||:|||||.||..:..:|.||:.::|||||||||.|.::.::|..|:: |:.::.|::::|.
  Rat   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAHVEEKVLA 196

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            :|.|.||.||||||||||||||||:.::.||:.|.|.|..:..||||:||:.||||.||||||.|
  Rat   197 SNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIFY 261

  Fly   201 QLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMN-------LESKKFDAVTMA-----FTV 253
            ||.|..|:            :|| |:|...::|:.|..       :|... |...||     ||:
  Rat   262 QLCASAQQ------------SEF-KHLKLGSAEEFNYTRMGGNTVIEGVD-DRADMAETQKTFTL 312

  Fly   254 LQIPQ-FVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLI 317
            |...: |.:| |||::::||.|||::...|..|.:.::..|.. :.:...||||......:.|..
  Rat   313 LGFKKDFQMD-VFKILAAILHLGNVQVTTVGNERSAVSEDDSH-LKVFCELLGLETIKVAQWLCN 375

  Fly   318 RQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFE 382
            |:|.........|:...:|:..|.||||.:|:.:|.::|.:||...:.......|:|||||:|||
  Rat   376 RKIVTSSETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTFIGVLDIYGFE 440

  Fly   383 NFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVF 447
            .|..|||||.||||.||||.:.||.:||.|||..|..|.|.:..::|.||.|.::::| ....:.
  Rat   441 TFDVNSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIE-AKMGIL 504

  Fly   448 KLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNR 512
            :||.|:|.:|.|:|..:|..::..|.:..:..:  ..|...:.|.|:|:|..|.|...||:||||
  Rat   505 ELLDEECLLPHGTDENWLQKLYNNFVNKNSLFE--KPRMSNSSFIIQHFADKVEYQCEGFLEKNR 567

  Fly   513 DVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRG------SSKS---------KCTVSDNF 562
            |...|::.|.:..||  |....:.:|:....:|  |.|      |:|.         :.||.:.|
  Rat   568 DTVYDMLVEVLRASK--FHLCAAFFQESPVPSS--PFGAMITVKSAKQVIKPNTKHFRTTVGNKF 628

  Fly   563 RNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHK 627
            |:.|..|::.|..|.|.||||||||.:|.|..::|..::.||:..||::.|||..:.:|...::.
  Rat   629 RSSLFLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYL 693

  Fly   628 DFIVRYKCLIKNKSFEYPQK--YLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYK 690
            :|..||..|:..:......|  ....:|.:....:.::|.|::|||.|......||..|.|.|.:
  Rat   694 EFYSRYGVLMTQQELSLSDKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRLDKLRQ 758

  Fly   691 NAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRG----------------WR------------L 727
            ..::|||:.:.:..:|.|||.::|.|.||..:||                |.            :
  Rat   759 GCIVIQKHVRGWLQRKKFLRERRAALTIQQYFRGQQTVRKAITATALKEAWAAIILQKHCRGYLV 823

  Fly   728 RIRFMRMRRSAIVIQSRLRGVFAR--------EVAAAL--------------------------- 757
            |..:..:|.:.|.||:..||..||        |..|.:
  Rat   824 RNLYQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRFVLNIQLT 888

  Fly   758 ----REMKRVDEELKKRDGIYEQLTSITTKTLADCER--SIQEELSVLA-----------HISDN 805
                |..|:::::.::..|:.|:|||:....:.|.|:  .::.||...|           ...|:
  Rat   889 YRVQRLQKKLEDQNRENHGLVEKLTSLAALRVGDLEKVQRLEAELEKAATHRHSYEEKGRRYRDS 953

  Fly   806 IRASAKPLSDKN---DSDSNTARSSIKQNTVNLDNMFDFLCES---------------KGAFE-- 850
            :......|...|   :|....|..|:::.|..|....|.|...               :.:||
  Rat   954 MEERLSKLQKHNAELESQRERAEQSLQERTEELKEKMDQLTRQLFDDVQKEEQQRLLLEKSFELK 1018

  Fly   851 -NALIKEINDNWNNLVKNLDEEIGLCIHTED---SFDSQKTGKLFTTKTVRTLPEPTVPPPPPPV 911
             .|..|||......:....||...|....|:   :.||.|......:|..:|:.|
  Rat  1019 TQAYEKEIESLREEIKALKDERTQLHHQLEEGRVTSDSLKGEVARLSKQAKTISE---------- 1073

  Fly   912 SISANLNSEPIYEAINLYKLTTTKEIKKEK-----------------YMLLDYK---SIKDNSKK 956
                   .|...|.:...|:...|.::.:|                 |.:.|.:   |::|....
  Rat  1074 -------FEKEIELLQAQKIDVEKHVQSQKREMRERMSEVTKQLLESYDIEDVRSRLSVEDLEHL 1131

  Fly   957 PSTSSVFVKYQ--------IDERENRRKQRVEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFN 1013
            .....::..|:        ::.....:|...||:|..|....:|
  Rat  1132 NEDGELWFAYEGLKKATRVLESHFQSQKDCYEKEIEGLNFKVVH--------------------- 1175

  Fly  1014 THDLSSDCNFISTPTQKGKSSDKTAKHEMT-MFSKSDKIP--TSHIHMYDPENVVLSCSMFRELC 1075
               ||.:.|.:....::....:::.:||:| :.|::..||  ...|...:.:...|. |..:|..
  Rat  1176 ---LSQEINHLQKLFREETDINESIRHEVTRLTSENMMIPDFKQQISELERQKQDLE-SRLKEQA 1236

  Fly  1076 KYMRGE-------LNAERELQIIQYIVGLGIEREELRDEI---FIQCIR-QSRNNPNIDWTDRIW 1129
            :.|.|:       ||.             |:|.|..:.:.   |::.:. ||..:|
  Rat  1237 EKMEGKQEEPFSHLNR-------------GLEEEGRQGKAPRPFLRAVEAQSETHP--------- 1279

  Fly  1130 IILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPSSVEVAA 1194
                                     :....|.||:::..:            ...:|....|.
  Rat  1280 -------------------------EGKERLVGKIQEPQE------------AIKFPKKQAEA-- 1305

  Fly  1195 MRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYD 1259
                          :...::|           :::.|.:|:|         :|| |.||.:...|
  Rat  1306 --------------EEEVESI-----------LRQEASRLSL---------ENR-DLEEELDMKD 1335

  Fly  1260 YLYDVISSWEMKQATYAGTKKTTNGSSSGENQFV----FKK----RLFKS-THELSQDPVEVSML 1315
            .:...:.. ::|..|....|..:....||..:::    :||    :|.:: ..:|....|.|:|:
  Rat  1336 RMIRKLQD-QVKTLTRTIEKANSVPLPSGSREYLGMLEYKKEDETKLIQNLILDLKPRGVVVNMI 1399

  Fly  1316 YSQAVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFW 1380
            .....|.:.....:..|...|..|..|......|  ......|::.|:...           .||
  Rat  1400 PGLPAHILFMCVRYADSLNDANMLKSLMNSAING--IKHVVKEHFEDLEML-----------SFW 1451

  Fly  1381 IPILAQAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMF-KVN-------------YKGYWNLAS 1431
                             |:....:|:|:.||.  |...| |.|             ...|..:.|
  Rat  1452 -----------------LSNTCHFLNCLKQYS--GEEEFMKCNSPQQNKNCLNNFDLTEYRQILS 1497

  Fly  1432 NIILGIHYDGIMFINPEDKSVVF--QFKYVDIESIL-LDPSDSFITISLNRSAQLLKTSLYGSSL 1493
            ::.:.|::..|:.:....:.::.  ..:|..::.|. |.|     |....||:.:..|..|..:.
  Rat  1498 DVAIRIYHQFILVMENNLQPIIVPGMLEYESLQGISGLKP-----TGFRKRSSSIDDTDAYTMTS 1557

  Fly  1494 IESQKCFVFETPQKNDIGSLIIS------YY----PALSNWILNNLECSKKYKGTTKEDRLRLYQ 1548
            |..|..:.:.|..:|.:...|:.      :|    ..|::.:|....||.: ||      :::..
  Rat  1558 ILQQLSYFYSTMCQNGLDPEIVRQAVKQLFYLIGAVTLNSLLLRKDMCSCR-KG------MQIRC 1615

  Fly  1549 NVVLCRRHLVDMNIVKKPHDFGGFLRNTLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTFWAF 1613
            |:......|.|.|           |:|:|.:                     ||.:..|...|..
  Rat  1616 NISFLEEWLKDKN-----------LQNSLAK---------------------ETLEPLSQAAWLL 1648

  Fly  1614 --------SKQQIPFCISTISDQEEALMIQVFDSILTYSGLGSSGESISRAEDEHIRIIQSIM-D 1669
                    ..::|..|.:::|      .:|:...:.:|:.:   .:...|.....:|.:|::: :
  Rat  1649 QVKKTTDSDAKEISQCCTSLS------AVQIIKILNSYTPI---DDFEKRVNPSFVRKVQALLNN 1704

  Fly  1670 KCMKKESLLNELYL-QLIKQTTDHPDA 1695
            :....:.:|:..|| |:....|..|.|
  Rat  1705 RGDSSQLMLDTKYLFQVTFPFTASPHA 1731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	250/681 (37%)
		MyTH4	1091..1194	CDD:459939	12/106 (11%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	17/108 (16%)
		B41	1202..1419	CDD:214604	38/225 (17%)
		PH-like	1415..1523	CDD:473070	24/134 (18%)
		MyTH4	1664..1771	CDD:459939	8/34 (24%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728
		B41	1781..1992	CDD:214604
		PH-like	1988..2076	CDD:473070
Myo5c	XP_006243475.1	MYSc_Myo5	81..741	CDD:276831	250/682 (37%)
		IQ	755..776	CDD:197470	5/20 (25%)
		IQ	831..851	CDD:459869	8/19 (42%)
		SMC_prok_B	<850..>1385	CDD:274008	103/673 (15%)
		Myo5c_CBD	1376..1743	CDD:271260	75/441 (17%)