Protein Alignment Myo81F and myo7aa

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_073784889.1
• Gene: myo7aa / 252846
• ZFINID: ZDB-GENE-020709-1
• Length: 2232
• Species: Danio rerio
• Alignment Length: 2278
• Identity: 600/2278 - (26%)
• Similarity: 1001/2278 - (43%)
• Gaps: 372/2278 - (16%)

  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIY------TYTGSILLAVNPYKTINIFNKQTISEYHT 67
            |..||..:.:::|.||.:||.:||...:||      |||||||:|||||:.:.|:....|..|..
Zfish    95 GVEDMIRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTN 159

  Fly    68 CKLGDLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQQQ 132
            .|:|::.||:||:|:..|.::..:|.:|.|:||||||||||||||.|||:|..| |...||::||
Zfish   160 KKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAI-SGQHSWIEQQ 223

  Fly   133 ILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYH 197
            :||||.||||||||||.||||||||||::.:.|:....|:|..|..||||:||:..|:..|||||
Zfish   224 VLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQARDERNYH 288

  Fly   198 IMY----QLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQ 258
            |.|    .:....:|.:|::.      |..|.||...|....:...:.|::..:..|..||....
Zfish   289 IFYCMLKGMTPDQKKQLGLSK------ATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTD 347

  Fly   259 FVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQ------EAISIISMLLGLSRCDFKKVLLI 317
            .....:.|::::||.:||:.:     |.......|.      .|::..::||.:...|....|..
Zfish   348 KENWEISKLLAAILHMGNLRY-----EARTYDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLTS 407

  Fly   318 RQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCT-NPGQDDAK----FLGVLD 377
            |.|..||.....||.|::||:.|.|..|.:|.::|.|:|.|||... .|...:.|    .:|:||
Zfish   408 RTIITRGETVSTPLSIEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRSIGLLD 472

  Fly   378 IFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKP 442
            |||||||..|||||||||:.||.|.:||..:||.|||..|..|.|.:.|:|||||...|:::...
Zfish   473 IFGFENFMVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIK 537

  Fly   443 PRCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGF 507
            |..:..|:.|:...|:|:|...|:.::::.:.:.|||  ..:..:||:|||:|:||:|.|...||
Zfish   538 PMNIISLIDEESKFPKGTDTTMLNKLNSQHKLNTNYI--PPKNTYETQFGIQHFAGVVYYETRGF 600

  Fly   508 VEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFI----------NSSYPRGSS--KSKCTVSD 560
            :|||||.....:.:.:..||:.|||.:.......|:          ..|..:|:.  |...|:|.
Zfish   601 LEKNRDTLHGDIIQLVHSSKNKFIKQIFQADVAMFLCGYWSDSLGKAGSLHKGAETRKRSPTLSS 665

  Fly   561 NFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLS 625
            .|:..|:.|:..|...:|::|||||||..|:|..::..|.:.||:|.|:::.|||||.|:||..:
Zfish   666 QFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYT 730

  Fly   626 HKDFIVRYKCLIKNKSFEYPQKYLTNILEKNGMPT----TEWQIGKSKIFLRNAAYELLETNR-- 684
            ..:|:.||:.|:......|.|:.|....::.....    .:||:||:||||::....|||..|
Zfish   731 FVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIAEAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDK 795

  Fly   685 ----------------KD-----TLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRL- 727
                            ||     .:.|:|::|||.|:.||.:|::...:....|:|..||..:|
Zfish   796 AITDKVILIQKVVRGFKDRSNFLKMKKSAMLIQKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLY 860

  Fly   728 ---------------RIRFMRMRR-------SAIVIQSRLRGVFAREVAAALR---------EMK 761
                           |.|...:||       :.|.||:..||:.||.:...|:         |..
Zfish   861 QTYHVARQRIMLFQGRCRGFLVRRAFRHRLWAVITIQAYTRGMIARRLYKRLKGEYRRRLEAEKL 925

  Fly   762 RVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLAHISDNIRASAKPLSDKNDSDSNTARS 826
            |:.||.|.|:    |:::  .|...:.|:..||.|:.||. .|..|...:....:...:......
Zfish   926 RLAEEQKLRN----QMSA--RKAKEEAEKMHQERLAQLAR-EDAEREKKERQEARRKMEMLDQME 983

  Fly   827 SIKQNTVN----LDNMFDFL----------CESKGAFEN--ALIKEINDNWNNLVKNLDEEIGLC 875
            ..:|..||    :|.||.||          .::...||:  ...:|:.      |::|||.:.|.
Zfish   984 KARQEPVNDSDMVDKMFGFLGTTNSFPGQEGQAPAGFEDLERTHRELE------VEDLDESLPLP 1042

  Fly   876 IHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPP-PPPVSISANLNSEPIYEAINLYKLTTTKEIKK 939
            ....:.....|..|...|....|.....:..| ..|:....:...:....|:.:..|....::.:
Zfish  1043 EDDLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQLAALAVWITVLRFMGDLPE 1107

  Fly   940 EKYMLLDYKSIKDNSKK-PSTSSVFVKYQIDERENRRKQRVEKKIHEL------TLIDIHKDIHI 997
            .||    :.:|.|.|:| |..:.::        |...|:..::::..|      |.|:.||...:
Zfish  1108 PKY----HTAISDGSEKIPVMTKIY--------ETLGKKTYKRELQALQGEGENTHIESHKKSSV 1160

  Fly   998 DNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPE 1062
            .:...::                     |..:|.|.:::..|                 .:.|.|
Zfish  1161 RHKLVSL---------------------TLKKKSKITEEVTK-----------------RLNDGE 1187

  Fly  1063 NVVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDR 1127
            ..|...||..:     |...|.|:    :.:|:|.||.|..|||||:.|..:|...||:.....|
Zfish  1188 YTVHGNSMLED-----RPTSNLEK----LHFIIGNGILRPGLRDEIYCQICKQLNQNPSKSSHAR 1243

  Fly  1128 IWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVS-TRMYPPSSVE 1191
            .||::.|.:..|.||:...:|..:||.:..       ..|:.:|.:..:.|.|: ||..|||.:|
Zfish  1244 GWILMSLCVGCFAPSEKFVKYLRNFISEGP-------PGYAPYCEERLRRTFVNGTRTQPPSWLE 1301

  Fly  1192 VAAMRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIK 1256
            :.|.:....|:....|:|..||.:......||.:....|::|::|....|:::|....|....:.
Zfish  1302 LQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALSDKISLQDRFGFSLYIALFDKVSSLG 1366

  Fly  1257 S-YDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAV 1320
            | .|::.|.:|..|.    ||  |:......:...:..|:|.:|...|:.::|.|..:::|.|.|
Zfish  1367 SGNDHVMDAVSQCEQ----YA--KEQGAQERNAPWRLFFRKEIFTPWHDPAEDAVATNLIYQQIV 1425

  Fly  1321 HSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIR-ISKTREQQFWIPIL 1384
            .. ||..|:....:...:||..|..|..|  |........|.|.|::|.| ||..:..:.|...:
Zfish  1426 RG-VKFGEYRCDREDLAELASQQYYVDYG--SEILVERLLSLIPSYIPDREISSAKTVERWAQFI 1487

  Fly  1385 AQAHRQYGSSRNALTAKVLYLSCV----MQYPLYGTTMFKV-NYKGYWNLASNIILGIHYDGIMF 1444
            ..||::...::..:..:.:....|    .::||..:..::. .:.|.....:::|:.:::.|:.|
Zfish  1488 MAAHKKGVYTQKRVDPQKVKEEVVDFARYKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNWTGVYF 1552

  Fly  1445 INPEDKSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTSLYGSSLIESQKCFVFETPQKND 1509
            ::.:             |.:||:.|...||...:.....|:...:..:.|::.: |.|.:....|
Zfish  1553 VDEQ-------------EQVLLELSFPEITAVSSSKGGKLQAQSFTLATIKADE-FTFTSNNAED 1603

  Fly  1510 IGSLIISYYPAL--------------------------------------------SNWILNNLE 1530
            |..|::::...|                                            |.|.....:
Zfish  1604 IRDLVVTFLEGLRKRSKFVVALQDNPSPAADDSTFLSFLKGDLIVLDQDTGEQVMTSGWAHGTND 1668

  Fly  1531 CSKKYKGTTKEDRLRLYQNVVLCRRHLVDMNIVKKPHDFGGFLRNTLRRLSKHRLEKLR-SEVG- 1593
            .:|: :|....|.:.:...|            |:.|||...|:..|    ...|.|.|| |.|.
Zfish  1669 RTKQ-RGDFPADCVYVLPTV------------VRPPHDVVAFVTMT----PDQRQESLRISHVPA 1716

  Fly  1594 -SNTQEHGETY--KGFSHTF-----------------------WAFSKQQI-----PFCISTISD 1627
             :.|:|..:.|  :.||:.:                       |..:::.|     ..|......
Zfish  1717 LTETEERVKPYTLEEFSYDYFRPPPKHTLSRVMITKNRGKDKLWCCTREPIKQALLKKCGGHEEL 1781

  Fly  1628 QEEALMIQVFDSILTYSGLGSSGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDH 1692
            .:||.|  .|.:::.|  :|......:|:.:|   :...|.:..:|.|.|.:|:|.|::||.|::
Zfish  1782 SQEACM--AFIAVMKY--MGDYPSKRTRSVNE---LTDQIFEGALKAEPLKDEIYCQILKQLTEN 1839

  Fly  1693 PDANSRVNLKNWALLSVLCSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRTQGT 1757
            ....|..  |.|.||.:...:..||     ..|:.|::|    ||..: |:...|.:|..|.|..
Zfish  1840 HIKYSEE--KGWELLWLCVGLFPPS-----NVLLPHVQR----FLQSK-KHHPLALDCMQRLQKA 1892

  Fly  1758 RR---RQWTPSREEILCTTNR-RPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDNAK 1818
            .|   |::.|...|:....:: ...:.|.||.|....:.|.:.|:.|.|....|..:: ||...:
Zfish  1893 LRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCLNISSRL-LLKTPE 1956

  Fly  1819 GYSIYEVIGNSERSLSSEEKVCDV---MAKWEKYQITSQQGFQKNTTLISQQNQYMFLFKKHLFF 1880
            |:|::..|.:...|:...:...|.   :..|.|....::.|...:.|       |...|.|.|:.
Zfish  1957 GFSLFVKISDKVISVPEGDFFFDFVRHLTDWIKKARPAKDGIVPSLT-------YQVFFMKKLWT 2014

  Fly  1881 DNYINLEDIVEKELLYHQILHNLRSERYPITEMEAIMLTALQSQLERGDCCESITDYRAVASHCL 1945
            ......:...:....|:|.|.......:..:..|...|.||..:::..|..........:....:
Zfish  2015 TTVPGKDSFADSIFHYYQELPKYLRGYHKCSREEVFQLGALIYRVKFEDDKSHFPSIPKMLKEMI 2079

  Fly  1946 PPRFV----PNIPHEAVAMHHQSLRGMLPIEAKKAFLNLIKSWPLHRATIFDVMQSFTTNWPRTL 2006
            |...:    |:....::..:.....|....|||..||.:|..||...:..|:|.|:...::|..|
Zfish  2080 PQDLIRQLSPDDWKRSIVAYFNRHAGKSREEAKLMFLKIIFKWPTFGSAFFEVKQTTEPHFPEIL 2144

  Fly  2007 WLAIDQKGIHLLEHRSRNVLCTYGYDSIISFSPNLNSLMIFTGTEKKQSKVILTTPQAYQITTLI 2071
            .:||::.|:.|::.:::::|.||.:..|.::|.......|..|...:.||::..|...|::..|:
Zfish  2145 LIAINKYGVSLIDPKNKDILTTYPFTKISNWSSGNTYFHITIGNLVQGSKLLCETSLGYKMDDLL 2209

  Fly  2072 REY 2074
            ..|
Zfish  2210 TSY 2212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	262/686 (38%)
		MyTH4	1091..1194	CDD:459939	34/103 (33%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	23/101 (23%)
		B41	1202..1419	CDD:214604	51/222 (23%)
		PH-like	1415..1523	CDD:473070	18/152 (12%)
		MyTH4	1664..1771	CDD:459939	31/109 (28%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	24/108 (22%)
		B41	1781..1992	CDD:214604	43/217 (20%)
		PH-like	1988..2076	CDD:473070	22/87 (25%)
myo7aa	XP_073784889.1	None