DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo81F and Myo5b

DIOPT Version :9

Sequence 1:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster
Sequence 2:XP_008770307.1 Gene:Myo5b / 25132 RGDID:621347 Length:1854 Species:Rattus norvegicus


Alignment Length:1971 Identity:473/1971 - (23%)
Similarity:785/1971 - (39%) Gaps:565/1971 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.||: .|:.||||.|.:|:|:|||:.:.|:.:..|..|....:|
  Rat    77 VGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMG 141

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSW-VQQQILE 135
            |:.||:|||||.||..:..|..||:.::|||||||||.|.|:.::|..|:..:.|.. :::::|.
  Rat   142 DMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLA 206

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            ::.|:||.||||||||||||||||::::.||....|.|..:..||||:||:.||::.||||||.|
  Rat   207 SSPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFY 271

  Fly   201 QLVAQGQ----KNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVI 261
            ||.|...    |.:.      |..||.:.|.....:..|....:::.|:....|.|:|.:.:...
  Rat   272 QLCAAASLPEFKELA------LTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQ 330

  Fly   262 DGVFKVISSILWLGNIEF-IDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINVRGN 325
            ..:||:|:|||.||::|. .:.||:...::..| |.:|....|||:.....:..|..|::.....
  Rat   331 ISIFKIIASILHLGSVEIQAERDGDSCSISPQD-EHLSNFCRLLGIEHSQMEHWLCHRKLVTTSE 394

  Fly   326 ITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFENFSHNSFE 390
            .....:.:::.:..|:||||.:|:::|:|:|..||...........|:|||||:|||.|..||||
  Rat   395 TYVKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSFIGVLDIYGFETFEINSFE 459

  Fly   391 QLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTEQCH 455
            |.||||.||||.:.||.:||.|||..|..|.|.:..::|.||.||::::| ....:..||.|:|.
  Rat   460 QFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIE-AKLGILDLLDEECK 523

  Fly   456 MPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRDVQQDVMF 520
            :|:|:|..:...:   :|.|.|.......|...|.|.:.|:|..|.|...||:|||||...:...
  Rat   524 VPKGTDQNWAQKL---YERHSNSQHFQKPRMSNTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQI 585

  Fly   521 EYMSYSKDVFIKDLSTYQD----IQFINSSYPRGSSK----------------SKCTVSDNFRNQ 565
            ..:..||...:.||  ::|    :...|::..|.|||                .|.:|...||..
  Rat   586 NILKASKFPLVADL--FRDDKDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTS 648

  Fly   566 LQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFI 630
            |..|::.|..|.|.||||||||.:|.|.:::....:.||:..||::.|||...|:|...::.||.
  Rat   649 LNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFF 713

  Fly   631 VRYKCLIKNKSFEYPQKYLTNILEKNGM----------PTTEWQIGKSKIFLRNAAYELLETNRK 685
            .||:.|:|.:.       |.|..:|..:          ...::|.|::|||.|......||..|.
  Rat   714 NRYRVLMKKRE-------LANTTDKKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRA 771

  Fly   686 DTLYKNAVIIQK---NW---KKY----------------YI-----------------QKSF--L 709
            |...:..::|||   .|   .||                |:                 ||.:  |
  Rat   772 DKFREATIMIQKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLRRTRAAIVFQKQYRML 836

  Fly   710 RNKQAVLRIQHA--------------------------------YRGWRLRIRFMRMRRSAIVIQ 742
            :.::|..|::.|                                .|||..|..|.|.|.:|||||
  Rat   837 KARRAYCRVRRAAVIIQSYTRAMCVRRSYRQVLTEHKATIIQKYARGWMARRHFQRQRDAAIVIQ 901

  Fly   743 SRLRGVFAREVAAALR-------EMKR---------------VDEELKKRDGIYEQLTSITT--- 782
            ...|.:.||:...||:       .:||               :|::.|:...:.|||:::|:   
  Rat   902 CAFRRLKARQALKALKIEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSTHA 966

  Fly   783 -------KTL--------ADCERSIQEELSVLAHISDNIRASAKPLSDKNDSDSNTARSSIKQNT 832
                   |.|        ||....:|||:..|........:..:.|.|.:    |.....:::..
  Rat   967 MEVEKLKKELARYQQNQEADPSLQLQEEVQSLRTELQKAHSERRVLEDTH----NRENGELRKRV 1027

  Fly   833 VNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVR 897
            .:|::            ||||:|:..::.||.:          :....:..||.           
  Rat  1028 ADLEH------------ENALLKDEKEHLNNQI----------LRQSKAESSQS----------- 1059

  Fly   898 TLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKEK---------YMLLD--YKSIK 951
                          |:..||          |.|    ||:::|:         |..|:  |::::
  Rat  1060 --------------SVEENL----------LIK----KELEEERSRYQNLVKEYSQLEQRYENLR 1096

  Fly   952 DNSKKPSTSSVFVKYQIDERENRRKQRVEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFNTHD 1016
            |..:.|.                                 |:               :|..|...
  Rat  1097 DEQQTPG---------------------------------HR---------------KNPSNQSS 1113

  Fly  1017 LSSDCNFISTPTQK-GKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRG 1080
            |.||.|:.|..|.: |.:.|...:.|.....|:                .:..::|.:|.|.:| 
  Rat  1114 LESDSNYPSISTSEIGDTEDALQQVEEIGIEKA----------------AMDMTVFLKLQKRVR- 1161

  Fly  1081 ELNAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLL 1145
            ||..||:...:|      :|:|: :|...:| :.|..|..::|                |.:.:.
  Rat  1162 ELEQERKKLQVQ------LEKEQ-QDSKKVQ-VEQQNNGLDVD----------------QDADIA 1202

  Fly  1146 FRYFVSFIKKSMIELDGK--------LRQ--YSQWCFDNCKSTKVSTRMYPPS----------SV 1190
            :    :.:|:..:|.:.|        ||:  ..|...||      ||...|.|          :.
  Rat  1203 Y----NSLKRQELESENKKLKNDLNELRKAVADQAMQDN------STHSSPDSYSLLLNQLKLAN 1257

  Fly  1191 EVAAMRRLGTIVCRFFFLDA---RTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGE 1252
            |...:|:...::.|...::|   |....::.|               |:.....|      |:.|
  Rat  1258 EELEVRKEEVLILRTQIMNADQRRLSGKNMEP---------------NINARTSW------PNSE 1301

  Fly  1253 EHIKSYDYLYDVISSWEMKQATYAGTKKTTNG-------SSSGENQFVFK-----KRLFKS---- 1301
            :|:...|.:           ..|.|..:|.:.       :..||....::     .||.::    
  Rat  1302 KHVDQEDAI-----------EAYHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQA 1355

  Fly  1302 ---THELSQDPVEVSMLYSQAVHSVVKKDEFPVSEKVALQ--LAGLQAQVALGD----------- 1350
               .||     .||..|.:|.   ...|:|....::...|  |...:|||..|.           
  Rat  1356 QNLKHE-----EEVEHLKAQV---EAMKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNEN 1412

  Fly  1351 ----------PSNQPKPEYYSDINSFLPIRISKTREQQFWIPILAQAHRQYGSSRNALTAKVLYL 1405
                      ..|:.|      :...|.|.:.|.::.:     .|||..|.....:.||.:|   
  Rat  1413 LDFKELVEKLEKNEKK------LKKQLKIYMKKVQDLE-----AAQALAQSDRRHHELTRQV--- 1463

  Fly  1406 SCVMQYPLYGTTMFKVNYKGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKYVDIESILLDPS- 1469
                      |...|..               .:.|::..:.||::::.:....|::..:|..: 
  Rat  1464 ----------TVQRKEK---------------DFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTV 1503

  Fly  1470 ---DSFITISLNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSNWILNN--- 1528
               .::|.....|.|......|...||:.|....:.:..:|::      ..:...|.|:.|.   
  Rat  1504 PCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHN------EDFEMTSFWLSNTCRL 1562

  Fly  1529 LECSKKYKG--------TTKEDR-------------------LRLYQNVVLCRRHLVDMNIVKKP 1566
            |.|.|:|.|        |.|::.                   :::||.::.....|:...||   
  Rat  1563 LHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIV--- 1624

  Fly  1567 HDFGGFLRN-TLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQ-- 1628
               ...|.| :::.||..|....|..  |::...||.    |:...|..: |:.|..:.:.||  
  Rat  1625 ---SAMLENESIQGLSGVRPTGYRKR--SSSMVDGEN----SYCLEAIIR-QMNFFHTVLCDQGL 1679

  Fly  1629 EEALMIQVFDSI------LTYSGLGSSGESISRAEDEHIRIIQSIMDKCMKKESLLNE------- 1680
            :..:::|||..:      :|.:.|....::.|.:....:|...|.:::.::.::|...       
  Rat  1680 DPEIILQVFKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYNISQLEEWLRGKNLQQSGAVQTME 1744

  Fly  1681 ------LYLQLIKQTTDHPDA 1695
                  ..|||.|:|.:..:|
  Rat  1745 PLIQAAQLLQLKKKTQEDAEA 1765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo81FNP_001303492.1 MYSc 8..685 CDD:214580 252/713 (35%)
Motor_domain 23..673 CDD:277568 243/686 (35%)
MyTH4 1091..1194 CDD:279165 22/122 (18%)
B41 1202..1419 CDD:214604 44/261 (17%)
UBQ 1202..1297 CDD:294102 15/109 (14%)
FERM_M 1307..1419 CDD:278785 25/134 (19%)
PH-like 1415..1523 CDD:302622 15/111 (14%)
MyTH4 1664..1771 CDD:279165 8/45 (18%)
UBQ 1780..1860 CDD:294102
B41 1781..1992 CDD:214604
FERM_B-lobe 1893..1984 CDD:271216
PH-like 1988..2076 CDD:302622
Myo5bXP_008770307.1 MYSc 72..770 CDD:214580 252/712 (35%)
MYSc_Myo5 91..759 CDD:276831 243/687 (35%)
IQ 871..891 CDD:197470 4/19 (21%)
DUF1690 910..1002 CDD:285231 19/91 (21%)
Rab5-bind 919..1179 CDD:286404 66/396 (17%)
RILP-like <979..1069 CDD:304877 24/154 (16%)
Uso1_p115_C 1155..1267 CDD:282695 30/146 (21%)
GBP_C <1340..1416 CDD:303769 16/83 (19%)
coiled coil 1385..1396 CDD:293879 2/10 (20%)
coiled coil 1405..1416 CDD:293879 0/10 (0%)
Myo5b_CBD 1480..1851 CDD:271261 57/305 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.