DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo81F and Myo5a

DIOPT Version :9

Sequence 1:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster
Sequence 2:XP_038936774.1 Gene:Myo5a / 25017 RGDID:3143 Length:1880 Species:Rattus norvegicus


Alignment Length:2060 Identity:502/2060 - (24%)
Similarity:825/2060 - (40%) Gaps:521/2060 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.||: :|.:||||.|.:|:|:|||:.:.|:.:..|:.|....:|
  Rat    69 VGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMG 133

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVS-SWVQQQILE 135
            |:.||:|||||.||..:..|..||:.::|||||||||.|.|:.::|..|::.:.| :.|::::|.
  Rat   134 DMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLA 198

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            :|.|:|:.||||||||||||||||::::.||....|.|..:..||||:||:.||:|.||||||.|
  Rat   199 SNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFY 263

  Fly   201 QLVAQGQ------KNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQF 259
            ||.|..:      ..:|.|::||        |.....|..|....::|:......|.|:|.|.:.
  Rat   264 QLCASAKLPEFKMLRLGNADSFH--------YTKQGGSPMIEGVDDAKEMAHTRQACTLLGISES 320

  Fly   260 VIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKV---LLIRQIN 321
            ...|:|::::.||.|||:.|...|.:...:. ...|.:.|...|:|:   |::::   |..|::.
  Rat   321 YQMGIFRILAGILHLGNVGFASRDSDSCTIP-PKHEPLIIFCDLMGV---DYEEMCHWLCHRKLA 381

  Fly   322 VRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFENFSH 386
            ........|:...:|...|.||||.:|:|:|.|:|..:|...:.......|:|||||:|||.|..
  Rat   382 TATETYIKPISKLQATNARDALAKHIYAKLFNWIVGHVNQALHSAVKQHSFIGVLDIYGFETFEI 446

  Fly   387 NSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLT 451
            |||||.||||.||||.:.||.:||.|||..|..|.|.:..::|.||.||:.::|. ...:..||.
  Rat   447 NSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIES-KLGILDLLD 510

  Fly   452 EQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDR-RHWETEFGIKHYAGLVIYAVGGFVEKNRDVQ 515
            |:|.||:|:|..:...:   :.:|.|.....:: |.....|.|||:|..|.|...||:|||:|..
  Rat   511 EECKMPKGTDDTWAQKL---YNTHLNKCALFEKPRMSNKAFIIKHFADKVEYQCEGFLEKNKDTV 572

  Fly   516 QDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSS----------------------KSKCTV 558
            .:...:.:..||...:.:|  :||.:...|.....||                      :.|.||
  Rat   573 FEEQIKVLKSSKFKMLPEL--FQDDEKAISPTSATSSGRTPLTRVPVKPTKGRPGQTAKEHKKTV 635

  Fly   559 SDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIH 623
            ...|||.|..|::.|..|.|.||||||||..|.|..::....:.||:..||::.|||...|||..
  Rat   636 GLQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSR 700

  Fly   624 LSHKDFIVRYKCLIKNKSFEYPQKY-LTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDT 687
            .::::|..||:.|:|.|.....:|. ..|:|||..:...::|.||:|||.|......||..|.|.
  Rat   701 WTYQEFFSRYRVLMKQKDVLGDRKQTCQNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADK 765

  Fly   688 L------------------------------------------------YKNAVIIQKNWKKYYI 704
            |                                                .|.|..|||.|:.|.:
  Rat   766 LRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVV 830

  Fly   705 QKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRR--SAIVIQSRLRGVFAR---------------- 751
            ::.:...:.|.:.:|...||:..|.|:.::.|  .|::||.|:||..||                
  Rat   831 RRKYKIRRAATIVLQSYLRGYLARNRYRKILREHKAVIIQKRVRGWLARTHYKRTMKAIIYLQCC 895

  Fly   752 -EVAAALREMK----------------------------RVDEELKKRDGIYEQLTSI------- 780
             ....|.||:|                            :|||:.|....:.|:||::       
  Rat   896 FRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSE 960

  Fly   781 TTKTLADCER----------------SIQEELSVLAHISDNIRASAKPLSDKNDSDSNTARSSIK 829
            |.|...|.||                |:|||::.|....:..|:..|.:.::.|        ..|
  Rat   961 TEKLRNDVERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEERAD--------KYK 1017

  Fly   830 QNTVNL-DNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTT 893
            |.|..| .|:.:         ||.|:|:..:..|:|:....:|:                    |
  Rat  1018 QETEQLVSNLKE---------ENTLLKQEKETLNHLMVEQAKEM--------------------T 1053

  Fly   894 KTV-RTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKE----IKKEKYMLLDYKSIKDN 953
            :|: |.|.|.|       ..:..:||.|.:.....|.:.:..:|    :|:|..::|       |
  Rat  1054 ETMERKLVEET-------KQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLML-------N 1104

  Fly   954 SKKPSTSSVFVKYQIDERENRRKQRVEKKIHELTLIDIHKDIHIDN-SFYNILEFAENYFNTHDL 1017
            ..||.                         |:.|     ...|..| |.|.   |:..:..|.|:
  Rat  1105 VPKPG-------------------------HKRT-----DSTHSSNESEYT---FSSEFAETEDI 1136

  Fly  1018 SSDCNFISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGEL 1082
            :..   ...||:|....|      |::|.|..|..|.    .:.|..::...:.|:..:.:|.:.
  Rat  1137 APR---TEEPTEKKVPLD------MSLFLKLQKRVTE----LEQEKQLMQDELDRKEEQVLRSKA 1188

  Fly  1083 NAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFR 1147
            ..|...|    |.|..:|.|.|:        ||...:.|                          
  Rat  1189 KEEERPQ----IRGAELEYESLK--------RQELESEN-------------------------- 1215

  Fly  1148 YFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDART 1212
                  ||...||: :||:        ..|.|.:..:..|.:.....:....|.|..  .||.|.
  Rat  1216 ------KKLKNELN-ELRK--------ALSEKSAPEVTAPGAPAYRVLMEQLTAVSE--ELDVRK 1263

  Fly  1213 KAIDVHPTDTAG--DAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISSWEMKQATY 1275
            :.:.:..:....  :|:|...:|  .|.||...:.::             :..:....|:.|| |
  Rat  1264 EEVLILRSQLVSQKEAIQPKDDK--NTMTDSTILLED-------------VQKMKDKGEIAQA-Y 1312

  Fly  1276 AGTKKTTNGSS--------SGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAVHSVVKKDEFPVS 1332
            .|.|:|...|:        .||...|::.  .|..:.|.:     |.|.||      |:.....:
  Rat  1313 IGLKETNRSSAMDYQELNEDGELWLVYEG--LKQANRLLE-----SQLQSQ------KRSHENEA 1364

  Fly  1333 EKVALQLAGLQ----AQVALGDPSNQPKPEYYSDINSFLPIRISK-TREQQFWIPILAQAHRQYG 1392
            |.:..::..|:    .|..|...:.|..||  :.|.:.|...|:: |.|..::..:.|...::|.
  Rat  1365 EALRGEIQSLKEENNRQQQLLAQNLQLPPE--ARIEASLQHEITRLTNENLYFEELYADDPKKYQ 1427

  Fly  1393 SSRNALTAKVLYL------------SCVMQYPLYGTTMFKVNYKGYWNLASNIILG--------- 1436
            |.|.:|..:::.|            ....|..::...:.::......|::...|:.         
  Rat  1428 SYRISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIP 1492

  Fly  1437 ---IHYDGIMFINPED-----KSVVFQFKYVDIESILLDPSDSFITISLNRSAQLLKTSLYGSSL 1493
               ..:.|::....||     |:::.:.|...:...|:....::|.....|.|..|.        
  Rat  1493 RKEKDFQGMLEYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLN-------- 1549

  Fly  1494 IESQKCFVFETPQKNDIGSLIISY---YPALSNWILNN---LECSKKYKG--------TTKEDR- 1543
             :.||.....|...|.|..::...   :..:|.|:.|.   |.|.|:|.|        |::::. 
  Rat  1550 -DDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEH 1613

  Fly  1544 ------------------LRLYQNVVLCRRHLVDMNIVKKPHDFGGFLRN-TLRRLSKHRLEKLR 1589
                              :::||.:|....:::...||      .|.|.: |::.:|..:...||
  Rat  1614 CLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIV------SGMLEHETIQGVSGVKPTGLR 1672

  Fly  1590 SEVGSNTQEHGETYKGFSHTFWAFSKQQI-----PFCISTISDQEEALMIQVFDSILTYSGLGSS 1649
            ....|...|...|.........:|.....     |..|..:..|    |..:..:| |.:.|...
  Rat  1673 KRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQ----MFYIVGAI-TLNNLLLR 1732

  Fly  1650 GESISRAEDEHIRIIQSIMDKCMKKESLLNE-------------LYLQLIKQTTDHPDANSRVNL 1701
            .:..|.::...||...|.:::.::.::|:|.             ..||:.|:|.|..:|      
  Rat  1733 KDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEA------ 1791

  Fly  1702 KNWALLSVLCSVILPS--MKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRTQGTRRRQWTP 1764
                 :..:|:.:..:  :|.:..|             :...::.......|.||...|.|....
  Rat  1792 -----ICSMCNALTTAQIVKVLNLY-------------TPVNEFEERVSVSFIRTIQVRLRDRKD 1838

  Fly  1765 SREEILCTTNRRPCYSKFYFMDGQY---YSIEFQPSSTANDVLEI 1806
            |.:               ..||.::   .:..|.|||.|.:.::|
  Rat  1839 SPQ---------------LLMDAKHIFPVTFPFNPSSLALETIQI 1868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo81FNP_001303492.1 MYSc 8..685 CDD:214580 259/711 (36%)
Motor_domain 23..673 CDD:277568 250/684 (37%)
MyTH4 1091..1194 CDD:279165 17/102 (17%)
B41 1202..1419 CDD:214604 47/243 (19%)
UBQ 1202..1297 CDD:294102 21/104 (20%)
FERM_M 1307..1419 CDD:278785 24/128 (19%)
PH-like 1415..1523 CDD:302622 17/127 (13%)
MyTH4 1664..1771 CDD:279165 18/121 (15%)
UBQ 1780..1860 CDD:294102 8/30 (27%)
B41 1781..1992 CDD:214604 8/29 (28%)
FERM_B-lobe 1893..1984 CDD:271216
PH-like 1988..2076 CDD:302622
Myo5aXP_038936774.1 COG5022 7..1275 CDD:227355 382/1375 (28%)
MYSc_Myo5 83..751 CDD:276831 250/685 (36%)
Smc 1157..>1484 CDD:224117 75/416 (18%)
Myo5a_CBD 1506..1880 CDD:271262 74/422 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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