Protein Alignment Myo81F and MYO16

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_001185879.1
• Gene: MYO16 / 23026
• HGNCID: 29822
• Length: 1880
• Species: Homo sapiens
• Alignment Length: 1068
• Identity: 275/1068 - (25%)
• Similarity: 453/1068 - (42%)
• Gaps: 237/1068 - (22%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTC--KL-GDL 73
            |:..:||:::..:...:..|:.::.|||:.|.|||.|||||.:.|::......|.:.  || ..|
Human   427 DLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSL 491

  Fly    74 SPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQQQILEANT 138
            .||:|:..|.|:..:..:...|..::|||.|:||:|::|.|:::|........:.:..:......
Human   492 PPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVC 556

  Fly   139 ILEAFGNAKTTRNDNSSRFGKFMQVCF-DDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMYQL 202
            ||||||:||||.||.||.|.|:.::.| :....:.|..|..||||:||:..|..|:.|:.|.|.|
Human   557 ILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLL 621

  Fly   203 V--AQGQKNIGIANTFHLRPAEFYKYLN------TSNSEKINMNLESKKFDAVTMAFTVLQIPQF 259
            :  ...::..|:    ||.....::|||      .|..|:   :|..:|...:..|..|:.....
Human   622 MDGLSAEEKYGL----HLNNLCAHRYLNQTIQDDASTGER---SLNREKLAVLKRALNVVGFSSL 679

  Fly   260 VIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCD-----------FKK 313
            .::.:|.::::||.||:|.|..:: |......||.:.:..::.:|.:|..:           ||.
Human   680 EVENLFVILAAILHLGDIRFTALN-EGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKG 743

  Fly   314 VLLIRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKF-----L 373
            .::||:..::  |.|.         .|..|||:|||::|::||:.:|:|.: .||:.|.     :
Human   744 DMIIRRHTIQ--IAEF---------FRDLLAKSLYSRLFSFLVNTMNSCLH-SQDEQKSMQTLDI 796

  Fly   374 GVLDIFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDN-TPCLE 437
            |:|||||||.|..|.|||||:|.||||:|.:.|..:|..||.....||:.........| ...|:
Human   797 GILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLD 861

  Fly   438 ILEKPPRCVFKLLTEQCHMPQGSDLAFLSNMHTEFE-SHPNYIKGSDR--------RHWETEFGI 493
            ...:.|.....||.|:..|....:..|...:.:..| |:.|.:....:        :...|.|.|
Human   862 FFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTI 926

  Fly   494 KHYAGLVIYAVGGFVEKNRD-VQQDVMFEYMSYSKDVFIKDL------------STYQDIQF--- 542
            .||||.|:|.|.|.:|||:| :.|:::| .|..|::|.|..|            |.|...:|
Human   927 MHYAGRVMYDVVGAIEKNKDSLSQNLLF-VMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGH 990

  Fly   543 ----------------INSSY--------PRGSSK--------SKCTVSDNFRNQLQSLIDVLQN 575
                            .|.:|        .:|:|.        ...|::...|..|..:|..||.
Human   991 KSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQK 1055

  Fly   576 TKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNK 640
            ..|.::.||:||..|.|:.:::..|..||:|:||:::::|.|.|:|:.||..||:.|||.|..
Human  1056 CTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLAD-- 1118

  Fly   641 SFEYPQKYLTNILEKNGMPTTE-------------WQIGKSKIFLRNAAYELLETNRKDTLYKNA 692
                     |.:.||......|             ||:|..|:||
Human  1119 ---------TFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFL-------------------- 1154

  Fly   693 VIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAAL 757
                    ||:                ||.   :|....::::|..|..|..:||..||
Human  1155 --------KYW----------------HAD---QLNDLCLQLQRKIITCQKVIRGFLAR------ 1186

  Fly   758 REMKRVDEELKKRDGIYEQ-LTSITT-------KTLADCERSIQEELSVLAHISDNIRAS----- 809
                   :.|.:|..|.:| :|||.:       ..|...:..:.:..|.:|..:|.:|:.
Human  1187 -------QHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPY 1244

  Fly   810 -AKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIG 873
             .:.|..:|..:..:.|:..|....:.......:|.:.                       :.:|
Human  1245 HKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAV-----------------------DGLG 1286

  Fly   874 LCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIK 938
            .|: ...|..|.....:|:.....:||.|...|||.| ....|......|||::.. |:..:|..
Human  1287 QCL-VGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKP-KRDPNTRLSASYEAVSAC-LSAAREAA 1348

  Fly   939 KEKYMLL-----DYKSIKD-NSKKPSTS 960
            .|.....     ||.::|. ..:||..|
Human  1349 NEALARPRPHSDDYSTMKKIPPRKPKRS 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	217/748 (29%)
		MyTH4	1091..1194	CDD:459939
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728
		B41	1202..1419	CDD:214604
		PH-like	1415..1523	CDD:473070
		MyTH4	1664..1771	CDD:459939
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728
		B41	1781..1992	CDD:214604
		PH-like	1988..2076	CDD:473070
MYO16	NP_001185879.1	ANKYR	67..347	CDD:440430
		ANK repeat	86..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		ANK repeat	309..335	CDD:293786
		MYSc_Myo16	437..1155	CDD:276844	218/777 (28%)
		NYAP_N	1243..1590	CDD:464717	30/160 (19%)
		NYAP_C	1652..1880	CDD:464724