DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo81F and Myo5c

DIOPT Version :9

Sequence 1:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster
Sequence 2:XP_006510998.1 Gene:Myo5c / 208943 MGIID:2442485 Length:1749 Species:Mus musculus


Alignment Length:1922 Identity:461/1922 - (23%)
Similarity:784/1922 - (40%) Gaps:491/1922 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.:|: .|.:||||:|.||:|:||||.:.|:....|..|....:|
Mouse    67 VGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMG 131

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTIT-SNVSSWVQQQILE 135
            |:.||:|||||.||..:..:|.||:.::|||||||||.|.::.::|..|:: |:.::.|:.::|.
Mouse   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAHVEDKVLA 196

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            :|.|.||.||||||||||||||||:.::.||:.|.|.|..:..||||:||:.||||.||||||.|
Mouse   197 SNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIFY 261

  Fly   201 QLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMN-----------------LESKKFDAVT 248
            ||.|..|:            :|| |:|...::|:.|..                 :|::|     
Mouse   262 QLCASAQQ------------SEF-KHLKLGSAEEFNYTRMGGNTVIEGVNDRADMVETQK----- 308

  Fly   249 MAFTVLQIPQ-FVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFK 312
             .||:|...: |.:| |||::::||.|||::...|..|.:.::..|.. :.:...||||......
Mouse   309 -TFTLLGFKKDFQMD-VFKILAAILHLGNVQVTTVGNERSSVSEDDSH-LKVFCELLGLETSKVA 370

  Fly   313 KVLLIRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLD 377
            :.|..|:|.........|:...:|:..|.||||.:|:.:|.::|.:||...:.......|:||||
Mouse   371 QWLCNRKIVTSSETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTFIGVLD 435

  Fly   378 IFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKP 442
            |:|||.|..|||||.||||.||||.:.||.:||.|||..|..|.|.:..::|.||.|.::::| .
Mouse   436 IYGFETFDVNSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIE-A 499

  Fly   443 PRCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGF 507
            ...:.:||.|:|.:|.|:|..:|..::..|.:..:..:  ..|...:.|.|:|:|..|.|...||
Mouse   500 KMGILELLDEECLLPHGTDENWLQKLYNNFVNKNSLFE--KPRMSNSSFIIQHFADKVEYQCEGF 562

  Fly   508 VEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRG------SSKS---------KCT 557
            :|||||...|::.|.:..||  |....:.:|:....:|  |.|      |:|.         :.|
Mouse   563 LEKNRDTVYDMLVEILRASK--FHLCAAFFQESPVPSS--PFGAMITVKSAKQVIKPNTKHFRTT 623

  Fly   558 VSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPI 622
            |.:.||:.|..|::.|..|.|.||||||||.:|.|..::|..::.||:..||::.|||..:.:|.
Mouse   624 VGNKFRSSLYLLMETLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLRACGVLETIRISAQSYPS 688

  Fly   623 HLSHKDFIVRYKCLIKNKSFEYPQK--YLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRK 685
            ..::.:|..||..|:..:......|  ....:|.:....:.::|.|::|||.|......||..|.
Mouse   689 RWTYLEFYSRYGILMTQQELSLSDKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRL 753

  Fly   686 DTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRG----------------WR-------- 726
            |.|.::.::|||:.:.:..::.|||.:||.|.||..:||                |.        
Mouse   754 DKLRQDCIMIQKHVRGWLQRRKFLRERQAALTIQRYFRGQQTVRKAITATALKEAWAAIILQKYC 818

  Fly   727 ----LRIRFMRMRRSAIVIQSRLRGVFAR--------EVAAAL---------------------- 757
                :|..:..:|.:.|.||:..||..||        |..|.:                      
Mouse   819 RGYLVRNLYQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRFVL 883

  Fly   758 ---------REMKRVDEELKKRDGIYEQLTSITTKTLADCER----------------------- 790
                     |..|:::::.::..|:.|:|||:....:.|.|:                       
Mouse   884 NIQLTYRVQRLQKKLEDQNRENHGLVEKLTSLAALRVGDLEKVQKLEAELEKAATHRHSYEEKGR 948

  Fly   791 ----SIQEELSVL-----------AHISDNIRASAKPLSDKNDSDSNTARSSI---KQNTVNLDN 837
                :::|.||.|           ......::..::.|.:|.|..:......:   :|..:.|:.
Mouse   949 RYRDTVEERLSKLQKHNAELELQRERAEQMLQEKSEELKEKMDKLTRQLFDDVQKEEQQRLVLEK 1013

  Fly   838 MFDFLCESKGAFENAL------IKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTV 896
            .|:...:   |:|..:      ||.:.|..:.|...|:|       .:.:.|..|......:|..
Mouse  1014 GFELKTQ---AYEKQIESLREEIKALKDERSQLHHQLEE-------GQVTSDRLKGEVARLSKQA 1068

  Fly   897 RTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSS 961
            :|:.|                 .|...|.:...|:...|.::.:|..:.:..|       ..|..
Mouse  1069 KTISE-----------------FEKEIELLQAQKIDVEKHVQSQKREMRERMS-------EVTKQ 1109

  Fly   962 VFVKYQIDERENRRKQRVEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNFIST 1026
            :...|.|::..:|           |::.|:.   |::       |..|.:|....|......:.:
Mouse  1110 LLESYDIEDVRSR-----------LSVEDLE---HLN-------EDGELWFAYEGLKKATRVLES 1153

  Fly  1027 PTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQII 1091
            ..|..|..     :|..:...:.|:    :|:....|.:.  .:|||             |..| 
Mouse  1154 HFQSQKDC-----YEKEIEGLNFKV----VHLSQEINHLQ--KLFRE-------------ETDI- 1193

  Fly  1092 QYIVGLGIEREELRDEIFIQCIRQSRNNPNI-DWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKK 1155
                     .|.:|.|:    .|.:..|..| |:..:|      |.:..|...|..|     :|:
Mouse  1194 ---------NESIRHEV----TRLTSENMMIPDFKQQI------SELERQKQDLESR-----LKE 1234

  Fly  1156 SMIELDGKLRQYSQWCFDNCKSTKVSTRM-----YPPSSVEVAAMRRLGTIVCRFFFLDARTKAI 1215
            ...:::|||.:    .|.:....:...||     :|                    ||.|.....
Mouse  1235 QAEKIEGKLEE----PFSHLNRIREEERMQGRAPHP--------------------FLRAVEAQS 1275

  Fly  1216 DVHP--TDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISSWEMKQATYAGT 1278
            ::||  .:....|:.:..|.:...        :.:|:.||.::|.          ..::|:....
Mouse  1276 EMHPEGKERLVGAIHEPHEAIKFP--------KKQPEAEEEVESI----------LQQEASRLSL 1322

  Fly  1279 KKTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAVHSV---------------VKKDE 1328
            :|     ...|.:...|.|:.:..    ||.|:.....::..:.|               .|:||
Mouse  1323 EK-----RDLEEELDMKDRMIRRL----QDQVKTLTKTTEKANHVHLPSGSREYLGMLEYKKEDE 1378

  Fly  1329 FPVSEKVALQL----------AGLQAQV---------ALGDPSNQPKPEYYSDINSFLPI---RI 1371
            ..:.:.:.|.|          .||.|.:         :|.| :|..|....|.||....:   ..
Mouse  1379 GKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLND-ANMLKSLMNSAINGIKHVVKEHF 1442

  Fly  1372 SKTREQQFWIPILAQAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNYKG----------- 1425
            .......||                 |:....:|:|:.||.  |...| :.|..           
Mouse  1443 EDLEMLSFW-----------------LSNTCHFLNCLKQYS--GEEEF-MKYNSPQQNKNCLNNF 1487

  Fly  1426 ----YWNLASNIILGIHYDGIMFINPEDKSVVF--QFKYVDIESIL-LDPSDSFITISLNRSAQL 1483
                |..:.|::.:.|::..|:.:....:.::.  ..:|..::.|. |.|     |....||:.:
Mouse  1488 DLTEYRQILSDVAIRIYHQFIIVMENNLQPIIVPGMLEYESLQGISGLKP-----TGFRKRSSSI 1547

  Fly  1484 LKTSLYGSSLIESQKCFVFETPQKNDIGSLIIS------YY----PALSNWILNNLECSKKYKGT 1538
            ..|..|..:.|..|..:.:.|..:|.:...|:.      :|    ..|::.:|....||.: || 
Mouse  1548 DDTDAYTMTSILQQLSYFYSTMCQNGLDPEIVRQAVKQLFYLVGAVTLNSLLLRKDMCSCR-KG- 1610

  Fly  1539 TKEDRLRLYQNVVLCRRHLVDMNIVKKPHDFGGFLRNTLRRLSKHRLEKLRSEVGSNTQEHGETY 1603
                 :::..|:......|.|.|:...              |:|..||.|               
Mouse  1611 -----MQIRCNISFLEEWLKDKNVQSS--------------LAKETLEPL--------------- 1641

  Fly  1604 KGFSHTFWAF--------SKQQIPFCISTISDQEEALMIQVFDSILTYSGLGSSGESISRAEDEH 1660
               |...|..        ..::|..|.:::|      .:|:...:.:|:.:   .:...|.....
Mouse  1642 ---SQAAWLLQVKKTTDSDAKEIAQCCTSLS------AVQIIKILNSYTPI---DDFEKRVNPSF 1694

  Fly  1661 IRIIQSIM-DKCMKKESLLNELYL-QLIKQTTDHPDA 1695
            :|.:|::: ::....:.:|:..|| |:....|..|.|
Mouse  1695 VRKVQALLNNRGDSAQLMLDTKYLFQVTFPFTASPHA 1731

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo81FNP_001303492.1 MYSc 8..685 CDD:214580 257/713 (36%)
Motor_domain 23..673 CDD:277568 248/686 (36%)
MyTH4 1091..1194 CDD:279165 20/108 (19%)
B41 1202..1419 CDD:214604 43/255 (17%)
UBQ 1202..1297 CDD:294102 15/96 (16%)
FERM_M 1307..1419 CDD:278785 27/148 (18%)
PH-like 1415..1523 CDD:302622 23/135 (17%)
MyTH4 1664..1771 CDD:279165 8/34 (24%)
UBQ 1780..1860 CDD:294102
B41 1781..1992 CDD:214604
FERM_B-lobe 1893..1984 CDD:271216
PH-like 1988..2076 CDD:302622
Myo5cXP_006510998.1 MYSc_Myo5 81..741 CDD:276831 248/687 (36%)
DUF3584 <767..>1043 CDD:378817 46/278 (17%)
SMC_prok_A <922..1276 CDD:274009 76/481 (16%)
ERM 1220..>1354 CDD:366293 30/189 (16%)
Myo5c_CBD 1376..1743 CDD:271260 75/430 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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