Protein Alignment Myo81F and myo-3

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_506065.2
• Gene: myo-3 / 179676
• WormBaseID: WBGene00003515
• Length: 1969
• Species: Caenorhabditis elegans
• Alignment Length: 2213
• Identity: 503/2213 - (22%)
• Similarity: 874/2213 - (39%)
• Gaps: 599/2213 - (27%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            ||..::.::|..:..||..||...:||||:|...:.:||||.:.|:::..|..:...:..::.||
 Worm    90 DMANLTFLNEASVLGNLKDRYKDLMIYTYSGLFCVVINPYKRLPIYSESVIKHFMGKRRNEMPPH 154

  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSS------------WV 129
            :|||::.||.::|.|..||:.:|:|||||||||:||.::.|...:.:..::            .:
 Worm   155 LFAVSDEAYRNMVQDKENQSMLITGESGAGKTENTKKVISYFAIVGATQAASGKEAKDGKKGGTL 219

  Fly   130 QQQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGER 194
            ::||::.|.:|||||||||.||:||||||||::..|..:..:.|..|..||||:||:..|:.|||
 Worm   220 EEQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRTHFSGSGKLAGGDIEHYLLEKSRVVRQAPGER 284

  Fly   195 NYHIMYQLVAQGQKN----IGIANTFHLRPAEFYKYLNTSN------SEKINMNLESKKFDAV-- 247
            .|||.||:::....:    :.::|..     .:|.:.:.:.      .:|..|.|..:.||.:
 Worm   285 CYHIFYQIMSGNDPSLRGKLKLSNDI-----TYYHFCSQAELTIEGMDDKEEMRLTQEAFDIMGF 344

  Fly   248 ----TMAFTVLQIPQFVIDGVFKVISSILWLGNIEF--------IDVDGEVTDLTRSDQEAISII 300
                ||             .:::..:.|:.:|.::|        .:.|||        ::|::..
 Worm   345 EDNETM-------------DLYRSTAGIMHMGEMKFKQRPREEQAEPDGE--------EDALNAA 388

  Fly   301 SMLLGLSRCDFKKVLLIRQINV------RG-NITEIPLKIKEALENRHALAKALYSKMFTWLVSK 358
            :| ||:...:|.|.|...::.|      :| |:.::...:.       .||||:|::||.|::::
 Worm   389 AM-LGIQAEEFLKALTKPRVRVGTEWVNKGQNLEQVNWAVS-------GLAKAIYARMFKWIITR 445

  Fly   359 INNCTNPGQDDAK-FLGVLDIFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGI 422
            .|...:..:.:.| |:|||||.|||.|..||||||.||:.||:|.:||||::|.|||..|:.|||
 Worm   446 CNKTLDAKEIERKHFIGVLDIAGFEIFDLNSFEQLWINFVNERLQQFFNHHMFVLEQEEYKREGI 510

  Fly   423 YFNHVEF-TDNTPCLEILEKPPRCVFKLLTEQCHMPQGSDLAF---LSNMHTEFESHPNYIKGS- 482
            .:..::| .|...|:|::|| |..:..:|.|:|.:|:.:|:.:   |.:.|  ...|||:.|..
 Worm   511 AWTFIDFGLDLQACIELIEK-PLGIISILDEECIVPKATDMTYAQKLLDQH--LGKHPNFQKPKP 572

  Fly   483 -DRRHWETEFGIKHYAGLVIYAVGGFVEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSS 546
             ..:..:..|.|.||||.|.|....|:|||:|...|.....:.:|.|..:. |..:||.|....:
 Worm   573 PKGKQGDAHFAIVHYAGTVRYNATNFLEKNKDPLNDTAVALLKHSTDNSLM-LDIWQDYQTQEEA 636

  Fly   547 Y-----------PRGSSKSKCTVSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLV 600
            .           .||.|.|..|||..:|..|.:|:::|..|.|.::|||.||.:|.....:|:||
 Worm   637 AEAAKAGQTAGGKRGKSSSFATVSMIYRESLNNLMNMLYQTHPHFIRCIIPNEKKASGVIDSALV 701

  Fly   601 LDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCLIKNKSFEY-PQKYLTNILEK----NGMPT 660
            |:||...||::.|||.|:|||..:.:.||..||..|..:.:.|. |:|....||:|    ..:..
 Worm   702 LNQLTCNGVLEGIRICRKGFPNRMLYPDFKHRYAILAADAAKESDPKKASVGILDKISVDGNLTD 766

  Fly   661 TEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQKNWKKYYIQKSFLRNK----QAVLRIQHA 721
            .|:::|::|||.:......||..|.:.|.:...:.|...:. |:.|:.:|.:    ..:|.:|..
 Worm   767 EEFKVGETKIFFKAGVLAKLEDLRDEILSRIVTMFQSRIRS-YLAKAEVRRRYEQQTGLLVVQRN 830

  Fly   722 YRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALR-EMKRVDEELKKRDGIYEQLTSITTKTL 785
            .|.| ..:|.....:....::..|:....:|....|. ::::::|.:::.:....||.|    .:
 Worm   831 VRAW-CTLRTWEWFKLFGKVKPMLKAGKEQEAMGELAVKIQKLEEAVQRGEIARSQLES----QV 890

  Fly   786 ADCERSIQEELSVLAHISDNIRASAKPLSDKNDSDSN---TARSSIKQNTVNLDNMFDFLCESKG 847
            ||    :.||.:.|....:..:|:.....::|:..:.   |..|.:...|..|::|
 Worm   891 AD----LVEEKNALFLSLETEKANLADAEERNEKLNQLKATLESKLSDITGQLEDM--------- 942

  Fly   848 AFENALIKEINDNWNNLVKNLDEEIG-LCIHTED---SFDSQKTGKLFTTKTVRTLPEPTVPPPP 908
                   :|.|::.....|..|:|:. ...|.:|   |....:..|......:|:|.:......
 Worm   943 -------QERNEDLARQKKKTDQELSDTKKHVQDLELSLRKAEQEKQSRDHNIRSLQDEMANQD- 999

  Fly   909 PPVSISANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDE--- 970
               ...|.||.|..::..:..||....:.:::|...|:    |..:|        ::.|:||
 Worm  1000 ---EAVAKLNKEKKHQEESNRKLNEDLQSEEDKVNHLE----KIRNK--------LEQQMDELEE 1049

  Fly   971 ---RENRRKQRVEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGK 1032
               ||.|.:..:||...:     :..|:.:...  ||.|..:   ..||:
 Worm  1050 NIDREKRSRGDIEKAKRK-----VEGDLKVAQE--NIDEITK---QKHDV--------------- 1089

  Fly  1033 SSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQIIQYIVGL 1097
                    |.|:..|.:.:..::..:.:..:::   :..:.|.|.:... |||.|
 Worm  1090 --------ETTLKRKEEDLHHTNAKLAENNSII---AKLQRLIKELTAR-NAELE---------- 1132

  Fly  1098 GIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDG 1162
                |||..|      |.||..     :||              |:       |..::.:.||..
 Worm  1133 ----EELEAE------RNSRQK-----SDR--------------SR-------SEAERELEELTE 1161

  Fly  1163 KLRQYSQWCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTA---- 1223
            :|.|..       .:|............|:|.:|              |.|..|....:||
 Worm  1162 RLEQQG-------GATAAQLEANKKREAEIAKLR--------------REKEEDSLNHETAISSL 1205

  Fly  1224 ----GDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISSWEMKQATYAGTKKTTNG 1284
                ||:|.:|.|:|.                                          |.:....
 Worm  1206 RKRHGDSVAELTEQLE------------------------------------------TLQKLKA 1228

  Fly  1285 SSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAVHSVVKKDEFPVSE---KVALQLAGLQAQV 1346
            .|..|     |.:|.:...| ||...:..:...|.:...:|..|...||   |...|...||...
 Worm  1229 KSEAE-----KSKLQRDLEE-SQHATDSEVRSRQDLEKALKTIEVQYSELQTKADEQSRQLQDFA 1287

  Fly  1347 ALGDPSNQPKPEYYSDINSFLP---------IRISKTREQQFWIPILAQAHRQY---GSSRNALT 1399
            ||.:..|...    ||:|..|.         .|:..|.:.|     |.:..|.|   ...|.||.
 Worm  1288 ALKNRLNNEN----SDLNRSLEEMDNQLNSLHRLKSTLQSQ-----LDETRRNYDEESRERQALA 1343

  Fly  1400 AKVLYLSCVMQYPLYGTTMFKVNYKGYWNLASNIILGIHYD-----------GIMFINPEDKSVV 1453
            |....|.                       ..|.||..|.|           .|..:|.|.:...
 Worm  1344 ATAKNLE-----------------------HENTILREHLDEEAESKADLTRQISKLNAEIQQWK 1385

  Fly  1454 FQFKYVDIESILLDPSDSFITISLNRSAQLLKT--------SLYGSSLIESQKCFVFETPQ---- 1506
            .:|   |.|.:     :....|...:.|..||.        .|:..  |.||:...|:..|
 Worm  1386 ARF---DSEGL-----NKLEEIEAAKKALQLKVQELTDTNEGLFAK--IASQEKVRFKLMQDLDD 1440

  Fly  1507 -KNDI--GSLIISYY--------PALSNW------ILNNLECSKK---------YKGTTKEDRLR 1545
             ::|:  .:..:::|        ..::.|      :.:.|:.:::         :|..|..|.|.
 Worm  1441 AQSDVEKAAAQVAFYEKHRRQFESIIAEWKKKTDDLSSELDAAQRDNRQLSTDLFKAKTANDELA 1505

  Fly  1546 LYQNVVLCRRHLVDMNIVKKPHDF------GG----FLRNTLRRL--SKHRLEK----------- 1587
            .|.:..  ||.  :.::.::..|.      ||    .|:..:|:|  .|..|:|
 Worm  1506 EYLDST--RRE--NKSLAQEVKDLTDQLGEGGRSVAELQKIVRKLEVEKEELQKALDEAEAALEA 1566

  Fly  1588 --------------LRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQEEALMIQVFD 1638
                          :|||:....||..|.::                  :|..:.:.||
 Worm  1567 EEAKVLRAQIEVSQIRSEIEKRIQEKEEEFE------------------NTRRNHQRAL------ 1607

  Fly  1639 SILTYSGLGSSGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKN 1703
                 ..:.::.|:.::.::|.:||.:       |.||.:|:|.:.|......:.||...:. |.
 Worm  1608 -----ESMQATLEAETKQKEEALRIKK-------KLESDINDLEIALDHANRAYADAQKTIK-KY 1659

  Fly  1704 WALLSVLCSVILPSMK---AVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRTQGTRRRQWTPS 1765
            ...:..|...|....:   .:|:..:|..|| ::...||:.:.|:.|| ...|.:.....:....
 Worm  1660 METVQELQFQIEEEQRQKDEIREQFLASEKR-NAILQSEKDELAQQAE-AAERARRNAEAECIEL 1722

  Fly  1766 REE--------ILCTTNRRPCYSKFYFMDGQYYSIEFQPSSTANDV------------------- 1803
            ||:        ...|..||.       ::|:..:...:....||::
 Worm  1723 REQNNDLNAHVSALTGQRRK-------LEGELLAAHAELEEIANELKNAVEQGQKASADAARLAE 1780

  Fly  1804 -----------LEIIKKKIGL--------LDNAKGYSI---YEVIGNSERSLSSEEKVCDVMAKW 1846
                       :|.|:|.:.|        ||:|:..::   .::|...|..:.:.|:..|  .:.
 Worm  1781 ELRQEQEHSMHIERIRKGLELQIKEMQIRLDDAENAALKGGKKIIAQLEARIRAIEQELD--GEQ 1843

  Fly  1847 EKYQITSQQGFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVEKELLYHQILHNLRSERYPIT 1911
            .::|.| ::.::|....:.:....:...||     |...|.::|:|      :...|:..:..:.
 Worm  1844 RRHQDT-EKNWRKAERRVKEVEFQVVEEKK-----NEERLTELVDK------LQCKLKIFKRQVE 1896

  Fly  1912 EMEAI---------MLTALQSQL-ERGDCCESI-----TDYRAVASHCLPPRFVPNIPHEAVAMH 1961
            |.|.:         :|||...|. ||.|..|:.     ...||.|| ..||...|.:|..:.|:.
 Worm  1897 EAEEVAASNLNKYKVLTAQFEQAEERADIAENALSKMRNKIRASAS-MAPPDGFPMVPSASSALI 1960

  Fly  1962 HQS 1964
            ..|
 Worm  1961 RSS 1963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	235/715 (33%)
		MyTH4	1091..1194	CDD:459939	17/102 (17%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	15/108 (14%)
		B41	1202..1419	CDD:214604	46/239 (19%)
		PH-like	1415..1523	CDD:473070	23/141 (16%)
		MyTH4	1664..1771	CDD:459939	23/117 (20%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	21/145 (14%)
		B41	1781..1992	CDD:214604	44/240 (18%)
		PH-like	1988..2076	CDD:473070
myo-3	NP_506065.2	COG5022	32..1420	CDD:227355	394/1601 (25%)
		MYSc_class_II	100..779	CDD:276951	235/716 (33%)
		SMC_prok_B	1182..1933	CDD:274008	163/918 (18%)