DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo81F and Myo5b

DIOPT Version :9

Sequence 1:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster
Sequence 2:XP_006525777.1 Gene:Myo5b / 17919 MGIID:106598 Length:1849 Species:Mus musculus


Alignment Length:1969 Identity:484/1969 - (24%)
Similarity:792/1969 - (40%) Gaps:548/1969 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.||: .|:.||||.|.:|:|:|||:.:.|:.:..|..|....:|
Mouse    69 VGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMG 133

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSW-VQQQILE 135
            |:.||:|||||.||..:..|..||:.::|||||||||.|.|:.::|..|:..:.|.. :::::|.
Mouse   134 DMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLA 198

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            ::.|:||.|||||||||||||||||:::.||....|.|..:..||||:||:.||::.||||||.|
Mouse   199 SSPIMEAIGNAKTTRNDNSSRFGKFIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFY 263

  Fly   201 QLVAQGQ----KNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVI 261
            ||.|...    |.:.      |..||.:.|.....:..|....::..|:....|.|:|.:.....
Mouse   264 QLCAAASLPEFKELA------LTCAEDFFYTAHGGNTTIEGVNDADDFEKTRQALTLLGVRDSHQ 322

  Fly   262 DGVFKVISSILWLGNIEF-IDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINVRGN 325
            ..:||:|:|||.||::|. .:.||:...::..| |.:|....|||:.....:..|..|::.....
Mouse   323 ISIFKIIASILHLGSVEIQSERDGDSCSISPQD-EHLSNFCSLLGIEHSQMEHWLCHRKLVTTSE 386

  Fly   326 ITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGFENFSHNSFE 390
            .....:.:::.:..|.||||.:|:::|:|:|..||...:.......|:|||||:|||.|..||||
Mouse   387 TYVKTMSLQQVVNARDALAKHIYAQLFSWIVEHINKALHTSLKQHSFIGVLDIYGFETFEINSFE 451

  Fly   391 QLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTEQCH 455
            |.||||.||||.:.||.:||.|||..|..|.|.:..::|.||.||::::| ....:..||.|:|.
Mouse   452 QFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIE-AKLGILDLLDEECK 515

  Fly   456 MPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRDVQQDVMF 520
            :|:|:|..:...:   :|.|.|.......|...|.|.:.|:|..|.|...||:|||||...:...
Mouse   516 VPKGTDQNWAQKL---YERHSNSQHFQKPRMSNTAFIVNHFADKVEYLSDGFLEKNRDTVYEEQI 577

  Fly   521 EYMSYSKDVFIKDLSTYQD----IQFINSSYPRGSSK----------------SKCTVSDNFRNQ 565
            ..:..||...:.||  :.|    ....|::..|.|||                .|.:|...||..
Mouse   578 NILKASKFPLVADL--FHDDKDSAPATNTAKNRSSSKINVRSSRPLIKVPNKEHKKSVGYQFRTS 640

  Fly   566 LQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFI 630
            |..|::.|..|.|.||||||||.:|.|.:::....:.||:..||::.|||...|:|...::.||.
Mouse   641 LNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFF 705

  Fly   631 VRYKCLIKNKSFEYPQKYLTNILEKNGMPTT---------EWQIGKSKIFLRNAAYELLETNRKD 686
            .||:.|:|.:.       |||..:||...:.         ::|.|::|||.|......||..|.|
Mouse   706 NRYRVLMKKRE-------LTNTDKKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRAD 763

  Fly   687 TLYKNAVIIQKN---W------------------------------------------KKYYIQK 706
            ...:..::|||:   |                                          |:|.:.|
Mouse   764 KFREATIMIQKSVRGWLQRVKYRRLRAATLSLQRFCRGYLARRLAEHLRRTRAAIVFQKQYRMLK 828

  Fly   707 ----------------SFL------RNKQAVLR------IQHAYRGWRLRIRFMRMRRSAIVIQS 743
                            ||.      ||.:.||.      ||...|||..|.||:|.|.:|||||.
Mouse   829 ARRAYRRVCRATVIIQSFTRAMFVRRNYRQVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQC 893

  Fly   744 RLRGVFAREVAAALR-------EMKR---------------VDEELKKRDGIYEQLTSITTKTLA 786
            ..|.:.||:...||:       .:||               :|::.|:...:.|||:::|:....
Mouse   894 AFRRLKARQELKALKIEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSSHAV 958

  Fly   787 DCERSIQEELSVLAHISDNIRASA----------------KPLSDKN--DSDSNTARSSIKQNTV 833
            :.|:..:|    |||...|..|..                |..|::.  :...|.....:::...
Mouse   959 EVEKLKKE----LAHYQQNQEADTSLQLQEEVQSLRTELQKAHSERRVLEDAHNKENGELRKRVA 1019

  Fly   834 NLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRT 898
            :|::            ||||:|:..:..||.:        ||....:|..|              
Mouse  1020 DLEH------------ENALLKDEKEYLNNQI--------LCQSKAESSQS-------------- 1050

  Fly   899 LPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVF 963
                         |:..||          |.|    ||:::|:                      
Mouse  1051 -------------SVEENL----------LMK----KELEEER---------------------- 1066

  Fly   964 VKYQ-IDERENRRKQRVEKKIHELTLIDI---HKDIHIDNSFYNILEFAENYFNTHDLSSDCNFI 1024
            .:|| :.:..::.:||.|....|:|::..   |:               :|..|...|.||.|:.
Mouse  1067 SRYQNLVKEYSQLEQRYENLRDEVTILKQTPGHR---------------KNPSNQSSLESDSNYP 1116

  Fly  1025 STPTQK-GKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAEREL 1088
            |..|.: |.:.|...:.|.....|:                .:..::|.:|.|.:| ||..||:.
Mouse  1117 SISTSEIGDTEDALQQVEEIGIEKA----------------AMDMTVFLKLQKRVR-ELEQERKK 1164

  Fly  1089 QIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFI 1153
            ...|...|   :::..:.:     :.|..|..::|                |.:.:.:    :.:
Mouse  1165 LQAQLEKG---QQDSKKGQ-----VEQQNNGLDVD----------------QDADIAY----NSL 1201

  Fly  1154 KKSMIELDGK--------LRQ--YSQWCFDNCKSTKVSTRMYPPS----------SVEVAAMRRL 1198
            |:..:|.:.|        ||:  ..|...||      ||...|.|          :.|...:|:.
Mouse  1202 KRQELESENKKLKNDLNELRKAVADQAMQDN------STHSSPDSYSLLLNQLKLANEELEVRKE 1260

  Fly  1199 GTIVCRFFFLDA---RTKAIDVHPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDY 1260
            ..::.|...::|   |....::.|               |:.....|      |:.|:|:...|.
Mouse  1261 EVLILRTQIMNADQRRLSGKNMEP---------------NINARTSW------PNSEKHVDQEDA 1304

  Fly  1261 LYDVISSWEMKQATYAGTKKTTNG-------SSSGENQFVFK-----KRLFKS-------THELS 1306
            :           ..|.|..:|.:.       :..||....::     .||.::       .||  
Mouse  1305 I-----------EAYHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHE-- 1356

  Fly  1307 QDPVEVSMLYSQAVHSVVKKDEFPVSEKVALQ--LAGLQAQVALGD------------------- 1350
               .||..|.:| |.::  |:|....::...|  |...:|||..|.                   
Mouse  1357 ---EEVEHLKAQ-VEAL--KEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVE 1415

  Fly  1351 --PSNQPKPEYYSDINSFLPIRISKTREQQFWIPILAQAHRQYGSSRNALTAKVLYLSCVMQYPL 1413
              ..|:.|      :...|.|.:.|.::.:     .|||..|.....:.||.:|           
Mouse  1416 KLEKNERK------LKKQLKIYMKKVQDLE-----AAQALAQSDRRHHELTRQV----------- 1458

  Fly  1414 YGTTMFKVNYKGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKYVDIESILLDPS----DSFIT 1474
              |...|..               .:.|::..:.||::::.:....|::..:|..:    .::|.
Mouse  1459 --TVQRKEK---------------DFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYIL 1506

  Fly  1475 ISLNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSNWILNN---LECSKKYK 1536
            ....|.|......|...||:.|....:.:..:|::      ..:...|.|:.|.   |.|.|:|.
Mouse  1507 YMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHN------DDFEMTSFWLSNTCRFLHCLKQYS 1565

  Fly  1537 G--------TTKEDR-------------------LRLYQNVVLCRRHLVDMNIVKKPHDFGGFLR 1574
            |        |.|::.                   :::||.::.....|:...||      ...|.
Mouse  1566 GDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIV------SAMLE 1624

  Fly  1575 N-TLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQ--EEALMIQV 1636
            | :::.||..|....|..  |::...||.    |:...|..:|...| .:.:.||  :..:::||
Mouse  1625 NESIQGLSGVRPTGYRKR--SSSMVDGEN----SYCLEAIVRQMNSF-HTVLCDQGLDPEIILQV 1682

  Fly  1637 FDSI------LTYSGLGSSGESISRAEDEHIRIIQSIMDKCMKKESL--------LNEL-----Y 1682
            |..:      :|.:.|....::.|.:....:|...|.:::.::.::|        :..|     .
Mouse  1683 FKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYNISQLEEWLRGKNLHQSGAVQTMEPLIQAAQL 1747

  Fly  1683 LQLIKQTTDHPDANSRVNL 1701
            |||.|:|  |.||.:..:|
Mouse  1748 LQLKKKT--HEDAEAICSL 1764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo81FNP_001303492.1 MYSc 8..685 CDD:214580 255/712 (36%)
Motor_domain 23..673 CDD:277568 246/685 (36%)
MyTH4 1091..1194 CDD:279165 19/122 (16%)
B41 1202..1419 CDD:214604 45/261 (17%)
UBQ 1202..1297 CDD:294102 15/109 (14%)
FERM_M 1307..1419 CDD:278785 26/134 (19%)
PH-like 1415..1523 CDD:302622 15/111 (14%)
MyTH4 1664..1771 CDD:279165 12/51 (24%)
UBQ 1780..1860 CDD:294102
B41 1781..1992 CDD:214604
FERM_B-lobe 1893..1984 CDD:271216
PH-like 1988..2076 CDD:302622
Myo5bXP_006525777.1 COG5022 11..>1268 CDD:227355 377/1371 (27%)
MYSc_Myo5 83..750 CDD:276831 246/686 (36%)
EnvC 1136..>1449 CDD:227278 70/414 (17%)
Myo5b_CBD 1475..1846 CDD:271261 61/311 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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