Protein Alignment Myo81F and zip

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_061501560.1
• Gene: zip / 1269708
• VectorBaseID: AGAMI1_003426
• Length: 1964
• Species: Anopheles gambiae
• Alignment Length: 2156
• Identity: 500/2156 - (23%)
• Similarity: 905/2156 - (41%)
• Gaps: 487/2156 - (22%)

  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76
            ||.|::.::|..:..|:..||.|.:||||:|...:.|||||.:.|:.::.:.:|...|..::.||
Mosquito    91 DMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMEKYKGIKRHEVPPH 155

  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSN-------------VSSW 128
            |||:.:.||.|::.|..:|:.:.:|||||||||:||.::|||..:.::             :...
Mosquito   156 VFAITDTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAYVAASKPKGSVATPTPALIIGE 220

  Fly   129 VQQQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGE 193
            ::||:|:||.||||||||||.:||||||||||:::.||.:..|.|..|..||||:||...|::.|
Mosquito   221 LEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGYISGANIETYLLEKSRAIRQAKDE 285

  Fly   194 RNYHIMYQLVA-----QGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTV 253
            |.:||.|||:|     |.::       |.|...:.|.:|:........:: :..:|.|...:..:
Mosquito   286 RTFHIFYQLLAGASPEQRER-------FILDDVKTYPFLSNGGLPVPGVD-DYAEFQATVKSMNI 342

  Fly   254 LQIPQFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIR 318
            :.:.....:.:|:::|::|..|::.| ..:......|..|......|:.||||:..|..|..|..
Mosquito   343 MGMTSEDFNSIFRIVSAVLLFGSMTF-KQERNSDQATLPDNTVAQKIAHLLGLNVTDMTKAFLTP 406

  Fly   319 QINV-RGNITEIPLK--IKEALENRHALAKALYSKMFTWLVSKIN-NCTNPGQDDAKFLGVLDIF 379
            :|.| |..:|:...:  ::.|:|   |:|||.|.|||.|||::|| :.....:..|.|:|:||:.
Mosquito   407 RIKVGRDFVTKAQTREQVEFAVE---AIAKACYEKMFKWLVNRINRSLDRTKRQGASFIGILDMA 468

  Fly   380 GFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKPP 443
            |||.|..|||||||||||||||.:.|||.:|.|||..|:.|||.:..::| .|..|.:::::||.
Mosquito   469 GFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG 533

  Fly   444 RCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFV 508
            . :..||.|:|..|:.:|.:|:..:......||.::|...|  ...:|.:.||||.|.|:...::
Mosquito   534 G-IMALLDEECWFPKATDKSFVEKLAAAHSMHPKFMKTDFR--GVADFAVVHYAGKVDYSATKWL 595

  Fly   509 EKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPR------GSSKSK---CTVSDNFRN 564
            .||.|...:.:...:..|:|.|:  :..::|.:.:..:...      |:...|   .|||..::.
Mosquito   596 MKNMDPLNENVVSLLQASQDPFV--VQIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKE 658

  Fly   565 QLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDF 629
            ||..|:|.|:||.|.:||||.||.:||....::.||||||:..||::.|||.|:|||..:..::|
Mosquito   659 QLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEF 723

  Fly   630 IVRYKCLIKN---KSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYK- 690
            ..||:.|..|   |.|...::....:::...:.:..::||:||||.|......||..|.   ||
Mosquito   724 RQRYELLTPNVIPKGFMDGKRACEQMIKSLELDSNLYRIGQSKIFFRAGVLAHLEEERD---YKI 785

  Fly   691 -----------NAVIIQKNWKKYYIQKSFL----RNKQAVLRIQHAYRGWRLRIRFMRMRRSAIV 740
                       ...:.::|::|...|.:.:    ||..|.|:::: ::.|||..:...:
Mosquito   786 TDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRN-WQWWRLYTKVKPL------ 843

  Fly   741 IQSRLRGVFAREVAAALREMKRVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLAHISDN 805
                      .||.....::.:.::||::   |.::|.:: :|...:.|:..|:.:....|:::.
Mosquito   844 ----------LEVTKQEEKLVQKEDELRQ---IRDKLENL-SKNSQEYEKKYQQAMEEKTHLAEQ 894

  Fly   806 IRAS-----------AKPLSDKNDSDS----------------NTARSSIKQNTVNLDNMFDFLC 843
            ::|.           |:.::.|.:.:.                |...|..|:..:|:.::.:.|.
Mosquito   895 LQAEIELCAEAEEGRARLVARKQELEELMQDLESRIEEEEERVNALTSEKKKLQINIQDLEEQLE 959

  Fly   844 ESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPP 908
            |.:.|.:...::::  ..:..:|.::|::.|   .||     :..||  .|..:.|.|
Mosquito   960 EEEAARQKLQLEKV--QLDAKLKKMEEDVAL---IED-----QNHKL--VKEKKLLEE------- 1005

  Fly   909 PPVSISANLNSEPIYE----AINLYKLTTTKE---IKKEKYMLLDYKSIK--DNSK-KPSTSSVF 963
                 .||..|:.:.|    |.:|.||....|   .:.|:.:|.|::..:  |.|| |..|....
Mosquito  1006 -----RANDLSQTLAEEEEKAKHLAKLKVKHESTIAELEERLLKDHQQRQEADRSKRKIETEVAD 1065

  Fly   964 VKYQIDERE---NRRKQRVEKKIHEL--TLIDIHKDI-----------HIDNSFYNILE--FAEN 1010
            :|.||:||.   ...:|::.|:..||  ||:.|.::.           .:::....|.|  .||.
Mosquito  1066 LKEQINERRMQIEEMQQQLVKREEELAQTLVRIDEESAAKAAAQKTQRELESQLAEIQEDLEAEK 1130

  Fly  1011 YFNT------HDLSSDCNFI-----------------------STPTQKGKSSDKTAKHEMTMFS 1046
            ...:      .||:.:...:                       ...|.|....|::|.||.|:
Mosquito  1131 LARSKAEKQKRDLNEELEALKNELLDSLDTTAAQQELRSKREQEVATLKKTLEDESANHESTL-- 1193

  Fly  1047 KSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFIQ 1111
                :...|.|..:    :.|.:...|..|.|:|.|...::        .|..|..:|..|  ::
Mosquito  1194 ----MDMRHKHAQE----ISSINEQLENLKKMKGGLEKSKQ--------QLEAENADLATE--LR 1240

  Fly  1112 CIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCK 1176
            .:.|||..     .||........|...|..       ::.:.:..:||..|:.:..|      :
Mosquito  1241 NVNQSRQE-----NDRRRKQAETQIAELQVK-------LADVDRVRVELQDKVTKLQQ------E 1287

  Fly  1177 STKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLA--EKLNLTTT 1239
            |..::.::........||::..|.:..:.      |:|..:...:|.    ||||  .||....:
Mosquito  1288 SENITQQLDEAELKASAAIKSAGNLESQL------TEAQQLLEEETR----QKLALSSKLRQIES 1342

  Fly  1240 DGWAIYQNRPDGEEHIKSYDYLYDVISSWEMKQA----TYAGTKKTTNGSSSGENQFVFKKRLFK 1300
            :..|:.:...:.||...:|          |.|.|    |....||.:...|.      ..|.|.:
Mosquito  1343 EKEALQEQLEEDEEAKTNY----------EKKLAELNFTIQEMKKRSEEDSD------IAKELEE 1391

  Fly  1301 STHELSQDPVEVSMLYSQAVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDI-N 1364
            |..::::|                       .|.:..|:..||   |..|..::.|.:..|:: :
Mosquito  1392 SKKKMNKD-----------------------IETLQRQIQELQ---AANDRLDKSKKKIQSELED 1430

  Fly  1365 SFLPIRISKT------REQQFWIPILAQ---AHRQYGSSRNAL-------TAKVLYLSCVMQYPL 1413
            :.:.:...:|      ::|:.:..:||:   ...|....|:|.       ..|||.|:..:....
Mosquito  1431 ATIELDTQRTKVLELEKKQKNFDKVLAEEKAISEQVAQERDAAEREAREKETKVLSLTRELDEAF 1495

  Fly  1414 YGTTMFKVNYKGYWN----LASNIILGIHYDGIMFINPEDKSVVFQFKYV-----DIESILLDPS 1469
            ......:...||..|    ||:.  .|.....:..:....:::..|...:     ::|..|....
Mosquito  1496 EKIDELETKRKGLQNELDELANT--QGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTE 1558

  Fly  1470 DSFITISLNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISYYPALSNWILNNLECSKK 1534
            |:.:.:.:|..|            :.:|    ||    .||.:              ...:..:|
Mosquito  1559 DAKLRLEVNMQA------------LRAQ----FE----RDIQA--------------KEEQSEEK 1589

  Fly  1535 YKGTTK----------EDRLRLYQNVVLCRR---HLVDMNIVKKPHDFGGFLRNTLRRLSKHRLE 1586
            .:|..|          |:|.:....|...::   .|.||....:       :.|.::..:..:.:
Mosquito  1590 RRGLVKALRDLEAELDEERKQRAAAVAAKKKLEGDLKDMEATLE-------MNNKVKEDALKQAK 1647

  Fly  1587 KLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQE----EALMIQVFDSILTYSGLG 1647
            ||::::....:: .|..|.......|.||:         |:::    ||.::|:.:.:
Mosquito  1648 KLQAQIKDAIRD-AEEAKAAKEELAAISKE---------SERKVKTLEADLMQLTEDL------- 1695

  Fly  1648 SSGESISR-AEDEHIRIIQSIMDKCMKKESLLN-----ELYLQLIKQTTDHPDANSRV----NLK 1702
            ||.|...| ||.|...:::.|.....|...:::     |..:..:::..:...:|..:    |.|
Mosquito  1696 SSSERARRAAEGERDELLEEINSNSSKGSLMIDEKRRLEARIAALEEELEEEQSNLELMVDRNRK 1760

  Fly  1703 NWALLSVLCSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRTQGTRRRQWTPSRE 1767
            ....:..|.:.:.......:.   ....:|..:.|::|.| |:.:|            |.|..|.
Mosquito  1761 AQLTIEQLTTELATEKSNSQN---NETLKCGLERLNKELK-AKLSE------------QETALRT 1809

  Fly  1768 EILCTTNRRPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDNAKGYSIYEVIGNSERS 1832
            ::...|..         .:.:..::|.|..:...:.|.:.|....|....|..::         :
Mosquito  1810 KLKAATAA---------SEAKNLNLEKQLENETKERLAVQKANRKLEKRIKELTM---------N 1856

  Fly  1833 LSSEEKVCDVMAKWEKYQITSQQGFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVEKELLYH 1897
            :..|.:..|        |...|         |.:.|..|...|::|         |..|:|:...
Mosquito  1857 IEDERRHAD--------QYKEQ---------IEKANNRMKTLKRNL---------DEAEEEIQKE 1895

  Fly  1898 QILHNLRSERYPITEM----EAIM--LTALQSQLERGDCCESITDYRAVASHCLPPRFVPNIPHE 1956
            :.|.  |..:....:|    ||:.  :.||:|:|.||....|::.          .|..|...::
Mosquito  1896 KTLK--RKAQRECEDMLESHEALSREVNALKSKLRRGGAMGSLSS----------TRLTPKREND 1948

  Fly  1957 AVAMHHQSLRG 1967
            ::::..:||.|
Mosquito  1949 SISVQDESLDG 1959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	241/684 (35%)
		MyTH4	1091..1194	CDD:459939	16/102 (16%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	22/106 (21%)
		B41	1202..1419	CDD:214604	43/239 (18%)
		PH-like	1415..1523	CDD:473070	17/116 (15%)
		MyTH4	1664..1771	CDD:459939	16/115 (14%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	15/104 (14%)
		B41	1781..1992	CDD:214604	35/193 (18%)
		PH-like	1988..2076	CDD:473070
zip	XP_061501560.1	None