Protein Alignment Myo81F and myo5c

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_012815050.1
• Gene: myo5c / 100495210
• XenbaseID: XB-GENE-1004095
• Length: 1721
• Species: Xenopus tropicalis
• Alignment Length: 1959
• Identity: 521/1959 - (26%)
• Similarity: 826/1959 - (42%)
• Gaps: 464/1959 - (23%)

  Fly     8 VGFADMTEMSEIDEIGINQNLNVRY-NSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLG 71
            ||..|:|.:|.:.|..:..||.||: .|::||||:|.||:|:||||.:.|:....|..|....:|
 Frog    72 VGENDLTALSYLHEPAVLHNLKVRFVESNVIYTYSGIILVAINPYKELPIYGDAIIHAYSGQNMG 136

  Fly    72 DLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVS-SWVQQQILE 135
            |:.||:|||||.||..:..:|.||:.::|||||||||.|.::.::|..|::...| :.|:.::|.
 Frog   137 DIDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYTMRYFATVSKTSSKAHVEDKVLA 201

  Fly   136 ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY 200
            :|.|.||.||||||||||||||||:.::.||....|.|..:..||||:||:.||||.||||||.|
 Frog   202 SNPITEAIGNAKTTRNDNSSRFGKYTEISFDRRYKIIGANLRTYLLEKSRVVFQSENERNYHIFY 266

  Fly   201 QLVAQGQKNIGIANTFHLRPAEFYKYLN-------TSNSEKINMNLESKKFDAVTMAFTVLQI-P 257
            ||.|...|  ......||..||.:.|.:       |...:|.:| |:::|      .|.:|.: .
 Frog   267 QLCASANK--PEFEHLHLTRAEEFNYTSMGGCTVITGVDDKKDM-LDTQK------TFALLGLGT 322

  Fly   258 QFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINV 322
            .|.:| ||||:::||.|||:|...|..:.:.:..:|:. :.|...||.|......:.|..|:|..
 Frog   323 DFQMD-VFKVVAAILHLGNVEIKRVSDDRSSVDVNDKH-LKIFCDLLNLEASKVAQWLCNRRIVT 385

  Fly   323 RGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTN-PGQDDAKFLGVLDIFGFENFSH 386
            ..:....|:..::|...|.||||.:||.:|.:::.||||... ||:... |:|||||:|||.|..
 Frog   386 VSDTVIKPMTKQQADNARDALAKKIYSHLFDYVIDKINNALQYPGKQHT-FIGVLDIYGFETFEI 449

  Fly   387 NSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLT 451
            |||||.||||.||||.:.||.:||.|||..|..|.|.:..::|.||...::::| ....:..||.
 Frog   450 NSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQIVIDLIE-AKMGILDLLD 513

  Fly   452 EQCHMPQGSDLAFLSNMHTEF-ESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRDVQ 515
            |:|.:|||:|..:|..::..: ..:|.:.|   .|.....|.|:|:|..|.|...||:|||||..
 Frog   514 EECLLPQGTDENWLQKLYNNYLNKNPLFEK---PRMSNRSFIIQHFADKVEYKCDGFLEKNRDTV 575

  Fly   516 QDVMFEYMSYSK----DVFIKDLSTYQDIQF-----INSSYPRGSSKSK---CTVSDNFRNQLQS 568
            .||:.:.:..||    ..|.:| :|.:..||     :.|:.|...|.:|   .||...|||.|..
 Frog   576 YDVLIDLLRTSKFQLCSSFFQD-NTSKSAQFSSGIQVKSARPAIKSSNKEFRMTVGSKFRNSLCL 639

  Fly   569 LIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRY 633
            |::.|..|.|.||||||||..|.|..:::..|:.||:..||::.|||..:.:|...::.:|..||
 Frog   640 LMETLNATTPHYVRCIKPNDLKLPFEFDAKRVVQQLRACGVLETIRISAQSYPSRWTYIEFFGRY 704

  Fly   634 KCLIKNKSFEY-PQKYLTNI-LEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTLYKNAVIIQ 696
            ..|:..:.... .:||:..| |::....:.::|.|::|||.|......||..|.|.|....||||
 Frog   705 SILMTQQELSLNDKKYICKIVLQRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRSDKLRNACVIIQ 769

  Fly   697 KNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFA----------R 751
            |                       :.|||..:.:|.|.||||||||...||..|          :
 Frog   770 K-----------------------SVRGWVQKKKFSRARRSAIVIQQYFRGQRAVRQAISGKALK 811

  Fly   752 EVAAALREMKRVDEELKKRDGIYEQLTSITTKTLADCER---------SIQEELSVL-------- 799
            ...||:...|.|...|.:|  || ||..:.|.|:....|         .::||...|
 Frog   812 HAWAAIIIQKYVRGFLVRR--IY-QLILVATVTIQSFTRGYLARKRYHKMREEHKALILQKYARA 873

  Fly   800 ----------------AHISDNIRASAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGA 848
                            ..:|..::...|.|.|:|           |:|
 Frog   874 WLARRRFQNVRRFVLNIQLSYRVQRLQKKLEDQN-----------KEN----------------- 910

  Fly   849 FENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSI 913
              :.|::.:    .:|..:         ||.|                              |..
 Frog   911 --HGLLERL----TSLASS---------HTHD------------------------------VDK 930

  Fly   914 SANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQR 978
            ...|.||       |.|:::.|:...||     .|..|:.:::..|.......::.|::::.:.:
 Frog   931 VHKLESE-------LEKISSQKKHLDEK-----GKKYKEEAEEKMTKLQAQNAELLEQKHQMEVK 983

  Fly   979 VEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMT 1043
            :|.|..|:      || .:|..             |:.|.:|..      ::.|...|..||...
 Frog   984 LETKTQEM------KD-QMDQL-------------TNQLFTDVE------KEEKQRMKLEKHFEA 1022

  Fly  1044 MFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREELRDEI 1108
            ..::.|.:    |.....|..||     :|..|::..:...|:       :|..|: |||: |::
 Frog  1023 QVTEFDTM----IEKLKDEIQVL-----KERNKHLLKQAEEEQ-------LVNDGL-REEI-DQL 1069

  Fly  1109 FIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFD 1173
            .||.    :..|... ||         |...:..|....:.:...|:.|.|   ||.:.::...:
 Frog  1070 SIQV----KKIPTFQ-TD---------IELLENQKRDLEHQLQEQKREMRE---KLDEMAKQLLN 1117

  Fly  1174 NCKSTKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTAGDAVQKLAEKLNLTT 1238
            :.:...|..|:   :..|:..:...|.|...:..|...|:.::.| ..|..:..:|..|.||...
 Frog  1118 SFEIEDVKARL---AEEELGNLNEDGEIWFAYEGLKKATRILEAH-FQTQRENYEKDIELLNFKV 1178

  Fly  1239 TDGWAIYQNRPDGEEHIKSYDYLYDVISSW-EMKQATYAGTKKTTNGSSSGENQFVFKKRLFKST 1302
                          ||:  :|.:..:.:|: |.|.:..:.|.:.....|  :|:.|  |.|.|..
 Frog  1179 --------------EHL--HDDIKQIQNSYMEEKDSKESITLEVERLRS--DNKVV--KDLRKKL 1223

  Fly  1303 HELSQDPVEV-SMLYSQAVHSVVK---KDEFPVSEKVALQLAGLQAQVALGDPSN------QPKP 1357
            .||.:..::: ..||.|.:....|   :..:|..::|:|:|...|.:   .|.:|      |...
 Frog  1224 AELEEQNMDLQGRLYEQTMKLPEKSNRRKNYPDEDEVSLKLWNGQRE---NDMANVKIQAIQTDN 1285

  Fly  1358 EYYSDINSFLPIRISKTREQQFWIPILAQAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVN 1422
            .|..:.|.      :.||:.:..:.:..:..|:......||| |.:.....::.|    |:|| :
 Frog  1286 MYMKEQNE------ADTRDFEEQVDMKDRTIRKLQDQIKALT-KSIEKDDEVRVP----TVFK-D 1338

  Fly  1423 YKGYWNLAS--------NIILGIHYDGIM--FINPEDKSVVFQ-FKYVDIESILLDPSDSFITIS 1476
            |.|....||        |:||.:...|::  .|......::|. .:|.|           :|
 Frog  1339 YLGMLEFASEDESKLIRNLILDLKPRGVVVNMIPGLPAHIMFMCVRYTD-----------YI--- 1389

  Fly  1477 LNRSAQLLKTSLYGSSLIESQKCFVFETPQKNDIGSLIISY---YPALSNWILN---NLECSKKY 1535
              .:|:.:| ||..:|:              |.|..:|..:   :..||.|:.|   .|.|.|:|
 Frog  1390 --NNAERIK-SLMNASI--------------NSIKQVIKEHADDFEMLSFWLSNVHHFLNCLKQY 1437

  Fly  1536 KGTTKEDRLRLY----------QNVVLCR-RHLVDMNIVKKPHDFGGFLRNTLRRL--------- 1580
            .|   |:....|          :|..|.. |.::....::..|.|...:.|.|:.:
 Frog  1438 SG---EEEFMKYNQPLQNKNCLKNFDLSEYRQIISDLAIRIYHQFITVMENNLQPMIVPGMLEYE 1499

  Fly  1581 SKHRLE-------KLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTI----SDQE--EAL 1632
            |.|.:.       :.||....:|.         |:|..:. .||:.:..:|:    .|.|  :..
 Frog  1500 SLHGISVSKPTGFRKRSSSIDDTD---------SYTMTSI-LQQLSYFYTTMCQHGMDPELLKQT 1554

  Fly  1633 MIQVFDSI--LTYSGLGSSGESISRAEDEHIRIIQSIMDKCMK------------KESLLNELYL 1683
            |.|:|..|  :|.:.|....:..|..:...||...|.:::.::            .|.|....:|
 Frog  1555 MKQLFFLIATVTINSLFLRKDMCSCRKGMQIRCNISYLEEWLQGKNLQGATAKETLEPLSQAAWL 1619

  Fly  1684 QLIKQTTDHPDANSRVNLKNWALLSVLCSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAE 1748
            ..:|:.||  |....:..:..||.||....||.|...:            .||
 Frog  1620 LQVKKITD--DDAKEIYERCTALSSVQIVKILNSYTPI------------DDF------------ 1658

  Fly  1749 NCFFRTQGTRRRQWTPS--REEILCTTNRRPCY-----SKFYFMDGQYYSIEFQPSSTANDVLEI 1806
                      .::.|||  |:......||..|.     ||:.|.    .:..|.||..|.::::|
 Frog  1659 ----------EKRVTPSFVRKVQSMLNNREDCSQLMLDSKYLFQ----VTFPFSPSPHALEMIQI 1709

  Fly  1807 IKK-KIGLL 1814
            ... |:|.|
 Frog  1710 PSSLKLGFL 1718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	260/675 (39%)
		MyTH4	1091..1194	CDD:459939	21/102 (21%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	21/101 (21%)
		B41	1202..1419	CDD:214604	46/227 (20%)
		PH-like	1415..1523	CDD:473070	25/121 (21%)
		MyTH4	1664..1771	CDD:459939	21/120 (18%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	13/46 (28%)
		B41	1781..1992	CDD:214604	10/35 (29%)
		PH-like	1988..2076	CDD:473070
myo5c	XP_012815050.1	COG5022	15..1330	CDD:227355	422/1480 (29%)
		MYSc_Myo5	86..746	CDD:276831	260/676 (38%)
		Myo5c_CBD	1348..1715	CDD:271260	88/450 (20%)