Protein Alignment Myo81F and myo7b

DIOPT Version :10

• Sequence 1: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: XP_002936659.2
• Gene: myo7b / 100491953
• -ID: -
• Length: 2118
• Species: Xenopus tropicalis
• Alignment Length: 2288
• Identity: 584/2288 - (25%)
• Similarity: 981/2288 - (42%)
• Gaps: 469/2288 - (20%)

  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDL 73
            |..||..:.|::|.||..|:::||..:.|||||||||:|||||:.:.:::.:.:..|...::|:|
 Frog    66 GVEDMIRLGELNEAGIVHNIHIRYKENNIYTYTGSILVAVNPYQELPLYDTEQLEMYRNRRIGEL 130

  Fly    74 SPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSNVSSWVQQQILEANT 138
            .||:||:.:..:.::...|.:|.||||||||||||||||.:||:|.: .|...||::|||||||.
 Frog   131 PPHIFALGDTCFFNMQRTNTDQCCVISGESGAGKTESTKLMLQFLAS-ASGQHSWIEQQILEANP 194

  Fly   139 ILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIMY-QL 202
            |:||||||||.||||||||||::::.|.:.:.|:|..|..:|||:||:..||.|||||||.| .|
 Frog   195 IMEAFGNAKTIRNDNSSRFGKYIEIHFSNKHVIEGARIEQFLLEKSRVCRQSPGERNYHIFYCML 259

  Fly   203 VAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFVIDGVFKV 267
            :..|.:.   ....:|.....||||...|....:...:.|.|..:..|..:|.:.:.....:||:
 Frog   260 LGMGSEQ---KKQLNLESPSDYKYLTMGNCTNCDGRDDHKAFSQIRTAMKILLLSEIEQQEIFKM 321

  Fly   268 ISSILWLGNIEF---IDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQINVRGNITEI 329
            :::||.|||::|   :..:.|..|:..|..  :|.::.||.:........|....|.|||.....
 Frog   322 LAAILHLGNLKFKAAMCGNLECCDVPESIH--LSTVATLLEVDSAQLTNCLSNHTIIVRGESVSK 384

  Fly   330 PLKIKEALENRHALAKALYSKMFTWLVSKINNC--TNPGQDDAKFLGVLDIFGFENFSHNSFEQL 392
            ||...:|.::|.|..|.:|.::|.|:|:|||..  |...::..:.:|:|||||||:|..||||||
 Frog   385 PLSCTQASDSRDAFVKGIYGRLFMWIVNKINKAIFTPDSENGRRSVGLLDIFGFEHFDTNSFEQL 449

  Fly   393 CINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPPRCVFKLLTEQCHMP 457
            |||:.||.|.:||..::|.|||..|..|.|.:.|::|:||...|:::...|..:..|:.|:...|
 Frog   450 CINFANEHLQQFFVRHIFKLEQEEYNAEQIPWEHIDFSDNQRTLDVIALRPLNIISLIDEESKFP 514

  Fly   458 QGSD---LAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGFVEKNRD-VQQDV 518
            ||:|   |..|:|:|    |..|....|...| :|:|||.||||:|.|...||::|||| :..|:
 Frog   515 QGTDATMLVKLNNVH----SKTNVYIASKSVH-DTKFGINHYAGIVYYETEGFLDKNRDLLSTDI 574

  Fly   519 MFEYMSYSKDVFIKDLSTYQDI---------QFINSSYPR---GSSKSKCTVSDNFRNQLQSLID 571
            |. .:..|.:.|:|.:...:.|         :.|.:||.:   .:::|..|:...|:..|:.|:.
 Frog   575 ML-MIHTSSNYFLKQVFQMEKITKSSGSVTYRHIINSYSQKTADTNRSLPTLGGQFKQSLEQLMK 638

  Fly   572 VLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHKDFIVRYKCL 636
            :|::.:|:::||||||..|:|..::..|.:.||:|.|:::.||||:.|:||..|..:|..||:.|
 Frog   639 ILESCQPYFIRCIKPNEFKKPKMFDRELCIRQLQYSGMMETIRIRKAGYPIRYSFSEFFQRYRVL 703

  Fly   637 IKNKSFEYPQK---------YLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTL---- 688
            :..:| .|.:|         ...:::.|:    .:|::||:|:||::.....||..|...:
 Frog   704 LPIQS-PYRKKENFREGCIDIAKSVIGKH----EDWKVGKTKLFLKDNHDTKLEVERDKAITASA 763

  Fly   689 ---------YKN----------AVIIQKNWKKYYIQKSF-----------------------LRN 711
                     ||:          |:.||..||.||.:|:|                       .:.
 Frog   764 IRIQKVVRGYKDRKRFLRQREAAIKIQSAWKSYYCRKTFQKMLHGFQRLQAIIRSRPVQMQYKKK 828

  Fly   712 KQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRGVFAREVAAALREMKRVD-------EELKK 769
            ::.::::|...||:.||.:..:.:.:.:|:|:..||:.||:   ..|.|||.:       ||.:|
 Frog   829 REVIIQLQGLSRGYLLRKKIAKRKNAVLVLQTYTRGMLARK---EYRRMKRNEYPSQQDWEEAEK 890

  Fly   770 RDGIYEQLTSITTKTLADCERSIQEELSVLAHISDNIRA---SAKPLSDKNDSDSNTARSSIKQN 831
            |..:.:.|       |...|:   |.|.::..:...:.|   ...|.||:.|.|:.......::.
 Frog   891 RKEMQKAL-------LLQQEK---ENLEMVEQVFGFLPAMDMDTSPFSDEIDLDTLLYEPDKEEE 945

  Fly   832 TVNLDNMFDFLCESKGAFENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFD---SQKTGKLFTT 893
                   :.|...:...|:.:...      .::.|.|.:.:   ::.||..|   |....|:. .
 Frog   946 -------YTFPKFAATYFQGSATD------THIRKALQQPL---LYHEDKNDVLASLAVWKII-L 993

  Fly   894 KTVRTLPEPTVPPPPPPVSISANLNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPS 958
            :.:..||||.:..|        |.:||.......:|...|.|....        ..||||..|.:
 Frog   994 RFMGELPEPALYTP--------NSSSERSSVLTQIYDTLTRKNNIT--------AGIKDNVPKVN 1042

  Fly   959 TSSVFVKYQIDERENRRKQRVEKKIHELTLIDIHKDIHIDNSFYNILEFAENYFNTHDLSSDCNF 1023
                             |:...|:|..:.|
 Frog  1043 -----------------KKGKGKEISSMKL----------------------------------- 1055

  Fly  1024 ISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAEREL 1088
                    |.:.|.|.......|..::|......:.|               |.|       ..|
 Frog  1056 --------KRASKLAGQVSRQLSNGEEIMLEESSIID---------------KPM-------SNL 1090

  Fly  1089 QIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFI 1153
            :.|.:|.|.||.|.|:||||:.|..:|...|.|.....|.||:|.|.:..|.||....||..:||
 Frog  1091 EKIHFIAGNGILRPEIRDEIYCQICKQLSGNNNKTSVARGWILLALCLGCFPPSDKFLRYLQNFI 1155

  Fly  1154 KKSMIELDGKLRQYSQWCFDNCKST-KVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDV 1217
            :.|.|       .|:..|......| :...|..|||.:|:.|::.:|:.......:...:..|..
 Frog  1156 RTSQI-------AYNAICIKRLNRTLQNGVRSEPPSWLELQAIKGVGSFSVPVTLMTGHSMNIQT 1213

  Fly  1218 HPTDTAGDAVQKLAEKLNLTTTDGWAIYQNRPD-------GEEHIKSYDYLYDVISSWEMKQATY 1275
            .....|.:..:.:|:||.|..|.|:::|.:..:       |.||      |.|.||..|..
 Frog  1214 DSATNAREMCKVIAQKLQLKDTFGFSVYISVYNKVWSLGFGSEH------LMDGISQCEQL---- 1268

  Fly  1276 AGTKKTTNGSSSGENQ------FVFKKRLFKSTHELSQDPVEVSMLYSQAVHSVVKKDEFPVSEK 1334
                    ....||.:      ..|:|.:|...|:.|.|.|...::|.|.:..:...:.....|:
 Frog  1269 --------AKEQGEQERHSPWRLNFRKEIFTPWHDSSTDSVSTELIYCQVIRGLCFGEYRCDKEQ 1325

  Fly  1335 VALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFWIPIL--AQAHRQYGSSRN- 1396
            ...:|......:..|:.......|  |.:...:|.:..:|::...|:.:|  .||..||...::
 Frog  1326 ELAELMLKHHYIKYGEVLTDQHVE--SVMQDCVPPKQLETKQMSHWLSLLKERQAVAQYVKEKHP 1388

  Fly  1397 ALTAKVLYLS-CVMQYPLYGTTMFKVN-YKGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKYV 1459
            ||..|..::. ..:|:||..:..|:.: :.|.....::.|:.|::..|.|::.::|.:: |..:.
 Frog  1389 ALQVKEAFVEYSRLQWPLLFSKFFEASKFTGPSISRNHFIVAINWKEINFLDEKEKRLL-QLSFP 1452

  Fly  1460 DIESI---------------------------------------LLD--PSDSFITISLNRSAQL 1483
            ::..|                                       .||  .:.|...::|..|:..
 Frog  1453 ELIGIRTKRAEKTFGQCCILNTLRGEEFVLTSQHSDEIAHLLLYFLDELKARSHYAVALQDSSHT 1517

  Fly  1484 LKTSLYGSSLIESQKCFVFETP-----QKNDIGSLIISYYPAL---SNWILNNLECSKKYKGTTK 1540
            :|.||  ||..::|.    :.|     :..|:  |::...|.|   :|||.            .|
 Frog  1518 VKESL--SSTKKAQT----DEPDLLSFRSGDV--LLLDRSPELQLRANWIF------------AK 1562

  Fly  1541 EDRLRLYQNVVLCRRHLVD----------MNIVKKPHDFGGFLRN---------------TLRRL 1580
            .:|......|.|...|::.          ..||..|.:......|               ||...
 Frog  1563 NERTGKTGAVSLSSIHIIPTLSTPSSEILRLIVMSPEERKSEFYNALVEDFEKQEEVKPYTLEEF 1627

  Fly  1581 SKHRLEKLRSEVGSNT---QEHGETYKGFSHTFWAFSKQQI--PFC--ISTISDQEEALMIQVFD 1638
            |.|.......|..|..   :..|:|:      .||:|::.:  |..  :..|||..: .....|.
 Frog  1628 SLHHFRNPDPESLSRAVLQRSRGKTH------LWAYSREPLRQPLLRKVCEISDLRD-YACTAFT 1685

  Fly  1639 SILTYSGLGSSGESISRAEDEHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKN 1703
            :|:.|     .|:..|:.....:.:...|....:|:|:|.:|:|.|::||.|.:..:.| || ..
 Frog  1686 AIMKY-----MGDYPSKQTHSPVELTDQIFSGPIKEEALRDEIYCQILKQMTGNSKSYS-VN-SG 1743

  Fly  1704 WALLSVLCSVILPSMKAVRKYLIAHLKRCSSDFLSEEGK--YARYAENCFFRTQGTRRRQWTPSR 1766
            |.|| .||:.:.|.    .|.|:.|:|:    |:....|  .|:.:.....|.|....|:..|..
 Frog  1744 WQLL-WLCTGLFPP----TKLLLVHVKK----FIENRQKEPLAKASLRRILRVQQYGARKQPPHL 1799

  Fly  1767 EEILCTTN-RRPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDNAKGYSIYEVIGNSE 1830
            .|:..... ....|.|.||.:|:..:.|...::...::.:.|..|: .|.:.:|:|::..||:..
 Frog  1800 VEVEAIQQMSTKIYHKVYFPNGKEETFEVGTNTKVRELCQNISSKL-QLTSWEGFSLFLKIGDKV 1863

  Fly  1831 RSLSSEEKVCDVMAK------------------------WEKYQITSQQGFQKNTTLISQQNQYM 1871
            .|.:.::...|.:.:                        ..|..|..|.|.......|...:|.:
 Frog  1864 ISQNEQDYFYDSLRQLNDFIRKTRPTAGTPAFASFQLYFMRKLWINVQPGKDIKADCIFHYHQEV 1928

  Fly  1872 FLFKKHLFFDNYINLEDIVEKELLYHQILHNLRSERYPITEMEAIMLTALQSQLERGDCCESITD 1936
               .|::...|..::||.|....|.:::.:|          .:...|..|...:.     :.:.:
 Frog  1929 ---PKYMRGYNLCSVEDAVNLAGLMYKVQYN----------NDRTHLATLNKNVR-----DLVPE 1975

  Fly  1937 YRAVASHCLPPRFVPNI-----PHEAVAMHHQSLRGMLPIEAKKAFLNLIKSWPLHRATIFDVMQ 1996
            |....|  .|..:..||     .|||..:.          |||.|||..|..||...:..|:|.|
 Frog  1976 YLLRLS--TPEEWKKNIIAAYNKHEAKTVD----------EAKVAFLRQICRWPTFGSAFFEVKQ 2028

  Fly  1997 SFTTNWPRTLWLAIDQKGIHLLEHRSRNVLCTYGYDSIISFSPNLNSLMIFTGTEKKQSKVILTT 2061
            |...::|..:.:||::.|:.|...:::.:|.|:.::.|..::.......:.||:..:.:|::..|
 Frog  2029 SSEPSYPDIVLIAINKHGVSLFHPKTKELLITHPFNKISRWNSGNTYFQMTTGSLVRDNKILCET 2093

  Fly  2062 PQAYQITTLIREY 2074
            ...|::..|:..|
 Frog  2094 SLGYKMDDLLTSY 2106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	256/680 (38%)
		MyTH4	1091..1194	CDD:459939	37/103 (36%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	22/113 (19%)
		B41	1202..1419	CDD:214604	47/233 (20%)
		PH-like	1415..1523	CDD:473070	25/157 (16%)
		MyTH4	1664..1771	CDD:459939	31/108 (29%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	22/128 (17%)
		B41	1781..1992	CDD:214604	46/239 (19%)
		PH-like	1988..2076	CDD:473070	19/87 (22%)
myo7b	XP_002936659.2	MYSc_Myo7	79..744	CDD:276832	256/681 (38%)
		IQ	759..779	CDD:197470	2/19 (11%)
		IQCD	776..805	CDD:467745	9/28 (32%)
		CBD_MYO6-like	<844..>872	CDD:409646	8/30 (27%)
		MyTH4	964..1192	CDD:214535	74/336 (22%)
		B41	1199..1412	CDD:214604	47/232 (20%)
		FERM1_F1_Myosin-VII	1199..1294	CDD:340612	22/112 (20%)
		FERM_C1_MyoVII	1406..1504	CDD:270019	12/98 (12%)
		SH3	1505..1570	CDD:473055	19/84 (23%)
		MyTH4	1657..1806	CDD:214535	41/165 (25%)
		FERM2_F1_Myosin-VII	1811..1907	CDD:340613	16/96 (17%)
		B41	1814..2024	CDD:214604	46/240 (19%)
		FERM_C2_MyoVII	2020..2112	CDD:270020	19/87 (22%)