DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pzl and PIEZO1

DIOPT Version :9

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2326 Species:Drosophila melanogaster
Sequence 2:NP_001136336.2 Gene:PIEZO1 / 9780 HGNCID:28993 Length:2521 Species:Homo sapiens


Alignment Length:2667 Identity:709/2667 - (26%)
Similarity:1158/2667 - (43%) Gaps:526/2667 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IFLPLTLILVSLVRPVGLSYFYLLTFFLSPWL-------LQSNSLK-QRTFLNVFIIFLCVLSTF 68
            :.||..|:...|:|..|||..|||...|.||.       ||.::.: .|..|.:.::||......
Human    13 LLLPCALLAACLLRFSGLSLVYLLFLLLLPWFPGPTRCGLQGHTGRLLRALLGLSLLFLVAHLAL 77

  Fly    69 GIVGHIIFNLINLFFVDLSSKNSFSFILRQFGFLYFKGLSFVSIAHWILPDI-IVLLNTIVFFIF 132
            .|..||:..|..|.....|...:.|   |..|..........:....:.||: |::::::...|.
Human    78 QICLHIVPRLDQLLGPSCSRWETLS---RHIGVTRLDLKDIPNAIRLVAPDLGILVVSSVCLGIC 139

  Fly   133 SEI----KYKREKRVIQNDD-DVFYKKSKELKGALKVAEINRVLIIVYIR-----SVLKTSLIFS 187
            ..:    :.....|.:.:|: ||....:..|:.|..:|...|..:....|     .::....:.:
Human   140 GRLARNTRQSPHPRELDDDERDVDASPTAGLQEAATLAPTRRSRLAARFRVTAHWLLVAAGRVLA 204

  Fly   188 LIVLYFAATLRPSLPGSLYFCMFIIAGSYWAL-FRQRKMYYSVIFMIVALL--VHITCIFAYQLP 249
            :.:|..|....||...|:|..:|:...::||. |......:|.:.:.|...  .|:.|::.||:|
Human   205 VTLLALAGIAHPSALSSVYLLLFLALCTWWACHFPISTRGFSRLCVAVGCFGAGHLICLYCYQMP 269

  Fly   250 VLQNTINCDKLWTRLMGMEVLIRLNKDNRNGKILELNPKLNLDSYLSPIALMLAYFATTLSLINR 314
            :.|..:....:|.|::|::..:.....: :...|.||..|:...|.||..|:|..:||. ||...
Human   270 LAQALLPPAGIWARVLGLKDFVGPTNCS-SPHALVLNTGLDWPVYASPGVLLLLCYATA-SLRKL 332

  Fly   315 SQYEISFNTIRMNLGPKSNSI----YDNIQPSNEENEEISIFTEPSMLEQFFYIVYELSS----- 370
            ..|..|........|.::..:    .|. .|...|:::..:.|.|. .|....||:||:.     
Human   333 RAYRPSGQRKEAAKGYEARELELAELDQ-WPQERESDQHVVPTAPD-TEADNCIVHELTGQSSVL 395

  Fly   371 ----------------------FVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANILWMIPNQR 413
                                  .:...||:...|.||:|||.||||||||||:||.::|.:.::.
Human   396 RRPVRPKRAEPREASPLHSLGHLIMDQSYVCALIAMMVWSITYHSWLTFVLLLWACLIWTVRSRH 460

  Fly   414 RSMMRSSLFVVFYSQILLLAQYIYGMNLYESELPTKVTSCGLNLEQIGFVHPQSKDSLPWIPLTV 478
            :..|..|..::.|...|...:|::.|:| ..||||  |...::|.|:|..|.:    .|.:.|..
Human   461 QLAMLCSPCILLYGMTLCCLRYVWAMDL-RPELPT--TLGPVSLRQLGLEHTR----YPCLDLGA 518

  Fly   479 KTVFLFVFWVTSRQYFREISLDRQQSD--LLQQIFA-THRSRSEHLLSKKSQTPQIFIYILKSTS 540
            ..::...||:..||:.:|..|...:|.  |.:...| |..:|::.||....:       ::|.. 
Human   519 MLLYTLTFWLLLRQFVKEKLLKWAESPAALTEVTVADTEPTRTQTLLQSLGE-------LVKGV- 575

  Fly   541 HFITRIWMWLLIFLIFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLYGYWIFLIFYA 605
              ..:.|:::...:..:.:...|.:. .:|.||.||||.|.:||:...||.:.|..:|..::.|.
Human   576 --YAKYWIYVCAGMFIVVSFAGRLVV-YKIVYMFLFLLCLTLFQVYYSLWRKLLKAFWWLVVAYT 637

  Fly   606 MTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVIFTVVQLHYFH 670
            |.:|.|:||:||..|..||............|:||.::...:||..:|:|...::..::||||||
Human   638 MLVLIAVYTFQFQDFPAYWRNLTGFTDEQLGDLGLEQFSVSELFSSILVPGFFLLACILQLHYFH 702

  Fly   671 RRFVE----------SVRRPR-------------STEGQNFHLAPNAETRASQKT-----LDI-- 705
            |.|::          ..|.||             ..|.|..|.....|....::.     |.:  
Human   703 RPFMQLTDMEHVSLPGTRLPRWAHRQDAVSGTPLLREEQQEHQQQQQEEEEEEEDSRDEGLGVAT 767

  Fly   706 -HRQS--------WKVFFD------AGYENVRAKGRQLFNPGKIVAWKFLEMHMIKTVTLASFYC 755
             |:.:        |.:..:      ||:.:|.::       .::...:.||:|:.|.|.|.:.:.
Human   768 PHQATQVPEGAAKWGLVAERLLELAAGFSDVLSR-------VQVFLRRLLELHVFKLVALYTVWV 825

  Fly   756 AISEICFLNLFLVILSLLGICGNRFLRRVIFRAVTFWISLLVLMKMIYQIKYLDQSHYNFKC--- 817
            |:.|:..:||.||:|....:...|| |.:.....|.|..::::.||:||:|.::...|:..|   
Human   826 ALKEVSVMNLLLVVLWAFALPYPRF-RPMASCLSTVWTCVIIVCKMLYQLKVVNPQEYSSNCTEP 889

  Fly   818 -GNVT----------------VNFAEWMGLRKTGTVFGV-HLRYISSYIIYMILTSLHAVV-KLR 863
             .|.|                |:.|.|.|:||     |. :|.||.:::..::|....|:| :.:
Human   890 FPNSTNLLPTEISQSLLYRGPVDPANWFGVRK-----GFPNLGYIQNHLQVLLLLVFEAIVYRRQ 949

  Fly   864 DHLIRYSTHKQKDTKLLFPDITRQDAERDFPGLLKYVLNYGYFKFGFEITMIGLMSTIAHRRDLF 928
            :|..|.........:.:|...|||..::|..|.|||.:|:.::|||.||..:..::.|..|.:..
Human   950 EHYRRQHQLAPLPAQAVFASGTRQQLDQDLLGCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFL 1014

  Fly   929 ALTYLIWLVLLLC-LSRFRCARIWEMLQLYFVLSIFVQYVYLLNFPPNLCNVISYNSLWSISGSK 992
            ...:..|||.:|. ..|...||:|....|:..|.:..||:..|..||.||  |.|...||.:...
Human  1015 VTLHGCWLVAILTRRHRQAIARLWPNYCLFLALFLLYQYLLCLGMPPALC--IDYPWRWSRAVPM 1077

  Fly   993 NYT--------------NRSNIMFDYIVLLLISRQRKSFRVEMRHINDLSYRGGVNTNVVHNIAK 1043
            |..              |.:|::.|:::||..|:|.:.|..|  ...:.....||||:.:..:. 
Human  1078 NSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAE--RTEEWQRMAGVNTDRLEPLR- 1139

  Fly  1044 LGHVYFENPTHDFCTYVRNYADVLKTAIFFSFFWITLAIVFLGGVCSTDILSLGYIIFALIFLLQ 1108
             |.   .||..:| .:.|:|.|:||.|:|...||:.|.:||:.|.....|..|||::.....||.
Human  1140 -GE---PNPVPNF-IHCRSYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLF 1199

  Fly  1109 GSEIYLQNIHFIICRWNCLIAFNIFNIIVKVAIIVLEGTINLEHKSILSIVFNVMHQTAPCENIM 1173
            |:.:..::....:..|:|||.:|:..||.|..:            |:|:.||....||..|..| 
Human  1200 GTALLQRDTRARLVLWDCLILYNVTVIISKNML------------SLLACVFVEQMQTGFCWVI- 1251

  Fly  1174 DGKFFEINEISEKKYCYGPSDMIFKNT----------LVWHAIIFSFVVFQYRIFGSYYFCHVIM 1228
              :.|.:  :...|..|.|.:|:.::.          ::|.::.|.|::.|.|:|.|:|:.||..
Human  1252 --QLFSL--VCTVKGYYDPKEMMDRDQDCLLPVEEAGIIWDSVCFFFLLLQRRVFLSHYYLHVRA 1312

  Fly  1229 DTQANTILASRGAAIIENLHYKQIYDRRKNEQSVLERVKMKMERIRITNRRHQK--------QAT 1285
            |.||..:|||||.|:....:.|.|...|:.|:..|.::|.:|||||....:|::        |.|
Human  1313 DLQATALLASRGFALYNAANLKSIDFHRRIEEKSLAQLKRQMERIRAKQEKHRQGRVDRSRPQDT 1377

  Fly  1286 ------GLDFQPHKPPSSIIHVHYRAEEKSKLKTLNNEFLTTIKQAERDTYFSRSLKPRR---RD 1341
                  ||:..|..|                                     ..|..|||   |.
Human  1378 LGPKDPGLEPGPDSP-------------------------------------GGSSPPRRQWWRP 1405

  Fly  1342 LSLHPHAVRTGDYYMFNELDDDDDLDVYEE------------YD--------FLEKEDVRARQMR 1386
            ...|...:.:|||::|....::::..|.|:            |.        .|.:......|.|
Human  1406 WLDHATVIHSGDYFLFESDSEEEEEAVPEDPRPSAQSAFQLAYQAWVTNAQAVLRRRQQEQEQAR 1470

  Fly  1387 QSLRSRASNYNRSKSFLNDENSDTDTKKLETHPV--IILTSE--------LIVLLTFRLNRLSKN 1441
            |....:..........:.......:.....:|.|  ::.|::        |:..||..|...:::
Human  1471 QEQAGQLPTGGGPSQEVEPAEGPEEAAAGRSHVVQRVLSTAQFLWMLGQALVDELTRWLQEFTRH 1535

  Fly  1442 FRFVHKMLSAEKKKL-QNI--------SIMNRLGLSNTAAMFKFLNKSLN--------------- 1482
            ...:..:|.||:..| |.:        .::::|..|...|......::.|               
Human  1536 HGTMSDVLRAERYLLTQELLQGGEVHRGVLDQLYTSQAEATLPGPTEAPNAPSTVSSGLGAEEPL 1600

  Fly  1483 NKVIKEAGS-----YYVSQDNDFTTLDHND----------------------------------- 1507
            :.:..:.||     |:....::....|..:                                   
Human  1601 SSMTDDMGSPLSTGYHTRSGSEEAVTDPGEREAGASLYQGLMRTASELLLDRRLRIPELEEAELF 1665

  Fly  1508 ------FVQMLIALWYALIANTETICYLVVFLNQAANSSVISLPMPFLVLCWGALTLPRPSKTFW 1566
                  .:::|.|::..:.|::|.:||.::.||....:|..||.:|.||..|..|::|||||.||
Human  1666 AEGQGRALRLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFW 1730

  Fly  1567 VTLITYNLTMIFVKSIM-------HQRVLLDQQLVSRSNSLSFE-----LIMKRGRAVYDLLLLV 1619
            :|.|.:....:.||.:.       :..|:|.:.    .|...|.     |....|...|||:.|:
Human  1731 MTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRY----ENKPYFPPRILGLEKTDGYIKYDLVQLM 1791

  Fly  1620 VLFWHQYMLKKQGIWTIQRTNSELLLLEKKRNHYKRSFSKERPENIRKLLREEGGGE-------- 1676
            .||:|:..|...|:|                :|.:.|.|||..    |...||.|.|        
Human  1792 ALFFHRSQLLCYGLW----------------DHEEDSPSKEHD----KSGEEEQGAEEGPGVPAA 1836

  Fly  1677 ------QVKA--------------VRPN-----AIEFKREMDDILLPALENKYVY-----QNIES 1711
                  ||:|              :||.     ::.|:|...:  .||.:.....     :..|.
Human  1837 TTEDHIQVEARVGPTDGTPEPQVELRPRDTRRISLRFRRRKKE--GPARKGAAAIEAEDREEEEG 1899

  Fly  1712 EYYRKAMQGLANK-----------GGLLSGF------------RKFFLALRH-KSRLSTDVYTLL 1752
            |..::|..|...:           |..|.||            |:||..:.| |.|.:||||.|:
Human  1900 EEEKEAPTGREKRPSRSGGRVRAAGRRLQGFCLSLAQGTYRPLRRFFHDILHTKYRAATDVYALM 1964

  Fly  1753 FLCDFISFFILLFGFPKFVYRYKYSTSV-LETYIQGNKVPFTFLLMLIVQFITIVTERAIYLRKA 1816
            ||.|.:.|.|::|||..|   .|:|.:. :.:.:..::||..||:||::||.|:|.:||:||||.
Human  1965 FLADVVDFIIIIFGFWAF---GKHSAATDITSSLSDDQVPEAFLVMLLIQFSTMVVDRALYLRKT 2026

  Fly  1817 LIYKIFFHFISVLGIHIWMFFLVPYITSHSFGETAPV-LFYLIKCLHMLLSAYQIRCGYPKRILG 1880
            ::.|:.|....||.||:||||::|.:|...|.:.... |:|.:||::..|||||||||||.||||
Human  2027 VLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILG 2091

  Fly  1881 NVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKMEDIFQSVFIVRCYRQMD 1945
            |..||.|:..|...|:.:..:|||..||.::|||..||||::..|:.:|||:.::||::|.|:.:
Human  2092 NFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETE 2156

  Fly  1946 TDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALV-GTVGKPNIPQKADITVKINHYEP 2009
            ..:|..:|:.|....|..:||.|||.|||:||.||...:|| ..||..|.|....:|:|:..|||
Human  2157 KKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEP 2221

  Fly  2010 IY-VSQSNSDILQFSNSDFQKLTNHIILDNYASDSMMLYDAVDVTAIKFYENSISLWNMPPPDKE 2073
            :: :|.....|:.|:...:::|:........|...:..|...|:...:...:|.:||.:.||.:.
Human  2222 LFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRA 2286

  Fly  2074 RLLHDLSNGETLDIHLTLT------LKCNLTPEAVIYETTYTLTENKVHTRDKLIRLMSNNFSNE 2132
            ::..:|.|| |.||.|..|      |....|.|....:....|..|.. .|.:|..|:... |::
Human  2287 QMKRELYNG-TADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNST-ARRQLASLLEGT-SDQ 2348

  Fly  2133 KVIIPNILPKFI---------TVQRQQANAKFIKDYDGKFNRPIILTKIGKSQ-------VYWWE 2181
            .|:|||:.||:|         .|::.|.|.:  .||.|      :..::.:.|       :.|| 
Human  2349 SVVIPNLFPKYIRAPNGPEANPVKQLQPNEE--ADYLG------VRIQLRREQGAGATGFLEWW- 2404

  Fly  2182 MNDYCNDRFYTEILSALPLSNCE---NGVVLYVFNDKSFPSAMSFLEKTGIIGLYTTFVYVVSRI 2243
                           .:.|..|.   |.:.:.:|:||..|.::.||...||:|||.:.|.|:.:.
Human  2405 ---------------VIELQECRTDCNLLPMVIFSDKVSPPSLGFLAGYGIMGLYVSIVLVIGKF 2454

  Fly  2244 IRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYGKLIFLYRSPETLIKWTRF 2308
            :|...:.....||||:||.|||:||||.||:|||||:|..|||:||.|||||||||||:|||||.
Human  2455 VRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRE 2519

  Fly  2309 KE 2310
            ||
Human  2520 KE 2521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1201..1388 CDD:292539 53/223 (24%)
Piezo_RRas_bdg 1901..2308 CDD:288978 150/433 (35%)
PIEZO1NP_001136336.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 738..769 5/30 (17%)
PIEZO 1235..1459 CDD:292539 62/265 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1356..1402 14/82 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1462..1498 3/35 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1576..1630 5/53 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1811..1921 22/115 (19%)
Piezo_RRas_bdg 2111..2519 CDD:288978 150/434 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 485 1.000 Domainoid score I397
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1094 1.000 Inparanoid score I239
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46055
OrthoDB 1 1.010 - - D13738at2759
OrthoFinder 1 1.000 - - FOG0001637
OrthoInspector 1 1.000 - - mtm8662
orthoMCL 1 0.900 - - OOG6_102664
Panther 1 1.100 - - O PTHR13167
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1528
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.980

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