DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pzl and PIEZO2

DIOPT Version :10

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2161 Species:Drosophila melanogaster
Sequence 2:NP_001365112.1 Gene:PIEZO2 / 63895 HGNCID:26270 Length:2865 Species:Homo sapiens


Alignment Length:2983 Identity:724/2983 - (24%)
Similarity:1211/2983 - (40%) Gaps:797/2983 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AEPLLFIITRIFLPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQRTFLNVFIIFLCVLS 66
            :|.:..:|.|:.||:.|.:....|..|||:.||:...|.|...:......:......:..||.:|
Human     3 SEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLFSEPTKTTMQGHTGRLLKSLCFIS 67

  Fly    67 TFGIVGHIIFNLINLFFVDLSSK---------NSFSFILRQFGFLYFKGLSFVSIAHWILPDIIV 122
            ...::.||||::.   .|.|.::         :::....||.||...||....:.....:|||.:
Human    68 LSFLLLHIIFHIT---LVSLEAQHRIAPGYNCSTWEKTFRQIGFESLKGADAGNGIRVFVPDIGM 129

  Fly   123 LLNTIVFFIF---------------SEIKYKREK----RVIQNDDDVFYKK--------SKELKG 160
            .:.::..::.               |..:::.|:    ..|.:::.:.|::        ..||:.
Human   130 FIASLTIWLLCRNIVQKPVTDEAAQSNPEFENEELAEGEKIDSEEALIYEEDFNGGDGVEGELEE 194

  Fly   161 ALKVAEINRVLIIV-----YIRSVLKTS-LIFSLIVLYFAATLRPSLPGSLYFCMFIIAGSYWAL 219
            :.|:....|:..:.     :|.:::.|: .:...|:|..:..:.|||..|:||.:|:...::|:.
Human   195 STKLKMFRRLASVASKLKEFIGNMITTAGKVVVTILLGSSGMMLPSLTSSVYFFVFLGLCTWWSW 259

  Fly   220 FRQ-RKMYYSVIFMIVALLV--HITCIFAYQLPVLQNTINCDKLWTRLMGMEVLIRLNKDNRNGK 281
            .|. ..:.:|.:.:::|:..  |:..::.||....|..:..:..:.||.|::.:|:.:..: ..|
Human   260 CRTFDPLLFSCLCVLLAIFTAGHLIGLYLYQFQFFQEAVPPNDYYARLFGIKSVIQTDCSS-TWK 323

  Fly   282 ILELNPKLNLDSYLSPIALMLAYF--ATTLSL--------------------------------- 311
            |: :||.|:...:.:||.|::.|:  ||.:.:                                 
Human   324 II-VNPDLSWYHHANPILLLVMYYTLATLIRIWLQEPLVQDEGTKEEDKALACSPIQITAGRRRS 387

  Fly   312 ----------------INRSQYE-------------ISFNTIRMNL----GPKSNSIYDNIQ--- 340
                            :.:..|:             :.::||..:|    ||....:|...|   
Human   388 LWYATHYPTDERKLLSMTQDDYKPSDGLLVTVNGNPVDYHTIHPSLPMENGPGKADLYSTPQYRW 452

  Fly   341 -PSN-------EENEEISIFTEPSMLEQ----FFYIVYELSSFVYKNSYILLNIIMMIWSIVYHS 393
             ||:       ||.||...|.|....|:    ..:.:..:..|:.|.|||...|.||.|||.|||
Human   453 EPSDESSEKREEEEEEKEEFEEERSREEKRSIKVHAMVSVFQFIMKQSYICALIAMMAWSITYHS 517

  Fly   394 WLTFVLLIWANILWMIPNQRRSMMRSSLFVVFYSQILLLAQYIYGMNLYE-SELPTKVTSCGLNL 457
            |||||||||:..||||.|:|:..|.||.|:|.|..:||:.|||:...|.| .::|          
Human   518 WLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKVP---------- 572

  Fly   458 EQIGFVHPQSKDSLPWIPLTVKTVFLFVFWVTSRQYFREISLDRQQSDLLQQIFATHRSRSEHLL 522
               ||:..:....     |..|.:|...||:..||:..|....:::..||.::....:...|   
Human   573 ---GFLEKKEPGE-----LASKILFTITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEE--- 626

  Fly   523 SKKSQTPQIFIY---------------------------------ILKSTSHFITRIWMWLLIFL 554
             |..:...|.:.                                 |:|...:.:..:::...|::
Human   627 -KDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYV 690

  Fly   555 ---IFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLYGYWIFLIFYAMTILTAIYTYQ 616
               :|.....:..:...:|.||.|||..:.::|:..:.|.:.|..:|:.::.|.|.:|..|||||
Human   691 CGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQ 755

  Fly   617 FDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVIFTVVQLHYFHRRFVE------ 675
            |::|...|:....:......|:||:::...:||..:.|||..::..::.|||||.||:|      
Human   756 FENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDLKS 820

  Fly   676 ------------------------------------------------------SVRRPR----- 681
                                                                  |:.:|.     
Human   821 IPSKEDNTIYSHAKVNGRVYLIINSIKKKLPIHQNELAHPEGSLPDLTMMHLTASLEKPEVRKLA 885

  Fly   682 ----------STEGQNFHLAPNA-----------ETRASQKTLDIHRQSWKVFFDAGYENVRAKG 725
                      |.:.|...|..::           |:...::|.|: |..|.:..|. ...:..|.
Human   886 EPGEEKLEGYSEKAQKGDLGKDSEESEEDGEEEEESEEEEETSDL-RNKWHLVIDR-LTVLFLKF 948

  Fly   726 RQLFNPGKIVAWKFLEMHMIKTVTLASFYCAISEICFLNLFLVILSLLGICGNRFLRRVIFRAVT 790
            .:.|:..::..|..||:|:||.|:....:.::.|:...| ::.::|.........|||:.....|
Human   949 LEYFHKLQVFMWWILELHIIKIVSSYIIWVSVKEVSLFN-YVFLISWAFALPYAKLRRLASSVCT 1012

  Fly   791 FWISLLVLMKMIYQIKYLDQSHYNFKCG-------NVTVNF-------------AEWMGLRKTGT 835
            .|..::::.||:||::.:...:::..|.       |:..|.             .||:||||:..
Human  1013 VWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSP 1077

  Fly   836 VFGVHLRYISSYIIYMILTSLHAVVKLRDHLIRYSTHKQKDTKLLFPDITRQDAERDFPGLLKYV 900
            :. |:||  ::.::..||.....:.:.:::....:......::.:|.||||...:.......||.
Human  1078 LL-VYLR--NNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYF 1139

  Fly   901 LNYGYFKFGFEITMIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRC-ARIWEMLQLYFVLSIFV 964
            :||.::|||.|...:..::.|..|.|.:|:.:..||:.:|...|.:. |.||.....:....|..
Human  1140 INYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITF 1204

  Fly   965 QYVYLLNFPPNLCNVISYNSLWSISGSK------------NYTNRSN---IMFDYIVLLLISRQR 1014
            ||...:..||..|.    :..|...|:.            ::..|.|   :::|:::||..|.||
Human  1205 QYFICIGIPPAPCR----DYPWRFKGASFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQR 1265

  Fly  1015 KSFRVEMRHINDLSYR--GGVNTNVVHNI--AKLGHVYFENPTHDFCTYVRNYADVLKTAIFFSF 1075
            :.|..|    |..:.|  .|.|..:..|:  |....   .||..|| .:.|:|.|:.|..||...
Human  1266 QIFEDE----NKAAVRIMAGDNVEICMNLDAASFSQ---HNPVPDF-IHCRSYLDMSKVIIFSYL 1322

  Fly  1076 FWITLAIVFLGGVCSTDILSLGYIIFALIFLLQGSEIYLQNIHFIICRWNCLIAFNIFNIIVK-V 1139
            ||..|.|:|:.|.....|..:||::....|||.|.::.|:.|..|:..|:.|||:|:|.|.:| :
Human  1323 FWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNI 1387

  Fly  1140 AIIVLEGTI-NLEHKS-----ILSIVFNVMHQTAPCENIMDGKFFEINEISEKKYCYGPSDMIFK 1198
            ..|...|.| .|.|.|     ..|:...|.....|..|               ..|..||.   :
Human  1388 LSIGACGYIGTLVHNSCWLIQAFSLACTVKGYQMPAAN---------------SPCTLPSG---E 1434

  Fly  1199 NTLVWHAIIFSFVVFQYRIFGSYYFCHVIMDTQANTILASRGAAIIENLHYKQIYDRRKNEQSVL 1263
            ..::|.:|.|:|::.|.|:|.||||.||:.|.:|:.|||||||.:.:....|.:..|.:.|:..:
Human  1435 AGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSM 1499

  Fly  1264 ERVKMKMERIRITNRRHQK---QATGLDFQPHKPPSSIIHVHYRAEEKSKLKTLNNEFLTTIKQA 1325
            :::|.:|:||:...::::|   :...|..:|.:           .::..||...::|     ::|
Human  1500 DQLKRQMDRIKARQQKYKKGKERMLSLTQEPGE-----------GQDMQKLSEEDDE-----REA 1548

  Fly  1326 ERDTYFSRSLKPRRRDLSLHPHAVRTGDYYMFNELDDDDDLDVYEEYDFLEKED----------- 1379
            ::.....:. |...|....|...||:||||:| |.|.::     ||.:.|:|||           
Human  1549 DKQKAKGKK-KQWWRPWVDHASMVRSGDYYLF-ETDSEE-----EEEEELKKEDEEPPRRSAFQR 1606

  Fly  1380 ---------------------------VRARQM---------RQSLRSRASNYNRSKSFLN---- 1404
                                       :||.:.         :.:||.|.....||.....    
Human  1607 AIGKFASAILALPKSVIKLPKTILQYLIRAAKFVYQAWITDPKTALRQRHKEKKRSAREERKRRR 1671

  Fly  1405 ----------DENSDTDTKKLETHPVIILTSELIVL-------------LTFRLNRLSKN----- 1441
                      ::..|...||....|..|:.....:|             .|..||.:|:.     
Human  1672 KGSKEGPVEWEDREDEPIKKKSDGPDNIIKRIFNILKFTWVLFLATVDSFTTWLNSISREHIDIS 1736

  Fly  1442 --FRFVHKMLSAEKKK------------LQNISIMN---RLGLSN-------------------- 1469
              .|....||:.|.||            .|| .|||   ..||..                    
Human  1737 TVLRIERCMLTREIKKGNVPTRESIHMYYQN-HIMNLSRESGLDTIDEHPGAASGAQTAHRMDSL 1800

  Fly  1470 ----------TAAMFKFLNKS----LNNKVI---------------------------------- 1486
                      |.|...|..:|    |:.:.|                                  
Human  1801 DSHDSISSCYTEATMLFSRQSTLDDLDGQEIPKTSERARPRLRKMLSMDMSSSSADSGSLASSEP 1865

  Fly  1487 ------------------------KEAGS---------------YYV-------------SQDND 1499
                                    :||||               |.|             .:...
Human  1866 TQCTMLYSRQGTTETIEEVEAEQEEEAGSTAPEPREAKEYEATGYDVGAMGAEEASLTPEEELTQ 1930

  Fly  1500 FTTLD------------------------------------------------------------ 1504
            |:|||                                                            
Human  1931 FSTLDGDVEAPPSYSKAVSFEHLSFGSQDDSAGKNRMAVSPDDSRTDKLGSSILPPLTHELTASE 1995

  Fly  1505 -------HND--------------FVQMLIALWYALIANTETICYLVVFLNQAANSSVISLPMPF 1548
                   |:|              |:.:..|::..|:|.:|.:||.|:.||...::|:|:|.:|.
Human  1996 LLLKKMFHDDELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPI 2060

  Fly  1549 LVLCWGALTLPRPSKTFWVTLITYNLTMIFVKSIM-------HQRVLLDQ-QLVSRSNSLSFELI 1605
            |:..|..|::||||:.||:..|.|....|.||...       ::.|.::: :.....|.:..|  
Human  2061 LIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVE-- 2123

  Fly  1606 MKRGRAVYDLLLLVVLFWHQYMLKKQGIW----------TIQRTNSELLL--------------- 1645
            .|.|..:|||:.|:.||:|:.:||..|:|          ..:.::.||.|               
Human  2124 KKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSIN 2188

  Fly  1646 ------------------LEKKRN------HYKRSFSKERPENIRKLLREEG-GGEQVKAVRPNA 1685
                              :.:||:      ..:.|||..|.:......|... .|..|.:::...
Human  2189 LAASVESVHVTFPEQQTAVRRKRSGSSSEPSQRSSFSSNRSQRGSTSTRNSSQKGSSVLSIKQKG 2253

  Fly  1686 IEFKREMDDILLPALENKYVYQNIESEYYRKAMQGLANKG-GLLSGFRKFFLALRHKSRLS-TDV 1748
               |||:             |.....|:..||......|. .:....::||..|.|....: |||
Human  2254 ---KREL-------------YMEKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDV 2302

  Fly  1749 YTLLFLCDFISFFILLFGFPKFVYRYKYSTSV-LETYIQGNKVPFTFLLMLIVQFITIVTERAIY 1812
            |.|:||.|.:.|.|::|||..|   .|:|.:. :.:.:..::||..||:|:::||.|:|.:||:|
Human  2303 YVLMFLADTVDFIIIVFGFWAF---GKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALY 2364

  Fly  1813 LRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGET-APVLFYLIKCLHMLLSAYQIRCGYPK 1876
            |||.::.|:.|..|.|.|||.||||::|.:|...|.:. ...|:|.:||::..|||||||||||.
Human  2365 LRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPT 2429

  Fly  1877 RILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKMEDIFQSVFIVRCY 1941
            |:|||..||.|:..|...|:.:..:|||..||.::|||..||||::..||.:|||:..:||::|:
Human  2430 RVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCW 2494

  Fly  1942 RQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALVGTV-GKPNIPQKADITVKIN 2005
            |:.:..:|..||:.|....|..:||.||::||.::|.||...:|:.:| |..|.|....:|:.:.
Human  2495 RESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG 2559

  Fly  2006 HYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNYASDSMMLYDAVDVTAIKFYENSISLWNMPP 2069
            .|:||: :|...|.:.......|.|.......|..|...:..|:..|:|..:...||.|||.:.|
Human  2560 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISP 2624

  Fly  2070 PDKERLLHDLSN-GETLDIHLTLTLKCNLT----PEAVIYETTYTLTENKVHTRDKLIRLMSNN- 2128
            |.|::::|:|.: ..:..:..:.:::.||:    .|....:.::.|   |..||..:.::::.| 
Human  2625 PSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPL---KNITRKNIAKMIAGNS 2686

  Fly  2129 --FSNEKVIIPNILPKFITVQRQQANAKFIKDYDGKFN---RPIILTK--IGKSQVYWWEMNDYC 2186
              .|...|.|..|.|.::... ..:|:|.||....:.|   ..|||::  ..|....||.:| ..
Human  2687 TESSKTPVTIEKIYPYYVKAP-SDSNSKPIKQLLSENNFMDITIILSRDNTTKYNSEWWVLN-LT 2749

  Fly  2187 NDRFYTEILSALPLSNCENGVVLYVFNDKSFPSAMSFLEKTGIIGLYTTFVYVVSRIIRSLIANN 2251
            .:|.|.....||.         |.|||||..|.::.||...||:|||.:.|.|:.:.:|...:..
Human  2750 GNRIYNPNSQALE---------LVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGI 2805

  Fly  2252 HRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYGKLIFLYRSPETLIKWTRFK 2309
            ...||||:||.|||:|||||||:|||||.|..||||||.|||||||||||:|||||.|
Human  2806 SHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1202..1391 CDD:464941 57/238 (24%)
Piezo_RRas_bdg 1901..2307 CDD:463481 151/420 (36%)
PIEZO2NP_001365112.1 PIEZO 1391..1658 CDD:464941 71/307 (23%)
Piezo_RRas_bdg 2453..2862 CDD:463481 152/422 (36%)

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