DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pzl and piezo1

DIOPT Version :10

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2161 Species:Drosophila melanogaster
Sequence 2:XP_696355.4 Gene:piezo1 / 567949 ZFINID:ZDB-GENE-041111-255 Length:2538 Species:Danio rerio


Alignment Length:2679 Identity:710/2679 - (26%)
Similarity:1176/2679 - (43%) Gaps:541/2679 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQRTFLNVFIIFLCVLSTFGIVGHIIFNL 78
            ||:.|:...:.|...||..|||...|.||....|....|.....:|..|...|...|:||:.|.:
Zfish    15 LPIFLLAACIFRYNALSLVYLLYLLLLPWFQWPNKHTLRGHTGCYIKALFSTSLIFILGHVTFQI 79

  Fly    79 INLFFVDLSSK-----NSFSFILRQFGFLYFKGLSFVSIAH-----WIL-PDI-IVLLNTIVFFI 131
            .......|...     :|:..:.|..      |:|.:.:..     |:| ||: :.:::.|...:
Zfish    80 CLYTIPSLDDALGHNCSSWETLSRHV------GVSRLPLEDPQGVLWLLTPDLGVFIMSLITLIL 138

  Fly   132 FSEIKYKREKRVI--------------QNDDDVFYKKSKELKGALKVAEI---------NRVLII 173
            .|.:..||::..:              .:|:||    ..|.:|.|..:|.         :...:.
Zfish   139 CSRLLKKRDEGSVPHMSALLHEADETEDDDEDV----EGEDEGMLSCSETEDEESPSSSSAAQLA 199

  Fly   174 VYIRSVLKTSL-----IFSLIVLYFAATLRPSLPGSLYFCMFIIAGSYWAL-FRQRKMYYSVIFM 232
            ..:|:..:..|     |.::.:|..|....||...:.||.:||...::||. |....:.::.:.:
Zfish   200 ARLRATAQRFLRNMGRILAVTLLALAGITLPSAFSAFYFLLFIGVCTWWACHFPISHLGFNALCV 264

  Fly   233 IVALLV--HITCIFAYQLPVLQNTINCDKLWTRLMGMEVLIRLNKDNRNGKILELNPKLNLDSYL 295
            :||...  |:.|::.||....|...:...||.||.|::.|:  ...|.....:.||.:.:...|:
Zfish   265 MVAFFTGGHLVCLYLYQSSFAQAMFSPAGLWARLFGLKDLV--TPGNCTTFEVTLNTQYDWPVYV 327

  Fly   296 SPIALMLAYFATTLSL-IN--------RSQYEISFNTIRMNLGPKSN-SIYDNIQPSNEENEEIS 350
            :|..|:|.|.:.|:.| ||        :::...:..|::...|.:.. .:::..:.|:|::.:.:
Zfish   328 NPGILLLLYISVTIVLKINSNSLGDADKAREGEAVKTVQGEAGEEVELRLWEARRQSSEDDTKQT 392

  Fly   351 IFTEPSMLEQFFYIVYE-------------------------LSSFVYKNSYILLNIIMMIWSIV 390
            :.|.........:|..|                         :...|.:.|||...|.||:|||.
Zfish   393 LLTTVDSTLSESHITKEPVINGSSQHDIGPSGEATVDNPLRLVGRMVLQQSYICALIAMMVWSIT 457

  Fly   391 YHSWLTFVLLIWANILWMIPNQRRSMMRSSLFVVFYSQILLLAQYIYGMNLYESELPTKVTSCGL 455
            ||||||||||:|:.::||:..::|.....|.|::.|...|...||::.|:| |:|||..:.|  :
Zfish   458 YHSWLTFVLLLWSCVIWMLRTRQRFAAYCSPFILLYGLALCCLQYVWAMDL-ETELPQHIGS--M 519

  Fly   456 NLEQIGFVHPQSKDSLPWIPLTVKTVFLFVFWVTSRQYFREISLDRQQSDL--LQQIFATHRS-- 516
            :|.|:|....|    .|.:.|....:|...||:..||..:: :..|::|..  ||:: .|..|  
Zfish   520 SLHQLGLDRAQ----YPCLRLGALLLFTLTFWLLLRQSVKD-TFSRKKSLTVPLQEV-TTGESTG 578

  Fly   517 RSEHLLSKKSQTPQIFIYILKSTSHFITRIWMWLLIFLIFLCAMIDRTMTGIRICYMSLFLLFLM 581
            |:|.:|       ::|..::.|   ...:.|:::...:..:.:...: :...:|.||.||||.:.
Zfish   579 RNESIL-------KVFGGLVMS---LYAKYWIYVCGGMFIMVSFAGK-LVAYKIVYMLLFLLCMC 632

  Fly   582 VFQMSLQLWIRFLYGYWIFLIFYAMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTK 646
            ::|:...||.|.|..:|..::.|.|.:|.||||:||:.|..||..|.........|:||..::..
Zfish   633 LYQVYYSLWRRLLKAFWWMVVAYTMVVLIAIYTFQFEDFPGYWGNFTGFTEQQLADMGLETFKLS 697

  Fly   647 DLFLHLLIPTLTVIFTVVQLHYFHRRF--------VESVRRPRSTEGQNFHLAPNAETRASQKTL 703
            :||..::||...::..::||||||:.|        |..:.|.|..:..:. :....|.|..::.|
Zfish   698 ELFTSIVIPGFFLLACILQLHYFHKPFMKITDLENVSPIHRKRGIDNPDL-VQSTEEVRPEEEEL 761

  Fly   704 ------------DIHRQSWKVFFDAGYENVRAKGRQLFNPGKIVAWKFLEMHMIKTVTLASFYCA 756
                        ::....|.:..|......|.....|.:....: |:.||:|::|.|.....:.|
Zfish   762 IVDQDDYPSEADEVIPSKWGLVMDRLMVLSRKFSDTLTHVQSFI-WRVLELHIVKIVAFFVVWVA 825

  Fly   757 ISEICFLNLFLVILSLLGICGNRFLRRVIFRAVTFWISLLVLMKMIYQIKYLDQSHYNFKCG--- 818
            :.|...:||.||:|....:...|| |.:.....|.|:.::::.||:||:..::.:.|:..|.   
Zfish   826 LLEPSAMNLVLVVLWSFAMPYGRF-RAMASCLSTIWVCVIIVCKMLYQLSVVNPAEYSNNCTAPM 889

  Fly   819 -----------------NVTVNFAEWMGLRKTGTVFGVHLRYISSYIIYMILTSLHAVVKLRDHL 866
                             ..:|:.|.|.|:||..||.|    |:..:::.::|....|.|  ..|.
Zfish   890 VNETSLEPDEVLNSTLYRASVDPASWFGVRKDDTVLG----YVKDHLLVLMLLVFEATV--YRHQ 948

  Fly   867 IRYSTHKQKD---TKLLFPDITRQDAERDFPGLLKYVLNYGYFKFGFEITMIGLMSTIAHRRDLF 928
            |.:...:|:.   ..::||..||...::.....:||:|||.::|||.||..:..::.|..|.:..
Zfish   949 IHHYRQQQRSPPPIPVIFPQATRDTLDQGLLHCIKYMLNYSFYKFGLEICFLMTVNVIGQRMNFL 1013

  Fly   929 ALTYLIWLV-LLLCLSRFRCARIWEMLQLYFVLSIFVQYVYLLNFPPNLCNVISYNSLWSISGSK 992
            .:.:..||| :::...|...|.||....|:.|:.:..|||..:..||.||  |.|...|..:.:.
Zfish  1014 VIIHGCWLVAIMVRRRRANIATIWSKYCLFLVVFMIYQYVLCVGIPPALC--IDYPWRWRSTVTI 1076

  Fly   993 N------------YT--NRSNIMFDYIVLLLISRQRKSFRVEMRHINDLSYRGGVNTNVVHNIAK 1043
            :            ||  |..|::.|:::|:..|:|...|..|.:  .:....||.|.:   |...
Zfish  1077 HSALVKWMYLPDFYTVPNSKNLISDFLLLMCASQQWTVFDNEKK--EEWMVMGGENRD---NPDP 1136

  Fly  1044 LGHVYFENPTHDFCTYVRNYADVLKTAIFFSFFWITLAIVFLGGVCSTDILSLGYIIFALIFLLQ 1108
            :.::.| ||..:|.. .|:|.|:.|..:|...||..|::||:.|.....:..|||::....|||.
Zfish  1137 MENMLF-NPAPNFIN-CRSYLDMAKILVFRYMFWFVLSVVFVTGATRISVFGLGYLMACFFFLLF 1199

  Fly  1109 GSEIYLQNIHFIICRWNCLIAFNIFNIIVKVAIIVLEGTINLEHKSILSIVFNVMHQTAPCENIM 1173
            |:::..:.....:..|:|||.:|       ||:|:.:..:     |||:.||.:..|...|..| 
Zfish  1200 GTKLLTKPSRTRLVMWDCLIIYN-------VAVIISKNIL-----SILACVFVMEMQKNFCWVI- 1251

  Fly  1174 DGKFFEINEISEKKYCYGPSDMIFKNT--------LVWHAIIFSFVVFQYRIFGSYYFCHVIMDT 1230
              :.|.:  :...|..|.|..:..|:.        ::|.:|.|.|::.|.|:|.|:||.||..|.
Zfish  1252 --QLFSL--VCTVKGYYDPESVCNKDCSLPVEEAGIIWDSICFFFLLLQRRVFLSFYFLHVSADL 1312

  Fly  1231 QANTILASRG-----AAIIENLHYKQIYDRRKNEQSVLERVKMKMERIRITNRRHQKQATG---- 1286
            ||:...||||     |:||:|:|:.|..:|:.     ::::|..|:|||   .:.||...|    
Zfish  1313 QASARQASRGFELFRASIIKNMHFHQQAERKS-----IQQLKESMKRIR---GKQQKYKDGRITS 1369

  Fly  1287 -LDFQPHKPPSSIIHVHYRAEEKSKLKTLNNEFLTTIKQAERDTYFSRSLKPRRRDLSLHPHAVR 1350
             ::.||..|                            |:.:::|..|:| |..:.....|...:.
Zfish  1370 DIEEQPSDP----------------------------KEQKKETKLSKS-KSWQYPWVDHATVLH 1405

  Fly  1351 TGDYYMFNELDDDDDLDVYEEY--------------------DFLEKEDVRARQMR-----QSLR 1390
            :|:||||.....::|....||.                    |.|::...|.|:.|     |...
Zfish  1406 SGEYYMFESDSGEEDETFQEEQKPRRQTAFQLAYQAWVTSAKDALKERQQRQRKQRAEAEKQQNA 1470

  Fly  1391 SRASNYNRSKSFLNDENSDTDTKKLE--------------THPVIILTSELIVL-------LTFR 1434
            ....:....::..:.|||....:..|              ...::.:...|.||       .|..
Zfish  1471 QATDDAEEGETVFDGENSQHAEEMQEEGEDAASQATGSDMVQRILDILKFLWVLFLAMVDGFTMW 1535

  Fly  1435 LNRLSKNFRFVHKMLSAEKKK-LQNISIMNRLGLSNTAAMFKFLNKSL----------------N 1482
            ||.|:|.:.....:||.|:.. :.|:|  .|....|........::.|                .
Zfish  1536 LNLLTKQYVDTSMVLSEERYLFIHNVS--QRASRENMDDQISHDSEDLTLETCLDETDTDNICDT 1598

  Fly  1483 NKVIKEA-GSYYVSQDNDFTTL------------------------------------------- 1503
            |.|..|. |.:..|:|...|||                                           
Zfish  1599 NVVESETLGGFAKSRDFSSTTLSSELTLELDCEPFYSQQTHRPHRSRTASELLSERPFRVDELIQ 1663

  Fly  1504 ------DHNDFVQMLIALWYALIANTETICYLVVFLNQAANSSVISLPMPFLVLCWGALTLPRPS 1562
                  ..|..:::|.||:..|.|::|.:||.::.||....:|||||.:|.||..|..|::||||
Zfish  1664 SREFYSSQNRLLKLLFALYNVLAAHSELVCYFIIVLNNLVTASVISLVLPVLVFLWAMLSVPRPS 1728

  Fly  1563 KTFWVTLITYNLTMIFVKSIMHQRVLLDQQLVSRSNSLSFELIMKRGRAV--------------- 1612
            |.||:|.|.|...|:.||.:.        |......:..:||.:...:..               
Zfish  1729 KRFWMTAIIYTEVMVVVKYLF--------QFGFFPWNTEYELKLNEDKPFFPPRILGLEKTDNYI 1785

  Fly  1613 -YDLLLLVVLFWHQYMLKKQGIWTIQ-----------RTNSELLLLEKKRNHYKRSFSKERPENI 1665
             ||||.|:|||:|:.:|::.|:|..:           ..||:....|||..|.....|:.:||..
Zfish  1786 RYDLLQLLVLFFHRSLLQRYGLWDQEGPLEEKSDLSPAENSKNENDEKKFQHSDEEDSQAQPEPN 1850

  Fly  1666 RKLLREEGGGE----------------------------------------QVKAVRPNAIE--- 1687
            .::|......|                                        :.|...|:|::   
Zfish  1851 TEVLSLTPSAETPTDAEIQTDPEPNSHTNNTKTSDTVKNDGMKKSHFLRFRKKKKAEPDAVQKEP 1915

  Fly  1688 ----------FKREMDDILLPALENKY--VYQNIESEYYRKAMQGLANKGGLLSGFRKFFLALRH 1740
                      ..:|....||.|:|.|:  ::.::....||....              ||..:.|
Zfish  1916 KKKKKKCKTKHSKETSKKLLNAIEGKFKSLFLSVVKNVYRPTWD--------------FFQNILH 1966

  Fly  1741 -KSRLSTDVYTLLFLCDFISFFILLFGFPKFVYRYKYSTSV-LETYIQGNKVPFTFLLMLIVQFI 1803
             :.|.|||||.|:||.|.:.|.|::|||..|   .|:|.:. :.:.:..::||..||:||::||.
Zfish  1967 AEYRASTDVYALMFLTDVVDFIIIIFGFWAF---GKHSAAADIASSLSEDQVPEAFLVMLLIQFS 2028

  Fly  1804 TIVTERAIYLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGETAPV-LFYLIKCLHMLLSA 1867
            |::.:||:||||:::.|:.|..|.|.|||:||||::|.:|...|...:.. |:|..||::..|||
Zfish  2029 TMIIDRALYLRKSILGKLIFQVILVFGIHLWMFFILPAVTERMFNHNSVAQLWYFFKCIYFTLSA 2093

  Fly  1868 YQIRCGYPKRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKMEDIF 1932
            ||||||||.|||||..||.::..|...|:.:..:|||..||.::|||..||||::..|:.:|||:
Zfish  2094 YQIRCGYPTRILGNFLTKKFNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIY 2158

  Fly  1933 QSVFIVRCYRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALV-GTVGKPNIPQ 1996
            .::||::|.|:.:..:|..:|:.|....|..:||.|||.||.:||.||...:|| ..||..|.|.
Zfish  2159 ANIFIIKCSRETEKKYPQPKGQKKKRIVKYGMGGLIILFLICIIWFPLLFISLVKSVVGVVNHPV 2223

  Fly  1997 KADITVKINHYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNYASDSMMLYDAVDVTAIKFYEN 2060
            ...:|||:..|||:: :|.....|..|:.|.:.:|.|....:..|...:.:|...|:.......:
Zfish  2224 DVTVTVKLGGYEPLFTMSVQQQSIQPFTESRYNQLNNQFSKNAVAMQFITMYSYEDIVTANIEGS 2288

  Fly  2061 SISLWNMPPPDKERLLHDL--SNGETLDIHLTLTLKCNL--------TPEAVIYETTYTLT-ENK 2114
            |.|:|.:.||.::.|:.:|  |.|:     :||.|..|.        |.|....:.:.:|. :|.
Zfish  2289 SGSVWRISPPSRQELIKELLSSTGD-----MTLRLDWNFQRDLGKGGTVENTFDKHSISLAPKNP 2348

  Fly  2115 VHTRDKLIRLMSNNFSNEKVIIPNILPKFITVQRQQANAK-----FIKDYDG------KFNRPII 2168
            |  |..|..|:... ..:.|.:|::.|.:|... ..|.||     |..|.:|      ...|...
Zfish  2349 V--RADLASLLLGT-RKDPVHVPHMFPNYIRAP-SGAEAKPVMQLFDGDEEGFQDVTVSLMREAS 2409

  Fly  2169 LTKIGKSQVYWWEMNDYCNDRFYTEILSALPLSNCE---NGVVLYVFNDKSFPSAMSFLEKTGII 2230
            :...|..:  ||:::                :::|:   |.:.:.:||||..|.::.||...||:
Zfish  2410 VNTTGAQE--WWDIS----------------IADCKESCNVLPMIIFNDKVSPPSLGFLAGYGIM 2456

  Fly  2231 GLYTTFVYVVSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYGKLIFL 2295
            |||.:.|.|:.:.:|...:.....||||:||..||:||||.||:|||||.|..|||:||.|||||
Zfish  2457 GLYVSVVLVIGKFVRGFFSEISHSIMFEELPCADRILKLCMDIFLVRETGELELEEELYSKLIFL 2521

  Fly  2296 YRSPETLIKWTRFK 2309
            ||||||:|||||.|
Zfish  2522 YRSPETMIKWTREK 2535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1202..1391 CDD:464941 57/223 (26%)
Piezo_RRas_bdg 1901..2307 CDD:463481 147/432 (34%)
piezo1XP_696355.4 PIEZO 1235..1452 CDD:464941 64/258 (25%)
Piezo_RRas_bdg 2126..2534 CDD:463481 148/434 (34%)

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